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  1. Article ; Online: Salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report.

    Murakami, Naoya / Nakatani, Fumihiko / Takahashi, Kana / Nakamura, Satoshi / Igaki, Hiroshi / Shikama, Naoto

    Journal of radiation research

    2023  Volume 64, Issue 4, Page(s) 746–749

    Abstract: An 80-year-old male presented with T1N0M0 myxofibrosarcoma in or next to the humeral canal, which is located between the biceps and triceps of the right upper arm. Because the tumor was close to critical anatomical structures such as the brachial artery, ...

    Abstract An 80-year-old male presented with T1N0M0 myxofibrosarcoma in or next to the humeral canal, which is located between the biceps and triceps of the right upper arm. Because the tumor was close to critical anatomical structures such as the brachial artery, median nerve and ulnar nerve, it was deemed impossible to perform limb-sparing surgery with an adequate resection margin. Therefore, preoperative external beam radiation therapy (EBRT) followed by limb-sparing surgery was offered. Magnetic resonance imaging taken after 40 Gy/20 fractions of EBRT showed an inadequate response, and limb-sparing surgery was not deemed possible at this point. Amputation of the right arm was offered, but the patient refused. Therefore, salvage high-dose-rate interstitial brachytherapy (HDR-ISBT) was offered. Under local anesthesia and sedation, 14 plastic needles were inserted, and 36 Gy in 6 fractions of HDR-ISBT was performed. Although radiation-induced incomplete paralysis of the median nerve was noted, no local progression or distant metastasis was found on the CT that was taken 2 years after the treatment.
    MeSH term(s) Aged, 80 and over ; Humans ; Male ; Arm ; Brachytherapy/methods ; Radiotherapy Dosage
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 603983-2
    ISSN 1349-9157 ; 0449-3060
    ISSN (online) 1349-9157
    ISSN 0449-3060
    DOI 10.1093/jrr/rrad041
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  2. Article: [I. The role of microRNA for musculoskeletal cancer].

    Nakatani, Fumihiko

    Gan to kagaku ryoho. Cancer & chemotherapy

    2012  Volume 39, Issue 3, Page(s) 369–372

    MeSH term(s) Humans ; MicroRNAs/genetics ; Neoplasms, Connective and Soft Tissue/genetics ; Oncogene Proteins/genetics ; Tumor Suppressor Proteins/genetics
    Chemical Substances MicroRNAs ; Oncogene Proteins ; Tumor Suppressor Proteins
    Language Japanese
    Publishing date 2012-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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  3. Article ; Online: Blocking FSTL1 boosts NK immunity in treatment of osteosarcoma.

    Ogiwara, Yamato / Nakagawa, Makoto / Nakatani, Fumihiko / Uemura, Yasushi / Zhang, Rong / Kudo-Saito, Chie

    Cancer letters

    2022  Volume 537, Page(s) 215690

    Abstract: Osteosarcoma (OS) is the most common primary bone malignancy. Many patients develop relapse and metastasis after treatments, and more effective treatments are needed for improving the clinical outcome. FSTL1 overexpression has been reported in murine and ...

    Abstract Osteosarcoma (OS) is the most common primary bone malignancy. Many patients develop relapse and metastasis after treatments, and more effective treatments are needed for improving the clinical outcome. FSTL1 overexpression has been reported in murine and human OS, while the functional roles of FSTL1 remain unclear. Here, we elucidated tumor biological and immunological mechanisms underlying the refractory OS using mouse and human OS cell lines, mouse OS models, and clinical specimens. FSTL1 knockout in OS cells significantly suppressed cellular functions, including proliferation, invasion, sphere colony formation, and ALCAM expression. The FSTL1-ablated tumor cells were completely rejected due to generation of potent NK cells in the in vivo setting. Indeed, FSTL1 stimulation suppressed NK activity partly via apoptosis induction, but blocking FSTL1 or CD6, a receptor for ALCAM, significantly restored NK activity. Anti-FSTL1 therapy significantly suppressed tumor growth and metastasis in mouse OS models, and synergized with anti-CD6 therapy in providing significantly better prognosis. These suggest that blocking FSTL1 is a promising strategy for successfully treating OS. This study demonstrates a rationale of targeting the FSTL1-ALCAM axis in the treatment of OS in clinical settings.
    MeSH term(s) Activated-Leukocyte Cell Adhesion Molecule/metabolism ; Animals ; Apoptosis ; Bone Neoplasms/drug therapy ; Bone Neoplasms/genetics ; Cell Line, Tumor ; Cell Proliferation ; Follistatin-Related Proteins/genetics ; Follistatin-Related Proteins/metabolism ; Humans ; Mice ; Neoplasm Recurrence, Local ; Osteosarcoma/drug therapy ; Osteosarcoma/genetics
    Chemical Substances Activated-Leukocyte Cell Adhesion Molecule ; Follistatin-Related Proteins ; Fstl1 protein, mouse ; FSTL1 protein, human (158709-61-6)
    Language English
    Publishing date 2022-04-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2022.215690
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  4. Article ; Online: Nursing Practice and Care Structure for Children and Their Families in Need of Pediatric Palliative and End-of-Life Care in Japan: A Nationwide Survey.

    Nagoya, Yuko / Matsuoka, Mari / Takenouchi, Naoko / Hirata, Mika / Arita, Naoko / Kawakatsu, Kazuko / Furuhashi, Tomoko / Ishiura, Mitsuyo / Nakatani, Fumi

    Journal of hospice and palliative nursing : JHPN : the official journal of the Hospice and Palliative Nurses Association

    2023  Volume 25, Issue 2, Page(s) E41–E48

    Abstract: Many nurses experience difficulties in pediatric palliative care practice. The study aimed to describe the current situation and structure of pediatric palliative and end-of-life care nursing practices for children and their families in Japan. The ... ...

    Abstract Many nurses experience difficulties in pediatric palliative care practice. The study aimed to describe the current situation and structure of pediatric palliative and end-of-life care nursing practices for children and their families in Japan. The research subjects were nurses working in hospitals; facilities for persons with severe physical, motor, and intellectual disabilities; and home-visit nursing stations. The practice ratio was calculated using a 79-item survey form, and factor analysis was conducted. A total of 113 facilities (acceptance rate: 26.5%) and 777 nurses (response rate: 44.6%) responded. Five items had a "Practicing" ratio of ≥90%. In factor analysis, 7 domains were identified: "preparing to face the time of death with the child and family," "ensuring child-centered care," "managing symptoms with the child and family," "considering and coordinating for the child's peaceful time of death," "understanding and respecting the culture of the child and family," "assessing the child and family as a whole person," and "performing self-reflection on an ethical issue." Nurses' practice of pediatric palliative care differs by practice domain. It is necessary to reflect on the educational programs under development to improve the quality of life of children and their families.
    MeSH term(s) Humans ; Child ; Japan ; Quality of Life ; Terminal Care ; Palliative Care ; Nurses
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2070862-2
    ISSN 1539-0705 ; 1522-2179
    ISSN (online) 1539-0705
    ISSN 1522-2179
    DOI 10.1097/NJH.0000000000000933
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  5. Article: [Molecular targeting for treatment of connective and soft tissue neoplasms].

    Nakatani, Fumihiko

    Gan to kagaku ryoho. Cancer & chemotherapy

    2008  Volume 35, Issue 3, Page(s) 411–414

    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Biomarkers, Tumor/metabolism ; Humans ; Immunotherapy ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Neoplasms, Connective and Soft Tissue/blood supply ; Neoplasms, Connective and Soft Tissue/classification ; Neoplasms, Connective and Soft Tissue/metabolism ; Neoplasms, Connective and Soft Tissue/therapy
    Chemical Substances Angiogenesis Inhibitors ; Biomarkers, Tumor ; Neoplasm Proteins
    Language Japanese
    Publishing date 2008-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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  6. Article: Clinical usefulness of 2-hydroxyglutarate as a biomarker in IDH-mutant chondrosarcoma.

    Nakagawa, Makoto / Yamaguchi, Masayuki / Endo, Makoto / Machida, Yukino / Hattori, Ayuna / Tanzawa, Fumie / Tsutsumi, Shinji / Kitabayashi, Issay / Kawai, Akira / Nakatani, Fumihiko

    Journal of bone oncology

    2022  Volume 34, Page(s) 100430

    Abstract: Background: Chondrosarcoma is a common form of malignant bone tumor with limited treatment options. Approximately half of chondrosarcomas harbor gain-of-function mutations in isocitrate dehydrogenase (IDH), and mutant IDH produces 2-hydroxyglutarate (2- ... ...

    Abstract Background: Chondrosarcoma is a common form of malignant bone tumor with limited treatment options. Approximately half of chondrosarcomas harbor gain-of-function mutations in isocitrate dehydrogenase (IDH), and mutant IDH produces 2-hydroxyglutarate (2-HG), which is an oncometabolite that contributes to malignant transformation. Therefore, inhibiting 2-HG production is a novel and promising treatment for advanced chondrosarcoma. 2-HG is also expected to be a useful biomarker for the diagnosis and treatment of IDH-mutant tumors. However, few studies have confirmed this using chondrosarcoma clinical specimens. Non-invasive monitoring of 2-HG levels is useful to infer that mutant IDH inhibitors reach therapeutic targets and to confirm their therapeutic efficacy in clinical practice.
    Methods: To evaluate the clinical utility of 2-HG as a surrogate biomarker for diagnosis and therapeutic efficacy, we measured intra-tumor and serum levels of 2-HG using frozen tissues and peripheral blood from patients with chondrosarcoma. We also developed a non-invasive method to detect intra-tumor 2-HG signals
    Results: Both intratumoral and serum 2-HG levels were significantly elevated in IDH-mutant tumors, and these levels correlated with decreased survival. Furthermore, we detected intratumoral 2-HG peaks using MR spectroscopy in a xenograft model of IDH-mutant chondrosarcoma, and observed that 2-HG peak signals disappeared after administering an inhibitor of mutant IDH1.
    Conclusions: Our findings suggest that both intratumoral and serum 2-HG levels represent potentially useful biomarkers for IDH-mutant tumors and that the 2-HG signal in MR spectra has potential value as a non-invasive biomarker. Taken together, these findings may positively impact the clinical development of mutant IDH inhibitors for the treatment of advanced chondrosarcoma.
    Language English
    Publishing date 2022-04-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2212-1366
    ISSN 2212-1366
    DOI 10.1016/j.jbo.2022.100430
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  7. Article: [I. Identification of a Possible Therapeutic Target for Chondrosarcoma with IDH Mutant Inhibitors].

    Nakagawa, Makoto / Nakatani, Fumihiko / Kitabayashi, Issay

    Gan to kagaku ryoho. Cancer & chemotherapy

    2017  Volume 44, Issue 3, Page(s) 212–216

    MeSH term(s) Biomarkers, Tumor/analysis ; Bone Neoplasms/drug therapy ; Bone Neoplasms/enzymology ; Bone Neoplasms/genetics ; Chondrosarcoma/drug therapy ; Chondrosarcoma/enzymology ; Chondrosarcoma/genetics ; Enzyme Inhibitors/therapeutic use ; Humans ; Isocitrate Dehydrogenase/antagonists & inhibitors ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; Mutation
    Chemical Substances Biomarkers, Tumor ; Enzyme Inhibitors ; Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language Japanese
    Publishing date 2017-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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  8. Article ; Online: A case of hemangiopericytoma of the pelvis.

    Asano, Naofumi / Nakatani, Fumihiko

    Japanese journal of clinical oncology

    2012  Volume 42, Issue 11, Page(s) 1110

    MeSH term(s) Antigens, CD34/analysis ; Hemangiopericytoma/diagnosis ; Hemangiopericytoma/metabolism ; Hemangiopericytoma/surgery ; Hemipelvectomy/methods ; Humans ; Immunohistochemistry ; Male ; Pelvis ; Young Adult
    Chemical Substances Antigens, CD34
    Language English
    Publishing date 2012-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 190978-2
    ISSN 1465-3621 ; 0368-2811
    ISSN (online) 1465-3621
    ISSN 0368-2811
    DOI 10.1093/jjco/hys174
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    Zs.A 1298: Show issues Location:
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  9. Article ; Online: Free latissimus dorsi musculocutaneous flap for external hemipelvectomy reconstruction.

    Tashiro, Kensuke / Arikawa, Masaki / Fukunaga, Yutaka / Nakatani, Fumihiko / Kobayashi, Eisuke / Kawai, Akira / Miyamoto, Shimpei

    Microsurgery

    2018  Volume 39, Issue 2, Page(s) 138–143

    Abstract: Introduction: External hemipelvectomy is one of the most extensive surgical procedures for locally advanced pelvic tumors. Stump coverage with the local tissues can be difficult in recurrent cases. Herein, we report our experience with immediate stump ... ...

    Abstract Introduction: External hemipelvectomy is one of the most extensive surgical procedures for locally advanced pelvic tumors. Stump coverage with the local tissues can be difficult in recurrent cases. Herein, we report our experience with immediate stump coverage using a free latissimus dorsi musculocutaneous (LDMC) flap after external hemipelvectomy for recurrent pelvic malignancies.
    Methods: Six patients underwent external hemipelvectomy and immediate reconstruction using a free LDMC flap between November 2012 and June 2017. The mean age of the patients was 65 years (range: 63-69 years). The primary tumors were myxoid liposarcoma, chondrosarcoma, osteosarcoma, squamous cell carcinoma, and pleomorphic liposarcoma. A free LDMC flap was harvested from the ipsilateral back and transferred to the defect. When an intercostal nerve was found at the recipient site, the thoracodorsal nerve was coaptated with the intercostal nerve to reinnervate the muscle.
    Results: The mean flap size was 23 × 10 cm and the range was 20 × 8-27 × 13.5 cm. The contralateral deep inferior epigastric vessels were used as recipient vessels in all patients. Thoracodorsal-intercostal nerve coaptation was performed in 2 patients. The flap survived in all patients. Three patients had complications of abscess formation. No patient developed postoperative hernia.
    Conclusion: Although it is challenging to do reconstruction after external hemipelvectomy, a free LDMC flap has several advantages, including a large coverage area, stability of circulation, ease of elevation, and preservation of the strength of the remaining abdominal wall. Technical tips for selecting anastomosis vessels are important and nerve coaptation could be effective.
    MeSH term(s) Aged ; Bone Neoplasms/pathology ; Bone Neoplasms/surgery ; Female ; Follow-Up Studies ; Graft Survival ; Hemipelvectomy/methods ; Humans ; Male ; Middle Aged ; Myocutaneous Flap/blood supply ; Myocutaneous Flap/transplantation ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Reconstructive Surgical Procedures/methods ; Recovery of Function/physiology ; Reoperation/methods ; Retrospective Studies ; Risk Assessment ; Sampling Studies ; Sarcoma/pathology ; Sarcoma/surgery ; Superficial Back Muscles/surgery ; Treatment Outcome ; Wound Healing/physiology
    Language English
    Publishing date 2018-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605524-2
    ISSN 1098-2752 ; 0738-1085
    ISSN (online) 1098-2752
    ISSN 0738-1085
    DOI 10.1002/micr.30373
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    Zs.A 1570: Show issues Location:
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  10. Article ; Online: Successful Treatment of Extra-Renal Noncerebral Rhabdoid Tumors with VIDE.

    Yasui, Naoko / Yoshida, Akihiko / Kobayashi, Eisuke / Nakatani, Fumihiko / Kawamoto, Hiroshi

    Pediatric blood & cancer

    2016  Volume 63, Issue 2, Page(s) 352–354

    Abstract: Extra-renal noncerebral rhabdoid tumors (ERRTs) are highly aggressive and often lethal. An optimal chemotherapy regimen for ERRT remains undetermined. We report on three pediatric patients successfully treated with vincristine, ifosfamide, doxorubicin, ... ...

    Abstract Extra-renal noncerebral rhabdoid tumors (ERRTs) are highly aggressive and often lethal. An optimal chemotherapy regimen for ERRT remains undetermined. We report on three pediatric patients successfully treated with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE). Two of our patients who had metastatic or refractory disease have survived more than 2 years, one disease free without myeloablative megatherapy. The treatment with high-dose alkylator therapy is reported to have a beneficial effect on survival. A VIDE regimen containing high-dose ifosfamide is feasible and appears to prolong the survival of patients with ERRT. This regimen may be a promising option for ERRT treatment without myeloablative megatherapy.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Child ; Child, Preschool ; Doxorubicin/administration & dosage ; Etoposide/administration & dosage ; Female ; Humans ; Ifosfamide/administration & dosage ; Rhabdoid Tumor/drug therapy ; Vincristine/administration & dosage
    Chemical Substances Vincristine (5J49Q6B70F) ; Etoposide (6PLQ3CP4P3) ; Doxorubicin (80168379AG) ; Ifosfamide (UM20QQM95Y)
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.25777
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