Article ; Online: Acute intermittent hypoxia alters disease course and promotes CNS repair including resolution of inflammation and remyelination in the experimental autoimmune encephalomyelitis model of MS.
2023 Volume 71, Issue 8, Page(s) 2045–2066
Abstract: Remyelination and neurodegeneration prevention mitigate disability in Multiple Sclerosis (MS). We have shown acute intermittent hypoxia (AIH) is a novel, non-invasive and effective therapy for peripheral nerve repair, including remyelination. Thus, we ... ...
| Abstract | Remyelination and neurodegeneration prevention mitigate disability in Multiple Sclerosis (MS). We have shown acute intermittent hypoxia (AIH) is a novel, non-invasive and effective therapy for peripheral nerve repair, including remyelination. Thus, we posited AIH would improve repair following CNS demyelination and address the paucity of MS repair treatments. AIH's capacity to enhance intrinsic repair, functional recovery and alter disease course in the experimental autoimmune encephalomyelitis (EAE) model of MS was assessed. EAE was induced by MOG |
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| MeSH term(s) | Encephalomyelitis, Autoimmune, Experimental/pathology ; Encephalomyelitis, Autoimmune, Experimental/therapy ; Multiple Sclerosis/pathology ; Multiple Sclerosis/therapy ; Remyelination ; Animals ; Mice ; Mice, Inbred C57BL ; Anaerobiosis ; Oxygen ; Female | |||||
| Chemical Substances | Oxygen (S88TT14065) | |||||
| Language | English | |||||
| Publishing date | 2023-05-03 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 639414-0 | |||||
| ISSN | 1098-1136 ; 0894-1491 | |||||
| ISSN (online) | 1098-1136 | |||||
| ISSN | 0894-1491 | |||||
| DOI | 10.1002/glia.24381 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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