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  1. Article: Validation of a small cough detector.

    Kuhn, Manuel / Nalbant, Elif / Kohlbrenner, Dario / Alge, Mitja / Kuett, Laura / Arvaji, Alexandra / Sievi, Noriane A / Russi, Erich W / Clarenbach, Christian F

    ERJ open research

    2023  Volume 9, Issue 1

    Abstract: Research question: The assessment of cough frequency in clinical practice relies predominantly on the patient's history. Currently, objective evaluation of cough is feasible with bulky equipment during a brief time (: Methods: We recorded cough ... ...

    Abstract Research question: The assessment of cough frequency in clinical practice relies predominantly on the patient's history. Currently, objective evaluation of cough is feasible with bulky equipment during a brief time (
    Methods: We recorded cough epochs with SIVA-P3 over eight consecutive days in patients suffering from chronic cough. During the first 24 h, the detector was validated against cough events counted by trained human listeners. The wearing comfort and the device usage were assessed using a questionnaire.
    Results: In total, 27 participants (mean±sd age 50±14 years) with either chronic unexplained cough (n=12), COPD (n=4), asthma (n=5) or interstitial lung disease (n=6) were studied. During the daytime, the sensitivity of SIVA-P3 cough detection was 88.5±2.49% and the specificity was 99.97±0.01%. During the night-time, the sensitivity was 84.15±5.04% and the specificity was 99.97±0.02%. The wearing comfort and usage of the device was rated as very high by most participants.
    Conclusion: SIVA-P3 enables automatic continuous cough monitoring in an outpatient setting for objective assessment of cough over days and weeks. It shows comparable sensitivity or higher sensitivity than other devices with fully automatic cough counting. Thanks to its wearing comfort and the high performance for cough detection, it has the potential for being used in routine clinical practice.
    Language English
    Publishing date 2023-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00279-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Fluorescein videoangiography data analysis protocol for mapping retinal vascular permeability in humans.

    Vavrek, Sarah / Kayaalp-Nalbant, Elif / Konopek, Nicholas / Bou-Ghanem, Ghazi / Fawzi, Amani A / Mieler, William F / Kang-Mieler, Jennifer J / Tichauer, Kenneth M

    Proceedings of SPIE--the International Society for Optical Engineering

    2023  Volume 12360

    Abstract: Fluorescein video angiographies (FVAs) are a diagnostic tool for eye diseases, such as diabetic retinopathy (DR). Currently, kinetic tracer model methods based on indicator-dilutions theory use FVAs to extract biomarkers (e.g., volumetric blood flow and ... ...

    Abstract Fluorescein video angiographies (FVAs) are a diagnostic tool for eye diseases, such as diabetic retinopathy (DR). Currently, kinetic tracer model methods based on indicator-dilutions theory use FVAs to extract biomarkers (e.g., volumetric blood flow and retinal vascular permeability) via pixel mapping using two-step non-linear least square fitting. Prior to biomarker extraction, the FVAs must attain optimal quality. The objective of this research is to create a program to remove all frames experiencing signal drops (causes include blinking, squinting, and head movement). 15 FVAs (6 healthy control subjects, 6 diabetes mellitus no DR (DMnoDR) subjects, and 3 mild non-proliferative DR (NPDR) subjects) were analyzed for low quality frames. The average signal of each frame was analyzed as top, middle, and bottom thirds. The frame with maximum average signal up to the final frame of a created "Gold Standard" was compared with the raw AVI's frame with maximum average signal and subsequent frames. All frames before maximum average signal and any remaining frames were compared with the previous good-quality raw frame to determine if the frame of interest was of good quality. All remaining frames were subsequently re-evaluated and flagged if they had a local minimum prominence of 10% of the maximum average signal. The flagged frames', as well as former and subsequent frames', quality were subjectively determined. The AVI quality was subsequently tested via pre-DTKM processing and biomarker extraction via DTKM methods. Results displayed that the semi-automated frame removal process provides sufficient quality AVIs.
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 0277-786X
    ISSN 0277-786X
    DOI 10.1117/12.2650304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Optimizing the protocol for retinal vascular permeability mapping from fluorescein videoangiography data.

    Nalbant, Elif Kayaalp / Annepureddy, Laasya / Hu, Shaoxian / Liu, Wenqiang / Tang, Fangyao / Sun, Zihan / Cheung, Carol Y / Mieler, William F / Kang-Mieler, Jennifer J / Tichauer, Kenneth M

    Proceedings of SPIE--the International Society for Optical Engineering

    2022  Volume 11941

    Abstract: An intact blood-retinal barrier is critical to maintaining the function of the retina. Many diseases of the eye have been directly associated with impairment in vascular permeability, and methods to measure vascular permeability could offer a window into ...

    Abstract An intact blood-retinal barrier is critical to maintaining the function of the retina. Many diseases of the eye have been directly associated with impairment in vascular permeability, and methods to measure vascular permeability could offer a window into early detection of disease; however, there exist no direct measures of vascular permeability that have be translated to the clinic. This work details a complete clinical workflow to quantify vascular permeability and volumetric blood flow from fluorescein videoangiography data, with validation through realistic simulations. For optimizing the protocol, this study carried on frame rate of fluorescein videoangiography to generate a high-resolution image while minimizing the error.
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 0277-786X
    ISSN 0277-786X
    DOI 10.1117/12.2610279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A paired-agent fluorescent molecular imaging strategy for quantifying antibody drug target engagement in

    Kayaalp Nalbant, Elif / Rounds, Cody / Sadeghipour, Negar / Meng, Boyu / Folaron, Margaret R / Haldar, Chandrika / Strawbridge, Rendall R / Samkoe, Kimberley S / Davis, Scott C / Tichauer, Kenneth M

    Proceedings of SPIE--the International Society for Optical Engineering

    2020  Volume 11219

    Abstract: A paired-agent fluorescent molecular imaging strategy is presented as a method to measure drug target engagement in whole tumor imaging. The protocol involves dynamic imaging of a pair of targeted and control imaging agents prior to and following ... ...

    Abstract A paired-agent fluorescent molecular imaging strategy is presented as a method to measure drug target engagement in whole tumor imaging. The protocol involves dynamic imaging of a pair of targeted and control imaging agents prior to and following antibody therapy. Simulations demonstrated that antibody "drug target engagement" can be estimated within a 15%-error over a wide range of tumor physiology (blood flow, vascular permeability, target density) and antibody characteristics (affinity, binding rates). Experimental results demonstrated the first in vivo detection of binding site barrier, highlighting the potential for this methodology to provide novel insights in drug distribution/binding imaging.
    Language English
    Publishing date 2020-02-19
    Publishing country United States
    Document type Journal Article
    ISSN 0277-786X
    ISSN 0277-786X
    DOI 10.1117/12.2545182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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