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Book ; Online ; E-Book: Kenzan method for scaffold-free biofabrication

Nakayama, Koichi

2021

Abstract: This is the first book about the “Kenzan” method for scaffold-free biofabrication, which does not rely on biomaterials as scaffolds to ensure correct multicellular spheroid positioning for building three dimensional construct only made from cells. The ... ...

Author's details	Koichi Nakayama, editor
Abstract	This is the first book about the “Kenzan” method for scaffold-free biofabrication, which does not rely on biomaterials as scaffolds to ensure correct multicellular spheroid positioning for building three dimensional construct only made from cells. The book explains the basic principles and concepts of the microneedle-based (“Kenzan”) method of building surgically-implantable tissue constructs using robotic cell spheroid-based three-dimensional bioprinting, a novel technology that opens up unique opportunities for the bioengineering of tissues and organs. First book on the novel Kenzan method of tissue engineering; Explains basic concepts and applications for organ regeneration modeling; Introduces a unique robotic system for scaffold-free cell construction.
Keywords	Tissue engineering ; Biomedical engineering ; Mechanical engineering
Subject code	610.28
Language	English
Size	1 online resource (VIII, 184 p. 63 illus., 44 illus. in color.)
Edition	1st ed. 2021.
Publisher	Springer
Publishing place	Cham, Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-58688-X ; 3-030-58687-1 ; 978-3-030-58688-1 ; 978-3-030-58687-4
DOI	10.1007/978-3-030-58688-1
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Characteristics of throwing arm movement for an elongated implement: a comparison of the javelin and baseball throwing.

Makino, Mizuki / Nakayama, Koichi / Ando, Yuka / Tauchi, Kenji

The Journal of sports medicine and physical fitness

2024

Abstract: Background: In javelin, although many previous studies have examined throwing movements that can increase initial velocity, the characteristics of throwing arm movement an elongated implement have not been clarified. The purpose of the present study was ...

Abstract	Background: In javelin, although many previous studies have examined throwing movements that can increase initial velocity, the characteristics of throwing arm movement an elongated implement have not been clarified. The purpose of the present study was to examine the characteristics of the throwing movement of an elongated implement by comparing throwing movement between a javelin and baseball. Methods: Twelve male javelin throwers were asked to perform a javelin throw (JT) and a baseball long toss (LT) twice. The three-dimensional coordinates of reflective markers attached to the athlete's body, javelin, and baseball were measured using an optical motion capture system. %Trajectory was used as an index to evaluate the degree to which the hand was moved linearly during the throw. A smaller value of this indicator meant that the hand was move closer to a straight line. The joint angles in the throwing arm were obtained by calculating the Euler angles between body segments. These data were used to compare JT and LT. Results: %Trajectory showed that JT was significantly smaller than LT. Significant differences in the joint angles of the throwing arm were noted between JT and LT. Conclusions: JT showed a kinematic pattern in which the hand was moved more linearly than in baseball long toss.
Language	English
Publishing date	2024-02-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	410823-1
ISSN	1827-1928 ; 0022-4707
ISSN (online)	1827-1928
ISSN	0022-4707
DOI	10.23736/S0022-4707.24.15706-4
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Article ; Online: Special Issue: Biofabrication with Spheroid and Organoid Materials.

Skylar-Scott, Mark / Declercq, Heidi / Nakayama, Koichi

Acta biomaterialia

2023 Volume 165, Page(s) 1–3

MeSH term(s)	Organoids ; Tissue Engineering
Language	English
Publishing date	2023-05-23
Publishing country	England
Document type	Editorial
ZDB-ID	2173841-5
ISSN	1878-7568 ; 1742-7061
ISSN (online)	1878-7568
ISSN	1742-7061
DOI	10.1016/j.actbio.2023.05.036
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Article: Kinematic Contribution to Javelin Velocity at Different Run-Up Velocities in Male Athletes.

Makino, Mizuki / Nakayama, Koichi / Ando, Yuka / Tauchi, Kenji

Journal of human kinetics

2023 Volume 89, Page(s) 43–52

Abstract: In javelin training, many athletes improve their throwing technique by throwing from a slower run-up velocity than in competitions. However, whether the acquisition of javelin velocity in throwing from a slower run-up velocity is the same as in full run- ... ...

Abstract	In javelin training, many athletes improve their throwing technique by throwing from a slower run-up velocity than in competitions. However, whether the acquisition of javelin velocity in throwing from a slower run-up velocity is the same as in full run-up throwing is unclear. The purpose of this study was to clarify the differences in the contribution of each movement to the javelin velocity caused by changes in the run-up velocity within an individual. Twelve collegiate male javelin throwers were included in this study. Athletes performed two types of throws: one-cross throwing (Cross) and full run-up throwing (Run). The coordinates of reflective markers attached to the thrower's body and the javelin were recorded using an optical motion capture system. The percentage contribution of each joint movement to the javelin velocity was calculated and compared between Cross and Run. Cross had a lower contribution of trunk forward lean to forward and upward javelin velocities compared to Run. On the other hand, Cross had a higher contribution of trunk counter-clockwise rotation to forward and upward javelin velocities than Run. These results suggest that as the velocity of run-up changes within an individual, the acquisition of javelin velocity also changes.
Language	English
Publishing date	2023-07-06
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2503989-1
ISSN	1899-7562 ; 1640-5544
ISSN (online)	1899-7562
ISSN	1640-5544
DOI	10.5114/jhk/168143
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Article ; Online: Differences in joint angles during pole vaulting between male pole vaulters with and without chronic low back pain

Enoki Shota / Kuramochi Rieko / Nakayama Koichi / Takigawa Hiroko / Shimizu Takuya

Biomedical Human Kinetics, Vol 15, Iss 1, Pp 131-

2023 Volume 138

Abstract: Study aim: To determine the difference in joint angles of the shoulder, hip, and trunk (angle of the upper torso and lower torso) during vaulting between male pole vaulters with and without chronic low back pain (LBP) and to examine the relationship ... ...

Abstract	Study aim: To determine the difference in joint angles of the shoulder, hip, and trunk (angle of the upper torso and lower torso) during vaulting between male pole vaulters with and without chronic low back pain (LBP) and to examine the relationship between the range of motion (ROM) and maximum angle of the same joint during vaulting in all participants.
Keywords	back pain ; lumbago ; track and field ; 3d-dlt ; Sports medicine ; RC1200-1245 ; Physiology ; QP1-981
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Total Gastrectomy for Gastric Invasion of Multiple Myeloma-A Case Report].

Miyamoto, Kotaro / Fujii, Ayumi / Tada, Takeshi / Nakayama, Koichi / Urazumi, Kojiro

Gan to kagaku ryoho. Cancer & chemotherapy

2023 Volume 50, Issue 10, Page(s) 1120–1122

Abstract: A 65-year-old woman was referred to our hospital for lumbago. The patient was diagnosed with multiple myeloma in 2020. She underwent chemotherapy and radiation therapy, and the disease progression stabilized. In 2022, the patient presented with severe ... ...

Abstract	A 65-year-old woman was referred to our hospital for lumbago. The patient was diagnosed with multiple myeloma in 2020. She underwent chemotherapy and radiation therapy, and the disease progression stabilized. In 2022, the patient presented with severe anemia(Hb 4.9 mg/dL), and upper gastrointestinal endoscopy revealed a type 1 tumor in the middle body of the stomach. Computed tomography showed masses in the stomach and pancreas. The patient required a large volume of blood transfusion and underwent total gastrectomy to control the bleeding. Histological examination of the resected specimen indicated infiltration of myeloma cells. The patient died from invasive lesions in other organs, a year after surgery. Usually, extramedullary multiple myeloma lesions occur in the liver, spleen, and lymph nodes. Gastric invasion of multiple myeloma is very rare. Because of poor prognosis, surgery for gastric invasion of multiple myeloma is even rarer. We report a case of gastric invasion of multiple myeloma with a literature review.
MeSH term(s)	Female ; Humans ; Aged ; Multiple Myeloma/surgery ; Stomach Neoplasms/drug therapy ; Gastrectomy/methods ; Lymph Nodes/pathology
Language	Japanese
Publishing date	2023-09-17
Publishing country	Japan
Document type	Review ; Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Bio-3D printing of scaffold-free osteogenic and chondrogenic constructs using rat adipose-derived stromal cells.

Fujimoto, Ryota / Murata, Daiki / Nakayama, Koichi

Frontiers in bioscience (Landmark edition)

2022 Volume 27, Issue 2, Page(s) 52

Abstract: Background: Although autogenous bone implantation is considered to be the gold standard for the reconstruction of bone defects, this approach remains challenging when treating extensive bone defects (EBDs). Therefore, artificial materials (AMs) such as ... ...

Abstract	Background: Although autogenous bone implantation is considered to be the gold standard for the reconstruction of bone defects, this approach remains challenging when treating extensive bone defects (EBDs). Therefore, artificial materials (AMs) such as artificial bone and scaffolds are often used for treating EBDs. Nevertheless, complications such as material failure, foreign body reaction, and infection are common. To overcome these issues, we aimed to develop a new treatment for an EBD using scaffold-free adipose-derived stromal cells (ADSCs) to fabricate chondrogenic/osteogenic-induced constructs without AMs. Methods: ADSCs were obtained from the subcutaneous adipose tissue of 8-week-old female Wistar rats (n = 3) and assessed to determine their potential for multilineage differentiation into adipocytes (Oil Red O staining), chondrocytes (hematoxylin and eosin, Alcian blue, and Safranin O staining), and osteoblasts (Alizarin red and von Kossa staining). Spheroids (n = 320), each containing 3.0 × 104 ADSCs, were then used to fabricate scaffold-free cell constructs using a bio-3D printer with a needle array. The spheroids and constructs were stimulated with induction medium to induce chondrogenic and osteogenic differentiation. The induced cartilage- and bone-like constructs were finally evaluated using micro-computed tomography (μCT) and histological analysis. Results: The collected ADSCs were capable of trilineage differentiation, and were successfully used to produce scaffold-free constructs. The fabricated constructs (n = 3) exhibited equivalent strength (load, 195.3 ± 6.1 mN; strength, 39.1 ± 1.2 kPa; and stiffness, 0.09 ± 0.01 N/mm) to that of soft tissues such as the muscles in the uninduced condition. In chondrogenic induction experiments, Alcian blue and Safranin O staining confirmed the differentiation of the constructs into cartilage, and cartilage tissue-like structures were produced. In the osteogenic induction experiment, Alizarin Red and von Kossa staining showed calcium salt deposition, and μCT images confirmed the same calcification level as that of the cortical bone. Conclusions: Scaffold-free constructs consisting of ADSCs without an AM were fabricated, and cartilage- and bone-like tissues were successfully generated, demonstrating their potential for bone reconstruction.
MeSH term(s)	Adipose Tissue ; Animals ; Cell Differentiation ; Cells, Cultured ; Female ; Osteogenesis/physiology ; Printing, Three-Dimensional ; Rats ; Rats, Wistar ; Stromal Cells ; Tissue Engineering/methods ; Tissue Scaffolds ; X-Ray Microtomography
Language	English
Publishing date	2022-02-28
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2704569-9
ISSN	2768-6698 ; 1093-9946
ISSN (online)	2768-6698
ISSN	1093-9946
DOI	10.31083/j.fbl2702052
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Article ; Online: Comparison of maximum joint angles during pole vaulting between male pole vaulters with and without lumbar disc degeneration or lumbar spondylolysis.

Enoki, Shota / Kuramochi, Rieko / Takigawa, Hiroko / Nakayama, Koichi / Mitsuyama, Hirohito

Journal of back and musculoskeletal rehabilitation

2022 Volume 36, Issue 3, Page(s) 629–636

Abstract: Background: Pole vaulting involves trunk flexion, extension, and rotation, which may place the lumbar spine under stress. Repeated pole vaulting may cause lumbar disc degeneration (DD) and lumbar spondylolysis (LS); however, this phenomenon is yet to be ...

Abstract	Background: Pole vaulting involves trunk flexion, extension, and rotation, which may place the lumbar spine under stress. Repeated pole vaulting may cause lumbar disc degeneration (DD) and lumbar spondylolysis (LS); however, this phenomenon is yet to be established. Objective: This study aimed to determine the difference in the maximum joint angles of the shoulder, hip, and trunk during pole vaulting between male pole vaulters with and without lumbar DD or LS. Methods: This retrospective study included 17 male pole vaulters. Four high-speed cameras were used to record the pole vaulters at 240 Hz. Radiography and magnetic resonance imaging were used to examine the lumbar spine in all athletes. Differences in the data between two sets of groups were analyzed using the unpaired t-test or the Mann-Whitney U test. Results: There was a significant difference in the maximum joint angle of hip flexion between pole vaulters with and without lumbar DD (p= 0.03). Conclusion: Pole vaulters with lumbar DD may use lumbar flexion instead of hip flexion during the rock-back movement. Moreover, LS may occur due to repeated failed vaulting. Therefore, trunk stability and functional movements should be prioritized to prevent organic changes in the lower back.
MeSH term(s)	Humans ; Male ; Intervertebral Disc Degeneration/diagnostic imaging ; Retrospective Studies ; Lumbar Vertebrae/diagnostic imaging ; Spondylolysis/diagnostic imaging ; Spondylolysis/pathology ; Athletes
Language	English
Publishing date	2022-12-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1184721-9
ISSN	1878-6324 ; 1053-8127
ISSN (online)	1878-6324
ISSN	1053-8127
DOI	10.3233/BMR-210331
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Article ; Online: Scaffold-free human vascular calcification model using a bio-three-dimensional printer.

Nagaishi, Yukiko / Murata, Daiki / Yoshizato, Hiromu / Nonaka, Toshihiro / Itoh, Manabu / Hara, Hideo / Nakayama, Koichi

Biofabrication

2023 Volume 15, Issue 4

Abstract: Morbidity and mortality rates associated with atherosclerosis-related diseases are increasing. Therefore, developing new research models is important in furthering our understanding of atherosclerosis and investigate novel treatments. Here, we designed ... ...

Abstract	Morbidity and mortality rates associated with atherosclerosis-related diseases are increasing. Therefore, developing new research models is important in furthering our understanding of atherosclerosis and investigate novel treatments. Here, we designed novel vascular-like tubular tissues from multicellular spheroids composed of human aortic smooth muscle cells, endothelial cells, and fibroblasts using a bio-3D printer. We also evaluated their potential as a research model for Mönckeberg's medial calcific sclerosis. The tubular tissues were sufficiently strong to be handled 1 week after printing and could still be cultured for 3 weeks. Histological assessment showed that calcified areas appeared in the tubular tissues within 1 week after culture in a medium containing inorganic phosphate (Pi) or calcium chloride as the calcification-stimulating factors. Calcium deposition was confirmed using micro-computed tomography imaging. Real-time quantitative reverse transcription polymerase chain reaction analysis revealed that the expression of osteogenic transcription factors increased in calcified tubular tissues. Furthermore, the administration of Pi and rosuvastatin enhanced tissue calcification. The bio-3D printed vascular-like tubular structures, which are composed of human-derived cells, can serve as a novel research model for Mönckeberg's medial calcific sclerosis.
MeSH term(s)	Humans ; Monckeberg Medial Calcific Sclerosis/metabolism ; Endothelial Cells/metabolism ; X-Ray Microtomography ; Vascular Calcification/diagnostic imaging ; Atherosclerosis
Language	English
Publishing date	2023-07-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2500944-8
ISSN	1758-5090 ; 1758-5082
ISSN (online)	1758-5090
ISSN	1758-5082
DOI	10.1088/1758-5090/ace000
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Article ; Online: Fabrication of Cardiac Constructs Using Bio-3D Printer.

Arai, Kenichi / Murata, Daiki / Takao, Shoko / Nakayama, Koichi

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2320, Page(s) 53–63

Abstract: The fabrication of three-dimensional (3D) cardiac tissue using human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is useful not only for regenerative medicine, but also for drug discovery. Here, we report a bio-3D printer that can ... ...

Abstract	The fabrication of three-dimensional (3D) cardiac tissue using human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is useful not only for regenerative medicine, but also for drug discovery. Here, we report a bio-3D printer that can fabricate tubular cardiac constructs using only human iPSC-CMs. Protocols to evaluate the contractile force and response to electrical stimulation in the cardiac constructs are described. We confirmed that the constructs can be applied for transplantation or drug response testing. In the near future, we expect that the constructs will be used as alternatives for heart transplantation and in animal experiments for new drug development.
MeSH term(s)	Cells, Cultured ; Heart Transplantation ; Human Umbilical Vein Endothelial Cells ; Humans ; Induced Pluripotent Stem Cells/cytology ; Myocytes, Cardiac/cytology ; Printing, Three-Dimensional ; Regenerative Medicine/methods ; Tissue Engineering/methods ; Tissue Scaffolds
Language	English
Publishing date	2021-07-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1484-6_6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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