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  1. Article ; Online: Placental transfer of tocilizumab in a patient with rheumatoid arthritis.

    Tada, Yoshifumi / Sakai, Mariko / Nakao, Yoshinobu / Maruyama, Akihito / Ono, Nobuyuki / Koarada, Syuichi

    Rheumatology (Oxford, England)

    2019  Volume 58, Issue 9, Page(s) 1694–1695

    MeSH term(s) Adult ; Antibodies, Monoclonal, Humanized/pharmacokinetics ; Antirheumatic Agents/pharmacokinetics ; Arthritis, Rheumatoid/drug therapy ; Female ; Humans ; Infant, Newborn ; Maternal-Fetal Exchange ; Pregnancy ; Pregnancy Complications/drug therapy ; Pregnancy Outcome ; Prenatal Exposure Delayed Effects
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antirheumatic Agents ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2019-09-10
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kez155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The balance between Foxp3 and Ror-γt expression in peripheral blood is altered by tocilizumab and abatacept in patients with rheumatoid arthritis.

    Tada, Yoshifumi / Ono, Nobuyuki / Suematsu, Rie / Tashiro, Satoko / Sadanaga, Yuri / Tokuda, Yukiko / Ono, Yukihide / Nakao, Yoshinobu / Maruyama, Akihito / Ohta, Akihide / Koarada, Syuichi

    BMC musculoskeletal disorders

    2016  Volume 17, Page(s) 290

    Abstract: Background: The balance between Th17 cells and regulatory T (Treg) cells has been shown to play an important role in the development of rheumatoid arthritis (RA). Recent studies have shown that treatment with abatacept (ABT) or tocilizumab (TCZ) affects ...

    Abstract Background: The balance between Th17 cells and regulatory T (Treg) cells has been shown to play an important role in the development of rheumatoid arthritis (RA). Recent studies have shown that treatment with abatacept (ABT) or tocilizumab (TCZ) affects Th17 and Treg cell populations. Although not unanimously accepted, several reports have shown that Treg cells are decreased by ABT and increased by TCZ, and that Th17 cells are decreased by TCZ. To further investigate the effects of ABT and TCZ on the skewing of T cell populations, we analyzed the expression of master regulators genes of helper T cell lineages following ABT/TCZ treatment of RA patients.
    Methods: Ten patients treated with ABT and 10 patients treated with TCZ were enrolled. Total RNA was extracted from peripheral blood cells at baseline, and after 12 and 24 weeks of therapy. The expression levels of T-bet, GATA3, Foxp3 and Ror-γt were semi-quantified using real-time PCR. The relative expression levels were expressed as the ratios of two genes (T-bet/GATA3, Foxp3/GATA3, Foxp3/T-bet, Foxp3/Ror-γt, Ror-γt/T-bet, Ror-γt/GATA3), and the changes in these ratios with treatment were determined.
    Results: The Foxp3/Ror-γt ratio was decreased after ABT therapy (0.67 ± 0.16 at 24 weeks, P = 0.0034) but was increased after TCZ therapy (2.00 ± 1.03 at 24 weeks, P = 0.0013). In addition, the Ror-γt/GATA3 ratio was decreased after TCZ therapy (0.78 ± 0.37 at 24 weeks, P = 0.0008). Except for these ratios, no significant skewing in the expression of these factors was detected. No significant relationship between clinical response to the treatment and change in the ratios of these factors was determined.
    Conclusion: Treatment with TCZ or ABT differently affected the balance between Foxp3 and Ror-γt expression in the peripheral blood of patients with RA.
    Language English
    Publishing date 2016-07-16
    Publishing country England
    Document type Journal Article
    ISSN 1471-2474
    ISSN (online) 1471-2474
    DOI 10.1186/s12891-016-1137-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Effectiveness of Certolizumab Pegol in Treating Rheumatoid Arthritis Patients with Persistent Inflamed Residual Mono- or Oligosynovitis Resistant to Prior TNF-α Inhibitors.

    Koarada, Syuichi / Tsuboi, Masahiko / Komine, Mitsunori / Nakao, Yoshinobu / Tokuda, Yukiko / Ono, Yukihide / Tashiro, Satoko / Maruyama, Akihito / Ono, Nobuyuki / Ohta, Akihide / Tada, Yoshifumi

    Case reports in rheumatology

    2015  Volume 2015, Page(s) 348614

    Abstract: We report four cases of successful treatment with certolizumab pegol (CZP) of rheumatoid arthritis (RA) patients with persistent inflamed residual mono- or oligosynovitis resistant to prior TNF-α inhibitors. Although the patients were in a moderate ... ...

    Abstract We report four cases of successful treatment with certolizumab pegol (CZP) of rheumatoid arthritis (RA) patients with persistent inflamed residual mono- or oligosynovitis resistant to prior TNF-α inhibitors. Although the patients were in a moderate disease activity, a low activity, or a remission of RA, they sustained inflammatory mono-/oligoarthritis even after treatment with prior TNF inhibitors. They were then all treated with CZP and observed in a serial ultrasonography. In all cases, the positive power Doppler signals in the joint have disappeared promptly and all of the patients were able to retain remission in the long term. The treatment of CZP to the refractory mono-/oligoarthritis of inflammatory synovitis in RA patients has not been previously described. The cases suggest that it may be associated with the feature of CZP, possible effective penetration into the site of inflammation.
    Language English
    Publishing date 2015-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2666708-3
    ISSN 2090-6897 ; 2090-6889
    ISSN (online) 2090-6897
    ISSN 2090-6889
    DOI 10.1155/2015/348614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of Corticosteroid and 1,24R-Dihydroxy-Vitamin D3 Administration on Lymphoproliferation and Autoimmune Disease in MRL/MP-lpr/lpr Mice

    Koizumi, Tamio / Nakao, Yoshinobu / Matsui, Toshimitsu / Nakagawa, Toshitaro / Matsuda, Shuichi / Komoriya, Keiji / Kanai, Yoshiyuki / Fujita, Takuo

    International Archives of Allergy and Immunology

    1985  Volume 77, Issue 4, Page(s) 396–404

    Abstract: The pharmacological effects of prolonged administration of a corticosteroid, betamethasone, and active vitamin D3 [1,24R-(OH)2D3] on lymphoproliferation and autoimmune disease of MRL/MP-lpr/lpr (MRL/l) mice were examined. Relatively high doses of ... ...

    Abstract The pharmacological effects of prolonged administration of a corticosteroid, betamethasone, and active vitamin D3 [1,24R-(OH)2D3] on lymphoproliferation and autoimmune disease of MRL/MP-lpr/lpr (MRL/l) mice were examined. Relatively high doses of betamethasone (0.25 mg/kg/day) prevented lymphoproliferation, reduced serum levels of anti-dsDNA, anti-ssDNA, and anti-poly (ADP-ribose) antibodies, and brought about clinical improvement, such as reduced proteinuria and diminution of skin lesions. It is noteworthy that not only did prevention of lymphoproliferation occur, but also recovery of the Lyt-2+ T cell subset in the thymus and the spleen was observed. The administration of 1,24R-(OH)2D3 (0.1 μg/kg/day) similarly prevented proteinuria, and produced recovery of a Lyt-2+ subset in the thymus.
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000233815
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  5. Article ; Online: Teleocidin-Induced Phenotypic Changes in Thymic ALL Cell Line, HPB-ALL

    Nakao, Yoshinobu / Matsuda, Shuichi / Kobayashi, Nobuhisa / Baba, Yasuto / Fujita, Takuo / Saida, Takahiko / Watanabe, Show / Morikawa, Shigeru / Ito, Yohei

    Oncology - International Journal of Cancer Research and Treatment

    1983  Volume 40, Issue 4, Page(s) 273–279

    Abstract: An indole alkaloid, teleocidin, induced phenotypic differentiation in the thymic ALL cell line HPB-ALL. Within 30 min of seeding in the presence of teleocidin, the cells formed a smooth round shape. Upon 5-day exposure to teleocidin, most of the cells ... ...

    Abstract An indole alkaloid, teleocidin, induced phenotypic differentiation in the thymic ALL cell line HPB-ALL. Within 30 min of seeding in the presence of teleocidin, the cells formed a smooth round shape. Upon 5-day exposure to teleocidin, most of the cells became smaller and reminiscent of large or atypical lymphocytes. A thymic antigen stained with monoclonal antibody OKT6 was remarkably reduced while Leu2a-positive cells were increased in the treated cells. Upon teleocidin-induced phenotypic differentiation, the growth rate of cells was inhibited, their ability to incorporate DNA via [3H]-labelled precursors was reduced, their ability to bind sRBC rosettes was increased. These changes were paralleled to that induced by 12-o-tetradecanoyl-phorbol-13-acetate.
    Keywords Teleocidin ; Phenotypic differentiation ; Monoclonal antibody ; Thymic ALL cell line ; HPB-ALL
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 250101-6
    ISSN 1423-0232 ; 0030-2414 ; 0030-2414
    ISSN (online) 1423-0232
    ISSN 0030-2414
    DOI 10.1159/000225742
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  6. Article ; Online: Multiple Point Mutation of N-ras and K-ras Oncogenes in Myelodysplastic Syndrome and Acute Myelogenous Leukemia

    Nakagawa, Toshitaro / Saitoh, Susumu / Imoto, Shion / Itoh, Mitsuhiro / Tsutsumi, Masayoshi / Hikiji, Kazumasa / Nakamura, Hiroyuki / Matozaki, Sachiko / Ogawa, Ryouiti / Nakao, Yoshinobu / Fujita, Takuo

    Oncology - International Journal of Cancer Research and Treatment

    1992  Volume 49, Issue 2, Page(s) 114–122

    Abstract: We analyzed activating mutations of N-ras and K-ras by the polymerase chain reaction and oligonucleotide hybridization in hematological disorders. Activating mutations of these codons were detected in 4 of 20 cases of myelodysplastic syndrome (MDS) and ... ...

    Abstract We analyzed activating mutations of N-ras and K-ras by the polymerase chain reaction and oligonucleotide hybridization in hematological disorders. Activating mutations of these codons were detected in 4 of 20 cases of myelodysplastic syndrome (MDS) and 15 of 77 cases of acute myelogenous leukemia (AML). Out of 19 cases of MDS and AML who carried active mutations, 7 cases were found to have two or more distinct mutations in activating codons of N-ras and K-ras. Ras mutation was found preferentially in progressive disease such as refractory anemia with excess of blasts (RAEB) of RAEB in transformation (RAEB-t). A relatively high incidence of ras mutation was found in M5 AML (40%). No ras mutations were found in other hematological disorders, such as acute lymphoblastic leukemia and chronic myelogenous-leukemia. The most frequent amino acid substitution was that of an aspartate for glycine at codon 12 of N-ras resulting from G to A mutation (11/35). The survival of AML patients who carried ras mutations showed no significant differences from those without ras mutations calculated by Kaplan-Meier. Seven cases of MDS and 7 cases of AML patients could be investigated at various points during their clinical course. Among these 14 cases, we found 2 interesting cases of MDS. The first case lost multiple clones carrying ras mutations during disease progression, the second case acquired mutation of the ras gene during disease progression. These results suggested that multiple point mutations of ras genes may not be initiating events but may contribute to a clonal evolution of MDS and AML.
    Keywords ras ; Acute myelogenous leukemia ; Myelodysplastic Syndrome ; Multiple point mutation
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 250101-6
    ISSN 1423-0232 ; 0030-2414 ; 0030-2414
    ISSN (online) 1423-0232
    ISSN 0030-2414
    DOI 10.1159/000227023
    Database Karger publisher's database

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