LIVIVO - Search results -

Search results

Result 1 - 10 of total 2455

Search options

Article: My memories of the Benson-Henry institute for mind-body medicine.

Nakao, Mutsuhiro

2023 Volume 17, Issue 1, Page(s) 13

Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Editorial
ZDB-ID	2265705-8
ISSN	1751-0759
ISSN	1751-0759
DOI	10.1186/s13030-023-00270-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: A web-based integrative transcriptome analysis, RNAseqChef, uncovers the cell/tissue type-dependent action of sulforaphane.

Etoh, Kan / Nakao, Mitsuyoshi

The Journal of biological chemistry

2023 Volume 299, Issue 6, Page(s) 104810

Abstract: RNA sequencing (RNA-seq) is a powerful technique for understanding cellular state and dynamics. However, comprehensive transcriptomic characterization of multiple RNA-seq datasets is laborious without bioinformatics training and skills. To remove the ... ...

Abstract	RNA sequencing (RNA-seq) is a powerful technique for understanding cellular state and dynamics. However, comprehensive transcriptomic characterization of multiple RNA-seq datasets is laborious without bioinformatics training and skills. To remove the barriers to sequence data analysis in the research community, we have developed "RNAseqChef" (RNA-seq data controller highlighting expression features), a web-based platform of systematic transcriptome analysis that can automatically detect, integrate, and visualize differentially expressed genes and their biological functions. To validate its versatile performance, we examined the pharmacological action of sulforaphane (SFN), a natural isothiocyanate, on various types of cells and mouse tissues using multiple datasets in vitro and in vivo. Notably, SFN treatment upregulated the ATF6-mediated unfolded protein response in the liver and the NRF2-mediated antioxidant response in the skeletal muscle of diet-induced obese mice. In contrast, the commonly downregulated pathways included collagen synthesis and circadian rhythms in the tissues tested. On the server of RNAseqChef, we simply evaluated and visualized all analyzing data and discovered the NRF2-independent action of SFN. Collectively, RNAseqChef provides an easy-to-use open resource that identifies context-dependent transcriptomic features and standardizes data assessment.
MeSH term(s)	Animals ; Mice ; Gene Expression Profiling/methods ; Gene Expression Profiling/standards ; Internet ; Isothiocyanates/pharmacology ; Sulfoxides/pharmacology ; RNA-Seq/methods ; RNA-Seq/standards ; Organ Specificity/drug effects ; Reproducibility of Results ; Mice, Obese ; Unfolded Protein Response/drug effects ; Liver/drug effects ; Muscle, Skeletal/drug effects ; Antioxidants/metabolism ; Data Visualization ; Software
Chemical Substances	Isothiocyanates ; sulforaphane (GA49J4310U) ; Sulfoxides ; Atf6 protein, mouse ; Nfe2l2 protein, mouse ; Antioxidants
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2023.104810
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.108: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Special series on "effects of board games on health education and promotion" board games as a promising tool for health promotion: a review of recent literature.

Nakao, Mutsuhiro

BioPsychoSocial medicine

2019 Volume 13, Page(s) 5

Abstract: Board games are played by moving game pieces in particular ways on special boards marked with patterns. To clarify the possible roles of board game use in psychosomatic medicine, the present review evaluated studies that investigated the effects of this ... ...

Abstract	Board games are played by moving game pieces in particular ways on special boards marked with patterns. To clarify the possible roles of board game use in psychosomatic medicine, the present review evaluated studies that investigated the effects of this activity on health education and treatment. A literature search conducted between January 2012 and August 2018 identified 83 relevant articles; 56 (67%) targeted education or training for health-related problems, six (7%) examined basic brain mechanisms, five (6%) evaluated preventative measures for dementia or contributions to healthy aging, and three (4%) assessed social communication or public health policies. The results of several randomized controlled trials indicated that the playing of traditional board games (e.g., chess, Go, and Shogi) helps to improve cognitive impairment and depression, and that the playing of newly developed board games is beneficial for behavioral modifications, such as the promotion of healthy eating, smoking cessation, and safe sex. Although the number of studies that have evaluated board game use in terms of mental health remains limited, many studies have provided interesting findings regarding brain function, cognitive effects, and the modification of health-related lifestyle factors.
Language	English
Publishing date	2019-02-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2265705-8
ISSN	1751-0759
ISSN	1751-0759
DOI	10.1186/s13030-019-0146-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Laser-assisted direct roller imprinting of large-area microstructured optical surfaces.

Nagato, Keisuke / Takahashi, Ken / Yajima, Yuki / Nakao, Masayuki

Microsystems & nanoengineering

2024 Volume 10, Page(s) 9

Abstract: In this study, a high-throughput fabrication method called laser-assisted direct roller imprinting (LADRI) was developed to lower the cost of nanoimprinting large-area polymer films and to address problems associated with nanoimprinting, namely, ... ...

Abstract	In this study, a high-throughput fabrication method called laser-assisted direct roller imprinting (LADRI) was developed to lower the cost of nanoimprinting large-area polymer films and to address problems associated with nanoimprinting, namely, microstructural damage and precision in flatness of entire film. With LADRI, the laser directly heats the microstructured surface of the roller mold, which heats and melts the surface of a polymethyl methacrylate (PMMA) film to replicate the microstructures on the mold rapidly. In this study, the effects of laser power density, scanning speed, size of the microstructures, and contact pressure on the replication speed were investigated experimentally. The replication speed increased as the power and scanning speed increased. However, because the film required heating until it filled the entire depth of the microstructure, an appropriate replication speed was necessary. This result was supported by simulation of the temperature distribution inside the mold and the PMMA using transient heat conduction analyses. To demonstrate the applications of LADRI, two different optical surfaces were replicated: an antireflection (AR) structure with conical structures sized several hundred nanometers and a light-extraction structure with a microlens array (MLA) comprising 10 μm lenses, for display and illumination, respectively. The replication degree of the MLA was governed by the contact pressure. Polymer flow simulation indicated that the heat conduction and flow speeds of the melted PMMA surface were comparable within several tens of micrometers. In addition, the reflectivity of the AR structure decreased from 4 to 0.5%, and the light intensity of the light-extraction structure increased by a factor of 1.47.
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ISSN	2055-7434
ISSN (online)	2055-7434
DOI	10.1038/s41378-024-00650-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Heart Rate Variability and Perceived Stress as Measurements of Relaxation Response.

Nakao, Mutsuhiro

Journal of clinical medicine

2019 Volume 8, Issue 10

Abstract: Stress is a term used to define the body's physiological and psychological reactions to circumstances that require behavioral adjustment [ ... ]. ...

Abstract	Stress is a term used to define the body's physiological and psychological reactions to circumstances that require behavioral adjustment [...].
Language	English
Publishing date	2019-10-16
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm8101704
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Iron supplementation is a residual piece of management in Asian patients with heart failure?

Nakao, Motoki / Nagai, Toshiyuki / Anzai, Toshihisa

International journal of cardiology

2024 , Page(s) 132014

Language	English
Publishing date	2024-04-04
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2024.132014
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1673: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Low-intensity mindfulness and cognitive-behavioral therapy for social anxiety: a pilot randomized controlled trial.

Noda, Shota / Shirotsuki, Kentaro / Nakao, Mutsuhiro

BMC psychiatry

2024 Volume 24, Issue 1, Page(s) 190

Abstract: Background: Cognitive-behavioral therapy (CBT) effectively improves the clinical symptoms of social anxiety disorder. However, there are non-responders who cannot decrease their cost/probability bias significantly; hence, their social anxiety symptoms ... ...

Abstract	Background: Cognitive-behavioral therapy (CBT) effectively improves the clinical symptoms of social anxiety disorder. However, there are non-responders who cannot decrease their cost/probability bias significantly; hence, their social anxiety symptoms remain unaddressed. Mindfulness training and cognitive-behavioral approaches promote a reduction in cost/probability bias and social anxiety symptoms. This study examines the effectiveness of a four-session program of mindfulness and CBT (M-CBT) in a non-clinical sample of individuals with high social anxiety. Methods: Participants were 50 Japanese undergraduate students (37 women and 13 men) randomly allocated to an intervention group (n = 27) and a control group (n = 23). The intervention group underwent a four-session M-CBT program, while the control group did not receive any treatment. Results: A group × time analysis of covariances showed significant interactions in the negative cognition generated when paying attention to others in probability bias, fear of negative evaluation by others, dispositional mindfulness, depressive symptoms, and subjective happiness. M-CBT also produced significant pre-post improvements in the above outcomes with moderate to high effect sizes (ds = .51-1.55). Conversely, there were no interactions in social anxiety symptoms and self-focused attention. Conclusions: These results indicate that M-CBT was effective for the negative cognition generated when paying attention to others in probability bias, fear of negative evaluation by others, dispositional mindfulness, depressive symptoms, and subjective happiness. The combination of mindfulness training with cognitive restructuring is proposed as potentially helpful for individuals with probability bias, leading to negative cognition from paying attention to others. Trial registration: University Hospital Medical Information Network (UMIN CTR) UMIN000036763. Registered May 16, 2019.
MeSH term(s)	Female ; Humans ; Male ; Anxiety/therapy ; Cognitive Behavioral Therapy/methods ; Fear ; Mindfulness/methods ; Pilot Projects ; Treatment Outcome
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-024-05651-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Mode of SUV420H2 heterochromatin localization through multiple HP1 binding motifs in the heterochromatic targeting module.

Nakao, Masaru / Sato, Yuko / Aizawa, Arisa / Kimura, Hiroshi

Genes to cells : devoted to molecular & cellular mechanisms

2024 Volume 29, Issue 5, Page(s) 361–379

Abstract: Constitutive heterochromatin is transcriptionally repressed and densely packed chromatin, typically harboring histone H3 Lys9 trimethylation (H3K9me3) and heterochromatin protein 1 (HP1). SUV420H2, a histone H4 Lys20 methyltransferase, is recruited to ... ...

Abstract	Constitutive heterochromatin is transcriptionally repressed and densely packed chromatin, typically harboring histone H3 Lys9 trimethylation (H3K9me3) and heterochromatin protein 1 (HP1). SUV420H2, a histone H4 Lys20 methyltransferase, is recruited to heterochromatin by binding to HP1 through its Heterochromatic Targeting Module (HTM). Here, we have identified three HP1 binding motifs within the HTM. Both the full-length HTM and its N-terminal region (HTM-N), which contains the first and second motifs, stabilized HP1 on heterochromatin. The intervening region between the first and second HP1 binding motifs in HTM-N was also crucial for HP1 binding. In contrast, the C-terminal region of HTM (HTM-C), containing the third motif, destabilized HP1 on chromatin. An HTM V374D mutant, featuring a Val374 to Asp substitution in the second HP1 binding motif, localizes to heterochromatin without affecting HP1 stability. These data suggest that the second HP1 binding motif in the SUV420H2 HTM is critical for locking HP1 on H3K9me3-enriched heterochromatin. HTM V374D, tagged with a fluorescent protein, can serve as a live-cell probe to visualize HP1-bound heterochromatin.
MeSH term(s)	Heterochromatin/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; Chromobox Protein Homolog 5/metabolism ; Humans ; Histone-Lysine N-Methyltransferase/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; Protein Binding ; Histones/metabolism ; Amino Acid Motifs ; HeLa Cells ; Binding Sites
Chemical Substances	Heterochromatin ; Chromosomal Proteins, Non-Histone ; Chromobox Protein Homolog 5 (107283-02-3) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; Histones ; KMT5C protein, human (EC 2.1.1.43)
Language	English
Publishing date	2024-02-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1330000-3
ISSN	1365-2443 ; 1356-9597
ISSN (online)	1365-2443
ISSN	1356-9597
DOI	10.1111/gtc.13109
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4539: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Estimation of Retinotopic Map of Awake Mouse Brain Based upon Retino-Cortical Response Model.

Togawa, R / Nakao, M / Katayama, N

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2021 Volume 2021, Page(s) 4092–4094

Abstract: We proposed a novel retino-cortical response model on which the fine retinotopic map of the primary visual cortex was estimated from the intrinsic optical signal (IOS) induced by visual stimulation in an awake mouse. Our method was developed to overcome ... ...

Abstract	We proposed a novel retino-cortical response model on which the fine retinotopic map of the primary visual cortex was estimated from the intrinsic optical signal (IOS) induced by visual stimulation in an awake mouse. Our method was developed to overcome practical restrictions of measurement time and disturbances such as eye movement and brain background activity instead of synchronous averaging. In our model, it was assumed that the response of the cortical region was given by integrating the product of the image projected on a spherical retina and the retino-cortical sensitive function. In addition, in order to estimate parameters of the sensitive function, Monte Carlo-based numerical integration and nonlinear least square algorithm were employed. By applying this method to the actual IOS data, we estimated a biologically plausible spatial distribution of the sensitivity function parameters and a retinotopic map. Similar to our pervious study, higher-order brain regions such as the secondary visual cortex were also visualized. These results suggested usefulness of our proposed method based on the novel retino-cortical response model.Clinical Relevance- The method for evaluating visual functions under restoration was proposed and its validity was examined in animal experiments.
MeSH term(s)	Animals ; Brain ; Mice ; Photic Stimulation ; Primary Visual Cortex ; Visual Cortex ; Wakefulness
Language	English
Publishing date	2021-12-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC46164.2021.9630950
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Statistical Modeling of Subjective Sleep Quality.

Choilek, S / Karashima, A / Motoike, I / Katayama, N / Kinoshita, K / Nakao, M

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2023 Volume 2023, Page(s) 1–6

Abstract: Effective maintenance/improvement of sleep quality requires knowledge of how sleep quality is connected to quantitative features of sleep and arbitrarily selected habitual lifestyles, which naturally depend on the demographic characteristics of ... ...

Abstract	Effective maintenance/improvement of sleep quality requires knowledge of how sleep quality is connected to quantitative features of sleep and arbitrarily selected habitual lifestyles, which naturally depend on the demographic characteristics of individuals. To fulfill these needs, a regression model of subjective sleep quality was constructed, whereby one might be able to design a practical strategy for achieving comfortable sleep adapted to individual conditions. Based on data obtained from our previous study, fundamental correlation profiles between day-to-day subjective and quantitative features of sleep were estimated. Obtained correlation profiles involving SRSs, quantitative features of sleep, and sleep habits across a week such as bedtime preference (chronotype), discrepancy between chronotype and social time cue (social jetlag), and habitual sleep-wake pattern (HSWP) were characterized specifically for each self-ratings of sleep quality (SRS) category through backward stepwise Linear Mixed Effect (LME) modeling. The LME model represented SRSs with acceptable accuracy, allowing identification of determinant factors for each category of SRS. The SRS is one possible option to clarify sleep status. In this study, we proposed a possible framework including model-based predictors of SRS in which self-awareness of sleep quality could be improved to facilitate healthy sleep practices.
MeSH term(s)	Humans ; Circadian Rhythm ; Sleep Quality ; Time Factors ; Surveys and Questionnaires ; Sleep
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC40787.2023.10340638
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED