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  1. Article ; Online: Host Susceptibility to Nontuberculous Mycobacterial Pulmonary Disease.

    Namkoong, Ho / Holland, Steven M

    Clinics in chest medicine

    2023  Volume 44, Issue 4, Page(s) 723–730

    Abstract: Nontuberculous mycobacteria (NTM) pulmonary disease is a chronic progressive pulmonary infectious disease caused by low virulence pathogens. The existence of host susceptibility to NTM infection has been recognized from a high incidence among Asians ... ...

    Abstract Nontuberculous mycobacteria (NTM) pulmonary disease is a chronic progressive pulmonary infectious disease caused by low virulence pathogens. The existence of host susceptibility to NTM infection has been recognized from a high incidence among Asians compared to other populations in the United States, a high incidence among slender, middle-aged women, and the presence of familial clusters. Recent whole exome sequencing and genome-wide association studies have identified immune, CFTR, cilia, connective tissue and ion homeostasis genes as host susceptibility genes. Large-scale international collaborative studies and functional analyses are expected to elucidate host susceptibility in the future.
    MeSH term(s) Middle Aged ; Humans ; Female ; United States ; Genome-Wide Association Study ; Mycobacterium Infections, Nontuberculous/microbiology ; Lung Diseases/epidemiology ; Lung ; Nontuberculous Mycobacteria/genetics
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2023.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Laryngitis after inhalation of liposomal amikacin.

    Morita, Atsuho / Namkoong, Ho / Hosoya, Makoto / Hasegawa, Naoki

    Clinical case reports

    2022  Volume 10, Issue 2, Page(s) e05350

    Abstract: A 56-year-old woman with ... ...

    Abstract A 56-year-old woman with pulmonary
    Language English
    Publishing date 2022-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.5350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Susceptibility of the obese population to COVID-19.

    Kimura, Takefumi / Namkoong, Ho

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 101, Page(s) 380–381

    Abstract: Obesity is a risk factor for disease severity in individuals with coronavirus disease (COVID-19). However, the increased susceptibility of this population to COVID-19 is unclear. We outline several underlying mechanisms that may explain the relationship ... ...

    Abstract Obesity is a risk factor for disease severity in individuals with coronavirus disease (COVID-19). However, the increased susceptibility of this population to COVID-19 is unclear. We outline several underlying mechanisms that may explain the relationship between obesity and COVID-19 severity. Obesity has an adverse effect on respiratory physiology because increased intra-abdominal adipose tissue can interfere with lung expansion, resulting in reduced lung compliance. Further, fat accumulation in the soft tissue of the pharynx can increase inspiratory resistance, and obesity may be associated with sleep apnea. Obesity is associated with several defects in cell-mediated immunity, including increased levels of pro-inflammatory cytokines. Impaired adipocyte-mediated immune function results in chronically high leptin levels, low adiponectin levels, and anti-inflammatory adipokines. Reduced physical activity can impair several steps of the immune response to viruses. Obesity also promotes a hypercoagulable state, leading to severe consequences. These factors may synergistically play a role in promoting the severity of the disease in obese individuals. A better understanding of the mechanisms by which obesity contributes to the severity of COVID-19 is important for developing more effective treatments.
    MeSH term(s) Blood Coagulation Disorders/complications ; COVID-19/etiology ; Disease Susceptibility ; Exercise ; Humans ; Obesity/complications ; Obesity/immunology ; SARS-CoV-2 ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-10-09
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.10.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Buffalo Chest Syndrome Following Esophagectomy.

    Kawakami, Naoki / Namkoong, Ho

    Internal medicine (Tokyo, Japan)

    2019  Volume 58, Issue 16, Page(s) 2413

    Language English
    Publishing date 2019-05-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.2465-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Minimum inhibitory concentrations of azithromycin in clinical isolates of

    Uwamino, Yoshifumi / Aoki, Wataru / Inose, Rika / Kamoshita, Yuka / Mikita, Kei / Namkoong, Ho / Nishimura, Tomoyasu / Matsushita, Hiromichi / Hasegawa, Naoki

    Microbiology spectrum

    2024  , Page(s) e0021824

    Abstract: The latest guidelines include azithromycin as a preferred regimen for ... ...

    Abstract The latest guidelines include azithromycin as a preferred regimen for treating
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00218-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Anal tuberculosis presenting as refractory perianal abscess.

    Sasahara, Kotaro / Kitahama, Keiichiro / Aiko, Satoshi / Namkoong, Ho

    Clinical case reports

    2021  Volume 9, Issue 9, Page(s) e04177

    Abstract: Although most cases occur in immunocompromised individuals, anal tuberculosis can occur in the absence of HIV infection. Anal tuberculosis should be considered in the differential diagnosis of chronic or recurrent anal fistulas. ...

    Abstract Although most cases occur in immunocompromised individuals, anal tuberculosis can occur in the absence of HIV infection. Anal tuberculosis should be considered in the differential diagnosis of chronic or recurrent anal fistulas.
    Language English
    Publishing date 2021-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.4177
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  7. Article: Cavitary lesions emerged rapidly in

    Kawakami, Naoki / Ohara, Shin / Namkoong, Ho

    Clinical case reports

    2020  Volume 8, Issue 3, Page(s) 576–577

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    Language English
    Publishing date 2020-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2704
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  8. Article: Cardiac tamponade secondary to empyema.

    Kawakami, Naoki / Kushimoto, Kohei / Saito, Fumitake / Namkoong, Ho

    Clinical case reports

    2020  Volume 8, Issue 3, Page(s) 574–575

    Abstract: A 70-year-old male presented with a 1-month history of malaise and fever. He was diagnosed with chronic empyema and went into shock by cardiac tamponade after treatment. This case shows that even chronic empyema can cause cardiac tamponade. It should be ... ...

    Abstract A 70-year-old male presented with a 1-month history of malaise and fever. He was diagnosed with chronic empyema and went into shock by cardiac tamponade after treatment. This case shows that even chronic empyema can cause cardiac tamponade. It should be considered as differential diagnoses of shock after empyema treatment.
    Language English
    Publishing date 2020-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Detection of the early stage of spontaneous hemopneumothorax by CT attenuation values.

    Koike, Yukiko / Namkoong, Ho / Otake, Sotaro / Asamura, Hisao

    Clinical case reports

    2020  Volume 8, Issue 7, Page(s) 1321–1322

    Abstract: Spontaneous hemopneumothorax is potentially fatal and can mimic spontaneous pneumothorax when changes in vital signs and bloody discharge from the chest tube are absent. Attenuation values at computed tomography may help detect this condition. ...

    Abstract Spontaneous hemopneumothorax is potentially fatal and can mimic spontaneous pneumothorax when changes in vital signs and bloody discharge from the chest tube are absent. Attenuation values at computed tomography may help detect this condition.
    Language English
    Publishing date 2020-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2849
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  10. Article ; Online: The effect of adding immune checkpoint inhibitors on the risk of pneumonitis for solid tumours: a meta-analysis of phase III randomised controlled trials.

    Fujiwara, Yu / Horita, Nobuyuki / Namkoong, Ho / Galsky, Matthew D

    European journal of cancer (Oxford, England : 1990)

    2021  Volume 150, Page(s) 168–178

    Abstract: Background: Immune checkpoint inhibitors (ICIs) have become one of the standard treatment options for solid tumours; however, treatment-related adverse events, including pneumonitis, sometimes disrupt the ongoing treatment. To evaluate the impact of ICI ...

    Abstract Background: Immune checkpoint inhibitors (ICIs) have become one of the standard treatment options for solid tumours; however, treatment-related adverse events, including pneumonitis, sometimes disrupt the ongoing treatment. To evaluate the impact of ICI addition on the risk of pneumonitis, a meta-analysis was conducted.
    Methods: Phase III randomised controlled trials comparing ICIs and conventional therapy with conventional therapy alone were selected by searching databases, including PubMed, Embase, Web of Science and Cochrane Library. The odds ratio (OR) of any grade and grade III-V pneumonitis was calculated. Meta-analysis was performed to compare the incidence of pneumonitis between the treatment arm with additional ICIs and the arm with conventional therapy.
    Results: A total of 25 randomised controlled trials (RCTs) representing 16,343 patients for grade I-V and 23 RCTs with 15,006 patients for grade III-V pneumonitis were analysed. Adding ICIs was associated with a significant increase in pneumonitis (grade I-V: OR, 2.67, 95% confidence interval [CI]: 2.12-3.37, grade III-V: OR, 1.83, 95% CI: 1.26-2.65). In subgroup analyses based on the mechanism of action of ICIs, cancer types (lung and non-lung cancer) and each ICI, no significant difference in heterogeneity was observed.
    Conclusions: Adding ICIs to the conventional treatment for solid tumours significantly increased both grade I-V and grade III-V pneumonitis regardless of the mechanisms of ICIs and cancer type. These results would be helpful for oncologists to choose the appropriate treatment options using ICIs, particularly for patients with known risk factors of pneumonitis or interstitial lung disease.
    MeSH term(s) Clinical Trials, Phase III as Topic ; Female ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Incidence ; Male ; Neoplasms/drug therapy ; Neoplasms/immunology ; Pneumonia/chemically induced ; Pneumonia/diagnosis ; Pneumonia/epidemiology ; Randomized Controlled Trials as Topic ; Risk Assessment ; Risk Factors ; Treatment Outcome
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-04-24
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2021.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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