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Article ; Online: Effect of low temperature on the shaping of yeast-derived metabolite compositions during wine fermentation.

Du, Qing / Ye, Dongqing / Zang, Xiaomin / Nan, Hao / Liu, Yanlin

Food research international (Ottawa, Ont.)

2022 Volume 162, Issue Pt A, Page(s) 112016

Abstract: Low-temperature fermentation is considered to enrich the aroma of wine. The metabolism of Saccharomyces cerevisiae responding to low temperatures is intricate and this complexity is further enhanced by various strains and culture media. However, the real ...

Abstract	Low-temperature fermentation is considered to enrich the aroma of wine. The metabolism of Saccharomyces cerevisiae responding to low temperatures is intricate and this complexity is further enhanced by various strains and culture media. However, the real effects of low-temperature fermentation on yeast metabolism are unclear. Aiming to clarify the yeast-derived metabolite formation in a low-temperature winemaking range, fermentations were performed at 10, 15, and 20 °C, using five wine yeast strains in two media respectively. Tolerance toward low temperatures and metabolite compositions (including basic chemical compositions and volatile aroma compounds) of wine yeasts were analyzed. Results showed that ethanol, ethyl acetate, and ethyl butanoate increased with the temperature decreasing, while acetic acid, phenylethanol, phenylethyl acetate, ethyl decanoate, and ethyl hexadecanoate decreased with decreasing temperature. The linear relationship between fermentation temperature and the formation of ethanol, acetic acid, and phenylethanol might be fundamentally due to the growth changes caused by temperature. The enhanced production of ethyl acetate and ethyl butyrate followed by decreasing temperature probably resulted from low-temperature-stimulated enzymes in metabolic pathways. These findings reveal a typical profile of yeast-derived metabolites at low-temperature fermentation and provide evidence to support the application of low-temperature winemaking in the wine industry.
MeSH term(s)	Saccharomyces cerevisiae ; Wine ; Fermentation ; Temperature ; Phenylethyl Alcohol ; Acetic Acid ; Ethanol
Chemical Substances	ethyl acetate (76845O8NMZ) ; Phenylethyl Alcohol (ML9LGA7468) ; Acetic Acid (Q40Q9N063P) ; Ethanol (3K9958V90M)
Language	English
Publishing date	2022-10-02
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2022.112016
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Article ; Online: Phase separation in DNA double-strand break response.

Liu, Huan-Lei / Nan, Hao / Zhao, Wan-Wen / Wan, Xiang-Bo / Fan, Xin-Juan

Nucleus (Austin, Tex.)

2023 Volume 15, Issue 1, Page(s) 2296243

Abstract: DNA double-strand break (DSB) is the most dangerous type of DNA damage, which may lead to cell death or oncogenic mutations. Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are two typical DSB repair mechanisms. Recently, many studies ... ...

Abstract	DNA double-strand break (DSB) is the most dangerous type of DNA damage, which may lead to cell death or oncogenic mutations. Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are two typical DSB repair mechanisms. Recently, many studies have revealed that liquid-liquid phase separation (LLPS) plays a pivotal role in DSB repair and response. Through LLPS, the crucial biomolecules are quickly recruited to damaged sites with a high concentration to ensure DNA repair is conducted quickly and efficiently, which facilitates DSB repair factors activating downstream proteins or transmitting signals. In addition, the dysregulation of the DSB repair factor's phase separation has been reported to promote the development of a variety of diseases. This review not only provides a comprehensive overview of the emerging roles of LLPS in the repair of DSB but also sheds light on the regulatory patterns of phase separation in relation to the DNA damage response (DDR).
MeSH term(s)	DNA Breaks, Double-Stranded ; Phase Separation ; DNA Repair ; Homologous Recombination ; DNA/genetics
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-12-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2619626-8
ISSN	1949-1042 ; 1949-1042
ISSN (online)	1949-1042
ISSN	1949-1042
DOI	10.1080/19491034.2023.2296243
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Article ; Online: Bone marrow‐derived mesenchymal stem cells inhibit NK cell function via Tim‐3/galectin‐9 in multiple myeloma patients

Zhao‐Yun Liu / Nan‐Hao Meng / Pan‐Pan Cao / Yue Jia / Hao Wang / Yun‐He Zhang / Hui Liu / Rong Fu

Clinical and Translational Medicine, Vol 13, Iss 3, Pp n/a-n/a (2023)

2023

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of low temperature on the shaping of yeast-derived metabolite compositions during wine fermentation

Du, Qing / Ye, Dong-Qing / Zang, Xiaomin / Nan, Hao / Liu, Yanlin

Food Research International. 2022 Dec., v. 162 p.112016-

2022

Abstract	Low-temperature fermentation is considered to enrich the aroma of wine. The metabolism of Saccharomyces cerevisiae responding to low temperatures is intricate and this complexity is further enhanced by various strains and culture media. However, the real effects of low-temperature fermentation on yeast metabolism are unclear. Aiming to clarify the yeast-derived metabolite formation in a low-temperature winemaking range, fermentations were performed at 10, 15, and 20 °C, using five wine yeast strains in two media respectively. Tolerance toward low temperatures and metabolite compositions (including basic chemical compositions and volatile aroma compounds) of wine yeasts were analyzed. Results showed that ethanol, ethyl acetate, and ethyl butanoate increased with the temperature decreasing, while acetic acid, phenylethanol, phenylethyl acetate, ethyl decanoate, and ethyl hexadecanoate decreased with decreasing temperature. The linear relationship between fermentation temperature and the formation of ethanol, acetic acid, and phenylethanol might be fundamentally due to the growth changes caused by temperature. The enhanced production of ethyl acetate and ethyl butyrate followed by decreasing temperature probably resulted from low-temperature-stimulated enzymes in metabolic pathways. These findings reveal a typical profile of yeast-derived metabolites at low-temperature fermentation and provide evidence to support the application of low-temperature winemaking in the wine industry.
Keywords	Saccharomyces cerevisiae ; acetic acid ; butyrates ; ethyl acetate ; fermentation ; food research ; metabolites ; odors ; phenylethyl alcohol ; temperature ; wine industry ; wine yeasts ; winemaking ; wines ; Low-temperature fermentation ; Aroma metabolites ; Fermentation rate ; Tolerance ; Regulation mechanism ; Correlations ; White wine
Language	English
Dates of publication	2022-12
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2022.112016
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Functional morphology of antennae and sensilla of Hippodamia variegata (Coleoptera

Ya-Nan Hao / Yuan-Xing Sun / Chang-Zhong Liu

PLoS ONE, Vol 15, Iss 8, p e

Coccinellidae).

2020 Volume 0237452

Abstract: The lady beetle Hippodamia variegata is an important biocontrol agent of many aphids. In this study, the fine morphology of antennae as well as the typology, morphology and distribution of antennal sensilla were comprehensively examined by scanning ... ...

Abstract	The lady beetle Hippodamia variegata is an important biocontrol agent of many aphids. In this study, the fine morphology of antennae as well as the typology, morphology and distribution of antennal sensilla were comprehensively examined by scanning electron microscopy. The antennal morphology of female and male are similar and consist of the scape, pedicel, and nine flagellomeres. No significant difference was detected in the length of each segment between two sexes, while the male antennae are much stronger than females. In total, six types of sensilla can be defined on antenna, including Böhm bristle, sensilla chaetica (with three subtypes), sensilla basiconica (with three subtypes), sensilla trichodea, sensilla placodea and sensilla coeloconica. It is worth noting that sensilla chaetica III distributed only on the fixed position of male antennae. In addition, the functional morphology of antennae of H. variegata were compared with other lady beetles from multiple perspectives. Specially, the function of sensilla were also discussed according to their morphology, location and information from previous studies.
Keywords	Medicine ; R ; Science ; Q
Subject code	590
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of Infection Time Courses Shows CII Levels Determine the Frequency of Lysogeny in Phage 186

Nan Hao / Dylan Agnew / Sandeep Krishna / Ian B. Dodd / Keith E. Shearwin

Pharmaceuticals, Vol 14, Iss 998, p

2021 Volume 998

Abstract: Engineered phage with properties optimised for the treatment of bacterial infections hold great promise, but require careful characterisation by a number of approaches. Phage–bacteria infection time courses, where populations of bacteriophage and ... ...

Abstract	Engineered phage with properties optimised for the treatment of bacterial infections hold great promise, but require careful characterisation by a number of approaches. Phage–bacteria infection time courses, where populations of bacteriophage and bacteria are mixed and followed over many infection cycles, can be used to deduce properties of phage infection at the individual cell level. Here, we apply this approach to analysis of infection of Escherichia coli by the temperate bacteriophage 186 and explore which properties of the infection process can be reliably inferred. By applying established modelling methods to such data, we extract the frequency at which phage 186 chooses the lysogenic pathway after infection, and show that lysogenisation increases in a graded manner with increased expression of the lysogenic establishment factor CII. The data also suggest that, like phage λ, the rate of lysogeny of phage 186 increases with multiple infections.
Keywords	lysogeny ; phage infection ; multiplicity of infection ; bacteriophage ; temperate phage ; phage therapy ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Subject code	500
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bone marrow-derived mesenchymal stem cells inhibit NK cell function via Tim-3/galectin-9 in multiple myeloma patients.

Liu, Zhao-Yun / Meng, Nan-Hao / Cao, Pan-Pan / Jia, Yue / Wang, Hao / Zhang, Yun-He / Liu, Hui / Fu, Rong

Clinical and translational medicine

2023 Volume 13, Issue 3, Page(s) e1224

MeSH term(s)	Humans ; Multiple Myeloma/therapy ; Hepatitis A Virus Cellular Receptor 2 ; Bone Marrow ; Killer Cells, Natural ; Galectins ; Mesenchymal Stem Cells
Chemical Substances	Hepatitis A Virus Cellular Receptor 2 ; Galectins
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2697013-2
ISSN	2001-1326 ; 2001-1326
ISSN (online)	2001-1326
ISSN	2001-1326
DOI	10.1002/ctm2.1224
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Article ; Online: Non-Invasive Remote Temperature Monitoring Using Microwave-Induced Thermoacoustic Imaging.

Nan, Hao / Fitzpatrick, Aidan / Wang, Ke / Arbabian, Amin

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2019 Volume 2019, Page(s) 6375–6378

Abstract: Non-invasive temperature monitoring of tissue at depth in real-time is critical to hyperthermia therapies such as high-intensity focused ultrasound. Knowledge of temperature allows for monitoring treatment as well as providing real-time feedback to ... ...

Abstract	Non-invasive temperature monitoring of tissue at depth in real-time is critical to hyperthermia therapies such as high-intensity focused ultrasound. Knowledge of temperature allows for monitoring treatment as well as providing real-time feedback to adjust deposited power in order to maintain safe and effective temperatures. Microwave-induced thermoacoustic (TA) imaging, which combines the conductivity/dielectric contrast of microwave imaging with the resolution of ultrasound, shows potential for estimating temperature non-invasively in real-time by indirectly measuring the temperature dependent parameters from reconstructed images. In this work, we study the temperature dependent behavior of the generated pressure in the TA effect and experimentally demonstrate simultaneous imaging and temperature monitoring using TA imaging. The proof-of-concept experiments demonstrate millimeter spatial resolution while achieving degree-level accuracy.
MeSH term(s)	High-Intensity Focused Ultrasound Ablation ; Humans ; Hyperthermia, Induced ; Microwaves ; Temperature ; Thermography/methods ; Ultrasonography
Language	English
Publishing date	2019-12-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2019.8857309
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Article ; Online: Smart Camera Aware Crowd Counting via Multiple Task Fractional Stride Deep Learning.

Tong, Minglei / Fan, Lyuyuan / Nan, Hao / Zhao, Yan

Sensors (Basel, Switzerland)

2019 Volume 19, Issue 6

Abstract: Estimating the number of people in highly clustered crowd scenes is an extremely challenging task on account of serious occlusion and non-uniformity distribution in one crowd image. Traditional works on crowd counting take advantage of different CNN like ...

Abstract	Estimating the number of people in highly clustered crowd scenes is an extremely challenging task on account of serious occlusion and non-uniformity distribution in one crowd image. Traditional works on crowd counting take advantage of different CNN like networks to regress crowd density map, and further predict the count. In contrast, we investigate a simple but valid deep learning model that concentrates on accurately predicting the density map and simultaneously training a density level classifier to relax parameters of the network to prevent dangerous stampede with a smart camera. First, a combination of atrous and fractional stride convolutional neural network (CAFN) is proposed to deliver larger receptive fields and reduce the loss of details during down-sampling by using dilated kernels. Second, the expanded architecture is offered to not only precisely regress the density map, but also classify the density level of the crowd in the meantime (MTCAFN, multiple tasks CAFN for both regression and classification). Third, experimental results demonstrated on four datasets (Shanghai Tech A (MAE = 88.1) and B (MAE = 18.8), WorldExpo'10(average MAE = 8.2), NS UCF_CC_50(MAE = 303.2) prove our proposed method can deliver effective performance.
Language	English
Publishing date	2019-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s19061346
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Article: Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis

Jiang, Yanfei / Nan, Hao / Shi, Na / Hao, Wenfang / Dong, Juane / Chen, Hongying

Molecular biology reports. 2021 Mar., v. 48, no. 3

2021

Abstract: Chlorogenic acid (CGA), a phenylpropanoid derived from Eucommia ulmoides Oliver, has been shown to exhibit potent cytotoxic and anti-proliferative activities against several human cancers. However, the effects of CGA on hepatocellular carcinoma (HCC) and ...

Abstract	Chlorogenic acid (CGA), a phenylpropanoid derived from Eucommia ulmoides Oliver, has been shown to exhibit potent cytotoxic and anti-proliferative activities against several human cancers. However, the effects of CGA on hepatocellular carcinoma (HCC) and the underlying mechanisms have not been intensively studied. In this study, the CGA treatment effects on the viability of human hepatoma cells were investigated by MTT assay. Our data showed that CGA could dose-dependently inhibit the activity of human hepatoma cells Hep-G2 and Huh-7, but did not affect the activity and growth of normal human hepatocyte QSG-7701. The genes and pathways influenced by CGA treatment were explored by RNA sequencing and bioinformatics analysis, which identified 323 differentially expressed genes (DEGs) involved in multiple pharmacological signaling pathways such as MAPK, NF-κB, apoptosis and TGF-β signaling pathways. Further analyses by real-time quantitative PCR, Western blot and flow cytometry revealed that CGA effectually suppressed the noncanonical NF-κB signaling pathway, meanwhile it activated the mitochondrial apoptosis of HCC by upregulation of the BH3-only protein Bcl-2 binding component 3 (BBC3). Our findings demonstrated the potential of CGA in suppressing human hepatoma cells and provided a new insight into the anti-cancer mechanism of CGA.
Keywords	Eucommia ulmoides ; RNA ; Western blotting ; apoptosis ; bioinformatics ; chlorogenic acid ; cytotoxicity ; flow cytometry ; gene expression regulation ; hepatoma ; humans ; mitochondria ; molecular biology ; quantitative polymerase chain reaction ; toxicity testing ; viability
Language	English
Dates of publication	2021-03
Size	p. 2351-2364.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-06267-3
Database	NAL-Catalogue (AGRICOLA)

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