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  1. Article ; Online: Ayurvedic preparations of Raudra Rasa inhibit agonist‐mediated platelet activation and restrict thrombogenicity without affecting cell viability

    Susheel Nidhi Chaurasia / Vipin Singh / Mohammad Ekhlak / Manoj Kumar Dash / Namrata Joshi / Debabrata Dash

    FEBS Open Bio, Vol 13, Iss 12, Pp 2342-

    2023  Volume 2355

    Abstract: Ayurveda is considered to be one of the most ancient forms of medicine still practiced. The Ayurvedic preparation Raudra Rasa and its derivatives have been widely employed against cancer since the 12th century, but the effect of these traditional ... ...

    Abstract Ayurveda is considered to be one of the most ancient forms of medicine still practiced. The Ayurvedic preparation Raudra Rasa and its derivatives have been widely employed against cancer since the 12th century, but the effect of these traditional formulations on platelet function and signaling has not previously been examined. Here we demonstrate that Raudra Rasa and its derivatives significantly reduce thrombin‐induced integrin activation and granule secretion in platelets, as observed by reduced PAC‐1 binding and P‐selectin externalization, respectively. These formulations also inhibited thrombin‐stimulated phosphatidylserine exposure, mitochondrial reactive oxygen species generation, and mitochondrial transmembrane potential in platelets. Consistent with the above, Raudra Rasa significantly reduced thrombin‐induced tyrosine phosphorylation of the platelet proteins, as well as phosphorylation of the enzymes AKT and GSK‐3β. In summary, Raudra Rasa inhibits agonist‐mediated platelet activation without affecting cell viability, suggesting it may have therapeutic potential as an anti‐platelet/anti‐thrombotic agent.
    Keywords AKT ; CRR ; mROS ; MRR ; platelets ; RRE ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Antipyretic activity of mrityunjaya rasa prepared by various compounds of mercury in experimental animals

    Manoj Kumar Dash / Namrata Joshi / Madhuri Vindhyaraj / Saroj M Parhate

    Journal of Ayurveda, Vol 15, Iss 1, Pp 2-

    2021  Volume 8

    Abstract: Introduction: Mrityunjaya Rasa(MR) is a herbomineral Ayurvedic anti-pyretic formulation containing Shuddha Hingula (Purified Cinnabar), Shuddha Gandhaka (Purified Sulphur), Shuddha Tankana (Purified Borax), Shuddha Vatsanabh (Purified Aconite) Pippali ( ... ...

    Abstract Introduction: Mrityunjaya Rasa(MR) is a herbomineral Ayurvedic anti-pyretic formulation containing Shuddha Hingula (Purified Cinnabar), Shuddha Gandhaka (Purified Sulphur), Shuddha Tankana (Purified Borax), Shuddha Vatsanabh (Purified Aconite) Pippali (Piper lonum) and Maricha (Piper nigrum). Objective: The present pharmacological study was undertaken to study the comparative antipyretic activity of different samples of Mrityunjaya Rasa with slight variations in ingredients; Mrityunjaya Rasa 'A' (Hingula based), Mrityunjaya Rasa 'B' (Kajjali based), Mrityunjaya Rasa 'C' (Rasasindura based), Mrityunjaya Rasa 'D' (without metallic content). Material and Method: Pyrexia was induced by subcutaneous injection of 20% wt/v of Brewer's yeast in distilled water (10ml/kg) in 36 animals divided into 6 groups, each group containing 6 animals. Basal rectal temperature was measured before the injection of yeast, and the rise in rectal temperature was recorded after 18 hrs of yeast injection. Group 'A' treated as normal control while group 'B' as standard control (treated with Paracetamol) Group C, D, E, F were drug tested groups. Results: The data generated during all stages of study showed that all samples of Mrityunjaya Rasa (22.5 mg/kg per day) exert highly significant (P<0.001) decrease in temperature after ½ hour and 1 hr of administration except Mrityunjaya Rasa D which was non-significant after 1 hr. Mrityunjaya Rasa ′C′ (Rasasindura based), was found to be significant (P<0.05) even after 3 hrs in comparison to standard drug (Paracetamol). Conclusion: The results of present study show the importance of mercury in intensifying the therapeutic efficacy of a formulation. Further, result obtained in Mrityunjaya Rasa containing Rasasindura group explains the importance of concept of gandhakaj jarana in rasashastra.
    Keywords brewer's yeast ; hingula ; kajjali ; mrityunjaya rasa ; paracetamol ; pyrexia ; rasasindura ; Other systems of medicine ; RZ201-999
    Subject code 630
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Pharmaceutical characterization and exploration of Arkeshwara rasa in MDA-MB-231 cells

    Remya Jayakumar / Manoj Kumar Dash / Pankaj Kumar / Shiwakshi Sharma / Saumya Gulati / Akanksha Pandey / Kaushavi Cholke / Zeeshan Fatima / S.K. Trigun / Namrata Joshi

    Journal of Ayurveda and Integrative Medicine, Vol 15, Iss 1, Pp 100823- (2024)

    2024  

    Abstract: Background: The diverse specificity mode of cancer treatment targets and chemo resistance demands the necessity of drug entities which can address the devastating dynamicity of the disease. Objectives: To check the anti-tumour potential of traditional ... ...

    Abstract Background: The diverse specificity mode of cancer treatment targets and chemo resistance demands the necessity of drug entities which can address the devastating dynamicity of the disease. Objectives: To check the anti-tumour potential of traditional medicine rich in polyherbal components and metal nanoparticle namely Arkeshwara rasa (AR). Material methods: The AR was prepared in a modified version with reference from Rasaratna Samuchaya and characterized using sophisticated instrumental analysis including XRD, SEM-EDAX, TEM, TGA-DSC, and LC-MS and tested against the MDA-MB-231 cell line to screen cell viability and the cytotoxicity with MTT, SRB and the AO assay. Results: XRD pattern shows cubic tetrahedrite structure with Sb, Cu, S peaks and trace elements like Fe, Mg, etc. The particle size of AR ranges between 20 and 30 nm. The TGA points thermal decomposition at 210 °C and the metal sulphide peaks in DSC. LC-MS analysis reveals the components of the formulation more on the flavonoid portion. The IC50 value of MTT and SRB are 25.28 μg/mL and 31.7 μg/mL respectively. The AO colorimeter substantiated the cell viability and the apoptosis figures of the same cell line. The AR exhibits cytotoxicity and reaffirms the apoptosis fraction with SRB assay. Conclusions: The Hesperidine, Neohesperidin, Rutin components in the phytochemical pool can synergize the anti-tumour potential with either influencing cellular pathways or decreasing chemo resistance to conventional treatment. AR need to be further experimented with reverse transcription, flow cytometry, western blotting, etc.
    Keywords Traditional medicine ; Cancer ; IC50 value ; Hesperidin ; In-vitro ; Arkeshwara rasa ; Miscellaneous systems and treatments ; RZ409.7-999
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Visaghna herbs and metals as neutralizing antibodies in the prevention and treatment of infection by severe acute respiratory syndrome-Coronavirus-2

    Manoj Kumar Dash / Namrata Joshi / D N. S. Gautam

    Journal of Ayurveda, Vol 14, Iss 4, Pp 112-

    2020  Volume 118

    Abstract: Introduction: The severe acute respiratory syndrome (SARS)-CoV2 is a viral respiratory disease threatening worldwide public health, social stability, and financial development. Pathological hallmark for SARS-CoV-2 is an ineffective innate immune reaction. ...

    Abstract Introduction: The severe acute respiratory syndrome (SARS)-CoV2 is a viral respiratory disease threatening worldwide public health, social stability, and financial development. Pathological hallmark for SARS-CoV-2 is an ineffective innate immune reaction. i.e., immune cells recognize it as dangerous toxins in place of self-antigen. Published data on neutralizing antibodies suggests their role in the prevention and treatment of infection SARS-CoV-2 through passive immunity in COVID-19. Objective: The present paper discusses the role of vishghna dravya in either flushing out or neutralization of toxins from the body. Material & Method: We developed the screening system based on Ayurveda & Modern pharmacology from different databases. Reported plants and minerals were retrieved from ancient texts. Furthermore, pharmacology method was used to preliminarily uncover the molecule mechanism. Results: Nine herbs and five metallic bhasmas having Vishaghna property were systematically reviewed, out of which four herbs and five metallic bhasmas have been reported to possess neutralizing antibody potential. Vishagna dravya works on concept of Samana pratyarbdha, the inherent qualities of the predominant mahabhutas. Madhura rasa (six), Katu Rasa (Five), Tikta Rasa (seven), Kasaya Rasa (two) have Prithvi, Vayu, Akash & Agni Mahabhuta that may exert neutralizing effect by making the cells more strong, inhibits the absorption of virus & increasing the various metabolic activities. Conclusion: To meet this challenge, this article discusses some published Ayurveda herbs and Nano metals which may neutralize the virus toxin for the prevention and treatment of infection by SARS-CoV-2.
    Keywords bhasma ; covid-19 ; immunity ; mahabhuta ; neutralizing antibodies ; vishaghna ; Other systems of medicine ; RZ201-999
    Subject code 570
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Effect of Navayasa Lauha, an ayurvedic herbomineral formulation on experimentally-induced iron deficiency anemia

    Namrata Joshi / Manoj Kumar Dash / Laxmikant Dwivedi / Gurudas Khilnani

    Ancient Science of Life, Vol 37, Iss 4, Pp 180-

    2018  Volume 187

    Abstract: Background: Navayasa lauha (NL) is a herbometallic preparation (Rasaushadhi) widely used in Ayurveda as a hematinic agent. Nutritional deficiency is a main cause of anemia worldwide. Materials and Methods: NL was trialed on nutritional iron deficiency ... ...

    Abstract Background: Navayasa lauha (NL) is a herbometallic preparation (Rasaushadhi) widely used in Ayurveda as a hematinic agent. Nutritional deficiency is a main cause of anemia worldwide. Materials and Methods: NL was trialed on nutritional iron deficiency anemia induced by rice milk diet given for 2 months in albino rats. Iron-deficient rats were then treated with NL for 45 days, and assessment was done on the basis of peripheral blood picture, blood parameters, viz., hemoglobin%, Packed cell volume (PCV), Total red blood cell (TRBC) count, mean cell volume (MCV), mean cell hemoglobin (MCH), MCH concentration serum iron, and “decrease in total iron binding capacity (TIBC).” Results: A highly significant improvement (P < 0.001) in PCV, MCV, MCH, and TRBC and significant increase in Hb% (P < 0.05) and serum iron (P < 0.01), and significant decrease in TIBC (P < 0.01) were also observed. Conclusion: Results of the present study demonstrate that NL could be a promising and safe herbomineral medicine in the treatment of iron deficiency anemia without any gastrointestinal upset, which are generally encountered with modern iron supplements. Significant increase in serum iron and significant decrease in TIBC are indicative of direct effect of trial drug on body iron store in the treatment of anemia.
    Keywords albino rats ; anemia ; hematinic ; iron deficiency ; lauha ; milk ; nutrition ; rice ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Toxicity study of Lauha Bhasma (calcined iron) in albino rats

    Namrata Joshi / Manoj Kumar Dash / Laxmikant Dwivedi / G D Khilnani

    Ancient Science of Life, Vol 35, Iss 3, Pp 159-

    2016  Volume 166

    Abstract: Background: Lauha Bhasma(LB) is a complex herbomineral preparation widely used as an Ayurvedic hematinic agent. It is an effective remedy for chronic fever (jīrṃa jvara), phthisis (kşaya), Breathlessness (śvāsa) etc., and possesses vitality enhancing ( ... ...

    Abstract Background: Lauha Bhasma(LB) is a complex herbomineral preparation widely used as an Ayurvedic hematinic agent. It is an effective remedy for chronic fever (jīrṃa jvara), phthisis (kşaya), Breathlessness (śvāsa) etc., and possesses vitality enhancing (vājīkara), strength promoting and anti aging (rasāyana) properties. Objectives: The present work was conducted to establish the safety aspects of the use of Lauha bhasma. Setting and Design: LB was prepared by Ayurvedic procedures of purification (śodhana), sun drying (bhānupāka), sthālīpāka, followed by repeated calcination (māraṃa) and “nectarization” (amṃṛtīkaraṃa). The resultant product was subjected to acute and sub acute toxicity studies. Materials and Methods: Acute and subacute toxicity study of LB was conducted in albino rats. Criteria for assessment included ponderal changes, change in biochemical parameters viz., LFT and KFT and hematological parameters. Histopathological studies of different organs including liver, kidney, spleen, testis etc., were also conducted to observe pathological changes if any. Results: In the acute toxicity study, the animal group did not manifest any signs of toxicity and no mortality was observed up to 100 times the therapeutic dose (TD). Significant increase in blood urea (27.83%, P< 0.01), serum creatinine (30.92%, P< 0.05), Aspartate aminotransferase (15.09%, P< 0.05), and serum alkaline phosphatase (27.5%, P< 0.01) was evident in group IV (10 TD). A significant increase in serum total protein (6.04%, P< 0.05) level was observed in group III (5 TD). Histopathological examination of livers in group IV (10 TD) showed mild inflammation in terms of bile stasis, peri-portal hepatic inflammation and sinusoidal congestion; lymphocyte infiltration in kidney and intracellular deposits in the splenic tissue. Conclusion: Lauha Bhasma was found to be safe at the therapeutic dose and also at five times the therapeutic dose levels. However, alteration in some of the biochemical and haematological parameters along with histopathological findings were evident at the highest dose level.
    Keywords Biochemical ; histopathology ; Lauha bhasma ; liver ; spleen Triphala ; toxicity ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Diet, wound healing and plastic surgery

    Nikhil Panse / Vijaya Sathe / Parag Sahasrabudhe / Namrata Joshi

    Indian Journal of Plastic Surgery, Vol 46, Iss 1, Pp 161-

    2013  Volume 163

    Keywords Surgery ; RD1-811 ; Medicine ; R
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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