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Article ; Online: Septic acute kidney injury: a review of basic research.

Nakano, Daisuke

2020 Volume 24, Issue 12, Page(s) 1091–1102

Abstract: Sepsis is a major cause of acute kidney injury (AKI) among patients in the intensive care unit. However, the numbers of basic science papers for septic AKI account for only 1% of all publications on AKI. This may be partially attributable to the specific ...

Abstract	Sepsis is a major cause of acute kidney injury (AKI) among patients in the intensive care unit. However, the numbers of basic science papers for septic AKI account for only 1% of all publications on AKI. This may be partially attributable to the specific pathophysiology of septic AKI as compared to that of the other types of AKI because it shows only modest histological changes despite functional decline and often requires real-time functional analysis. To increase the scope of research in this field, this article reviews the basic research information that has been reported thus far on the subject of septic AKI, mainly from the viewpoint of functional dysregulation, including some knowledge acquired with multiphoton intravital imaging. Moreover, the efficacy and limitation of the potential novel therapies are discussed. Finally, the author proposes several points that should be considered when designing the study, such as monitoring the long-term effects of the intervention and reflecting the clinical settings for identifying the molecular mechanisms and for challenging the intervention effects.
MeSH term(s)	Acute Kidney Injury/etiology ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/therapy ; Animals ; Glomerular Filtration Rate ; Humans ; Kidney/blood supply ; Microcirculation ; Prognosis ; Renal Circulation ; Risk Factors ; Sepsis/complications ; Sepsis/physiopathology ; Sepsis/therapy
Language	English
Publishing date	2020-08-11
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-020-01951-3
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Article: [Protective role of SGLT2 inhibition against the kidney disease].

Nakano, Daisuke / Kitada, Kento

Nihon yakurigaku zasshi. Folia pharmacologica Japonica

2021 Volume 156, Issue 3, Page(s) 157–160

Abstract: Physiologically, urine from the subject with normal kidney function does not contain detectable level of glucose unless otherwise renal glycosuria. Sodium glucose transporter (SGLT) families in proximal tubules of the kidney play detrimental role to ... ...

Abstract	Physiologically, urine from the subject with normal kidney function does not contain detectable level of glucose unless otherwise renal glycosuria. Sodium glucose transporter (SGLT) families in proximal tubules of the kidney play detrimental role to reabsorb the filtered glucose. Recently, the inhibitors for the SGLT2 are available for clinical use for purposing the urinary glucose excretion and lowering blood glucose level. Unexpectedly, the SGLT2 inhibitors have become famous for its cardio-renal protective effects with unknown mechanism. We have so far explored how its inhibition changes cell fate, how the drug affects glucose uptake in non-diabetic kidney, and if the drug suppresses the development of fibrosis. In this review, we will summarize our findings and provide the remaining questions.
MeSH term(s)	Blood Glucose ; Diabetes Mellitus, Type 2 ; Glucose ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Kidney ; Kidney Diseases/drug therapy ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology
Chemical Substances	Blood Glucose ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors ; Glucose (IY9XDZ35W2)
Language	Japanese
Publishing date	2021-05-05
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1097532-9
ISSN	1347-8397 ; 0015-5691
ISSN (online)	1347-8397
ISSN	0015-5691
DOI	10.1254/fpj.21005
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Article: Experimental models for acute kidney injury.

Nakano, Daisuke

Nihon yakurigaku zasshi. Folia pharmacologica Japonica

2016 Volume 148, Issue 3, Page(s) 163

MeSH term(s)	Acute Kidney Injury ; Animals ; Disease Models, Animal ; Humans
Language	Japanese
Publishing date	2016
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1097532-9
ISSN	1347-8397 ; 0015-5691
ISSN (online)	1347-8397
ISSN	0015-5691
DOI	10.1254/fpj.148.163
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Article: Erythropoietin-producing cells.

Nakano, Daisuke

Nihon yakurigaku zasshi. Folia pharmacologica Japonica

2016 Volume 148, Issue 5, Page(s) 281

MeSH term(s)	Animals ; Erythropoietin/biosynthesis ; Humans
Chemical Substances	Erythropoietin (11096-26-7)
Language	Japanese
Publishing date	2016
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1097532-9
ISSN	1347-8397 ; 0015-5691
ISSN (online)	1347-8397
ISSN	0015-5691
DOI	10.1254/fpj.148.281
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Article: Characteristics of diurnal and seasonal changes in fish detection patterns using environmental DNA metabarcoding in a mountain stream

Suzuki, Jumpei / Nakano, Daisuke / Kobayashi, Soh

Limnologica. 2022 Mar., v. 93

2022

Abstract: Environmental DNA (eDNA) techniques can be used to help monitor the presence of aquatic organisms without causing a disturbance and are expected to become useful tools in aquatic environmental monitoring. The results of eDNA techniques are largely ... ...

Abstract	Environmental DNA (eDNA) techniques can be used to help monitor the presence of aquatic organisms without causing a disturbance and are expected to become useful tools in aquatic environmental monitoring. The results of eDNA techniques are largely affected by the sampling method used. Few studies have investigated the effects of diurnal and seasonal changes on the detection of fish species using eDNA metabarcoding. In this study, diurnal (i.e., day, sunset, night, and sunrise) and seasonal (i.e., June, September, and December 2017 and April 2018) eDNA samplings were collected from a mountain stream, the Akabira River. The relationship between the number of analysed samples and the number of detected fish species, which was calculated using fish incidence data derived from eDNA metabarcoding, exhibited diurnal changes. In particular, a higher number of fish species were detected across all the seasons in the samples collected at night. Species with a low relative sequencing read abundance may be sensitive to diurnal changes. The detection frequencies of fish species and the total number of detected species in each season also demonstrated seasonal changes. In September and December, the number of detected fish species was higher than that in June and April. The community composition also showed seasonal changes based on detection frequencies, as determined by eDNA metabarcoding. The river environment and the spawning season possibly contribute to the success or failure of species detection using eDNA metabarcoding. Therefore, it is important to consider seasonal and diurnal changes when performing eDNA metabarcoding in mountain streams.
Keywords	DNA barcoding ; community structure ; environmental DNA ; fish ; rivers ; streams
Language	English
Dates of publication	2022-03
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	3380-7
ISSN	0075-9511
ISSN	0075-9511
DOI	10.1016/j.limno.2022.125955
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Article ; Online: Sodium/glucose cotransporter 2 and renoprotection: From the perspective of energy regulation and water conservation.

Kitada, Kento / Kidoguchi, Satoshi / Nakano, Daisuke / Nishiyama, Akira

Journal of pharmacological sciences

2021 Volume 147, Issue 3, Page(s) 245–250

Abstract: Sodium/glucose cotransporter 2 (SGLT2) is a renal low-affinity high-capacity sodium/glucose cotransporter expressed in the apical membrane of the early segment of proximal tubules. SGLT2 reabsorbs filtered glucose in the kidney, and its inhibitors ... ...

Abstract	Sodium/glucose cotransporter 2 (SGLT2) is a renal low-affinity high-capacity sodium/glucose cotransporter expressed in the apical membrane of the early segment of proximal tubules. SGLT2 reabsorbs filtered glucose in the kidney, and its inhibitors represent a new class of oral medications used for type 2 diabetes mellitus, which act by increasing glucose and sodium excretion in urine, thereby reducing blood glucose levels. However, clinical trials showed marked improvement of renal outcomes, even in nondiabetic kidney diseases, although the underlying mechanism of this renoprotective effect is unclear. We showed that long-term excretion of salt by the kidneys, which predisposes to osmotic diuresis and water loss, induces a systemic body response for water conservation. The energy-intensive nature of water conservation leads to a reprioritization of systemic body energy metabolism. According to current data, use of SGLT2 inhibitors may result in similar reprioritization of energy metabolism to prevent dehydration. In this review article, we discuss the beneficial effects of SGLT2 inhibition from the perspective of energy metabolism and water conservation.
MeSH term(s)	Administration, Oral ; Body Water/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Diuresis ; Energy Metabolism/drug effects ; Glucose/metabolism ; Humans ; Hypoglycemic Agents ; Kidney/metabolism ; Kidney Tubules, Proximal/metabolism ; Malus/chemistry ; Osmosis ; Phlorhizin/administration & dosage ; Phlorhizin/pharmacology ; Phytotherapy ; Sodium/metabolism ; Sodium/urine ; Sodium-Glucose Transporter 2/metabolism ; Sodium-Glucose Transporter 2/physiology
Chemical Substances	Hypoglycemic Agents ; SLC5A2 protein, human ; Sodium-Glucose Transporter 2 ; Sodium (9NEZ333N27) ; Phlorhizin (CU9S17279X) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2021-08-05
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1016/j.jphs.2021.07.006
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Article ; Online: Hazard function analysis of prognosis after recurrent colorectal cancer.

Ise, Ichiro / Kawai, Kazushige / Nakano, Daisuke / Takao, Misato / Natsume, Soichiro / Kato, Hiroki / Nakamori, Sakiko / Dejima, Akira / Yamaguchi, Tatsuro

Langenbeck's archives of surgery

2024 Volume 409, Issue 1, Page(s) 123

Abstract: Background and objectives: Mean survival time (MST) is used as the indicator of prognosis in patients with a colorectal cancer (CRC) recurrence. The present study aimed to visualize the changes in death risk after a CRC recurrence using hazard function ... ...

Abstract	Background and objectives: Mean survival time (MST) is used as the indicator of prognosis in patients with a colorectal cancer (CRC) recurrence. The present study aimed to visualize the changes in death risk after a CRC recurrence using hazard function analysis (HFA) to provide an alternative prognostic indicator to MST. Methods: The medical records of 725 consecutive patients with a recurrence following R0 radical surgery for CRC were retrospectively reviewed. Results: The five-year, post-recurrence survival rate was 37.8%, and the MST was 3.5 years while the risk of death peaked at 2.9 years post-recurrence. Seven variables were found to predict short-term survival, including the number of metastatic organs ≥ 2, non-surgical treatment for the recurrence, and a short interval before recurrence. In patients with a recurrence in one organ, the MST was four years, the peak time of death predicted by HFA was 2.9 years, and the five-year survival rate was 45.8%. In patients with a surgical resection of the recurrence, the MST was 8 years, the peak time of death was 3.3 years, and the five-year survival rate was 62%. Conclusions: The present study established a novel method of assessing changes in mortality risk over time using HFA in patients with a CRC recurrence.
MeSH term(s)	Humans ; Retrospective Studies ; Prognosis ; Colorectal Neoplasms/surgery
Language	English
Publishing date	2024-04-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-024-03308-w
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Article ; Online: Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (VIII): six new withanolides from Physalis philadelphica.

Nakano, Daisuke / Ishitsuka, Kenji / Deishi, Yurie / Tsuchihashi, Ryota / Kinjo, Junei / Nohara, Toshihiro / Okawa, Masafumi

Journal of natural medicines

2023 Volume 77, Issue 4, Page(s) 688–698

Abstract: Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature peripheral T-lymphocytes caused by human T-cell leukemia virus type I (HTLV-I). There are an estimated 5-20 million HTLV-1-infected individuals worldwide. Conventional chemotherapeutic ... ...

Abstract	Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature peripheral T-lymphocytes caused by human T-cell leukemia virus type I (HTLV-I). There are an estimated 5-20 million HTLV-1-infected individuals worldwide. Conventional chemotherapeutic regimens used against other malignant lymphomas have been administered to patients with ATL, but the therapeutic outcomes of acute and lymphoma-type ATL remain extremely poor. In the course of our screening program for novel chemotherapeutic candidate compounds from plants against two human T-cell leukemia virus I-infected T-cell lines (MT-1 and MT-2), we screened 16 extracts obtained from different parts of 7 Solanaceae plants. We identified that the extracts of Physalis pruinosa and P. philadelphica showed potent anti-proliferative activity in MT-1 and MT-2 cells. In our previous study, we have isolated withanolides from extract of aerial parts of P. pruinosa and examined their structure-activity relationships. In addition, we are also investigating further structure-activity relationships about other withanolides from Solanaceae plants (Withania somnifera, Withania coagulans, Physalis angulate, Nicandra physalodes, Petunia hybrida, and Solanum cilistum). In this study, we attempted to isolate their active compounds against MT-1 and MT-2 from extracts of P. philadelphica. We identified 13 withanolides, including six newly isolated compounds [24R, 25S-4β, 16β, 20R-trihydroxy-1-oxowitha-2-en-5β, 6 β -epoxy-22,26-olide (1), 4β, 7β,20R-trihydroxy-1-oxowitha-2-en-5β, 6β -epoxy-22,26-olide (2), 17β,20 S-dihydroxywithanone (3), 2,3-dihydro-3β-methoxy-23β-hydroxywithaphysacarpin (4), 3-O-(4-rhamnosyl)glucosyl-physalolactone B (5), and 17R, 20R, 22S, 23S, 24R, 25R-4β, 5α, 6β, 20β, 22α -tetrahydroxy-16β, 23-diepoxy-1-oxowitha-2-en-26, 23-olide (6)], from the extract and examined the structure-activity relationships. The 50% effective concentration of withaphysacarpin (compound 7) [MT-1: 0.10 µM and MT-2: 0.04 µM] was comparable to that of etoposide [MT-1: 0.08 µM and MT-2: 0.07 µM]. Therefore, withanolides might be promising candidates for the treatment of ATL.
MeSH term(s)	Humans ; Withanolides/pharmacology ; Physalis ; Leukemia-Lymphoma, Adult T-Cell/drug therapy ; Structure-Activity Relationship ; Solanaceae ; Plant Extracts/pharmacology
Chemical Substances	Withanolides ; Plant Extracts
Language	English
Publishing date	2023-05-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2227540-X
ISSN	1861-0293 ; 1340-3443
ISSN (online)	1861-0293
ISSN	1340-3443
DOI	10.1007/s11418-023-01705-x
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Article ; Online: A novel role of renin inhibitor in the complement cascade.

Nakano, Daisuke / Nishiyama, Akira

Kidney international

2018 Volume 94, Issue 4, Page(s) 650–652

Abstract: Aberrant regulation of an alternative pathway of the complement system could be a therapeutic target of C3 glomerulopathy, including dense deposit disease. In the current issue, Békássy and colleagues provide data on enzymatic conversion of C3 by renin ... ...

Abstract	Aberrant regulation of an alternative pathway of the complement system could be a therapeutic target of C3 glomerulopathy, including dense deposit disease. In the current issue, Békássy and colleagues provide data on enzymatic conversion of C3 by renin in vitro and on the efficacy of a direct renin inhibitor, aliskiren, on systemic and renal complement activation in patients with dense deposit disease.
MeSH term(s)	Amides ; Complement Activation ; Complement C3 ; Complement Pathway, Alternative ; Fumarates ; Glomerulonephritis, Membranoproliferative ; Humans ; Renin
Chemical Substances	Amides ; Complement C3 ; Fumarates ; aliskiren (502FWN4Q32) ; Renin (EC 3.4.23.15)
Language	English
Publishing date	2018-09-19
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2018.05.025
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Article ; Online: Luseogliflozin, a SGLT2 Inhibitor, Does Not Affect Glucose Uptake Kinetics in Renal Proximal Tubules of Live Mice.

Zhang, Anqi / Nakano, Daisuke / Kittikulsuth, Wararat / Yamashita, Yuka / Nishiyama, Akira

International journal of molecular sciences

2021 Volume 22, Issue 15

Abstract: Proximal tubules (PTs) take up most of the glucose in the glomerular filtrate and return it to peritubular capillary blood. Sodium-glucose cotransporter 2 (SGLT2) at the apical membrane takes up glucose into the cell. Glucose then flows across the cells ... ...

Abstract	Proximal tubules (PTs) take up most of the glucose in the glomerular filtrate and return it to peritubular capillary blood. Sodium-glucose cotransporter 2 (SGLT2) at the apical membrane takes up glucose into the cell. Glucose then flows across the cells and is transported to the interstitium via glucose transporter 2 (GLUT2) at the basolateral membrane. However, glucose transport under SGLT2 inhibition remains poorly understood. In this study, we evaluated the dynamics of a fluorescent glucose analog, 2-NBDG, in the PTs of live mice treated with or without the SGLT2 inhibitor, luseogliflozin. We employed real-time multiphoton microscopy, in which insulin enhanced 2-NBDG uptake in skeletal muscle. Influx and efflux of 2-NBDG in PT cells were compared under hypo-, normo-, and hyperglycemic conditions. Luseogliflozin did not exert significant effects on glucose influx parameters under any level of blood glucose. Our results suggest that blood glucose level per se does not alter glucose influx or efflux kinetics in PTs. In conclusion, neither SGLT2 inhibition nor blood glucose level affect glucose uptake kinetics in PTs. The former was because of glucose influx through basolateral GLUT2, which is an established bidirectional transporter.
MeSH term(s)	Animals ; Biological Transport/drug effects ; Blood Glucose/drug effects ; Cell Line ; Glucose/metabolism ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism ; Mice ; Mice, Inbred C57BL ; Sorbitol/analogs & derivatives ; Sorbitol/pharmacology
Chemical Substances	Blood Glucose ; Sorbitol (506T60A25R) ; 1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol (C596HWF74Z) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2021-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22158169
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