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  1. Article ; Online: Non-Targeted Metabolomics Investigation of a Sub-Chronic Variable Stress Model Unveils Sex-Dependent Metabolic Differences Induced by Stress.

    Kang, Seulgi / Kim, Woonhee / Nam, Jimin / Li, Ke / Kang, Yua / Bae, Boyeon / Chun, Kwang-Hoon / Chung, ChiHye / Lee, Jeongmi

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Depression is twice as prevalent in women as in men, however, most preclinical studies of depression have used male rodent models. This study aimed to examine how stress affects metabolic profiles depending on sex using a rodent depression model: sub- ... ...

    Abstract Depression is twice as prevalent in women as in men, however, most preclinical studies of depression have used male rodent models. This study aimed to examine how stress affects metabolic profiles depending on sex using a rodent depression model: sub-chronic variable stress (SCVS). The SCVS model of male and female mice was established in discovery and validation sets. The stress-induced behavioral phenotypic changes were similar in both sexes, however, the metabolic profiles of female plasma and brain became substantially different after stress, whereas those of males did not. Four stress-differential plasma metabolites-β-hydroxybutyric acid (BHB), L-serine, glycerol, and myo-inositol-could yield biomarker panels with excellent performance to discern the stressed individuals only for females. Disturbances in BHB, glucose, 1,5-anhydrosorbitol, lactic acid, and several fatty acids in the plasma of stressed females implied a systemic metabolic shift to β-oxidation in females. The plasma levels of BHB and corticosterone only in stressed females were observed not only in SCVS but also in an acute stress model. These results collectively suggest a sex difference in the metabolic responses by stress, possibly involving the energy metabolism shift to β-oxidation and the HPA axis dysregulation in females.
    MeSH term(s) Humans ; Male ; Female ; Mice ; Animals ; Sex Characteristics ; Hypothalamo-Hypophyseal System/metabolism ; Pituitary-Adrenal System/metabolism ; Metabolomics ; Brain/metabolism ; Corticosterone ; Stress, Psychological/metabolism
    Chemical Substances Corticosterone (W980KJ009P)
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Computational study of estimating 3D trabecular bone microstructure for the volume of interest from CT scan data.

    Kim, Jung Jin / Nam, Jimin / Jang, In Gwun

    International journal for numerical methods in biomedical engineering

    2018  Volume 34, Issue 4, Page(s) e2950

    Abstract: Inspired by the self-optimizing capabilities of bone, a new concept of bone microstructure reconstruction has been recently introduced by using 2D synthetic skeletal images. As a preliminary clinical study, this paper proposes a topology optimization- ... ...

    Abstract Inspired by the self-optimizing capabilities of bone, a new concept of bone microstructure reconstruction has been recently introduced by using 2D synthetic skeletal images. As a preliminary clinical study, this paper proposes a topology optimization-based method that can estimate 3D trabecular bone microstructure for the volume of interest (VOI) from 3D computed tomography (CT) scan data with enhanced computational efficiency and phenomenological accuracy. For this purpose, a localized finite element (FE) model is constructed by segmenting a target bone from CT scan data and determining the physiological local loads for the VOI. Then, topology optimization is conducted with multiresolution bone mineral density (BMD) deviation constraints to preserve the patient-specific spatial bone distribution obtained from the CT scan data. For the first time, to our knowledge, this study has demonstrated that 60-μm resolution trabecular bone images can be reconstructed from 600-μm resolution CT scan data (a 62-year-old woman with no metabolic bone disorder) for the 4 VOIs in the proximal femur. The reconstructed trabecular bone includes the characteristic trabecular patterns and has morphometric indices that are in good agreement with the anatomical data in the literature. As for computational efficiency, the localization for the VOI reduces the number of FEs by 99%, compared with that of the full FE model. Compared with the previous single-resolution BMD deviation constraint, the proposed multiresolution BMD deviation constraints enable at least 65% and 47% reductions in the number of iterations and computing time, respectively. These results demonstrate the clinical feasibility and potential of the proposed method.
    MeSH term(s) Bone Density ; Cancellous Bone/anatomy & histology ; Cancellous Bone/diagnostic imaging ; Computer Simulation ; Female ; Femur Head/diagnostic imaging ; Humans ; Imaging, Three-Dimensional ; Middle Aged ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-01-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2540968-2
    ISSN 2040-7947 ; 2040-7939
    ISSN (online) 2040-7947
    ISSN 2040-7939
    DOI 10.1002/cnm.2950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fully automated segmentation of a hip joint using the patient-specific optimal thresholding and watershed algorithm.

    Kim, Jung Jin / Nam, Jimin / Jang, In Gwun

    Computer methods and programs in biomedicine

    2018  Volume 154, Page(s) 161–171

    Abstract: Background and objective: Automated segmentation with high accuracy and speed is a prerequisite for FEA-based quantitative assessment with a large population. However, hip joint segmentation has remained challenging due to a narrow articular cartilage ... ...

    Abstract Background and objective: Automated segmentation with high accuracy and speed is a prerequisite for FEA-based quantitative assessment with a large population. However, hip joint segmentation has remained challenging due to a narrow articular cartilage and thin cortical bone with a marked interindividual variance. To overcome this challenge, this paper proposes a fully automated segmentation method for a hip joint that uses the complementary characteristics between the thresholding technique and the watershed algorithm.
    Methods: Using the golden section method and load path algorithm, the proposed method first determines the patient-specific optimal threshold value that enables reliably separating a femur from a pelvis while removing cortical and trabecular bone in the femur at the minimum. This provides regional information on the femur. The watershed algorithm is then used to obtain boundary information on the femur. The proximal femur can be extracted by merging the complementary information on a target image.
    Results: For eight CT images, compared with the manual segmentation and other segmentation methods, the proposed method offers a high accuracy in terms of the dice overlap coefficient (97.24 ± 0.44%) and average surface distance (0.36 ± 0.07 mm) within a fast timeframe in terms of processing time per slice (1.25 ± 0.27 s). The proposed method also delivers structural behavior which is close to that of the manual segmentation with a small mean of average relative errors of the risk factor (4.99%).
    Conclusion: The segmentation results show that, without the aid of a prerequisite dataset and users' manual intervention, the proposed method can segment a hip joint as fast as the simplified Kang (SK)-based automated segmentation, while maintaining the segmentation accuracy at a similar level of the snake-based semi-automated segmentation.
    MeSH term(s) Adult ; Algorithms ; Female ; Femur/diagnostic imaging ; Finite Element Analysis ; Hip Joint/anatomy & histology ; Hip Joint/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Middle Aged ; Pelvis/diagnostic imaging ; Reproducibility of Results ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-02
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2017.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Randomized Trial of Behavioral Nudges Delivered Through Text Messages to Increase Influenza Vaccination Among Patients With an Upcoming Primary Care Visit.

    Patel, Mitesh S / Milkman, Katherine L / Gandhi, Linnea / Graci, Heather N / Gromet, Dena / Ho, Hung / Kay, Joseph S / Lee, Timothy W / Rothschild, Jake / Akinola, Modupe / Beshears, John / Bogard, Jonathan E / Buttenheim, Alison / Chabris, Christopher / Chapman, Gretchen B / Choi, James J / Dai, Hengchen / Fox, Craig R / Goren, Amir /
    Hilchey, Matthew D / Hmurovic, Jillian / John, Leslie K / Karlan, Dean / Kim, Melanie / Laibson, David / Lamberton, Cait / Madrian, Brigitte C / Meyer, Michelle N / Modanu, Maria / Nam, Jimin / Rogers, Todd / Rondina, Renante / Saccardo, Silvia / Shermohammed, Maheen / Soman, Dilip / Sparks, Jehan / Warren, Caleb / Weber, Megan / Berman, Ron / Evans, Chalanda N / Lee, Seung Hyeong / Snider, Christopher K / Tsukayama, Eli / Van den Bulte, Christophe / Volpp, Kevin G / Duckworth, Angela L

    American journal of health promotion : AJHP

    2022  Volume 37, Issue 3, Page(s) 324–332

    Abstract: Purpose: To evaluate if nudges delivered by text message prior to an upcoming primary care visit can increase influenza vaccination rates.: Design: Randomized, controlled trial.: Setting: Two health systems in the Northeastern US between September ...

    Abstract Purpose: To evaluate if nudges delivered by text message prior to an upcoming primary care visit can increase influenza vaccination rates.
    Design: Randomized, controlled trial.
    Setting: Two health systems in the Northeastern US between September 2020 and March 2021.
    Subjects: 74,811 adults.
    Interventions: Patients in the 19 intervention arms received 1-2 text messages in the 3 days preceding their appointment that varied in their format, interactivity, and content.
    Measures: Influenza vaccination.
    Analysis: Intention-to-treat.
    Results: Participants had a mean (SD) age of 50.7 (16.2) years; 55.8% (41,771) were female, 70.6% (52,826) were White, and 19.0% (14,222) were Black. Among the interventions, 5 of 19 (26.3%) had a significantly greater vaccination rate than control. On average, the 19 interventions increased vaccination relative to control by 1.8 percentage points or 6.1% (
    Conclusions: Text messages encouraging vaccination and delivered prior to an upcoming appointment significantly increased influenza vaccination rates and could be a scalable approach to increase vaccination more broadly.
    MeSH term(s) Adult ; Humans ; Female ; Middle Aged ; Male ; Influenza, Human/prevention & control ; Influenza Vaccines ; Text Messaging ; Reminder Systems ; Vaccination ; Primary Health Care
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2022-10-04
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 645160-3
    ISSN 2168-6602 ; 0890-1171
    ISSN (online) 2168-6602
    ISSN 0890-1171
    DOI 10.1177/08901171221131021
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    Zs.A 2531: Show issues Location:
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  5. Article ; Online: Antidepressant-Induced Sexual Dysfunction among Newer Antidepressants in a Naturalistic Setting.

    Lee, Kyoung-Uk / Lee, Young Min / Nam, Ji-Min / Lee, Hae-Kook / Kweon, Yong-Sil / Lee, Chung Tai / Jun, Tae-Youn

    Psychiatry investigation

    2010  Volume 7, Issue 1, Page(s) 55–59

    Abstract: Objective: Antidepressants used to treat depression are frequently associated with sexual dysfunction. Sexual side effects affect the patient's quality of life and, in long-term treatment, can lead to non-compliance and relapse. However, studies ... ...

    Abstract Objective: Antidepressants used to treat depression are frequently associated with sexual dysfunction. Sexual side effects affect the patient's quality of life and, in long-term treatment, can lead to non-compliance and relapse. However, studies covering many antidepressants with differing mechanisms of action were scarce. The present study assessed and compared the incidence of sexual dysfunction among different antidepressants in a naturalistic setting.
    Methods: Participants were married patients diagnosed with depression, per DSM-IV diagnostic criteria, who had been taking antidepressants for more than 1 month. We assessed the participants via the Arizona Sexual Experiences Scale (ASEX), Beck Depression Inventory (BDI), and State-Trait Anxiety Inventory (STAI), and assessed their demographic variables, types and dosages of antidepressants, and duration of antidepressant use via their medical records.
    Results: One hundred and one patients (46 male, 55 female, age 42.2+/-7 years) completed the instruments. Thirteen were taking fluoxetine (mean dose 21.3+/-8.5 mg/day), 24 were taking paroxetine (mean dose 20.4+/-7.2 mg/day), 20 taking citalopram (mean dose 22.1+/-6.5 mg/day), 22, venlafaxine (mean dose 115.7+/-53.2 mg/day) and 22, mirtazapine (mean dose 18+/-8.7 mg/day). Mean ages, sex ratios, and BDI and STAI scores did not differ significantly across antidepressants. A substantial number of participants (46.5%, n=47) experienced sexual dysfunction. The prevalence of sexual dysfunction differed across drugs: citalopram 60% (n=12), venlafaxine 54.5% (n=12), paroxetine 54.2% (n=13), fluoxetine 46.2% (n=6), and mirtazapine 18.2% (n=4). Regression analyses revealed the significant factors for sexual dysfunction were being female, total scores on the BDI and SAI, and type of antidepressant (F=4.92, p<0.0001). Of the antidepressants, the mirtarzapine group's total ASEX score was significantly lower than the scores of the citalopram, fluoxetine, and paroxetine groups.
    Conclusion: The incidence of sexual dysfunction was substantially high during antidepressant treatment. The incidence of sexual dysfunction differed among antidepressants having different mechanisms of action. Our study suggests the need for clinicians to consider the impact of pharmacotherapy on patients' sexual functioning in the course of treatment with antidepressants.
    Language English
    Publishing date 2010-02-08
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2414364-9
    ISSN 1976-3026 ; 1738-3684
    ISSN (online) 1976-3026
    ISSN 1738-3684
    DOI 10.4306/pi.2010.7.1.55
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  6. Article ; Online: A megastudy of text-based nudges encouraging patients to get vaccinated at an upcoming doctor's appointment.

    Milkman, Katherine L / Patel, Mitesh S / Gandhi, Linnea / Graci, Heather N / Gromet, Dena M / Ho, Hung / Kay, Joseph S / Lee, Timothy W / Akinola, Modupe / Beshears, John / Bogard, Jonathan E / Buttenheim, Alison / Chabris, Christopher F / Chapman, Gretchen B / Choi, James J / Dai, Hengchen / Fox, Craig R / Goren, Amir / Hilchey, Matthew D /
    Hmurovic, Jillian / John, Leslie K / Karlan, Dean / Kim, Melanie / Laibson, David / Lamberton, Cait / Madrian, Brigitte C / Meyer, Michelle N / Modanu, Maria / Nam, Jimin / Rogers, Todd / Rondina, Renante / Saccardo, Silvia / Shermohammed, Maheen / Soman, Dilip / Sparks, Jehan / Warren, Caleb / Weber, Megan / Berman, Ron / Evans, Chalanda N / Snider, Christopher K / Tsukayama, Eli / Van den Bulte, Christophe / Volpp, Kevin G / Duckworth, Angela L

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 20

    Abstract: Many Americans fail to get life-saving vaccines each year, and the availability of a vaccine for COVID-19 makes the challenge of encouraging vaccination more urgent than ever. We present a large field experiment ( ...

    Abstract Many Americans fail to get life-saving vaccines each year, and the availability of a vaccine for COVID-19 makes the challenge of encouraging vaccination more urgent than ever. We present a large field experiment (
    MeSH term(s) Adult ; Aged ; COVID-19/prevention & control ; COVID-19 Vaccines ; Female ; Humans ; Influenza Vaccines ; Influenza, Human/prevention & control ; Male ; Middle Aged ; Office Visits/statistics & numerical data ; Physicians, Primary Care ; Reminder Systems ; Text Messaging ; Vaccination/psychology ; Vaccination/statistics & numerical data
    Chemical Substances COVID-19 Vaccines ; Influenza Vaccines
    Language English
    Publishing date 2021-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2101165118
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