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Article ; Online: Awareness and interventions to reduce dehydration in pregnant, postpartum women, and newborns in rural Kenya.

Lusambili, Adelaide / Nakstad, Britt

African journal of primary health care & family medicine

2023 Volume 15, Issue 1, Page(s) e1–e3

Abstract: Extreme heat exposure is associated with adverse outcomes in pregnancy and has the potential to impact maternal, neonatal and child health for a lifetime. In an extremely hot climate, pregnant women face an increased risk of premature birth, stillbirth, ... ...

Abstract	Extreme heat exposure is associated with adverse outcomes in pregnancy and has the potential to impact maternal, neonatal and child health for a lifetime. In an extremely hot climate, pregnant women face an increased risk of premature birth, stillbirth, low birth weight, congenital anomalies and pre-eclampsia. In low- and middle-income countries (LMICs), socio-demographic and behavioural practices may negatively affect body hydration during high temperatures. The possible causes and consequences of dehydration in the heat are poorly understood and have been little discussed in the literature.Living in a hot climate poses various challenges, including dehydration, where biological mechanisms and insufficient access to water can lead to dehydration in women and children, with consequences for the health of both mothers and children, particularly in relation to breastfeeding habits. During pregnancy, increased metabolic and cardiovascular demands interact with heat exhaustion and reduced availability of fresh water, which can affect the child's growth and development. In this opinion piece, we emphasise the possible causes and impacts of dehydration in extreme heat on the health and well-being of mothers and children. We encourage more research, focused on biology and epidemiology, related to raising awareness and implementing adaptations to reduce the risk of dehydration in pregnant, postpartum women and newborns in the context of climate change-related heat exposure.
MeSH term(s)	Child ; Pregnancy ; Female ; Infant, Newborn ; Humans ; Pregnant Women ; Kenya ; Dehydration/etiology ; Dehydration/prevention & control ; Postpartum Period ; Mothers
Language	English
Publishing date	2023-05-15
Publishing country	South Africa
Document type	Journal Article
ZDB-ID	2526836-3
ISSN	2071-2936 ; 2071-2936
ISSN (online)	2071-2936
ISSN	2071-2936
DOI	10.4102/phcfm.v15i1.3991
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial: Women in Neonatology 2022.

Nakstad, Britt / Oei, Ju-Lee

Frontiers in pediatrics

2023 Volume 11, Page(s) 1288980

Language	English
Publishing date	2023-10-10
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1288980
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Article: The diagnostic utility of procalcitonin, interleukin-6 and interleukin-8, and hyaluronic acid in the Norwegian consensus definition for early-onset neonatal sepsis (EONS).

Nakstad, Britt

publication RETRACTED

Infection and drug resistance

2018 Volume 11, Page(s) 359–368

Abstract: Introduction: A key challenge in identifying serious bacterial infection in new born infants is the nonspecific clinical presentation of early-onset neonatal sepsis (EONS). Routinely used C-reactive protein, white blood cell count, and platelets are ... ...

Abstract	Introduction: A key challenge in identifying serious bacterial infection in new born infants is the nonspecific clinical presentation of early-onset neonatal sepsis (EONS). Routinely used C-reactive protein, white blood cell count, and platelets are nonspecific. We assessed the diagnostic utility of single biomarkers or combinations of procalcitonin (PCT), interleukin (IL)-6, IL-8, and hyaluronic acid (HA) in newborn infant with EONS, and in human umbilical cord blood (HUCB) from deliveries with chorioamnionitis. Materials and methods: Blood was collected from term infants with strictly defined EONS (group 1, n=15), healthy term infants (group 2, n=15), and the umbilical vein from pregnancies with suspected chorioamnionitis (group 3, n=8), and from healthy pregnancies with no signs of infection (group 4, n=15). Results: Neonatal plasma PCT and IL-8 showed good predictive value (90% and 83%) for EONS, and the combination of IL-6 or HA with PCT increased the predictability to 87% and 90%, respectively. PCT, IL-6, IL-8, and HA were 8.4-, 4.5-, 3.6-, and 1.9-fold higher when compared with plasma levels in noninfected neonates. PCT, IL-6, and IL-8 in HUCB predicted chorioamnionitis and fever in the delivering mother (89%, 83%, and 72%, respectively). HA was a poor predictor (59%), but its predictability increased in combination with PCT, IL-8, or IL-6. In HUCB from chorioamnionitic deliveries, IL-6, IL-8, and PCT were 23-, 14-, and 2.4-fold higher, respectively, when compared with HUCB from healthy deliveries. There was no correlation between C-reactive protein, white blood cell, and platelet count with PCT, IL-6, IL-8, or HA. Conclusion: In neonates that fulfilled the Norwegian consensus definition of neonatal sepsis, PCT, IL-6, and IL-8, but not HA, have the potential to improve our management of neonates at risk. Except for PCT and IL-8, both with a predictability of >80% in neonatal plasma, combinations of biomarkers increased the predictability for EONS and chorioamnionitis.
Language	English
Publishing date	2018-03-08
Publishing country	New Zealand
Document type	Journal Article ; Retracted Publication
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S155965
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Article ; Online: Thermoregulation for very preterm infants in the delivery room: a narrative review.

Dunne, Emma A / O'Donnell, Colm P F / Nakstad, Britt / McCarthy, Lisa K

Pediatric research

2024

Abstract: Abnormal temperature in preterm infants is associated with increased morbidity and mortality. Infants born prematurely are at risk of abnormal temperature immediately after birth in the delivery room (DR). The World Health Organization (WHO) recommends ... ...

Abstract	Abnormal temperature in preterm infants is associated with increased morbidity and mortality. Infants born prematurely are at risk of abnormal temperature immediately after birth in the delivery room (DR). The World Health Organization (WHO) recommends that the temperature of newly born infants is maintained between 36.5-37.5
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-023-02902-w
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Article: Editorial: Neonatal health in low- and middle-income countries. Now is the time.

Steenhoff, Andrew P / Coffin, Susan E / Kc, Ashish / Nakstad, Britt

Frontiers in pediatrics

2023 Volume 11, Page(s) 1168915

Language	English
Publishing date	2023-04-13
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1168915
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Article ; Online: Editorial: miRNAs and inflammation: from biogenesis to therapeutic option.

Tahamtan, Alireza / Samadizadeh, Saeed / Salimi, Vahid / Natarelli, Lucia / Nakstad, Britt

Frontiers in immunology

2023 Volume 14, Page(s) 1296589

MeSH term(s)	Humans ; MicroRNAs/genetics ; Inflammation/genetics ; Gene Expression Regulation
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-10-03
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1296589
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Article ; Online: COVID-19 diagnosis: lessons to learn and hints for preparedness.

Samadizadeh, Saeed / Nakstad, Britt / Jamalpoor, Zahra / Tahamtan, Alireza

Expert review of molecular diagnostics

2022 Volume 22, Issue 9, Page(s) 851–853

MeSH term(s)	Humans ; COVID-19/diagnosis ; SARS-CoV-2 ; COVID-19 Testing ; Reverse Transcriptase Polymerase Chain Reaction
Language	English
Publishing date	2022-10-08
Publishing country	England
Document type	Editorial
ZDB-ID	2112530-2
ISSN	1744-8352 ; 1473-7159
ISSN (online)	1744-8352
ISSN	1473-7159
DOI	10.1080/14737159.2022.2132852
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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article: A systematic review of hot weather impacts on infant feeding practices in low-and middle-income countries.

Edney, Jessica M / Kovats, Sari / Filippi, Veronique / Nakstad, Britt

Frontiers in pediatrics

2022 Volume 10, Page(s) 930348

Abstract: Background: Increased rates of exclusive breastfeeding could significantly improve infant survival in low- and middle-income countries. There is a concern that increased hot weather due to climate change may increase rates of supplemental feeding due to ...

Abstract	Background: Increased rates of exclusive breastfeeding could significantly improve infant survival in low- and middle-income countries. There is a concern that increased hot weather due to climate change may increase rates of supplemental feeding due to infants requiring fluids, or the perception that infants are dehydrated. Objective: To understand how hot weather conditions may impact infant feeding practices by identifying and appraising evidence that exclusively breastfed infants can maintain hydration levels under hot weather conditions, and by examining available literature on infant feeding practices in hot weather. Methods: Systematic review of published studies that met inclusion criteria in MEDLINE, EMBASE, Global Health and Web of Science databases. The quality of included studies was appraised against predetermined criteria and relevant data extracted to produce a narrative synthesis of results. Results: Eighteen studies were identified. There is no evidence among studies of infant hydration that infants under the age of 6months require supplementary food or fluids in hot weather conditions. In some settings, healthcare providers and relatives continue to advise water supplementation in hot weather or during the warm seasons. Cultural practices, socio-economic status, and other locally specific factors also affect infant feeding practices and may be affected by weather and seasonal changes themselves. Conclusion: Interventions to discourage water/other fluid supplementation in breastfeeding infants below 6 months are needed, especially in low-middle income countries. Families and healthcare providers should be advised that exclusive breastfeeding (EBF) is recommended even in hot conditions.
Language	English
Publishing date	2022-09-06
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.930348
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Article ; Online: Epidemiology and clinical features of respiratory syncytial virus (RSV) infection in hospitalized children during the COVID-19 pandemic in Gorgan, Iran.

Ramzali, Mahnaz / Salimi, Vahid / Cheraghali, Fatemeh / Hosseini, Seyedeh Delafruz / Yasaghi, Mohammad / Samadizadeh, Saeed / Rastegar, Mostafa / Nakstad, Britt / Tahamtan, Alireza

Health science reports

2024 Volume 7, Issue 1, Page(s) e1787

Abstract: Background and aims: Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection in infants and young children. Given the altered circulation patterns of respiratory viruses during the coronavirus disease pandemic-2019 (COVID-19), ...

Abstract	Background and aims: Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection in infants and young children. Given the altered circulation patterns of respiratory viruses during the coronavirus disease pandemic-2019 (COVID-19), the study aimed to evaluate epidemiology and clinical features of RSV infections in hospitalized children during the COVID-19 pandemic in Gorgan, northeastern Iran. Molecular epidemiology studies on respiratory viral infections are necessary to monitor circulating viruses, disease severity, and clinical symptoms, in addition to early warning of new outbreaks. Methods: Overall, 411 respiratory swab samples from hospitalized children from October 2021 to March 2022 were collected at Taleghani Children's Hospital, Gorgan, Iran. The incidence of RSV, as well as the circulating subgroups and genotypes, were investigated and confirmed using PCR methods. Additionally, all samples tested for severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2) and influenza, and demographic and clinical data were analyzed using SPSS software. Results: The share of RSV, SARS-CoV-2, and influenza among hospitalized children with acute lower respiratory infections (ALRI) were 27%, 16.5%, and 4.1%, respectively. The RSV subgroup A (genotype ON1) was dominant over subgroup B (genotype BA9), with more severe clinical symptoms. Compared with the prepandemic era there were high numbers of hospitalized SARS-CoV-2 positive children and low numbers of other respiratory viruses. Despite this, the prevalence of ALRI-related RSV-disease among hospitalized children in our specialized pediatric center was higher than COVID-19 disease in the same cohort. Conclusions: Studying the epidemiology of respiratory viruses and determining the circulating strains can contribute to effective infection control and treatment strategies.
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.1787
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Article: Extreme heat, pregnancy and women's well-being in Burkina Faso: an ethnographical study.

Kadio, Kadidiatou / Filippi, Veronique / Congo, Mariam / Scorgie, Fiona / Roos, Nathalie / Lusambili, Adélaïde / Nakstad, Britt / Kovats, Sari / Kouanda, Seni

BMJ global health

2024 Volume 8, Issue Suppl 3

Abstract: Climate change is an increasing threat to the health of populations in Africa, with a shift in seasonal temperatures towards more extreme heat exposures. In Burkina Faso, like other countries in the Sahel, many women have little protection against ... ...

Abstract	Climate change is an increasing threat to the health of populations in Africa, with a shift in seasonal temperatures towards more extreme heat exposures. In Burkina Faso, like other countries in the Sahel, many women have little protection against exposure to high temperatures, either outside or inside the home or place of work. This paper investigates how women perceive the impacts of heat on their physical and mental health, in addition to their social relationships and economic activities. Qualitative methods (in-depth interviews and focus group discussions) were conducted with women, community representatives and healthcare professionals in two regions in Burkina Faso. A thematic analysis was used to explore the realities of participants' experiences and contextual perspectives in relation to heat. Our research shows extreme temperatures have a multifaceted impact on pregnant women, mothers and newborns. Extreme heat affects women's functionality and well-being. Heat undermines a woman's ability to care for themselves and their child and interferes negatively with breast feeding. Heat negatively affects their ability to work and to maintain harmonious relationships with their partners and families. Cultural practices such as a taboo on taking the baby outside before the 40th day may exacerbate some of the negative consequences of heat. Most women do not recognise heat stress symptoms and lack awareness of heat risks to health. There is a need to develop public health messages to reduce the impacts of heat on health in Burkina Faso. Programmes and policies are needed to strengthen the ability of health professionals to communicate with women about best practices in heat risk management.
MeSH term(s)	Infant ; Child ; Humans ; Female ; Infant, Newborn ; Pregnancy ; Burkina Faso ; Extreme Heat ; Anthropology, Cultural ; Mothers ; Interpersonal Relations
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2059-7908
ISSN	2059-7908
DOI	10.1136/bmjgh-2023-014230
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