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  1. Article ; Online: Calcium carbonate occluding a peritoneal dialysis catheter.

    Mitsuno, Ryunosuke / Nakayama, Takashin / Morimoto, Kohkichi

    Clinical and experimental nephrology

    2022  

    Language English
    Publishing date 2022-09-10
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-022-02269-y
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  2. Article ; Online: A systematic review and meta-analysis of the clinical impact of stopping renin-angiotensin system inhibitor in patients with chronic kidney disease.

    Nakayama, Takashin / Mitsuno, Ryunosuke / Azegami, Tatsuhiko / Sato, Yasunori / Hayashi, Kaori / Itoh, Hiroshi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 6, Page(s) 1525–1535

    Abstract: Although renin-angiotensin system (RAS) inhibitors reduce the risk of cardiovascular diseases and end-stage kidney disease (ESKD) in chronic kidney disease (CKD) patients, they are often discontinued in clinical practice due to drug-related adverse ... ...

    Abstract Although renin-angiotensin system (RAS) inhibitors reduce the risk of cardiovascular diseases and end-stage kidney disease (ESKD) in chronic kidney disease (CKD) patients, they are often discontinued in clinical practice due to drug-related adverse events. However, limited evidence is available about the clinical impact of RAS inhibitor discontinuation in CKD patients. A comprehensive search of publications investigating the effect of discontinuing RAS inhibitors on clinical outcomes in CKD patients in PubMed, the Cochrane Library, and Web of Science was conducted (inception to November 7, 2022), and potentially relevant studies were searched by hand (through November 30, 2022). Two reviewers independently extracted data according to the PRISMA and MOOSE guidelines and assessed the quality of each study with risk-of-bias tools, RoB2 and ROBINS-I. The pooled hazard ratio (HR) for each outcome was integrated with a random-effect model. A total of 1 randomized clinical trial and 6 observational studies involving 248,963 patients were included in the systematic review. The meta-analysis of observational studies showed that discontinuation of RAS inhibitors was associated with a higher risk of all-cause mortality (HR, 1.41 [95% CI, 1.23-1.62]; I
    MeSH term(s) Humans ; Renin-Angiotensin System ; Antihypertensive Agents/therapeutic use ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Kidney Failure, Chronic/drug therapy ; Kidney Failure, Chronic/complications ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Enzyme Inhibitors/pharmacology ; Randomized Controlled Trials as Topic
    Chemical Substances Antihypertensive Agents ; Angiotensin-Converting Enzyme Inhibitors ; Enzyme Inhibitors
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01260-8
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  3. Article ; Online: Calcified cerebral embolism due to aortic valve calcification.

    Nakayama, Takashin / Wakino, Shu / Itoh, Hiroshi

    Clinical and experimental nephrology

    2020  Volume 24, Issue 11, Page(s) 1084–1085

    MeSH term(s) Aged ; Aortic Valve/diagnostic imaging ; Aortic Valve/pathology ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/diagnostic imaging ; Calcinosis/complications ; Calcinosis/diagnostic imaging ; Diabetic Nephropathies/complications ; Echocardiography ; Humans ; Intracranial Embolism/etiology ; Kidney Failure, Chronic/complications ; Male ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-06-27
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-020-01923-7
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  4. Article ; Online: Peritoneal dialysis-related peritonitis caused by Paracoccus yeei.

    Nakayama, Takashin / Morimoto, Kohkichi / Uchiyama, Kiyotaka

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

    2020  Volume 25, Issue 5, Page(s) 715–717

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Ceftriaxone/therapeutic use ; Gram-Negative Bacterial Infections/complications ; Gram-Negative Bacterial Infections/drug therapy ; Humans ; Male ; Middle Aged ; Paracoccus/isolation & purification ; Peritoneal Dialysis/adverse effects ; Peritonitis/drug therapy ; Peritonitis/etiology ; Peritonitis/microbiology
    Chemical Substances Anti-Bacterial Agents ; Ceftriaxone (75J73V1629)
    Language English
    Publishing date 2020-12-13
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 2119809-3
    ISSN 1744-9987 ; 1091-6660 ; 1744-9979
    ISSN (online) 1744-9987
    ISSN 1091-6660 ; 1744-9979
    DOI 10.1111/1744-9987.13604
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    Zs.A 5208: Show issues Location:
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  5. Article ; Online: Comparison of the effects of angiotensin receptor-neprilysin inhibitors and thiazide diuretic/renin-angiotensin system inhibitor combination therapy in hypertensive patients: a retrospective cohort study.

    Mitsuno, Ryunosuke / Uchiyama, Kiyotaka / Nakayama, Takashin / Takahashi, Rina / Yoshimoto, Norifumi / Yamaguchi, Shintaro / Washida, Naoki / Kanda, Takeshi / Hayashi, Kaori / Itoh, Hiroshi

    Journal of human hypertension

    2023  Volume 37, Issue 12, Page(s) 1049–1055

    Abstract: Angiotensin receptor-neprilysin inhibitors (ARNIs) have been approved as antihypertensive agents in Japan, and thiazide diuretics (TZDs) are widely used concomitantly with renin-angiotensin system inhibitors (RASIs) for hypertension. This retrospective ... ...

    Abstract Angiotensin receptor-neprilysin inhibitors (ARNIs) have been approved as antihypertensive agents in Japan, and thiazide diuretics (TZDs) are widely used concomitantly with renin-angiotensin system inhibitors (RASIs) for hypertension. This retrospective study included patients with hypertension who switched from RASI to ARNI therapy (ARNI group) and those who were prescribed TZDs with RASIs (TZD/RASI group). Drug-related changes in the estimated glomerular filtration rate (eGFR), blood pressure (BP), body weight (BW), serum electrolytes, uric acid (UA), and triglyceride levels were compared between the two groups. Overall, 70 participants (31 and 39 in the ARNI and TZD/RASI groups, respectively) were enrolled and observed for a median of 2 months. According to linear mixed models, compared with the TZD/RASI group, the ARNI group exhibited a significant change in mean eGFR of 3.71 mL/min/1.73 m
    MeSH term(s) Humans ; Angiotensin Receptor Antagonists/adverse effects ; Antihypertensive Agents/adverse effects ; Heart Failure/drug therapy ; Hypertension/diagnosis ; Hypertension/drug therapy ; Neprilysin/pharmacology ; Neprilysin/therapeutic use ; Receptors, Angiotensin/therapeutic use ; Renin-Angiotensin System ; Retrospective Studies ; Sodium Chloride Symporter Inhibitors/therapeutic use ; Triglycerides
    Chemical Substances Angiotensin Receptor Antagonists ; Antihypertensive Agents ; Neprilysin (EC 3.4.24.11) ; Receptors, Angiotensin ; Sodium Chloride Symporter Inhibitors ; Triglycerides
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-023-00851-9
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    Zs.A 2380: Show issues Location:
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  6. Article ; Online: Seasonal variation in predialysis systolic blood pressure and cardiovascular events in patients on maintenance hemodialysis.

    Takahashi, Rina / Maruki, Tomomi / Uchiyama, Kiyotaka / Washida, Naoki / Shibagaki, Keigo / Yanai, Akane / Nakayama, Takashin / Hayashi, Kaori / Kanda, Takeshi / Itoh, Hiroshi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 9, Page(s) 2192–2202

    Abstract: Predialysis systolic blood pressure (SBP) in patients on hemodialysis (HD) consistently followed a seasonal pattern, reaching a peak in winter and nadir in summer, similar to blood pressure in the general population. However, the relationship between ... ...

    Abstract Predialysis systolic blood pressure (SBP) in patients on hemodialysis (HD) consistently followed a seasonal pattern, reaching a peak in winter and nadir in summer, similar to blood pressure in the general population. However, the relationship between seasonal variations in predialysis SBP and clinical outcomes is still under-investigated in Japanese patients on HD. This retrospective cohort study included 307 Japanese patients undergoing HD for >1 year in three dialysis clinics and evaluated the association between the standard deviation (SD) of predialysis SBP and clinical outcomes, including major adverse cardiovascular events (MACEs; cardiovascular death, nonfatal myocardial infarction or unstable angina, stroke, heart failure, and other severe cardiovascular events requiring hospitalization) with 2.5 years follow-up. The SD of predialysis SBP was 8.2 (6.4-10.9) mmHg. In the model fully adjusted for the SD of predialysis SBP, predialysis SBP, age, sex, HD vintage, Charlson comorbidity index, ultrafiltration rate, renin-angiotensin system inhibitors, corrected calcium, phosphorus, human atrial natriuretic peptide, C-reactive protein, albumin, hemoglobin, body mass index, normalized protein catabolism rate, and intradialytic SBP decline, Cox regression analyses showed that a higher SD of predialysis SBP (per 10 mmHg) was significantly associated with increased MACE risk (hazard ratio [HR], 1.89; 95% confidence interval [95% CI], 1.07-3.36) and all-cause hospitalization (HR, 1.57; 95% CI, 1.07-2.30). Therefore, greater seasonal variations in predialysis SBP were associated with worse clinical outcomes, including MACEs and all-cause hospitalization. Whether interventions to reduce seasonal variations in predialysis SBP will improve the prognosis of Japanese patients on HD must be investigated further.
    MeSH term(s) Humans ; Blood Pressure ; Heart Failure/complications ; Kidney Failure, Chronic/complications ; Renal Dialysis ; Retrospective Studies ; Seasons ; Male ; Female
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01364-1
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    Zs.A 3898: Show issues Location:
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  7. Article ; Online: Mean annual intradialytic blood pressure decline and cardiovascular events in Japanese patients on maintenance hemodialysis.

    Takahashi, Rina / Uchiyama, Kiyotaka / Washida, Naoki / Shibagaki, Keigo / Yanai, Akane / Nakayama, Takashin / Nagashima, Kengo / Sato, Yasunori / Kanda, Takeshi / Itoh, Hiroshi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 6, Page(s) 1536–1546

    Abstract: An intradialytic systolic blood pressure (SBP) decline, which defines intradialytic hypotension, may be associated with higher all-cause mortality. However, in Japanese patients on hemodialysis (HD), the association between intradialytic SBP decline and ... ...

    Abstract An intradialytic systolic blood pressure (SBP) decline, which defines intradialytic hypotension, may be associated with higher all-cause mortality. However, in Japanese patients on hemodialysis (HD), the association between intradialytic SBP decline and patient outcomes is unclear. This retrospective cohort study included 307 Japanese patients undergoing HD over 1 year in three dialysis clinics and evaluated the association between the mean annual intradialytic SBP decline (predialysis SBP-nadir intradialytic SBP) and clinical outcomes, including major adverse cardiovascular events (MACEs; cardiovascular death, nonfatal myocardial infarction or unstable angina, stroke, heart failure, and other severe cardiovascular events requiring hospitalization) by following up for 2 years. The mean annual intradialytic SBP decline was 24.2 (25-75th percentile, 18.3-35.0) mmHg. In the model fully adjusted for intradialytic SBP decline tertile group (T1, <20.4 mmHg; T2, 20.4 to <29.9 mmHg; T3, ≥29.9 mmHg), predialysis SBP, age, sex, HD vintage, Charlson comorbidity index, ultrafiltration rate, use of renin-angiotensin system inhibitors, corrected calcium, phosphorus, human atrial natriuretic peptide, geriatric nutritional risk index, normalized protein catabolism rate, C-reactive protein, hemoglobin, and use of pressor agents, Cox regression analyses showed that the hazard ratio (HR) was significantly higher for T3 than for T1 for MACEs (HR, 2.38; 95% confidence interval 1.12-5.09) and all-cause hospitalization (HR, 1.68; 95% confidence interval 1.03-2.74). Therefore, in Japanese patients on HD, a greater intradialytic SBP decline was associated with worse clinical outcomes. Further studies are warranted to investigate whether interventions to attenuate the intradialytic SBP decline will improve the prognosis of Japanese patients on HD.
    MeSH term(s) Humans ; Blood Pressure/physiology ; East Asian People ; Hypotension/etiology ; Kidney Failure, Chronic/complications ; Renal Dialysis/adverse effects ; Retrospective Studies
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01228-8
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  8. Article ; Online: Hemodialysis treatment of vancomycin-induced drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome in a patient undergoing peritoneal dialysis.

    Mitsuno, Ryunosuke / Nakayama, Takashin / Uchiyama, Kiyotaka / Yoshimoto, Norifumi / Kusahana, Ei / Morimoto, Kohkichi / Yoshino, Jun / Yoshida, Tadashi / Kanda, Takeshi / Yamaguchi, Shintaro / Hayashi, Kaori

    CEN case reports

    2024  

    Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a severe drug-induced hypersensitivity reaction with 10% mortality. To date, there is insufficient evidence regarding the ... ...

    Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a severe drug-induced hypersensitivity reaction with 10% mortality. To date, there is insufficient evidence regarding the association between DRESS/DIHS and serum levels of vancomycin (VCM). Here, we report the case of a 46-year-old woman undergoing peritoneal dialysis who developed VCM-induced DRESS/DIHS. She was hospitalized for peritonitis with abdominal pain and treated with VCM. On day 10 of hospitalization, her abdominal symptoms improved; however, fever, skin rash, lymphadenopathy, eosinophilia, atypical lymphocytes, and liver and renal dysfunction developed. Based on the clinical course and laboratory findings, we diagnosed the patient with DRESS/DIHS due to VCM. Since her serum VCM concentration was high at 39.8 μg/mL, hemodialysis (HD) was performed to remove VCM, which caused her symptoms to improve. However, serum levels of VCM rebounded and the same symptoms recurred. Therefore, we re-performed HD; no further relapse occurred. This clinical course showed that increased serum VCM levels were associated with DRESS/DIHS onset and severity, suggesting that it is a blood level-dependent disease and that removal of VCM by HD is a potential therapeutic option.
    Language English
    Publishing date 2024-02-10
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2660492-9
    ISSN 2192-4449 ; 2192-4449
    ISSN (online) 2192-4449
    ISSN 2192-4449
    DOI 10.1007/s13730-023-00847-x
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  9. Article ; Online: Renal cortical hypoperfusion caused by glyphosate-surfactant herbicide.

    Nakayama, Takashin / Mimura, Yu / Hirano, Keita

    Clinical and experimental nephrology

    2019  Volume 23, Issue 6, Page(s) 865–866

    MeSH term(s) Acute Kidney Injury/chemically induced ; Aged ; Female ; Glycine/analogs & derivatives ; Glycine/poisoning ; Herbicides/poisoning ; Humans ; Kidney Cortex/blood supply ; Kidney Cortex/drug effects ; Surface-Active Agents/poisoning ; Glyphosate
    Chemical Substances Herbicides ; Surface-Active Agents ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2019-01-19
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-019-01691-z
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  10. Article ; Online: Optimal imaging conditions for the diagnosis of pleuroperitoneal communication.

    Nakayama, Takashin / Hashimoto, Kohei / Kiriyama, Takeshi / Hirano, Keita

    BMJ case reports

    2019  Volume 12, Issue 3

    Abstract: A 70-year-old woman with end-stage renal disease caused by a polycystic kidney disease developed massive right-sided pleural effusion 10 days after the initiation of peritoneal dialysis (PD). Although pleuroperitoneal communication (PPC) was suspected, ... ...

    Abstract A 70-year-old woman with end-stage renal disease caused by a polycystic kidney disease developed massive right-sided pleural effusion 10 days after the initiation of peritoneal dialysis (PD). Although pleuroperitoneal communication (PPC) was suspected, computed tomographic peritoneography on usual breath holding did not show leakage. Therefore, we instructed her to strain with maximal breathing, which caused a jet of contrast material to stream from the peritoneal cavity into the right pleural cavity and allowed the identification of the exact site of the diaphragm defect. Following the thoracoscopic closure of the defect, she was discharged without recurrence of hydrothorax on PD. Hydrothorax due to PPC is a rare complication of PD. Notably, numerous previous modalities used to diagnose PPC lack sufficient sensitivity. Thus, an approach to spread the pressure gradient between the peritoneal cavity and the pleural cavity on imaging may improve this insufficient sensitivity.
    MeSH term(s) Aged ; Diaphragm/surgery ; Dyspnea ; Female ; Humans ; Hydrothorax/diagnostic imaging ; Hydrothorax/etiology ; Hydrothorax/surgery ; Kidney Failure, Chronic/therapy ; Peritoneal Dialysis/adverse effects ; Pleural Effusion/diagnostic imaging ; Pleural Effusion/etiology ; Pleural Effusion/surgery ; Thoracostomy/methods ; Treatment Outcome
    Language English
    Publishing date 2019-03-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2018-228940
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