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  1. Article ; Online: Fluorescent-Oxaboroles: Synthesis and Optical Property by Sugar Recognition.

    Nakano, Misaki / Nakamura, Rikako / Sumida, Yuto / Nagao, Kazunori / Furuyama, Taniyuki / Inagaki, Fuyuhiko / Ohmiya, Hirohisa

    Chemical & pharmaceutical bulletin

    2021  Volume 69, Issue 6, Page(s) 526–528

    Abstract: The optical property of fluorescent unit-conjugated aliphatic oxaboroles has been investigated. The oxaboroles provide good fluorescence quantum yields and selective recognition toward D-ribose and D-ribose containing molecules. The molecular recognition ...

    Abstract The optical property of fluorescent unit-conjugated aliphatic oxaboroles has been investigated. The oxaboroles provide good fluorescence quantum yields and selective recognition toward D-ribose and D-ribose containing molecules. The molecular recognition induced significant fluorescence quenching. The property of the boroles showed the possibility of the boron-based nicotinamide adenine dinucleotide (NAD) sensor probe.
    MeSH term(s) Boron Compounds/chemical synthesis ; Boron Compounds/chemistry ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/chemistry ; Molecular Structure ; NAD/chemistry ; Optical Phenomena ; Sugars/analysis
    Chemical Substances Boron Compounds ; Fluorescent Dyes ; Sugars ; NAD (0U46U6E8UK)
    Language English
    Publishing date 2021-05-24
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c21-00179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Structural Basis of Karrikin and Non-natural Strigolactone Perception in Physcomitrella patens.

    Bürger, Marco / Mashiguchi, Kiyoshi / Lee, Hyun Jee / Nakano, Misaki / Takemoto, Kodai / Seto, Yoshiya / Yamaguchi, Shinjiro / Chory, Joanne

    Cell reports

    2019  Volume 26, Issue 4, Page(s) 855–865.e5

    Abstract: In plants, strigolactones are perceived by the dual receptor-hydrolase DWARF14 (D14). D14 belongs to the superfamily of α/β hydrolases and is structurally similar to the karrikin receptor KARRIKIN INSENSITIVE 2 (KAI2). The moss Physcomitrella patens is ... ...

    Abstract In plants, strigolactones are perceived by the dual receptor-hydrolase DWARF14 (D14). D14 belongs to the superfamily of α/β hydrolases and is structurally similar to the karrikin receptor KARRIKIN INSENSITIVE 2 (KAI2). The moss Physcomitrella patens is an ideal model system for studying this receptor family, because it includes 11 highly related family members with unknown ligand specificity. We present the crystal structures of three Physcomitrella D14/KAI2-like proteins and describe a loop-based mechanism that leads to a permanent widening of the hydrophobic substrate gorge. We have identified protein clades that specifically perceive the karrikin KAR
    MeSH term(s) Bryopsida/enzymology ; Crystallography, X-Ray ; Hydrolases/chemistry ; Lactones/chemistry ; Plant Proteins/chemistry ; Protein Domains
    Chemical Substances Lactones ; Plant Proteins ; Hydrolases (EC 3.-)
    Language English
    Publishing date 2019-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2019.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G–L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from Cryptocarya laevigata

    Tsurumi, Fumika / Miura, Yuta / Nakano, Misaki / Saito, Yohei / Fukuyoshi, Shuichi / Miyake, Katsunori / Newman, David J / O’Keefe, Barry R / Lee, Kuo-Hsiung / Nakagawa-Goto, Kyoko

    Journal of natural products. 2019 Aug. 23, v. 82, no. 9

    2019  

    Abstract: A CH₃OH–CH₂Cl₂ (1:1) extract (N025439) of the leaves and twigs of Cryptocarya laevigata furnished eight new compounds, 1–8. Based on extensive 1D and 2D NMR spectroscopic data examination, the new δ-lactone derivatives 1–6 are monoterpene–polyketide ... ...

    Abstract A CH₃OH–CH₂Cl₂ (1:1) extract (N025439) of the leaves and twigs of Cryptocarya laevigata furnished eight new compounds, 1–8. Based on extensive 1D and 2D NMR spectroscopic data examination, the new δ-lactone derivatives 1–6 are monoterpene–polyketide hybrids containing a unique spiro[3.5]nonenyl moiety. Their trivial names, cryptolaevilactones G–L, follow those of the related known meroterpenoids cryptolaevilactones A–F. Cryptolaevilactone L (6) contains 11,12-cis-oriented substituents, while the other cryptolaevilactones contain trans-oriented groups. The structure of the linear δ-lactone 7, cryptolaevilactone M, was characterized from various spectroscopic data analysis, and the absolute configuration was determined by total synthesis through stereoselective allylation and Grubbs olefin metathesis. Compound 8 was elucidated to be an ionone derivative with a 3,4-syn-diol functionality.
    Keywords Cryptocarya ; allylation ; lactones ; meroterpenoids ; moieties ; nuclear magnetic resonance spectroscopy ; olefin ; spectral analysis ; stereoselectivity
    Language English
    Dates of publication 2019-0823
    Size p. 2368-2378.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.8b00732
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from

    Tsurumi, Fumika / Miura, Yuta / Nakano, Misaki / Saito, Yohei / Fukuyoshi, Shuichi / Miyake, Katsunori / Newman, David J / O'Keefe, Barry R / Lee, Kuo-Hsiung / Nakagawa-Goto, Kyoko

    Journal of natural products

    2019  Volume 82, Issue 9, Page(s) 2368–2378

    Abstract: ... A ... ...

    Abstract A CH
    MeSH term(s) Antineoplastic Agents, Phytogenic/chemistry ; Cell Line, Tumor ; Cryptocarya/chemistry ; Humans ; Lactones/chemistry ; Molecular Structure ; Monoterpenes/chemistry ; Plant Leaves/chemistry ; Spectrum Analysis/methods ; Spiro Compounds/chemistry
    Chemical Substances Antineoplastic Agents, Phytogenic ; Lactones ; Monoterpenes ; Spiro Compounds
    Language English
    Publishing date 2019-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.8b00732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hemorrhagic gastric and duodenal ulcers after the Great East Japan Earthquake Disaster.

    Yamanaka, Kenichi / Miyatani, Hiroyuki / Yoshida, Yukio / Asabe, Shinichi / Yoshida, Toru / Nakano, Misaki / Obara, Shin / Endo, Hidehiko

    World journal of gastroenterology

    2013  Volume 19, Issue 42, Page(s) 7426–7432

    Abstract: Aim: To elucidate the characteristics of hemorrhagic gastric/duodenal ulcers in a post-earthquake period within one medical district.: Methods: Hemorrhagic gastric/duodenal ulcers in the Iwate Prefectural Kamaishi Hospital during the 6-mo period ... ...

    Abstract Aim: To elucidate the characteristics of hemorrhagic gastric/duodenal ulcers in a post-earthquake period within one medical district.
    Methods: Hemorrhagic gastric/duodenal ulcers in the Iwate Prefectural Kamaishi Hospital during the 6-mo period after the Great East Japan Earthquake Disaster were reviewed retrospectively. The subjects were 27 patients who visited our hospital with a chief complaint of hematemesis or hemorrhagic stool and were diagnosed as having hemorrhagic gastric/duodenal ulcers by upper gastrointestinal endoscopy during a 6-mo period starting on March 11, 2011. This period was divided into two phases: the acute stress phase, comprising the first month after the earthquake disaster, and the chronic stress phase, from the second through the sixth month. The following items were analyzed according to these phases: age, sex, sites and number of ulcers, peptic ulcer history, status of Helicobacter pylori (H. pylori) infection, intake of non-steroidal anti-inflammatory drugs, and degree of impact of the earthquake disaster.
    Results: In the acute stress phase from 10 d to 1 mo after the disaster, the number of patients increased rapidly, with a nearly equal male-to-female ratio, and the rate of multiple ulcers was significantly higher than in the previous year (88.9% vs 25%, P < 0.005). In the chronic stress phase starting 1 mo after the earthquake disaster, the number of patients decreased to a level similar to that of the previous year. There were more male patients during this period, and many patients tended to have a solitary ulcer. All patients with duodenal ulcers found in the acute stress phase were negative for serum H. pylori antibodies, and this was significantly different from the previous year's positive rate of 75% (P < 0.05).
    Conclusion: Severe stress caused by an earthquake disaster may have affected the characteristics of hemorrhagic gastric/duodenal ulcers.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Chronic Disease ; Disasters ; Duodenal Ulcer/diagnosis ; Duodenal Ulcer/epidemiology ; Earthquakes ; Endoscopy, Gastrointestinal ; Female ; Helicobacter Infections/diagnosis ; Helicobacter Infections/epidemiology ; Helicobacter Infections/microbiology ; Humans ; Incidence ; Japan/epidemiology ; Male ; Middle Aged ; Peptic Ulcer Hemorrhage/diagnosis ; Peptic Ulcer Hemorrhage/epidemiology ; Prognosis ; Retrospective Studies ; Risk Factors ; Stomach Ulcer/diagnosis ; Stomach Ulcer/epidemiology ; Stress, Psychological/diagnosis ; Stress, Psychological/epidemiology ; Time Factors
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2013-10-23
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v19.i42.7426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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