Article ; Online: The Multifaceted Role of FUT8 in Tumorigenesis: From Pathways to Potential Clinical Applications.
International journal of molecular sciences
2024 Volume 25, Issue 2
Abstract: FUT8, the sole glycosyltransferase responsible for N-glycan core fucosylation, plays a crucial role in tumorigenesis and development. Aberrant FUT8 expression disrupts the function of critical cellular components and triggers the abnormality of tumor ... ...
| Abstract | FUT8, the sole glycosyltransferase responsible for N-glycan core fucosylation, plays a crucial role in tumorigenesis and development. Aberrant FUT8 expression disrupts the function of critical cellular components and triggers the abnormality of tumor signaling pathways, leading to malignant transformations such as proliferation, invasion, metastasis, and immunosuppression. The association between FUT8 and unfavorable outcomes in various tumors underscores its potential as a valuable diagnostic marker. Given the remarkable variation in biological functions and regulatory mechanisms of FUT8 across different tumor types, gaining a comprehensive understanding of its complexity is imperative. Here, we review how FUT8 plays roles in tumorigenesis and development, and how this outcome could be utilized to develop potential clinical therapies for tumors. |
|---|---|
| MeSH term(s) | Humans ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic/genetics ; Immunosuppression Therapy ; Fucosyltransferases/genetics |
| Chemical Substances | Glycoprotein 6-alpha-L-fucosyltransferase (EC 2.4.1.68) ; Fucosyltransferases (EC 2.4.1.-) |
| Language | English |
| Publishing date | 2024-01-15 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms25021068 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.