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Article ; Online: Secretin receptor-deficient mice exhibit robust food anticipatory activity.

Sugiyama, Mizuki / Nishijima, Ichiko / Nakamura, Wataru / Nakamura, Takahiro J

2022 Volume 772, Page(s) 136462

Abstract: In mammals, the suprachiasmatic nucleus (SCN) is a principal circadian pacemaker that optimizes the timing of behavioral rhythms and physiological events. Normally, circadian behavioral rhythms are entrained by the environmental light-dark (LD) cycle via ...

Abstract	In mammals, the suprachiasmatic nucleus (SCN) is a principal circadian pacemaker that optimizes the timing of behavioral rhythms and physiological events. Normally, circadian behavioral rhythms are entrained by the environmental light-dark (LD) cycle via the SCN. However, daily rhythms of other synchronizing signals, such as food availability, also emerge. When food availability is restricted to a single recurring daytime meal in nocturnal rodents, they exhibit increased activity during the hours immediately preceding feeding time; this is called food anticipatory activity (FAA). Many reports suggest that FAA is mediated by the food-entrainable oscillator (FEO) with circadian properties, but not the SCN. However, the neural locus and timekeeping mechanisms of the FEO, including its relationship with gastrointestinal hormone signaling, remain unclear. Herein, to examine whether secretin receptor signaling is necessary for the FEO, the effect of daily food restriction was studied in secretin receptor-deficient (Sctr
MeSH term(s)	Activity Cycles ; Animals ; Anticipation, Psychological ; Brain/metabolism ; Brain/physiology ; Eating ; Feeding Behavior ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, G-Protein-Coupled/deficiency ; Receptors, G-Protein-Coupled/genetics ; Receptors, Gastrointestinal Hormone/deficiency ; Receptors, Gastrointestinal Hormone/genetics
Chemical Substances	Receptors, G-Protein-Coupled ; Receptors, Gastrointestinal Hormone ; secretin receptor
Language	English
Publishing date	2022-01-18
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2022.136462
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Article ; Online: Diurnal variations of triglyceride accumulation in mouse and bovine adipocyte‐derived cell lines

Shiraishi, Rena / Morita, Satomi / Goto, Yoshikuni / Mizoguchi, Yasushi / Nakamura, Wataru / Nakamura, Takahiro J.

Animal Science Journal. 2022 Jan., v. 93, no. 1 p.e13802-

2022

Abstract: Several studies have suggested a strong interaction between the circadian clock and lipid metabolism in mammals. The circadian clock is driven by endogenous cyclic gene expression patterns, commonly referred to as clock genes, and transcription– ... ...

Abstract	Several studies have suggested a strong interaction between the circadian clock and lipid metabolism in mammals. The circadian clock is driven by endogenous cyclic gene expression patterns, commonly referred to as clock genes, and transcription–translation negative feedback loops. Clock genes regulate the transcription of some lipid metabolism‐related genes; however, the relationship between the circadian clock and triglyceride (TG) accumulation at the cellular level remains unclear. Here, we evaluated rhythms of intracellular TG accumulation levels as well as the expression of clock genes and lipid metabolism‐related genes for 54 h in mouse and bovine adipose‐derived cell cultures. To the best of our knowledge, this study represents the first report demonstrating that TG accumulation exhibits diurnal variations, with the pattern differing among cell types. Furthermore, we found that expression of clock genes and corresponding lipid metabolism‐related genes exhibited circadian rhythms. Our results suggest that the cellular clock regulates lipid metabolism‐related genes to relate circadian rhythms of TG accumulation in each cell type. We anticipate that the amount of fat stored depends on the timing of the supply of glucose‐the precursor of fat. The findings of this study will contribute to the advancement of chrono‐nutrition.
Keywords	animal science ; cattle ; circadian clocks ; eating habits ; gene expression ; lipid metabolism ; mice ; triacylglycerols
Language	English
Dates of publication	2022-01
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2095161-9
ISSN	1740-0929 ; 1344-3941
ISSN (online)	1740-0929
ISSN	1344-3941
DOI	10.1111/asj.13802
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Diurnal variations of triglyceride accumulation in mouse and bovine adipocyte-derived cell lines.

Shiraishi, Rena / Morita, Satomi / Goto, Yoshikuni / Mizoguchi, Yasushi / Nakamura, Wataru / Nakamura, Takahiro J

Animal science journal = Nihon chikusan Gakkaiho

2022 Volume 93, Issue 1, Page(s) e13802

Abstract	Several studies have suggested a strong interaction between the circadian clock and lipid metabolism in mammals. The circadian clock is driven by endogenous cyclic gene expression patterns, commonly referred to as clock genes, and transcription-translation negative feedback loops. Clock genes regulate the transcription of some lipid metabolism-related genes; however, the relationship between the circadian clock and triglyceride (TG) accumulation at the cellular level remains unclear. Here, we evaluated rhythms of intracellular TG accumulation levels as well as the expression of clock genes and lipid metabolism-related genes for 54 h in mouse and bovine adipose-derived cell cultures. To the best of our knowledge, this study represents the first report demonstrating that TG accumulation exhibits diurnal variations, with the pattern differing among cell types. Furthermore, we found that expression of clock genes and corresponding lipid metabolism-related genes exhibited circadian rhythms. Our results suggest that the cellular clock regulates lipid metabolism-related genes to relate circadian rhythms of TG accumulation in each cell type. We anticipate that the amount of fat stored depends on the timing of the supply of glucose-the precursor of fat. The findings of this study will contribute to the advancement of chrono-nutrition.
MeSH term(s)	Cattle ; Animals ; Mice ; Triglycerides ; Circadian Rhythm/genetics ; Circadian Clocks/genetics ; Cell Line ; Adipocytes ; Mammals
Chemical Substances	Triglycerides
Language	English
Publishing date	2022-12-23
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2095161-9
ISSN	1740-0929 ; 1344-3941
ISSN (online)	1740-0929
ISSN	1344-3941
DOI	10.1111/asj.13802
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Article: Oak extracts modulate circadian rhythms of clock gene expression in vitro and wheel-running activity in mice.

Haraguchi, Atsushi / Du, Yao / Shiraishi, Rena / Takahashi, Yuki / Nakamura, Takahiro J / Shibata, Shigenobu

Sleep and biological rhythms

2022 Volume 20, Issue 2, Page(s) 255–266

Abstract: Introduction: In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which coordinates the circadian rhythm and controls locomotor activity rhythms. In addition to SCN cells, the peripheral tissues ... ...

Abstract	Introduction: In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which coordinates the circadian rhythm and controls locomotor activity rhythms. In addition to SCN cells, the peripheral tissues and embryonic fibroblasts also have clock genes, such as Methods: We examined the effects of oak extract and its metabolites (urolithin A [ULT] and ellagic acid [EA]) on clock gene expression rhythms in mouse embryonic fibroblasts (MEFs) and SCN. Furthermore, locomotor activity rhythm was assessed in young and aged mice. Results: Chronic treatment with EA and ULT delayed the phase of PER2::LUC rhythms in SCN explants, and ULT prolonged the period of PER2::LUC rhythms in MEFs in a dose-dependent manner and increased the amplitude of PER2::LUC rhythms in MEFs, though only at low concentrations. Acute treatment with ULT affected the phase of PER2::LUC rhythms in MEFs depending on the concentration and timing of the treatment. In addition, oak extract prolonged the activity time of behavioral rhythms in old mice and tended to increase daily wheel-running revolutions in both young and old mice. Conclusions: These results suggest that oak extract is a novel modulator of the circadian clock in vitro and in vivo. Supplementary information: The online version contains supplementary material available at 10.1007/s41105-021-00365-2.
Language	English
Publishing date	2022-01-20
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2185804-4
ISSN	1479-8425 ; 1446-9235
ISSN (online)	1479-8425
ISSN	1446-9235
DOI	10.1007/s41105-021-00365-2
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Article: Long days restore regular estrous cyclicity in mice lacking circadian rhythms.

Nakamura, Takahiro J / Takasu, Nana N / Sakazume, Sayuri / Matsumoto, Yu / Kawano, Natsuko / Pendergast, Julie S / Yamazaki, Shin / Nakamura, Wataru

Heliyon

2023 Volume 9, Issue 6, Page(s) e16970

Abstract: Many female mammals have recurring cycles of ovulation and sexual behaviors that are regulated by reproductive hormones and confer reproductive success. In addition to sexual behaviors, circadian behavioral rhythms of locomotor activity also fluctuate ... ...

Abstract	Many female mammals have recurring cycles of ovulation and sexual behaviors that are regulated by reproductive hormones and confer reproductive success. In addition to sexual behaviors, circadian behavioral rhythms of locomotor activity also fluctuate across the estrous cycle in rodents. Moreover, there is a bidirectional relationship between circadian rhythms and estrous cyclicity since mice with disrupted circadian rhythms also have compromised estrous cycles resulting in fewer pregnancies. In the present study, we assessed whether extending day length, which alters circadian rhythms, normalizes estrous cyclicity in mice. We found that
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e16970
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Article: Circadian rhythm of PERIOD2::LUCIFERASE expression in the trigeminal ganglion of mice.

Shirakawa, Yukie / Ohno, Sachi N / Yamagata, Kanae A / Kuramoto, Eriko / Oda, Yoshiaki / Nakamura, Takahiro J / Nakamura, Wataru / Sugimura, Mitsutaka

Frontiers in neuroscience

2023 Volume 17, Page(s) 1142785

Abstract: Introduction: The trigeminal nerve conveys delicate sensations such as warmth, pain, and tactile pressure in the oral and facial regions, and most trigeminal afferent cell bodies are located in the trigeminal ganglion. Our previous study has shown that ... ...

Abstract	Introduction: The trigeminal nerve conveys delicate sensations such as warmth, pain, and tactile pressure in the oral and facial regions, and most trigeminal afferent cell bodies are located in the trigeminal ganglion. Our previous study has shown that sensations in trigeminal nerve innervated areas, specifically in the maxillofacial region, exhibit diurnal variation and that sensitivity changes time-dependently. In this study, we aimed to clarify the rhythm of expression of clock gene in the trigeminal ganglion of mice to elucidate the mechanism of circadian regulation in the same area. Methods: Immunohistochemistry examined the expression of the PER2 protein in the suprachiasmatic nucleus and trigeminal ganglion of wild-type mice. To measure gene expression as bioluminescence, PERIOD2::LUCIFERASE knock-in (PER2::LUC) mice were used. Unilateral trigeminal ganglion and brain sections including the suprachiasmatic nucleus were incubated Results: In the trigeminal ganglion, immunohistochemistry localized PER2 protein expression within the neuronal cell body. Mouse trigeminal ganglion Conclusion: The expression of
Language	English
Publishing date	2023-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2023.1142785
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Article ; Online: Diurnal Variation of Brain Activity in the Human Suprachiasmatic Nucleus.

Oka, Satoshi / Ogawa, Akitoshi / Osada, Takahiro / Tanaka, Masaki / Nakajima, Koji / Kamagata, Koji / Aoki, Shigeki / Oshima, Yasushi / Tanaka, Sakae / Kirino, Eiji / Nakamura, Takahiro J / Konishi, Seiki

The Journal of neuroscience : the official journal of the Society for Neuroscience

2024 Volume 44, Issue 8

Abstract: The suprachiasmatic nucleus (SCN) is the central clock for circadian rhythms. Animal studies have revealed daily rhythms in the neuronal activity in the SCN. However, the circadian activity of the human SCN has remained elusive. In this study, to reveal ... ...

Abstract	The suprachiasmatic nucleus (SCN) is the central clock for circadian rhythms. Animal studies have revealed daily rhythms in the neuronal activity in the SCN. However, the circadian activity of the human SCN has remained elusive. In this study, to reveal the diurnal variation of the SCN activity in humans, we localized the SCN by employing an areal boundary mapping technique to resting-state functional images and investigated the SCN activity using perfusion imaging. In the first experiment (
MeSH term(s)	Male ; Animals ; Female ; Humans ; Circadian Rhythm/physiology ; Suprachiasmatic Nucleus/physiology ; Rodentia ; Mammals ; Neurons
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.1730-23.2024
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Article ; Online: Electrophysiological Approaches to Studying the Suprachiasmatic Nucleus.

Michel, Stephan / Nakamura, Takahiro J / Meijer, Johanna H / Colwell, Christopher S

Methods in molecular biology (Clifton, N.J.)

2020 Volume 2130, Page(s) 303–324

Abstract: In mammals, the part of the nervous system responsible for most circadian behavior can be localized to a bilaterally paired structure in the hypothalamus known as the suprachiasmatic nucleus (SCN). Understanding the mammalian circadian system will ... ...

Abstract	In mammals, the part of the nervous system responsible for most circadian behavior can be localized to a bilaterally paired structure in the hypothalamus known as the suprachiasmatic nucleus (SCN). Understanding the mammalian circadian system will require a detailed multilevel analysis of neural SCN circuits ex vivo and in vivo. Many of the techniques and approaches that are used for the analysis of the circuitry driving circadian oscillations in the SCN are similar to those employed in other brain regions. There is, however, one fundamental difference that needs to be taken into consideration, that is, the physiological, cell, and molecular properties of SCN neurons vary with the time of day. In this chapter, we will consider the preparations and electrophysiological techniques that we have used to analyze the SCN circuit focusing on the acute brain slice and intact, freely moving animal.
MeSH term(s)	Animals ; Calcium Signaling ; Circadian Rhythm ; Electroencephalography/instrumentation ; Electroencephalography/methods ; Evoked Potentials ; Mice ; Microelectrodes ; Patch-Clamp Techniques/instrumentation ; Patch-Clamp Techniques/methods ; Suprachiasmatic Nucleus/metabolism ; Suprachiasmatic Nucleus/physiology
Language	English
Publishing date	2020-12-07
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-0381-9_23
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Article ; Online: Modeling circadian regulation of ovulation timing: age-related disruption of estrous cyclicity.

Ohara, Takayuki / Nakamura, Takahiro J / Nakamura, Wataru / Tokuda, Isao T

Scientific reports

2020 Volume 10, Issue 1, Page(s) 16767

Abstract: The circadian clocks within the hypothalamic-pituitary-gonadal axis control estrous cycles in female rodents. The suprachiasmatic nucleus (SCN), where the central clock is located, generates daily signals to trigger surge release of luteinizing hormone ( ... ...

Abstract	The circadian clocks within the hypothalamic-pituitary-gonadal axis control estrous cycles in female rodents. The suprachiasmatic nucleus (SCN), where the central clock is located, generates daily signals to trigger surge release of luteinizing hormone (LH), which in turn induces ovulation. It has been observed in aged rodents that output from the SCN such as neuronal firing activity is declined, and estrous cycles become irregular and finally stop. Circadian clock mutants display accelerated reproductive aging, suggesting the complicated interplay between the circadian system and the endocrine system. To investigate such circadian regulation of estrous cycles, we construct a mathematical model that describes dynamics of key hormones such as LH and of circadian clocks in the SCN and in the ovary, and simulate estrous cycles for various parameter values. Our simulation results demonstrate that reduction of the amplitude of the SCN signal, which is a symptom of aging, makes estrous cycles irregular. We also show that variation in the phase of the SCN signal and changes in the period of ovarian circadian clocks exacerbates the aging effect on estrous cyclicity. Our study suggests that misalignment between the SCN and ovarian circadian oscillations is one of the primary causes of the irregular estrous cycles.
MeSH term(s)	Circadian Clocks/physiology ; Circadian Rhythm/physiology ; Estrous Cycle/physiology ; Female ; Humans ; Models, Theoretical ; Mutation ; Ovulation/physiology ; Period Circadian Proteins/genetics
Chemical Substances	Period Circadian Proteins
Language	English
Publishing date	2020-10-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-73669-x
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Article ; Online: Secretin receptor-deficient mice exhibit altered circadian rhythm in wheel-running activity.

Sugiyama, Mizuki / Nishijima, Ichiko / Miyazaki, Shota / Nakamura, Takahiro J

Neuroscience letters

2020 Volume 722, Page(s) 134814

Abstract: In mammals, the timing of behavior and physiological activity is controlled by the suprachiasmatic nucleus (SCN) in the hypothalamus. Incidentally, secretin is a peptide hormone that promotes digestive activities and regulates water reabsorption. In ... ...

Abstract	In mammals, the timing of behavior and physiological activity is controlled by the suprachiasmatic nucleus (SCN) in the hypothalamus. Incidentally, secretin is a peptide hormone that promotes digestive activities and regulates water reabsorption. In recent studies, exogenous administration of secretin has been reported to induce secretion of oxytocin in the supraoptic nucleus of the hypothalamus and modulate social behavior. These results indicate that secretin is involved in the neural network that controls social behavior and plays important roles in the central nervous system. In the present study, we investigated the effects of secretin on circadian rhythms, by assessing circadian rhythms during wheel-running behavior in secretin receptor-deficient (Sctr
MeSH term(s)	Animals ; Brain/metabolism ; Circadian Rhythm/physiology ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Activity/physiology ; Receptors, G-Protein-Coupled/deficiency ; Receptors, G-Protein-Coupled/genetics ; Receptors, Gastrointestinal Hormone/deficiency ; Receptors, Gastrointestinal Hormone/genetics
Chemical Substances	Receptors, G-Protein-Coupled ; Receptors, Gastrointestinal Hormone ; secretin receptor
Language	English
Publishing date	2020-02-04
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2020.134814
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