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  1. Article ; Online: Venous thromboembolism in COVID-19 and inherited thrombophilia.

    Medina, Ester Martins Camillozzi / Ribeiro, Daniel Dias / Namen-Lopes, Maria Sueli Silva / Rezende, Suely Meireles

    Hematology, transfusion and cell therapy

    2022  Volume 46, Issue 1, Page(s) 93–95

    Language English
    Publishing date 2022-09-12
    Publishing country Brazil
    Document type Case Reports
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2022.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antigenic Peptides Capable of Inducing Specific Antibodies for Detection of the Major Alterations Found in Type 2B Von Willebrand Disease.

    Paro, Marina de Oliveira / Ferreira, Cyntia Silva / Vieira, Fernanda Silva / de Santana, Marcos Aurélio / Castro-Borges, William / Namen-Lopes, Maria Sueli Silva / Leclercq, Sophie Yvette / Velloso-Rodrigues, Cibele / Guerra de Andrade, Milton Hércules

    International journal of peptides

    2013  Volume 2013, Page(s) 590329

    Abstract: Von Willebrand disease (VWD) is an inherited hemorrhagic disorder promoted by either quantitative or qualitative defects of the von Willebrand factor (VWF). The disease represents the most common human coagulopathy afflicting 1.3% of the population. ... ...

    Abstract Von Willebrand disease (VWD) is an inherited hemorrhagic disorder promoted by either quantitative or qualitative defects of the von Willebrand factor (VWF). The disease represents the most common human coagulopathy afflicting 1.3% of the population. Qualitative defects are subdivided into four subtypes and classified according to the molecular dysfunction of the VWF. The differential diagnosis of the VWD is a difficult task, relying on a panel of tests aimed to assess the plasma levels and function of the VWF. Here, we propose biochemical approaches for the identification of structural variants of the VWF. A bioinformatic analysis was conducted to design seven peptides among which three were representatives of specific amino acid sequences belonging to normal VWF and four encompassed sequences found in the most common VWD subtype 2B. These peptides were used to immunize mice, after which, peptide-specific immunoglobulins were purified. This resulted in four Ig preparations capable of detecting alterations in the subtype 2B VWD plus additional three antibody fractions targeting the normal VWF. The panel of antibodies could serve many applications among them (1) assessment of VWF: antigen interaction, (2) VWF multimer analysis, and (3) production of monoclonal antibodies against VWF for therapeutic purposes as in thrombotic thrombocytopenic purpura.
    Language English
    Publishing date 2013-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2570929-X
    ISSN 1687-9775 ; 1687-9767
    ISSN (online) 1687-9775
    ISSN 1687-9767
    DOI 10.1155/2013/590329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluation of the use of real-time PCR for human T cell lymphotropic virus 1 and 2 as a confirmatory test in screening for blood donors.

    Andrade, Rafaela Gomes / Ribeiro, Maísa Aparecida / Namen-Lopes, Maria Sueli Silva / Silva, Sônia Mara Nunes / Basques, Fernando Valadares / Ribas, João Gabriel / Carneiro-Proietti, Anna Bárbara de Freitas / Martins, Marina Lobato

    Revista da Sociedade Brasileira de Medicina Tropical

    2010  Volume 43, Issue 2, Page(s) 111–115

    Abstract: Introduction: HTLV-1/2 screening among blood donors commonly utilizes an enzyme-linked immunosorbent assay (EIA), followed by a confirmatory method such as Western blot (WB) if the EIA is positive. However, this algorithm yields a high rate of ... ...

    Abstract Introduction: HTLV-1/2 screening among blood donors commonly utilizes an enzyme-linked immunosorbent assay (EIA), followed by a confirmatory method such as Western blot (WB) if the EIA is positive. However, this algorithm yields a high rate of inconclusive results, and is expensive.
    Methods: Two qualitative real-time PCR assays were developed to detect HTLV-1 and 2, and a total of 318 samples were tested (152 blood donors, 108 asymptomatic carriers, 26 HAM/TSP patients and 30 seronegative individuals).
    Results: The sensitivity and specificity of PCR in comparison with WB results were 99.4% and 98.5%, respectively. PCR tests were more efficient for identifying the virus type, detecting HTLV-2 infection and defining inconclusive cases.
    Conclusions: Because real-time PCR is sensitive and practical and costs much less than WB, this technique can be used as a confirmatory test for HTLV in blood banks, as a replacement for WB.
    MeSH term(s) Blood Donors ; Blotting, Western ; DNA, Viral/blood ; HTLV-I Infections/diagnosis ; HTLV-II Infections/diagnosis ; Human T-lymphotropic virus 1/genetics ; Human T-lymphotropic virus 2/genetics ; Humans ; Polymerase Chain Reaction/methods ; Sensitivity and Specificity
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2010-04-27
    Publishing country Brazil
    Document type Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1038126-0
    ISSN 1678-9849 ; 0037-8682
    ISSN (online) 1678-9849
    ISSN 0037-8682
    DOI 10.1590/s0037-86822010000200001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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