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  1. Article ; Online: Tissue engineering modalities in skeletal muscles: focus on angiogenesis and immunomodulation properties.

    Namjoo, Atieh Rezaei / Abrbekoh, Fateme Nazary / Saghati, Sepideh / Amini, Hassan / Saadatlou, Mohammad Ali Ebrahimi / Rahbarghazi, Reza

    Stem cell research & therapy

    2023  Volume 14, Issue 1, Page(s) 90

    Abstract: Muscular diseases and injuries are challenging issues in human medicine, resulting in physical disability. The advent of tissue engineering approaches has paved the way for the restoration and regeneration of injured muscle tissues along with available ... ...

    Abstract Muscular diseases and injuries are challenging issues in human medicine, resulting in physical disability. The advent of tissue engineering approaches has paved the way for the restoration and regeneration of injured muscle tissues along with available conventional therapies. Despite recent advances in the fabrication, synthesis, and application of hydrogels in terms of muscle tissue, there is a long way to find appropriate hydrogel types in patients with congenital and/or acquired musculoskeletal injuries. Regarding specific muscular tissue microenvironments, the applied hydrogels should provide a suitable platform for the activation of endogenous reparative mechanisms and concurrently deliver transplanting cells and therapeutics into the injured sites. Here, we aimed to highlight recent advances in muscle tissue engineering with a focus on recent strategies related to the regulation of vascularization and immune system response at the site of injury.
    MeSH term(s) Humans ; Tissue Engineering/methods ; Muscle, Skeletal/injuries ; Muscular Diseases/therapy ; Hydrogels ; Immunomodulation
    Chemical Substances Hydrogels
    Language English
    Publishing date 2023-04-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-023-03310-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multiprotein collagen/keratin hydrogel promoted myogenesis and angiogenesis of injured skeletal muscles in a mouse model.

    Namjoo, Atieh Rezaei / Hassani, Ayla / Amini, Hassan / Nazaryabrbekoh, Fateme / Saghati, Sepideh / Saadatlou, Mohammad Ali Ebrahimi / Khoshfetrat, Ali Baradar / Khosrowshahi, Nafiseh Didar / Rahbarghazi, Reza

    BMC biotechnology

    2024  Volume 24, Issue 1, Page(s) 23

    Abstract: Volumetric loss is one of the challenging issues in muscle tissue structure that causes functio laesa. Tissue engineering of muscle tissue using suitable hydrogels is an alternative to restoring the physiological properties of the injured area. Here, ... ...

    Abstract Volumetric loss is one of the challenging issues in muscle tissue structure that causes functio laesa. Tissue engineering of muscle tissue using suitable hydrogels is an alternative to restoring the physiological properties of the injured area. Here, myogenic properties of type I collagen (0.5%) and keratin (0.5%) were investigated in a mouse model of biceps femoris injury. Using FTIR, gelation time, and rheological analysis, the physicochemical properties of the collagen (Col)/Keratin scaffold were analyzed. Mouse C2C12 myoblast-laden Col/Keratin hydrogels were injected into the injury site and histological examination plus western blotting were performed to measure myogenic potential after 15 days. FTIR indicated an appropriate interaction between keratin and collagen. The blend of Col/Keratin delayed gelation time when compared to the collagen alone group. Rheological analysis revealed decreased stiffening in blended Col/Keratin hydrogel which is favorable for the extrudability of the hydrogel. Transplantation of C2C12 myoblast-laden Col/Keratin hydrogel to injured muscle tissues led to the formation of newly generated myofibers compared to cell-free hydrogel and collagen groups (p < 0.05). In the C2C12 myoblast-laden Col/Keratin group, a low number of CD31
    MeSH term(s) Animals ; Mice ; Muscle Development ; Muscle, Skeletal/injuries ; Muscle, Skeletal/metabolism ; Keratins/metabolism ; Cell Line ; Hydrogels/chemistry ; Neovascularization, Physiologic/drug effects ; Tissue Engineering/methods ; Disease Models, Animal ; Collagen/metabolism ; Myoblasts/metabolism ; Myoblasts/cytology ; Male ; Tissue Scaffolds/chemistry ; Angiogenesis
    Chemical Substances Keratins (68238-35-7) ; Hydrogels ; Collagen (9007-34-5)
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2052746-9
    ISSN 1472-6750 ; 1472-6750
    ISSN (online) 1472-6750
    ISSN 1472-6750
    DOI 10.1186/s12896-024-00847-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Exosome-bearing hydrogels and cardiac tissue regeneration.

    Amini, Hassan / Namjoo, Atieh Rezaei / Narmi, Maryam Taghavi / Mardi, Narges / Narimani, Samaneh / Naturi, Ozra / Khosrowshahi, Nafiseh Didar / Rahbarghazi, Reza / Saghebasl, Solmaz / Hashemzadeh, Shahriar / Nouri, Mohammad

    Biomaterials research

    2023  Volume 27, Issue 1, Page(s) 99

    Abstract: Background: In recent years, cardiovascular disease in particular myocardial infarction (MI) has become the predominant cause of human disability and mortality in the clinical setting. The restricted capacity of adult cardiomyocytes to proliferate and ... ...

    Abstract Background: In recent years, cardiovascular disease in particular myocardial infarction (MI) has become the predominant cause of human disability and mortality in the clinical setting. The restricted capacity of adult cardiomyocytes to proliferate and restore the function of infarcted sites is a challenging issue after the occurrence of MI. The application of stem cells and byproducts such as exosomes (Exos) has paved the way for the alleviation of cardiac tissue injury along with conventional medications in clinics. However, the short lifespan and activation of alloreactive immune cells in response to Exos and stem cells are the main issues in patients with MI. Therefore, there is an urgent demand to develop therapeutic approaches with minimum invasion for the restoration of cardiac function.
    Main body: Here, we focused on recent data associated with the application of Exo-loaded hydrogels in ischemic cardiac tissue. Whether and how the advances in tissue engineering modalities have increased the efficiency of whole-based and byproducts (Exos) therapies under ischemic conditions. The integration of nanotechnology and nanobiology for designing novel smart biomaterials with therapeutic outcomes was highlighted.
    Conclusion: Hydrogels can provide suitable platforms for the transfer of Exos, small molecules, drugs, and other bioactive factors for direct injection into the damaged myocardium. Future studies should focus on the improvement of physicochemical properties of Exo-bearing hydrogel to translate for the standard treatment options.
    Language English
    Publishing date 2023-10-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2775188-0
    ISSN 2055-7124 ; 1226-4601
    ISSN (online) 2055-7124
    ISSN 1226-4601
    DOI 10.1186/s40824-023-00433-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Phenolated alginate hydrogel induced osteogenic properties of mesenchymal stem cells via Wnt signaling pathway.

    Saghati, Sepideh / Avci, Çığır Biray / Hassani, Ayla / Nazifkerdar, Sajed / Amini, Hassan / Saghebasl, Solmaz / Mahdipour, Mahdi / Banimohamad-Shotorbani, Behnaz / Namjoo, Atieh Rezaei / Abrbekoh, Fateme Nazary / Rahbarghazi, Reza / Nasrabadi, Hamid Tayefi / Khoshfetrat, Ali Baradar

    International journal of biological macromolecules

    2023  Volume 253, Issue Pt 5, Page(s) 127209

    Abstract: Osteogenic properties of phenolated alginate (1.2 %) hydrogel containing collagen (0.5 %)/nano-hydroxyapatite (1 %) were studied on human mesenchymal stem cells in vitro. The phenolation rate and physical properties of the hydrogel were assessed using ... ...

    Abstract Osteogenic properties of phenolated alginate (1.2 %) hydrogel containing collagen (0.5 %)/nano-hydroxyapatite (1 %) were studied on human mesenchymal stem cells in vitro. The phenolation rate and physical properties of the hydrogel were assessed using nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), swelling ratio, gelation time, mechanical assay, and degradation rate. The viability of encapsulated cells was monitored on days 7, 14, and 21 using an MTT assay. Osteoblast differentiation was studied using western blotting, and real-time PCR. Using PCR array analysis, the role of the Wnt signaling pathway was also investigated. Data showed that the combination of alginate/collagen/nanohydroxyapatite yielded proper mechanical features. The addition of nanohydroxyapatite, and collagen reduced degradation, swelling rate coincided with increased stiffness. Elasticity and pore size were also diminished. NMR and FTIR revealed suitable incorporation of collagen and nanohydroxyapatite in the structure of alginate. Real-time PCR analysis and western blotting indicated the expression of osteoblast-related genes such as Runx2 and osteocalcin. PCR array revealed the induction of numerous genes related to Wnt signaling pathways during the maturation of human stem cells toward osteoblast-like cells. In vivo data indicated that transplantation of phenolated alginate/collagen/nanohydroxyapatite hydrogel led to enhanced de novo bone formation in rats with critical-sized calvarial defects. Phenolated alginate hydrogel can promote the osteogenic capacity of human amniotic membrane mesenchymal stem cells in the presence of nanohydroxyapatite and collagen via engaging the Wnt signaling pathway.
    MeSH term(s) Humans ; Rats ; Animals ; Osteogenesis ; Hydrogels/chemistry ; Wnt Signaling Pathway ; Alginates/chemistry ; Collagen/metabolism ; Cell Differentiation ; Mesenchymal Stem Cells ; Cells, Cultured ; Tissue Scaffolds/chemistry
    Chemical Substances Hydrogels ; Alginates ; Collagen (9007-34-5)
    Language English
    Publishing date 2023-10-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.127209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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