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  1. Book ; Online ; Thesis: Nesprin-2 giant at the nuclear envelope with roles in cell differentiation, proliferation and chromatin association

    Nanjundappa, Rashmi Rudrappa

    2011  

    Author's details vorgelegt von Rashmi Rudrappa Nanjundappa
    Language English
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2010
    Note Zsfassung in dt. und engl. Sprache ; Open Access
    HBZ-ID HT016905275
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Thesis: Nesprin-2 giant at the nuclear envelope with roles in cell differentiation, proliferation and chromatin association

    Nanjundappa, Rashmi Rudrappa

    2011  

    Author's details vorgelegt von Rashmi Rudrappa Nanjundappa
    Language English
    Size XI, 102, V S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2010
    Note Zsfassung in dt. und engl. Sprache
    HBZ-ID HT016905263
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 D 1221 order for loan Magazin

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  3. Article ; Online: Development of a multiciliated cell.

    Mahjoub, Moe R / Nanjundappa, Rashmi / Harvey, Megan N

    Current opinion in cell biology

    2022  Volume 77, Page(s) 102105

    Abstract: Multiciliated cells (MCC) are evolutionary conserved, highly specialized cell types that contain dozens to hundreds of motile cilia that they use to propel fluid directionally. To template these cilia, each MCC produces between 30 and 500 basal bodies ... ...

    Abstract Multiciliated cells (MCC) are evolutionary conserved, highly specialized cell types that contain dozens to hundreds of motile cilia that they use to propel fluid directionally. To template these cilia, each MCC produces between 30 and 500 basal bodies via a process termed centriole amplification. Much progress has been made in recent years in understanding the pathways involved in MCC fate determination, differentiation, and ciliogenesis. Recent studies using mammalian cell culture systems, mice, Xenopus, and other model organisms have started to uncover the mechanisms involved in centriole and cilia biogenesis. Yet, how MCC progenitor cells regulate the precise number of centrioles and cilia during their differentiation remains largely unknown. In this review, we will examine recent findings that address this fundamental question.
    MeSH term(s) Animals ; Cell Differentiation ; Centrioles/metabolism ; Cilia/metabolism ; Mammals ; Mice ; Xenopus laevis/metabolism
    Language English
    Publishing date 2022-06-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2022.102105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy.

    Brody, Steven L / Pan, Jiehong / Huang, Tao / Xu, Jian / Xu, Huihui / Koenitizer, Jeffrey / Brennan, Steven K / Nanjundappa, Rashmi / Saba, Thomas G / Berical, Andrew / Hawkins, Finn J / Wang, Xiangli / Zhang, Rui / Mahjoub, Moe R / Horani, Amjad / Dutcher, Susan K

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Motile cilia have essential cellular functions in development, reproduction, and homeostasis. Genetic causes for motile ciliopathies have been identified, but the consequences on cellular functions beyond impaired motility remain unknown. Variants ... ...

    Abstract Motile cilia have essential cellular functions in development, reproduction, and homeostasis. Genetic causes for motile ciliopathies have been identified, but the consequences on cellular functions beyond impaired motility remain unknown. Variants in
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.20.585965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells.

    Betleja, Ewelina / Nanjundappa, Rashmi / Cheng, Tao / Mahjoub, Moe R

    eLife

    2018  Volume 7

    Abstract: The two centrioles of the centrosome in quiescent cells are inherently asymmetric structures that differ in age, morphology and function. How these asymmetric properties are established and maintained during quiescence remains unknown. Here, we show that ...

    Abstract The two centrioles of the centrosome in quiescent cells are inherently asymmetric structures that differ in age, morphology and function. How these asymmetric properties are established and maintained during quiescence remains unknown. Here, we show that a daughter centriole-associated ciliopathy protein, Cep120, plays a critical inhibitory role at daughter centrioles. Depletion of Cep120 in quiescent mouse and human cells causes accumulation of pericentriolar material (PCM) components including pericentrin, Cdk5Rap2, ninein and Cep170. The elevated PCM levels result in increased microtubule-nucleation activity at the centrosome. Consequently, loss of Cep120 leads to aberrant dynein-dependent trafficking of centrosomal proteins, dispersal of centriolar satellites, and defective ciliary assembly and signaling. Our results indicate that Cep120 helps to maintain centrosome homeostasis by inhibiting untimely maturation of the daughter centriole, and defines a potentially new molecular defect underlying the pathogenesis of ciliopathies such as Jeune Asphyxiating Thoracic Dystrophy and Joubert syndrome.
    MeSH term(s) Animals ; Cell Cycle Proteins/metabolism ; Cell Line ; Centrioles/metabolism ; Centrosome/chemistry ; Centrosome/metabolism ; Ciliopathies/physiopathology ; Homeostasis ; Humans ; Mice
    Chemical Substances CEP120 protein, human ; Cell Cycle Proteins ; Cep120 protein, mouse
    Language English
    Publishing date 2018-05-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.35439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Nesprin-2 giant at the nuclear envelope with roles in cell differentiation, proliferation and chromatin association

    Nanjundappa, Rashmi Rudrappa

    2011  

    Abstract: Zsfassung in dt. und engl. ... ...

    Author's details vorgelegt von Rashmi Rudrappa Nanjundappa
    Abstract Zsfassung in dt. und engl. Sprache
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Köln, 2010
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

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    Inter-library loan at ZB MED

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  7. Article ; Online: Regulation of cilia abundance in multiciliated cells.

    Nanjundappa, Rashmi / Kong, Dong / Shim, Kyuhwan / Stearns, Tim / Brody, Steven L / Loncarek, Jadranka / Mahjoub, Moe R

    eLife

    2019  Volume 8

    Abstract: Multiciliated cells (MCC) contain hundreds of motile cilia used to propel fluid over their surface. To template these cilia, each MCC produces between 100-600 centrioles by a process termed centriole amplification. Yet, how MCC regulate the precise ... ...

    Abstract Multiciliated cells (MCC) contain hundreds of motile cilia used to propel fluid over their surface. To template these cilia, each MCC produces between 100-600 centrioles by a process termed centriole amplification. Yet, how MCC regulate the precise number of centrioles and cilia remains unknown. Airway progenitor cells contain two parental centrioles (PC) and form structures called deuterosomes that nucleate centrioles during amplification. Using an ex vivo airway culture model, we show that ablation of PC does not perturb deuterosome formation and centriole amplification. In contrast, loss of PC caused an increase in deuterosome and centriole abundance, highlighting the presence of a compensatory mechanism. Quantification of centriole abundance in vitro and in vivo identified a linear relationship between surface area and centriole number. By manipulating cell size, we discovered that centriole number scales with surface area. Our results demonstrate that a cell-intrinsic surface area-dependent mechanism controls centriole and cilia abundance in multiciliated cells.
    MeSH term(s) Animals ; Cell Size ; Cells, Cultured ; Centrioles/metabolism ; Cilia/metabolism ; Epithelial Cells/physiology ; Homeostasis ; Mice ; Organelle Biogenesis ; Respiratory Mucosa
    Language English
    Publishing date 2019-04-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.44039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy.

    Bowler, Mathew / Kong, Dong / Sun, Shufeng / Nanjundappa, Rashmi / Evans, Lauren / Farmer, Veronica / Holland, Andrew / Mahjoub, Moe R / Sui, Haixin / Loncarek, Jadranka

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 993

    Abstract: Centrioles are vital cellular structures that form centrosomes and cilia. The formation and function of cilia depends on a set of centriole's distal appendages. In this study, we use correlative super resolution and electron microscopy to precisely ... ...

    Abstract Centrioles are vital cellular structures that form centrosomes and cilia. The formation and function of cilia depends on a set of centriole's distal appendages. In this study, we use correlative super resolution and electron microscopy to precisely determine where distal appendage proteins localize in relation to the centriole microtubules and appendage electron densities. Here we characterize a novel distal appendage protein ANKRD26 and detail, in high resolution, the initial steps of distal appendage assembly. We further show that distal appendages undergo a dramatic ultra-structural reorganization before mitosis, during which they temporarily lose outer components, while inner components maintain a nine-fold organization. Finally, using electron tomography we reveal that mammalian distal appendages associate with two centriole microtubule triplets via an elaborate filamentous base and that they appear as almost radial finger-like protrusions. Our findings challenge the traditional portrayal of mammalian distal appendage as a pinwheel-like structure that is maintained throughout mitosis.
    MeSH term(s) Animals ; Aurora Kinase A ; CRISPR-Cas Systems ; Cell Cycle Proteins/ultrastructure ; Centrioles/ultrastructure ; Cilia/ultrastructure ; DNA-Binding Proteins ; Electron Microscope Tomography/methods ; HeLa Cells ; Humans ; Intercellular Signaling Peptides and Proteins ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron/methods ; Microtubule Proteins/ultrastructure ; Microtubules/ultrastructure ; Mitosis ; Protein Serine-Threonine Kinases ; Proto-Oncogene Proteins ; Species Specificity ; Transcription Factors ; Polo-Like Kinase 1
    Chemical Substances Ankrd26 protein, mouse ; Cell Cycle Proteins ; DNA-Binding Proteins ; Intercellular Signaling Peptides and Proteins ; Microtubule Proteins ; Proto-Oncogene Proteins ; Transcription Factors ; Aurora Kinase A (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2019-03-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-018-08216-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated Cells.

    Liu, Zhen / Nguyen, Quynh P H / Nanjundappa, Rashmi / Delgehyr, Nathalie / Megherbi, Alexandre / Doherty, Regan / Thompson, James / Jackson, Claire / Albulescu, Alexandra / Heng, Yew M / Lucas, Jane S / Dell, Sharon D / Meunier, Alice / Czymmek, Kirk / Mahjoub, Moe R / Mennella, Vito

    Developmental cell

    2020  Volume 55, Issue 2, Page(s) 224–236.e6

    Abstract: Motile cilia are cellular beating machines that play a critical role in mucociliary clearance, cerebrospinal fluid movement, and fertility. In the airways, hundreds of motile cilia present on the surface of a multiciliated epithelia cell beat ... ...

    Abstract Motile cilia are cellular beating machines that play a critical role in mucociliary clearance, cerebrospinal fluid movement, and fertility. In the airways, hundreds of motile cilia present on the surface of a multiciliated epithelia cell beat coordinately to protect the epithelium from bacteria, viruses, and harmful particulates. During multiciliated cell differentiation, motile cilia are templated from basal bodies, each extending a basal foot-an appendage linking motile cilia together to ensure coordinated beating. Here, we demonstrate that among the many motile cilia of a multiciliated cell, a hybrid cilium with structural features of both primary and motile cilia is harbored. The hybrid cilium is conserved in mammalian multiciliated cells, originates from parental centrioles, and its cellular position is biased and dependent on ciliary beating. Furthermore, we show that the hybrid cilium emerges independently of other motile cilia and functions in regulating basal body alignment.
    MeSH term(s) Basal Bodies/pathology ; Cell Differentiation/physiology ; Cells, Cultured ; Centrioles/pathology ; Centrioles/physiology ; Cilia/pathology ; Cilia/physiology ; Epithelial Cells/pathology ; Epithelium/pathology ; Humans ; Microscopy/methods
    Language English
    Publishing date 2020-10-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2020.09.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5742: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 76: Show issues

    Order via subito

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  10. Book ; Online ; Thesis: Nesprin-2 Giant at the nuclear envelope with roles in cell differentiation, proliferation and chromatin association

    Nanjundappa, Rashmi Rudrappa [Verfasser] / Noegel, Angelika A. [Akademischer Betreuer] / Roth, Siegfried [Akademischer Betreuer]

    2011  

    Author's details Rashmi Rudrappa Nanjundappa. Gutachter: Angelika A. Noegel ; Siegfried Roth
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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