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  1. Article: [The Efficacy of Fesoterodine Switched from Solifenacin for Overactive Bladder Patients].

    Nakanishi, Shinichi

    Hinyokika kiyo. Acta urologica Japonica

    2020  Volume 66, Issue 6, Page(s) 165–170

    Abstract: We investigated the efficacy of Fesoterodine, in 51 patients who did not respond to treatment with Solifenacin from January 2017 to December 2018. We assessed the overactive bladder symptom score (OABSS), thirst, constipation, and residual urine at ... ...

    Abstract We investigated the efficacy of Fesoterodine, in 51 patients who did not respond to treatment with Solifenacin from January 2017 to December 2018. We assessed the overactive bladder symptom score (OABSS), thirst, constipation, and residual urine at baseline, as well as at 3 and 6 months from the start of drug administration. The mean age of the patients was 83. 0±6. 55 years. The OABSS indicated significant improvement in urge urinary incontinence and residual urine at 6 months, and significant aggravation in urgency at 3 months. Thus, Fesoterodine is considered useful for patients who did not respond to treatment with Solifenacin.
    MeSH term(s) Benzhydryl Compounds ; Humans ; Muscarinic Antagonists ; Solifenacin Succinate ; Treatment Outcome ; Urinary Bladder, Overactive
    Chemical Substances Benzhydryl Compounds ; Muscarinic Antagonists ; fesoterodine (621G617227) ; Solifenacin Succinate (KKA5DLD701)
    Language Japanese
    Publishing date 2020-06-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604331-8
    ISSN 0018-1994
    ISSN 0018-1994
    DOI 10.14989/ActaUrolJap_66_6_165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Efficacy of mirabegron, a β3-adrenergic agonist, switched from an anticholinergic agent for female patients aged over 70 years].

    Nakanishi, Shinichi

    Hinyokika kiyo. Acta urologica Japonica

    2013  Volume 59, Issue 9, Page(s) 561–564

    Abstract: In the present study, we investigated the efficacy of mirabegron, a β3-adrenergic agonist, in patients aged >70 years who did not respond to treatment with an anticholinergic agent. From February 2012 to May 2012, we examined 37 patients who did not ... ...

    Abstract In the present study, we investigated the efficacy of mirabegron, a β3-adrenergic agonist, in patients aged >70 years who did not respond to treatment with an anticholinergic agent. From February 2012 to May 2012, we examined 37 patients who did not respond to treatment with an anticholinergic agent. We assessed the overactive bladder symptom score (OABSS), thirst, and constipation at baseline, as well as at 3 and 6 months from the start of drug administration. Theme an age of the female patients was 79.9±6.08 years. The OABSS indicated significant improvement in nocturia and urge incontinence at 3 and 6 months. Furthermore, mirabegron significantly relieved thirst (in 95.2% of cases) and constipation (in 87.5% of cases). Thus, mirabegron is considered useful for female patients aged >70 years who did not respond to treatment with an anticholinergic agent.
    MeSH term(s) Acetanilides/administration & dosage ; Adrenergic beta-2 Receptor Agonists/administration & dosage ; Age Factors ; Aged ; Aged, 80 and over ; Cholinergic Antagonists/therapeutic use ; Drug Substitution ; Female ; Humans ; Muscarinic Antagonists/administration & dosage ; Thiazoles/administration & dosage ; Treatment Outcome ; Urinary Bladder, Overactive/drug therapy
    Chemical Substances Acetanilides ; Adrenergic beta-2 Receptor Agonists ; Cholinergic Antagonists ; Muscarinic Antagonists ; Thiazoles ; mirabegron (MVR3JL3B2V)
    Language Japanese
    Publishing date 2013-09
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604331-8
    ISSN 0018-1994
    ISSN 0018-1994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Case of extensive retroperitoneal abscess in a subcutaneous mass].

    Nakanishi, Shinichi / Hatayama, Tadashi

    Hinyokika kiyo. Acta urologica Japonica

    2008  Volume 54, Issue 2, Page(s) 111–113

    Abstract: A 69-year-old woman consulted a doctor for subcutaneous mass and left hydronephrosis. Abdominal CT showed a left retroperitoneal abscess from the left perirenal lesion to the ileocccal region, subcutaneous abscess and left ureteral stone. Percutaneous ... ...

    Abstract A 69-year-old woman consulted a doctor for subcutaneous mass and left hydronephrosis. Abdominal CT showed a left retroperitoneal abscess from the left perirenal lesion to the ileocccal region, subcutaneous abscess and left ureteral stone. Percutaneous drainage and double J stent indwelling was performed. Retrograde pyelography revealed extravasation from upper calyx to perirenal space. The abscess fluid culture proved to be methicillin-resistant Staphylococcus aureus.
    MeSH term(s) Abdominal Abscess/diagnostic imaging ; Abdominal Abscess/surgery ; Aged ; Female ; Humans ; Tomography, X-Ray Computed
    Language Japanese
    Publishing date 2008-02
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 604331-8
    ISSN 0018-1994
    ISSN 0018-1994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Case of fungal endophthalmitis from pyelonephritis caused by ureterolithiasis].

    Nakanishi, Shinichi / Hatayama, Tadashi

    Hinyokika kiyo. Acta urologica Japonica

    2008  Volume 54, Issue 2, Page(s) 115–117

    Abstract: A 63-year-old woman presented with visual disturbance. A fever had been noted for 11 days. Right eye visual acuity was 20/50. Left eye visual acuity was 20/20. Inflammatory cclls wcrc present in the right aqueous and the vitreous humor. Tbc right retina ... ...

    Abstract A 63-year-old woman presented with visual disturbance. A fever had been noted for 11 days. Right eye visual acuity was 20/50. Left eye visual acuity was 20/20. Inflammatory cclls wcrc present in the right aqueous and the vitreous humor. Tbc right retina was edematous. The left retina and left ocular humors were normal. Urinalysis showcd many white blood cells. Urine culture showed Candida albicans. KUB revealed many small ureteral calculi bilaterally. A diagnosis of fungal endophthalmitis due to pyeloncphritis caused by ureterolithiasis was rendered. The paticnt rcccivcd an intravenous course of fosfiuconazole and fluconazole.
    MeSH term(s) Candidiasis/etiology ; Endophthalmitis/etiology ; Female ; Humans ; Middle Aged ; Pyelonephritis/etiology ; Ureterolithiasis/complications
    Language Japanese
    Publishing date 2008-02
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604331-8
    ISSN 0018-1994
    ISSN 0018-1994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Adenocarcinoma of the prostate associated with anti Jo-1 antibody positive polymyositis].

    Nakanishi, Shinichi / Hatayama, Tadasi

    Hinyokika kiyo. Acta urologica Japonica

    2006  Volume 52, Issue 4, Page(s) 289–291

    Abstract: A 76-year-old male was hospitalized with elevation of prostate specific antigen. We closely examined him further because creatine phosphate kinase was found to be 2,841 IU/l in the pre-operative examination. He was positive for anti Jo-1 antibody, and ... ...

    Abstract A 76-year-old male was hospitalized with elevation of prostate specific antigen. We closely examined him further because creatine phosphate kinase was found to be 2,841 IU/l in the pre-operative examination. He was positive for anti Jo-1 antibody, and was found to have muscular atrophy of lower extremities on magnetic resonance imaging, and fibrillation and positive sharp waves on the electromyogram. He was therefore diagnosed with polymyositis. Adenocarcinoma was classified as Gleason score 8 by needle biopsy of the prostate and the stage of the prostate carcinoma was cT3aN1M0. The patient was treated with hormonal ablation and oral steroids.
    MeSH term(s) Adenocarcinoma/complications ; Adenocarcinoma/pathology ; Aged ; Anti-Inflammatory Agents/administration & dosage ; Antibodies, Antinuclear/immunology ; Humans ; Magnetic Resonance Imaging ; Male ; Polymyositis/drug therapy ; Polymyositis/etiology ; Polymyositis/immunology ; Prednisolone/administration & dosage ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/pathology
    Chemical Substances Anti-Inflammatory Agents ; Antibodies, Antinuclear ; Jo-1 antibody ; Prednisolone (9PHQ9Y1OLM)
    Language Japanese
    Publishing date 2006-04
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604331-8
    ISSN 0018-1994
    ISSN 0018-1994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Open adrenalectomy for adrenal metastases from lung cancer--usefulness and problem of laparoscopic adrenalectomy].

    Nakanishi, Shinichi / Hori, Daisuke / Maeda, Sumihiro / Hatayama, Tadashi

    Hinyokika kiyo. Acta urologica Japonica

    2006  Volume 52, Issue 10, Page(s) 757–760

    Abstract: We examined the outcome of open adrenalectomy performed at our hospital to determine the effectiveness and problems of laparoscopic adrenalectomy for adrenal metastases from lung cancer. Between January 2001 and June 2004, eight open adrenalectomies were ...

    Abstract We examined the outcome of open adrenalectomy performed at our hospital to determine the effectiveness and problems of laparoscopic adrenalectomy for adrenal metastases from lung cancer. Between January 2001 and June 2004, eight open adrenalectomies were performed on six patients with adrenal metastases from lung cancer. Surrounding adhesion was observed in five of the eight cases (63%). The recurrence period was 17.8 months and 5.3 months in the cases with and without adhesion, respectively. Laparoscopic adrenalectomy for adrenal metastases may be safe and effective. However, potential surrounding adhesions meed to be adequately considered, if the primary lesion is the lung.
    MeSH term(s) Adenocarcinoma/pathology ; Adrenal Gland Neoplasms/secondary ; Adrenal Gland Neoplasms/surgery ; Adrenalectomy/methods ; Aged ; Carcinoma, Squamous Cell/pathology ; Female ; Humans ; Laparoscopy ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Treatment Outcome
    Language Japanese
    Publishing date 2006-10
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604331-8
    ISSN 0018-1994
    ISSN 0018-1994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Clinical study of stage a prostatic cancer detected incidentally by transurethral resection of the prostate].

    Nakanishi, Shinichi / Gotou, Takayuki / Sawada, Atsurou / Shibasaki, Noboru / Ishitoya, Touru / Okumura, Kazuhiro

    Hinyokika kiyo. Acta urologica Japonica

    2009  Volume 55, Issue 1, Page(s) 5–8

    Abstract: Transurethral resection of the prostate was performed on 584 consecutive patients with clinically diagnosed benign prostatic hyperplasia between April 2001 and July 2007. Pathological examinations revealed prostatic cancer in 30 (5.1%) of them. Seventeen ...

    Abstract Transurethral resection of the prostate was performed on 584 consecutive patients with clinically diagnosed benign prostatic hyperplasia between April 2001 and July 2007. Pathological examinations revealed prostatic cancer in 30 (5.1%) of them. Seventeen patients had stage A1, and 13 stage A2 cancer. Prostatic biopsy was performed on 7 patients. The mean patient age was 69.4 years (range 60-78 years) for stage A1 cancer and 76.6 years (range 62-90 years) for stage A2. The mean serum PSA concentration was 8.9 ng/ml (range 1.18-41.3 ng/ml) for stage A1 cancer and 9.55 ng/ml (range 2.0-23.9 ng/ml) for stage A2. The mean follow-up period was 25.8 months (range 3-82 months) for stage A1 cancer and 27.3 months (range 1-82 months) for stage A2. In stage A1, all patients had a Gleason sum of 6 or less. In stage A2, 11 patients had a Gleason sum of 7 and 2 patients were 8 or more. Total prostatectomy was performed on 2 patients and no therapy on 15 patients with stage A1. Endocrine therapy was given to 1 patient, radiation therapy to 1 patient and no therapy to 11 patients with stage A2. Adjuvant therapy was given to 2 patients with stage A1 and to no one with stage A2. We concluded that PSA monitoring is an option in stage A2 cancer.
    MeSH term(s) Aged ; Aged, 80 and over ; Biomarkers, Tumor/blood ; Combined Modality Therapy ; Humans ; Incidental Findings ; Male ; Middle Aged ; Monitoring, Physiologic ; Neoplasm Staging ; Prostate-Specific Antigen/blood ; Prostatic Hyperplasia/surgery ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Transurethral Resection of Prostate
    Chemical Substances Biomarkers, Tumor ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language Japanese
    Publishing date 2009-01
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604331-8
    ISSN 0018-1994
    ISSN 0018-1994
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  8. Article: [Clinical study of modified M-VAC therapy with one 21-day cycle for advanced urothelial cancer].

    Nakanishi, Shinichi / Matsuzaki, Masato / Morikawa, Hiroshi / Nakano, Masahiro / Komatsu, Hideki

    Hinyokika kiyo. Acta urologica Japonica

    2004  Volume 50, Issue 10, Page(s) 667–671

    Abstract: Although M-VAC therapy is a standard chemotherapy for advanced transitional cell carcinoma, the treatment schedule has to be delayed or cancelled in many patients because of the toxicity. To reduce the toxicity we modified the treatment schedule of M-VAC ...

    Abstract Although M-VAC therapy is a standard chemotherapy for advanced transitional cell carcinoma, the treatment schedule has to be delayed or cancelled in many patients because of the toxicity. To reduce the toxicity we modified the treatment schedule of M-VAC treatment. The dosages of this simplified M-VAC therapy were 30 mg/m2 methotrexate (on day 1), 3 mg/m2 vinblastine (on day 2), 30 mg/m2 doxorubicin (on day 2) and 70 mg/m2 cisplatin (on day 2), with courses repeated every 21 days for four cycles as a principle. Seventeen patients with histologically proven advanced transitional cell carcinoma were treated with this simplified M-VAC therapy without dose modification or delay. The median number of cycles was 4. Neutropenia, anemia and thrombopenia (grade 4) was observed in 2, 1 and 2 patients respectively, but no drug-related deaths were observed. Complete response and partial response were achieved in 2 (12%) and 10 (59%) patients respectively. Of 2 complete responders one patient was alive without evidence of disease at 12 months and another patient died of the disease at 42 months. Of 10 partial responders 6 patients underwent the additional surgical resection of residual tumors. Of these 6 patients 3 patients are alive without evidence of disease at 6, 30 and 31 months. The remaining 3 developed recurrence and 2 died of the disease at 13 and 29 months. Five non-responders died of the disease at 5 months after the start of the therapy. Response rate of simplified M-VAC therapy was excellent and treatment duration was short. However, relapses were commonly observed as well as the original M-VAC treatment.
    MeSH term(s) Aged ; Anemia/chemically induced ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/secondary ; Cisplatin/administration & dosage ; Cisplatin/adverse effects ; Doxorubicin/administration & dosage ; Doxorubicin/adverse effects ; Drug Administration Schedule ; Female ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Male ; Methotrexate/administration & dosage ; Methotrexate/adverse effects ; Middle Aged ; Neutropenia/chemically induced ; Thrombocytopenia/chemically induced ; Urologic Neoplasms/drug therapy ; Urologic Neoplasms/pathology ; Vinblastine/administration & dosage ; Vinblastine/adverse effects
    Chemical Substances Vinblastine (5V9KLZ54CY) ; Doxorubicin (80168379AG) ; Cisplatin (Q20Q21Q62J) ; Methotrexate (YL5FZ2Y5U1)
    Language Japanese
    Publishing date 2004-10
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604331-8
    ISSN 0018-1994
    ISSN 0018-1994
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  9. Article: Management of concomitant ureteral carcinoma in situ at radical cystectomy.

    Nakanishi, Shinichi / Nishiyama, Hiroyuki / Ito, Masaaki / Yoshimura, Koji / Kamoto, Toshiyuki / Ogawa, Osamu

    International journal of urology : official journal of the Japanese Urological Association

    2006  Volume 13, Issue 5, Page(s) 524–528

    Abstract: Objective: We conducted a retrospective study to evaluate and define the management of concomitant ureteral carcinoma in situ (CIS) at radical cystectomy.: Methods: For 158 consecutive patients, who underwent radical cystectomy for invasive bladder ... ...

    Abstract Objective: We conducted a retrospective study to evaluate and define the management of concomitant ureteral carcinoma in situ (CIS) at radical cystectomy.
    Methods: For 158 consecutive patients, who underwent radical cystectomy for invasive bladder cancer, ureteral CIS missed by preoperative examinations were evaluated by intraoperative analysis of frozen sections or postoperative histological analysis. The median follow-up period was 3.4 years.
    Results: In total, 15 concomitant ureteral CIS were diagnosed by intraoperative (n=9) or postoperative analysis (n=6). Additional ureteral resection achieved no malignancies in the final ureteral margins of eight patients. During the follow-up period, five patients (3.6%) suffered from tumor recurrence in the upper urinary tract in total, as did three (20%) among the 15 patients with ureteral CIS missed by preoperative examinations. No recurrence was identified in the eight patients with no malignancy in the final ureteral margins after additional resection. Furthermore, multivariate analysis indicated that the presence of bladder CIS was a risk factor for the presence of concomitant ureteral CIS.
    Conclusions: Detection of concomitant ureteral CIS by intraoperative studies, in combination with complete resection of ureteral CIS, might be beneficial for patients with risk factors such as bladder CIS.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cystectomy ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Risk Factors ; Ureteral Neoplasms/pathology ; Ureteral Neoplasms/surgery
    Language English
    Publishing date 2006-05
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1328401-0
    ISSN 0919-8172
    ISSN 0919-8172
    DOI 10.1111/j.1442-2042.2006.01349.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Prostate cancer with penile metastasis: a case report].

    Sawada, Atsuro / Segawa, Takehiko / Nakanishi, Shinichi / Kinoshita, Hidefumi / Yamamoto, Shingo / Kamoto, Toshiyuki / Ogawa, Osamu

    Hinyokika kiyo. Acta urologica Japonica

    2005  Volume 51, Issue 11, Page(s) 771–773

    Abstract: A 77-year-old man presented with complaints of dysuria, nocturia and painless nodule on his penis. Laboratory examination revealed elevated serum prostate-specific antigen (PSA) and CA19-9. Pathological examinations on prostate and penile biopsy ... ...

    Abstract A 77-year-old man presented with complaints of dysuria, nocturia and painless nodule on his penis. Laboratory examination revealed elevated serum prostate-specific antigen (PSA) and CA19-9. Pathological examinations on prostate and penile biopsy specimens revealed prostate adenocarcinoma with penile metastasis. The patient was diagnosed as having prostate cancer stage D2 (T4N1M1) with bone, lymph node and penile metastases. There was no response to initial hormonal therapy with the surgical castration and diethylstilbestrol. However, decrease of the tumor size, as well as PSA and CA19-9 values were achieved after the combined chemotherapy with Estramustine, Paclitaxel and Carboplatin.
    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/secondary ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/blood ; CA-19-9 Antigen/blood ; Carboplatin/administration & dosage ; Combined Modality Therapy ; Estramustine/administration & dosage ; Humans ; Male ; Orchiectomy ; Paclitaxel/administration & dosage ; Penile Neoplasms/drug therapy ; Penile Neoplasms/secondary ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology
    Chemical Substances Biomarkers, Tumor ; CA-19-9 Antigen ; Estramustine (35LT29625A) ; Carboplatin (BG3F62OND5) ; Prostate-Specific Antigen (EC 3.4.21.77) ; Paclitaxel (P88XT4IS4D)
    Language Japanese
    Publishing date 2005-11
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604331-8
    ISSN 0018-1994
    ISSN 0018-1994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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