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Article ; Online: Neurons promote encephalitogenic CD4

Nakazato, Yuki / Fujita, Yuki / Nakazato, Masamitsu / Yamashita, Toshihide

2020 Volume 10, Issue 1, Page(s) 7354

Abstract: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by neuroinflammation, leading to demyelination and axonal degeneration. Neuronal excitotoxity mediated by ... ...

Abstract	Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by neuroinflammation, leading to demyelination and axonal degeneration. Neuronal excitotoxity mediated by Ca
MeSH term(s)	Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Chemokine CCL2/genetics ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/genetics ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/immunology ; Neurodegenerative Diseases/metabolism ; Neurons/immunology ; Neurons/metabolism ; Proto-Oncogene Proteins c-fos/genetics ; Receptors, CCR2/genetics ; Tumor Necrosis Factor-alpha/genetics
Chemical Substances	Ccl2 protein, mouse ; Ccr2 protein, mouse ; Chemokine CCL2 ; Proto-Oncogene Proteins c-fos ; Receptors, CCR2 ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2020-04-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-64363-z
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Article: Prescription trend and lactic acidosis in patients prescribed metformin before and after the revision of package insert for allowing metformin administration to patients with moderately decreased kidney function based on real-world data from MID-NET

Waki, Takashi / Okada, Yusuke / Kinoshita, Yuki / Kajiyama, Kazuhiro / Ishiguro, Chieko / Nakazato, Yuki / Kimura, Ryota / Maniwa, Harumi / Horiuchi, Naoya / Iguchi, Toyotaka / Uyama, Yoshiaki

Frontiers in medicine

2024 Volume 10, Page(s) 1294696

Abstract: Introduction: This study was conducted to understand the impact of package insert (PI) revision in Japan on 18 June 2019 to allow metformin use for patients with moderately decreased kidney function (30 ≤ estimated glomerular filtration rate (eGFR) < 60 ...

Abstract	Introduction: This study was conducted to understand the impact of package insert (PI) revision in Japan on 18 June 2019 to allow metformin use for patients with moderately decreased kidney function (30 ≤ estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m Methods: A new user cohort design was employed to examine the prescription trend and the occurrence of lactic acidosis in patients prescribed metformin before and after PI revision using the Medical Information Database Network (MID-NET Results: From 12 May 2016 to 31 March 2020, 5,874 patients (before, Conclusion: The results of this study are useful for understanding the safety of metformin use in patients with decreased kidney function and suggest no worse impacts of PI revision in Japan, indicating no further safety concerns on metformin use in patients with moderately decreased kidney function under the situation with careful use and safety monitoring of metformin.
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1294696
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Article ; Online: Increased risk of hypocalcemia with decreased kidney function in patients prescribed bisphosphonates based on real-world data from the MID-NET

Hasegawa, Tomoaki / Komamine, Maki / Ishiguro, Chieko / Motomura, Haruka / Kajiyama, Kazuhiro / Nonaka, Takahiro / Nakazato, Yuki / Kimura, Ryota / Maniwa, Harumi / Iguchi, Toyotaka / Horiuchi, Naoya / Uyama, Yoshiaki

BMC nephrology

2024 Volume 25, Issue 1, Page(s) 134

Abstract: Background: In the post-marketing stage, cases of hypocalcemia associated with bisphosphonate preparations (BPs) have been reported in patients with decreased kidney function, despite warning against use of BPs in such patients in the package insert (PI) ...

Abstract	Background: In the post-marketing stage, cases of hypocalcemia associated with bisphosphonate preparations (BPs) have been reported in patients with decreased kidney function, despite warning against use of BPs in such patients in the package insert (PI) of Japan. The purpose of this study was to investigate the safety of BPs in patients with decreased kidney function. Methods: The cohort study was conducted in patients with osteoporosis and newly prescribed bisphosphonate utilizing real-world data from MID-NET Results: A total of 14,551 patients were included in the analysis, comprising 2,601 (17.88%) with normal (eGFR ≥ 90 mL/min/1.73m Conclusions: These findings suggest that the risk of hypocalcemia during BP prescription is higher in patients with decreased kidney function, particularly those with severely decreased kidney function. The quantitative real-world evidence on the safety risk of BPs obtained in this study has led to the PI revision describing a relationship between hypocalcemia risk and decreased kidney function as a regulatory action in Japan and will contribute to promoting the proper use of BPs with appropriate risk management in clinical practice.
MeSH term(s)	Humans ; Cohort Studies ; Hypocalcemia/chemically induced ; Hypocalcemia/epidemiology ; Japan/epidemiology ; Diphosphonates/adverse effects ; Kidney
Chemical Substances	Diphosphonates
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-024-03553-7
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Article ; Online: Cardiovascular risk of urate-lowering drugs: A study using the National Database of Health Insurance Claims and Specific Health Checkups of Japan.

Sawada, Sono / Kajiyama, Kazuhiro / Shida, Haruka / Kimura, Ryota / Nakazato, Yuki / Iguchi, Toyotaka / Oniyama, Yukio / Ishiguro, Chieko / Uyama, Yoshiaki

Clinical and translational science

2022 Volume 16, Issue 2, Page(s) 206–215

Abstract: In the present study, we aimed to investigate the association between urate-lowering drugs and cardiovascular events, primarily focusing on the risk of febuxostat and topiroxostat when compared with allopurinol in Japan. We conducted an observational ... ...

Abstract	In the present study, we aimed to investigate the association between urate-lowering drugs and cardiovascular events, primarily focusing on the risk of febuxostat and topiroxostat when compared with allopurinol in Japan. We conducted an observational study with a cohort design using the National Database of Health Insurance Claims and Specific Health Checkups of Japan, including new urate-lowering drugs users between August 1, 2010, and March 31, 2018. Exposure and control groups were defined based on the first prescription of urate-lowering drugs as follows: febuxostat or topiroxostat for exposure groups, allopurinol for the control group, and benzbromarone for the secondary control group. The primary outcome was cardiovascular events, defined as a composite of acute coronary syndrome, cerebral infarction, and cerebral hemorrhage. Hazard ratios were estimated using a Cox proportional hazards model. The number of patients in each exposure and control group was 1,357,671 in the febuxostat group, 83,683 in the topiroxostat group, 1,273,211 in the allopurinol group, and 258,786 in the benzbromarone group. The adjusted hazard ratios for the cardiovascular risk were 0.97 (95% confidence interval [CI]: 0.95-0.98) for febuxostat and 0.84 (95% CI: 0.78-0.90) for topiroxostat groups. The benzbromarone group exhibited similar results. No increased cardiovascular risk was observed with febuxostat or topiroxostat when compared with allopurinol in patients with hyperuricemia in Japan. These results provide real-world evidence regarding the cardiovascular risk associated with urate-lowering drugs, indicating that no additional safety-related regulatory actions are warranted in Japan.
MeSH term(s)	Humans ; Uric Acid ; Febuxostat ; Allopurinol ; Gout/drug therapy ; Gout Suppressants/adverse effects ; Benzbromarone/adverse effects ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/drug therapy ; Japan/epidemiology ; Risk Factors ; Insurance, Health ; Heart Disease Risk Factors ; Treatment Outcome
Chemical Substances	Uric Acid (268B43MJ25) ; Febuxostat (101V0R1N2E) ; FYX-051 (0J877412JV) ; Allopurinol (63CZ7GJN5I) ; Gout Suppressants ; Benzbromarone (4POG0RL69O)
Language	English
Publishing date	2022-11-11
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2433157-0
ISSN	1752-8062 ; 1752-8054
ISSN (online)	1752-8062
ISSN	1752-8054
DOI	10.1111/cts.13439
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Article ; Online: In Vivo

Kokubo, Eri / Sonoki, Hirofumi / Aizawa, Kenta / Takagi, Hiroki / Takada, Masayasu / Ito, Ayako / Nakazato, Yuki / Takeda, Yasuhiro / Miyaji, Kazuhiro

Journal of applied glycoscience

2022 Volume 69, Issue 3, Page(s) 57–63

Abstract: Slowly digestible carbohydrates are needed for nutritional support in diabetic patients with malnutrition. They are a good source of energy and have the advantage that their consumption produces a low postprandial peak in blood glucose levels because ... ...

Abstract	Slowly digestible carbohydrates are needed for nutritional support in diabetic patients with malnutrition. They are a good source of energy and have the advantage that their consumption produces a low postprandial peak in blood glucose levels because they are slowly and completely digested in the small intestine. A high-amount isomaltomegalosaccharide containing carbohydrate (H-IMS), made from starch by dextrin dextranase, is a mixture of glucose polymers which has a continuous linear structure of α-1,6-glucosidic bonds and a small number of α-1,4-glucosidic bonds at the reducing ends. It has a broad degree of polymerization (DP) distribution with glucans of DP 10－30 as the major component. In our previous study, H-IMS has been shown to exhibit slow digestibility
Language	English
Publishing date	2022-08-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2395554-5
ISSN	1880-7291 ; 1880-7291
ISSN (online)	1880-7291
ISSN	1880-7291
DOI	10.5458/jag.jag.JAG-2021_0013
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Article ; Online: Liver-expressed antimicrobial peptide 2 functions independently of growth hormone secretagogue receptor in calorie-restricted mice.

Islam, Md Nurul / Zhang, Weidong / Sakai, Katsuya / Nakazato, Yuki / Tanida, Ryota / Sakoda, Hideyuki / Takei, Toshiki / Takao, Toshifumi / Nakazato, Masamitsu

Peptides

2022 Volume 151, Page(s) 170763

Abstract: Ghrelin is a gastric-derived peptide that stimulates feeding, blood glucose elevation, body temperature reduction, and growth hormone (GH) secretion. Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist of the ghrelin receptor, ... ...

Abstract	Ghrelin is a gastric-derived peptide that stimulates feeding, blood glucose elevation, body temperature reduction, and growth hormone (GH) secretion. Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist of the ghrelin receptor, also called growth hormone secretagogue receptor (GHSR). We studied the effects of LEAP2 administration on feeding, body weight, glycemia, body temperature, and inflammation-related genes in the liver in C57BL/6 J mice and Ghsr-knockout (Ghsr-KO) mice. We found that a single administration of LEAP2 did not abolish fasting-induced food intake in 24-h fasted C57BL/6 J mice or Ghsr-KO mice. Moreover, continuous LEAP2 administration to mice fed ad libitum for 6 days did not affect feeding, body temperature, plasma ghrelin, or blood glucose. By contrast, continuous LEAP2 administration to calorie-restricted C57BL/6 J mice and Ghsr-KO mice induced body weight loss, hypoglycemia, body temperature reduction, and upregulation of Il-6 and Il-1β mRNAs in the liver. Our findings suggest that LEAP2 functions independently of GHSR, implying that LEAP2 affects physiology beyond the ghrelin-GHSR system.
MeSH term(s)	Animals ; Antimicrobial Cationic Peptides/pharmacology ; Blood Glucose/metabolism ; Caloric Restriction ; Ghrelin/genetics ; Ghrelin/pharmacology ; Liver/drug effects ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Ghrelin/genetics
Chemical Substances	Antimicrobial Cationic Peptides ; Blood Glucose ; Ghrelin ; Leap2 protein, mouse ; Receptors, Ghrelin
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	769028-9
ISSN	1873-5169 ; 0196-9781
ISSN (online)	1873-5169
ISSN	0196-9781
DOI	10.1016/j.peptides.2022.170763
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Article: Liver-expressed antimicrobial peptide 2 functions independently of growth hormone secretagogue receptor in calorie-restricted mice

Islam, Md Nurul / Zhang, Weidong / Sakai, Katsuya / Nakazato, Yuki / Tanida, Ryota / Sakoda, Hideyuki / Takei, Toshiki / Takao, Toshifumi / Nakazato, Masamitsu

Peptides. 2022 May, v. 151

2022

Abstract	Ghrelin is a gastric-derived peptide that stimulates feeding, blood glucose elevation, body temperature reduction, and growth hormone (GH) secretion. Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist of the ghrelin receptor, also called growth hormone secretagogue receptor (GHSR). We studied the effects of LEAP2 administration on feeding, body weight, glycemia, body temperature, and inflammation-related genes in the liver in C57BL/6 J mice and Ghsr-knockout (Ghsr-KO) mice. We found that a single administration of LEAP2 did not abolish fasting-induced food intake in 24-h fasted C57BL/6 J mice or Ghsr-KO mice. Moreover, continuous LEAP2 administration to mice fed ad libitum for 6 days did not affect feeding, body temperature, plasma ghrelin, or blood glucose. By contrast, continuous LEAP2 administration to calorie-restricted C57BL/6 J mice and Ghsr-KO mice induced body weight loss, hypoglycemia, body temperature reduction, and upregulation of Il-6 and Il-1β mRNAs in the liver. Our findings suggest that LEAP2 functions independently of GHSR, implying that LEAP2 affects physiology beyond the ghrelin–GHSR system.
Keywords	antagonists ; antimicrobial peptides ; blood glucose ; body temperature ; body weight changes ; food intake ; ghrelin ; ghrelin receptors ; hypoglycemia ; interleukin-6 ; liver ; secretion ; somatotropin
Language	English
Dates of publication	2022-05
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	769028-9
ISSN	1873-5169 ; 0196-9781
ISSN (online)	1873-5169
ISSN	0196-9781
DOI	10.1016/j.peptides.2022.170763
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Article ; Online: Neuromedin U uses Gαi2 and Gαo to suppress glucose-stimulated Ca2+ signaling and insulin secretion in pancreatic β cells.

Zhang, Weidong / Sakoda, Hideyuki / Nakazato, Yuki / Islam, Md Nurul / Pattou, François / Kerr-Conte, Julie / Nakazato, Masamitsu

PloS one

2021 Volume 16, Issue 4, Page(s) e0250232

Abstract: Neuromedin U (NMU), a highly conserved peptide in mammals, is involved in a wide variety of physiological processes, including impairment of pancreatic β-cell function via induction of mitochondrial dysfunction and endoplasmic reticulum (ER) stress, ... ...

Abstract	Neuromedin U (NMU), a highly conserved peptide in mammals, is involved in a wide variety of physiological processes, including impairment of pancreatic β-cell function via induction of mitochondrial dysfunction and endoplasmic reticulum (ER) stress, ultimately suppressing insulin secretion. NMU has two receptors, NMU receptor 1 (NMUR1) and NMUR2, both of which are G-protein-coupled receptors (GPCRs). Only NMUR1 is expressed in mouse islets and β cell-derived MIN6-K8 cells. The molecular mechanisms underlying the insulinostatic action mediated by NMUR1 in β cells have yet to be elucidated. In this study, we explored the molecular mechanism driving impairment of insulin secretion in β cells by the NMU-NMUR1 axis. Pretreatment with the Gαi/o inhibitor Bordetella pertussis toxin (PTX), but not the Gαq inhibitor YM254890, abolished NMU-induced suppression of glucose-stimulated insulin secretion and calcium response in β cells. Knockdown of Gαi2 and Gαo in β cells counteracted NMU-induced suppression of insulin secretion and gene alterations related to mitochondrial fusion (Mfn1, Mfn2), fission (Fis1, Drp1), mitophagy (Pink1, Park2), mitochondrial dynamics (Pgc-1α, Nrf1, and Tfam), ER stress (Chop, Atp2a3, Ryr2, and Itpr2), intracellular ATP level, and mitochondrial membrane potential. NMU decreased forskolin-stimulated intracellular cAMP in both mouse and human islets. We concluded that NMUR1 coupled to PTX-sensitive Gαi2 and Gαo proteins in β cells reduced intracellular Ca2+ influx and cAMP level, thereby causing β-cell dysfunction and impairment. These results highlight a novel signaling mechanism of NMU and provide valuable insights into the further investigation of NMU functions in β-cell biology.
MeSH term(s)	Animals ; Calcium Signaling/drug effects ; Cell Line ; GTP-Binding Proteins/metabolism ; Glucose/pharmacology ; Humans ; Insulin Secretion/drug effects ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Neuropeptides/pharmacology ; Receptors, Neurotransmitter/metabolism
Chemical Substances	Neuropeptides ; Receptors, Neurotransmitter ; neuromedin U receptor ; neuromedin U (117505-80-3) ; GTP-Binding Proteins (EC 3.6.1.-) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2021-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0250232
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Article ; Online: Ingestion of partially hydrolyzed whey protein suppresses epicutaneous sensitization to β-lactoglobulin in mice.

Matsubara, Takeshi / Iwamoto, Hiroshi / Nakazato, Yuki / Okamoto, Tomoyuki / Ehara, Tatsuya / Izumi, Hirohisa / Takeda, Yasuhiro

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2018 Volume 29, Issue 4, Page(s) 433–440

Abstract: Background: Epicutaneous sensitization to food allergens can occur through defective skin barriers. However, the relationship between oral tolerance and epicutaneous sensitization remains to be elucidated. We aimed to determine whether prior oral ... ...

Abstract	Background: Epicutaneous sensitization to food allergens can occur through defective skin barriers. However, the relationship between oral tolerance and epicutaneous sensitization remains to be elucidated. We aimed to determine whether prior oral exposure to whey proteins or their hydrolysates prevents epicutaneous sensitization and subsequent food-allergic reaction to the whey protein, β-lactoglobulin (β-LG), and investigated the underlying mechanisms. Methods: BALB/c mice were given whey protein concentrate (WPC), two kinds of partial whey protein hydrolysate (PWH1 or PWH2), or extensive whey protein hydrolysate (EWH) in drinking water for 21 days. The mice were then epicutaneously sensitized with β-LG on tape-stripped skin. Sensitization was assessed by basophil activation tests and by measuring the level of serum β-LG-specific antibodies and cytokines secreted from β-LG-restimulated spleen and mesenteric lymph node (MLN) cells. Development of an allergic reaction was assessed by monitoring body temperature and by measuring mast cell protease-1 level in plasma after the β-LG oral challenge. Activated T-cell population among β-LG-restimulated MLN cells was also analyzed. Results: In mice fed with WPC, PWH1, or PWH2, sensitization and the development of an allergic reaction were totally reduced. The acceleration of cytokine release from the spleen and MLN cells or T-cell activation was not evident after β-LG restimulation. In EWH-fed mice, a suppressive effect, though milder than that in WPC-, PWH1-, or PWH2-fed mice, was observed during the development of the allergic reaction. Conclusions: Prior oral exposure to partially hydrolyzed whey protein prevents epicutaneous sensitization and subsequent allergic response to β-LG in mice.
MeSH term(s)	Administration, Cutaneous ; Administration, Oral ; Allergens/administration & dosage ; Allergens/adverse effects ; Allergens/immunology ; Animals ; Female ; Immunization/methods ; Lactoglobulins/administration & dosage ; Lactoglobulins/adverse effects ; Lactoglobulins/immunology ; Mice ; Mice, Inbred BALB C ; Milk Hypersensitivity/immunology ; Milk Hypersensitivity/prevention & control ; Protein Hydrolysates/administration & dosage ; Protein Hydrolysates/adverse effects ; Protein Hydrolysates/immunology ; Treatment Outcome ; Whey Proteins/administration & dosage ; Whey Proteins/adverse effects ; Whey Proteins/immunology
Chemical Substances	Allergens ; Lactoglobulins ; Protein Hydrolysates ; Whey Proteins
Language	English
Publishing date	2018-04-15
Publishing country	England
Document type	Evaluation Studies ; Journal Article
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.12887
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Zs.A 3096: Show issues

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Article ; Online: Evaluation of the antigenicity of hydrolyzed cow's milk protein formulas using the mouse basophil activation test.

Iwamoto, Hiroshi / Matsubara, Takeshi / Nakazato, Yuki / Namba, Kazuyoshi / Takeda, Yasuhiro

Toxicology letters

2016 Volume 242, Page(s) 53–59

Abstract: Hypoallergenic infant formulas are widely used for infants with cow's milk allergy. The aim of this study was to assess the utility of the mouse basophil activation test (BAT) in the evaluation of residual antigenicity in these formulas. Whole blood ... ...

Abstract	Hypoallergenic infant formulas are widely used for infants with cow's milk allergy. The aim of this study was to assess the utility of the mouse basophil activation test (BAT) in the evaluation of residual antigenicity in these formulas. Whole blood samples derived from β-lactoglobulin- or casein-immunized mice were incubated with one of the following formulas: conventional, partially hydrolyzed, or extensively hydrolyzed. Basophilic activation was analyzed by flow cytometry using an IgE-dependent activation marker CD200R1 and an IgG-dependent activation marker CD200R3. Systemic anaphylaxis was induced by i.v. injection of milk formula and results were compared. Conventional formula induced pronounced changes in CD200R1 and CD200R3 expression on basophils, whereas extensively hydrolyzed formulas did not elicit any changes in these markers. Similarly, challenge with conventional formula induced anaphylaxis, whereas extensively hydrolyzed formulas did not induce anaphylaxis. Although the partially hydrolyzed formula also induced basophilic activation and systemic anaphylaxis, the magnitude of these effects was smaller than that observed with the conventional formula. Compared to CD200R1, the observed trend in CD200R3 expression resembled the results obtained from systemic anaphylaxis test more closely. These findings show that mouse BAT, in particular using CD200R3, is highly useful for the evaluation of antigenicity of milk formulas.
MeSH term(s)	Allergens/immunology ; Anaphylaxis/diagnosis ; Anaphylaxis/immunology ; Anaphylaxis/metabolism ; Animals ; Basophils/immunology ; Basophils/metabolism ; Biomarkers/metabolism ; Female ; Flow Cytometry ; Immunoglobulin E/immunology ; Immunoglobulin E/metabolism ; Immunoglobulin G/immunology ; Immunoglobulin G/metabolism ; Immunologic Tests/methods ; Infant Formula ; Membrane Glycoproteins/immunology ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred BALB C ; Milk Hypersensitivity/diagnosis ; Milk Hypersensitivity/immunology ; Milk Hypersensitivity/metabolism ; Milk Proteins/immunology ; Orexin Receptors/immunology ; Orexin Receptors/metabolism ; Predictive Value of Tests ; Protein Hydrolysates/immunology ; Risk Assessment ; Time Factors
Chemical Substances	Allergens ; Biomarkers ; CD200 receptor, mouse ; Cd200r1 protein, mouse ; Immunoglobulin G ; Membrane Glycoproteins ; Milk Proteins ; Orexin Receptors ; Protein Hydrolysates ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2016-02-03
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	433788-8
ISSN	1879-3169 ; 0378-4274
ISSN (online)	1879-3169
ISSN	0378-4274
DOI	10.1016/j.toxlet.2015.11.024
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