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  1. Article ; Online: Novel technique for cognitive magnetic resonance imaging-transperineal ultrasound fusion transperineal prostate biopsy with injection of bubbled jelly into urethra after abdominoperineal excision.

    Miyajima, Keiichiro / Urabe, Fumihiko / Nakano, Juria / Iwatani, Kosuke / Tashiro, Kojiro / Tsuzuki, Shunsuke / Sato, Shun / Takahashi, Hiroyuki / Kimura, Takahiro / Miki, Kenta

    IJU case reports

    2023  Volume 6, Issue 6, Page(s) 365–369

    Abstract: Introduction: Prostate biopsy is commonly performed using a transrectal ultrasound probe through a transrectal or transperineal approach. However, this is not possible for patients without a rectum.: Case presentation: A 75-year-old male was referred ...

    Abstract Introduction: Prostate biopsy is commonly performed using a transrectal ultrasound probe through a transrectal or transperineal approach. However, this is not possible for patients without a rectum.
    Case presentation: A 75-year-old male was referred to our hospital because of an elevated prostate-specific antigen and a suspicious prostate lesion (PIRADS 5) in the left peripheral zone. The patient had previously undergone abdominoperineal resection for rectal cancer, which excluded the use of transrectal ultrasound. We describe the use of the transperineal ultrasound-guided biopsy with cognitive magnetic resonance imaging-transperineal ultrasound fusion and the utility of the injection of bubbled lidocaine jelly into urethra to improve its visualization. The pathological findings revealed clinically significant cancer with a Gleason score of 5 + 4.
    Conclusion: Cognitive magnetic resonance imaging-transperineal ultrasound fusion transperineal prostate biopsy with injection of bubbled jelly into urethra is a feasible and practical technique that does not require any specialized equipment.
    Language English
    Publishing date 2023-08-14
    Publishing country Australia
    Document type Case Reports
    ISSN 2577-171X
    ISSN (online) 2577-171X
    DOI 10.1002/iju5.12624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effectiveness of Magnetic Resonance Imaging/Ultrasound-guided Target Biopsy in Detecting Clinically Significant Prostate Cancer.

    Kurokawa, Gaku / Mori, Keiichiro / Sasaki, Hiroshi / Nakano, Juria / Takahashi, Yusuke / Iwatani, Kosuke / Urabe, Fumihiko / Tsuzuki, Shunsuke / Koike, Yusuke / Sato, Shun / Takahashi, Hiroyuki / Miki, Kenta / Kimura, Takahiro

    Anticancer research

    2024  Volume 44, Issue 2, Page(s) 679–686

    Abstract: Background/aim: To evaluate the effectiveness of magnetic resonance imaging/ultrasound (MRI-US)-guided fusion biopsy in the detection of clinically significant prostate cancer (CSPC) and analyze the clinical features of patients highly suspected of ... ...

    Abstract Background/aim: To evaluate the effectiveness of magnetic resonance imaging/ultrasound (MRI-US)-guided fusion biopsy in the detection of clinically significant prostate cancer (CSPC) and analyze the clinical features of patients highly suspected of having prostate cancer (PCa) but shown to be negative in target biopsies (TB) among patients with prostate imaging reporting and data system (PI-RADS) 4 or 5 lesions on multiparametric MRI (mpMRI) evaluations.
    Patients and methods: We retrospectively evaluated all patients who underwent MRI/transrectal ultrasound (TRUS)-guided fusion biopsies at our institution between April 2018 and April 2022. All patients with at least one PI-RADS 3 or higher lesion and prostate-specific antigen (PSA) ≤20 ng/ml were enrolled in our study and subjected to TB in the region of interest (ROI). CSPC was defined as grade group (GG) ≥2 (equivalent to a Gleason score of 3+4).
    Results: The detection rates of CSPC were higher in patients who underwent systematic biopsy (SB) and TB (54%; 177/328) than in those who underwent SB alone (39%; 128/328). Significant differences were noted in the detection of CSPC depending on age, prostate volume, PI-RADS score, PSA density (PSAD), number of biopsies obtained, lesion location, and ROI.
    Conclusion: MRI/TRUS-guided fusion prostate biopsy increased the detection rate of CSPC. PCa was less likely to be detected in patients with a low PSAD, large prostate volume and no family history among those with PI-RADS 4 or 5 lesions and should be considered in such patients and addressed by performing additional SB for improving CSPC detection rate.
    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Prostate-Specific Antigen ; Retrospective Studies ; Image-Guided Biopsy/methods ; Ultrasonography, Interventional/methods
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2024-02-02
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1642: Show issues Location:
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  3. Article ; Online: The clinical impact of ureteroscopy for upper tract urothelial carcinoma: A multicenter study.

    Nakano, Juria / Urabe, Fumihiko / Kiuchi, Yuria / Takamizawa, Shigeyoshi / Suzuki, Hirotaka / Kawano, Shota / Miyajima, Keiichiro / Fukuokaya, Wataru / Takahashi, Kazuhiro / Iwatani, Kosuke / Imai, Yu / Kayano, Sotaro / Aikawa, Koichi / Yanagisawa, Takafumi / Tashiro, Kojiro / Yuen, Steffi / Sato, Shun / Tsuzuki, Shunsuke / Miki, Jun /
    Kimura, Takahiro

    International journal of urology : official journal of the Japanese Urological Association

    2023  Volume 31, Issue 4, Page(s) 394–401

    Abstract: Background: With the development of kidney-sparing surgery and neoadjuvant chemotherapy, ureteroscopic biopsy (URSBx) has become important for the management of upper tract urothelial carcinoma (UTUC).: Methods: We retrospectively analyzed data from ... ...

    Abstract Background: With the development of kidney-sparing surgery and neoadjuvant chemotherapy, ureteroscopic biopsy (URSBx) has become important for the management of upper tract urothelial carcinoma (UTUC).
    Methods: We retrospectively analyzed data from 744 patients with UTUC who underwent radical nephroureterectomy (RNU), stratified into no ureteroscopy (URS), URS alone, and URSBx groups. Intravesical recurrence-free survival (IVRFS) was examined using the Kaplan-Meier method. We conducted Cox regression analyses to identify risk factors for IVR. We investigated differences between clinical and pathological staging to assess the ability to predict the pathological tumor stage and grade of RNU specimens.
    Results: Kaplan-Meier curves and multivariate Cox regression revealed significantly more IVR and inferior IVRFS in patients who underwent URS and URSBx. Superficial, but not invasive, bladder cancer recurrence was more frequent in the URS and URSBx groups than in the no URS group. Clinical and pathological staging agreed for 55 (32.4%) patients. Downstaging occurred for 48 (28.2%) patients and clinical understaging occurred for 67 (39.4%) patients. Upstaging to muscle-invasive disease occurred for 39 (35.8%) of 109 patients with ≤cT1 disease. Clinical and pathological grading were similar for 72 (42.3%) patients. Downgrading occurred for 5 (2.9%) patients, and clinical undergrading occurred for 93 (54.7%) patients.
    Conclusion: URS and URSBx instrumentation will be risk factors for superficial, but not invasive, bladder cancer recurrence. Clinical understaging/undergrading and upstaging to muscle-invasive disease occurred for a large proportion of patients with UTUC who underwent RNU. These data emphasize the challenges involved in accurate UTUC staging and grading.
    MeSH term(s) Humans ; Urinary Bladder Neoplasms/surgery ; Carcinoma, Transitional Cell/surgery ; Carcinoma, Transitional Cell/etiology ; Ureteroscopy/adverse effects ; Ureteroscopy/methods ; Retrospective Studies ; Nephrectomy/methods ; Ureteral Neoplasms/surgery ; Ureteral Neoplasms/pathology ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/pathology
    Language English
    Publishing date 2023-12-27
    Publishing country Australia
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1328401-0
    ISSN 1442-2042 ; 0919-8172
    ISSN (online) 1442-2042
    ISSN 0919-8172
    DOI 10.1111/iju.15375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4460: Show issues Location:
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    Zs.MO 278: Show issues

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  4. Article ; Online: Comparison of neoadjuvant and adjuvant chemotherapy for upper tract urothelial carcinoma in real-world practice: a multicenter retrospective study.

    Takahashi, Kazuhiro / Urabe, Fumihiko / Suhara, Yushi / Nakano, Juria / Yoshihara, Kentaro / Goto, Yuma / Sadakane, Ibuki / Koike, Yuhei / Yata, Yuji / Suzuki, Hirotaka / Kurawaki, Shiro / Miyajima, Keiichiro / Iwatani, Kosuke / Imai, Yu / Sakanaka, Keigo / Nakazono, Minoru / Kurauchi, Takashi / Kayano, Sotaro / Onuma, Hajime /
    Aikawa, Koichi / Yanagisawa, Takafumi / Tashiro, Kojiro / Tsuzuki, Shunsuke / Koike, Yusuke / Furuta, Akira / Miki, Jun / Kimura, Takahiro

    Japanese journal of clinical oncology

    2023  Volume 53, Issue 12, Page(s) 1208–1214

    Abstract: Background: Multiple studies have demonstrated the effectiveness of neoadjuvant chemotherapy and adjuvant chemotherapy in patients with upper tract urothelial carcinoma compared with surgery alone. However, no clinical trial has established the ... ...

    Abstract Background: Multiple studies have demonstrated the effectiveness of neoadjuvant chemotherapy and adjuvant chemotherapy in patients with upper tract urothelial carcinoma compared with surgery alone. However, no clinical trial has established the superiority of neoadjuvant chemotherapy or adjuvant chemotherapy in terms of perioperative outcomes.
    Methods: We conducted a retrospective analysis encompassing 164 upper tract urothelial carcinoma patients who underwent radical nephroureterectomy and received perioperative chemotherapy. Of these patients, 65 (39.6%) and 99 (60.4%) received neoadjuvant chemotherapy and adjuvant chemotherapy, respectively. Recurrence-free survival and cancer-specific survival were computed using the Kaplan-Meier method. Additionally, we conducted Cox regression analyses to evaluate the risk factors for recurrence-free survival and cancer-specific survival.
    Results: Pathological downstaging was seen in 37% of the neoadjuvant chemotherapy group. However, no pathological complete response was observed in this cohort. The Kaplan-Meier curves demonstrated significantly lower recurrence-free survival and cancer-specific survival in patients who received adjuvant chemotherapy. Multivariate Cox regression analysis revealed patients treated with adjuvant chemotherapy exhibited a marked association with inferior recurrence-free survival and cancer-specific survival.
    Conclusion: Our study has suggested that neoadjuvant chemotherapy would be more effective in high-risk upper tract urothelial carcinoma patients compared with adjuvant chemotherapy.
    MeSH term(s) Humans ; Urinary Bladder Neoplasms/pathology ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/surgery ; Carcinoma, Transitional Cell/pathology ; Retrospective Studies ; Neoadjuvant Therapy ; Chemotherapy, Adjuvant ; Ureteral Neoplasms/drug therapy ; Ureteral Neoplasms/surgery ; Ureteral Neoplasms/pathology
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 190978-2
    ISSN 1465-3621 ; 0368-2811
    ISSN (online) 1465-3621
    ISSN 0368-2811
    DOI 10.1093/jjco/hyad118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1298: Show issues Location:
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