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Article ; Online: A case of chronic gastric anisakiasis coexisting with early gastric cancer

Eiko Sakurai / Masaaki Okubo / Yutaka Tsutsumi / Tomoyuki Shibata / Tomomitsu Tahara / Yuka Kiriyama / Ayano Michiba / Naoki Ohmiya / Tetsuya Tsukamoto

Fujita Medical Journal, Vol 9, Iss 2, Pp 163-

2023 Volume 169

Abstract: Background: Anisakiasis is a parasitic disease caused by the consumption of raw or undercooked fish that is infected with Anisakis third-stage larvae. In countries, such as Japan, Italy, and Spain, where people have a custom of eating raw or marinated ... ...

Abstract	Background: Anisakiasis is a parasitic disease caused by the consumption of raw or undercooked fish that is infected with Anisakis third-stage larvae. In countries, such as Japan, Italy, and Spain, where people have a custom of eating raw or marinated fish, anisakiasis is a common infection. Although anisakiasis has been reported in the gastrointestinal tract in several countries, reports of anisakiasis accompanied by cancer are rare. Case presentation: We present the rare case of a 40-year-old male patient with anisakiasis coexisting with mucosal gastric cancer. Submucosal gastric cancer was suspected on gastric endoscopy and endoscopic ultrasonography. After laparoscopic distal gastrectomy, granulomatous inflammation with Anisakis larvae in the submucosa was pathologically revealed beneath mucosal tubular adenocarcinoma. Histological and immunohistochemical investigation showed cancer cells as intestinal absorptive-type cells that did not produce mucin. Conclusion: Anisakis larvae could have invaded the cancer cells selectively because of the lack of mucin in the cancerous epithelium. Anisakiasis coexisting with cancer is considered reasonable rather than coincidental. In cancer with anisakiasis, preoperative diagnosis may be difficult because anisakiasis leads to morphological changes in the cancer.
Keywords	nematode ; anisakiasis ; stomach ; gastric cancer ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Fujita Medical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Automated Detection and Segmentation of Early Gastric Cancer from Endoscopic Images Using Mask R-CNN

Tomoyuki Shibata / Atsushi Teramoto / Hyuga Yamada / Naoki Ohmiya / Kuniaki Saito / Hiroshi Fujita

Applied Sciences, Vol 10, Iss 3842, p

2020 Volume 3842

Abstract: Gastrointestinal endoscopy is widely conducted for the early detection of gastric cancer. However, it is often difficult to detect early gastric cancer lesions and accurately evaluate the invasive regions. Our study aimed to develop a detection and ... ...

Abstract	Gastrointestinal endoscopy is widely conducted for the early detection of gastric cancer. However, it is often difficult to detect early gastric cancer lesions and accurately evaluate the invasive regions. Our study aimed to develop a detection and segmentation method for early gastric cancer regions from gastrointestinal endoscopic images. In this method, we first collected 1208 healthy and 533 cancer images. The gastric cancer region was detected and segmented from endoscopic images using Mask R-CNN, an instance segmentation method. An endoscopic image was provided to the Mask R-CNN, and a bounding box and a label image of the gastric cancer region were obtained. As a performance evaluation via five-fold cross-validation, sensitivity and false positives (FPs) per image were 96.0% and 0.10 FP/image, respectively. In the evaluation of segmentation of the gastric cancer region, the average Dice index was 71%. These results indicate that our proposed scheme may be useful for the detection of gastric cancer and evaluation of the invasive region in gastrointestinal endoscopy.
Keywords	deep learning ; gastric cancer ; endoscopy ; segmentation ; mask R-CNN ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Endoscopic features of lymphoid follicles in the colonic mucosa using the image enhanced endoscopy and its association with colorectal adenoma.

Tomomitsu Tahara / Kazuya Takahama / Sayumi Tahara / Noriyuki Horiguchi / Kohei Funasaka / Yoshihito Nakagawa / Tomoyuki Shibata / Tetsuya Tsukamoto / Hiro-O Ieda / Toshiro Fukui / Makoto Naganuma / Naoki Ohmiya

PLoS ONE, Vol 18, Iss 5, p e

2023 Volume 0286300

Abstract: Background/aim Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration ...

Abstract	Background/aim Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as intense infiltration of lymphocytes or plasmacytes. It is suggested that LH represents inflammatory immune response in the colonic mucosa. We investigated the presence of LH in the normal colonic mucosa and its association with incidence of colorectal lesions including colorectal cancer, adenoma and hyperplastic polyp. Patients/methods 605 participants undergoing colonoscopy for various indications were enrolled. Presence of LH in the proximal colon (appendix, cecum and the ascending colon) was observed using the blue laser imaging (BLI) endoscopy, a new generation image enhanced endoscopy (IEE) system. LH was defined as well demarcated white nodules. Elevated LH with erythema was distinguished as LH severe. Association between presence of LH and occurrence of colorectal lesions was investigated. Results Prevalence of all colorectal lesions and adenoma were significantly lower in LH severe group compared to the LH negative group (P = 0.0008, 0.0009, respectively). Mean number of all colorectal lesions and adenoma were also lower in LH severe group compared to the LH negative group (P = 0.005, 0.003 respectively). The logistic regression with adjustment for gender and age demonstrated that presence of LH severe held significantly lower risk of all colorectal lesions (OR = 0.48, 95%CI = 0.27-0.86) and adenoma (OR = 0.47, 95%CI = 0.26-0.86). Conclusion LH in the colonic mucosa visualized by IEE is useful endoscopic finding to predict risk of colorectal adenoma.
Keywords	Medicine ; R ; Science ; Q
Subject code	616 ; 610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical response and changes in the fecal microbiota and metabolite levels after fecal microbiota transplantation in patients with inflammatory bowel disease and recurrent Clostridioides difficile infection

Hayato Osaki / Yasutaka Jodai / Keishi Koyama / Takafumi Omori / Noriyuki Horiguchi / Toshiaki Kamano / Kohei Funasaka / Mitsuo Nagasaka / Yoshihito Nakagawa / Tomoyuki Shibata / Naoki Ohmiya

Fujita Medical Journal, Vol 7, Iss 3, Pp 87-

2021 Volume 98

Abstract: Objectives: We determined the efficacy of fecal microbiota transplantation (FMT) and subsequent changes in fecal microbiota and short-chain fatty acid (SCFA) levels in patients with ulcerative colitis (UC), Crohn’s disease (CD), and recurrent ... ...

Abstract	Objectives: We determined the efficacy of fecal microbiota transplantation (FMT) and subsequent changes in fecal microbiota and short-chain fatty acid (SCFA) levels in patients with ulcerative colitis (UC), Crohn’s disease (CD), and recurrent Clostridioides difficile infection (rCDI). Methods: A filtered solution of Japanese donor feces was endoscopically administered. The efficacy of FMT was evaluated after 8 weeks using the Mayo score, Crohn’s Disease Activity Index (CDAI), and the absence of diarrhea with stool toxin negativity in patients with active UC, CD, and rCDI, respectively. For fecal microbiota analysis, the 16S ribosomal RNA gene was sequenced, and fecal SCFA levels were measured. Results: Clinical response was achieved in 5/20 (25%), 3/4 (75%), and 4/4 (100%) patients with UC, CD, and rCDI, respectively. Clinical remission was achieved in 4/20 (20%) and 1/4 (25%) patients with UC and CD, respectively. Linear discriminant analysis illustrated that UC responders had lower counts of Clostridium cluster XIVa before FMT and higher counts after FMT. Higher Fusicatenibacter saccharivorans counts in donors were significantly correlated with 8-week clinical remission. Patients with CD exhibited lower Blautia, Dorea, and Eubacterium counts before FMT and higher Collinsella, Dorea, and Eubacterium counts after FMT, accompanied by functional profiles predictive of SCFA fermentation and elevated fecal butyrate concentrations. Patients with rCDI displayed significantly lower abundances of Clostridium clusters IV and XIVa before FMT and higher abundances after FMT accompanied by elevated fecal propionate concentrations. Conclusions: FMT exhibited various efficacy against UC, CD, and rCDI by altering the gut microbiota and SCFA production.
Keywords	fecal microbiota transplantation ; short-chain fatty acid ; gut microbiota ; ulcerative colitis ; crohn’s disease ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Fujita Medical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluations of primary lesions by endoscopy clearly distinguishes prognosis in patients with gastric cancer who receive chemotherapy.

Tomomitsu Tahara / Tomoyuki Shibata / Masaaki Okubo / Tomohiko Kawamura / Noriyuki Horiguchi / Dai Yoshida / Takamitsu Ishizuka / Mitsuo Nagasaka / Yoshihito Nakagawa / Naoki Ohmiya

PLoS ONE, Vol 12, Iss 3, p e

2017 Volume 0173663

Abstract: Chemotherapy may improve outcomes in gastric cancer (GC), especially for the patients with advanced stage. To explore useful predictive factor for GC performing chemotherapy, we compared the tumor responses assessed using computed tomography (CT) with ... ...

Abstract	Chemotherapy may improve outcomes in gastric cancer (GC), especially for the patients with advanced stage. To explore useful predictive factor for GC performing chemotherapy, we compared the tumor responses assessed using computed tomography (CT) with endoscopy based criteria.192 GC patients performing chemotherapy were retrospectively studied. CT based response assessment was performed after 2 courses of treatment. Endoscopic evaluation according to The Japanese classification of gastric carcinoma was also performed at same period. Data were correlated with overall survival (OS) and progression-free survival (PFS).Majority of the cases (n = 178, 93%) received S-1 based chemotherapy as the first line treatment. 55 (29%) and 91 (47%) cases were considered to be CT and endoscopic responders. Endoscopic responder was more clearly associated with better OS and PFS compared to CT based responder by the log-rank test (P<0.0001 vs. 0.01 and P<0.0001 vs. 0.008, respectively). The association was more striking among patients performing neoadjuvant chemotherapy (P<0.0001 vs. 0.15 and P<0.0001 vs. 0.1, respectively). Multivariate survival analysis using Cox's regression model revealed that endoscopic non-responder was the independent predictive factor, being more strongly associated with worse OS when compared to CT non-responder (hazard ratio: 4.60 vs. 1.77, 95% confidence interval: 2.83-7.49 vs.1.08-2.89, P<0.0001 vs. 0.02). More advanced T, N stage and cases who had peritoneal dissemination were significantly associated with endoscopic non-responder (all P values <0.01).Endoscopy based evaluation of primary lesions are clearly associated with prognosis in patients with GC who perform chemotherapy.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Possible Link between Gastric Mucosal Atrophy and Gastric Cancer after Helicobacter pylori Eradication.

Tomomitsu Tahara / Tomoyuki Shibata / Noriyuki Horiguchi / Tomohiko Kawamura / Masaaki Okubo / Takamitsu Ishizuka / Mitsuo Nagasaka / Yoshihito Nakagawa / Naoki Ohmiya

PLoS ONE, Vol 11, Iss 10, p e

2016 Volume 0163700

Abstract: The effect of H. pylori eradication in gastric cancer prevention can be attributed to the improvement of atrophic gastritis, which is a known risk of gastric cancer. However, gastric cancer has also been diagnosed after long-term H. pylori eradication. ... ...

Abstract	The effect of H. pylori eradication in gastric cancer prevention can be attributed to the improvement of atrophic gastritis, which is a known risk of gastric cancer. However, gastric cancer has also been diagnosed after long-term H. pylori eradication. This study aimed to clarify the association between gastric atrophy and gastric cancer after H. pylori eradication, including its clinicopathological features.A total of 55 consecutive patients with 64 early gastric cancers (EGCs) diagnosed after H. pylori eradication were enrolled. The degree of endoscopic atrophy and the histological degrees of mononuclear cell infiltration, atrophy, and metaplasia in the corpus and adjacent mucosa of the EGCs were determined and scored.The majority of EGCs (63/64) were located within the endoscopically assessed atrophic mucosa or along the atrophic border. The adjacent mucosa of the EGCs presented significantly higher degrees of all histological parameters than in the corpus (mononuclear cell infiltration, 0.86+/-0.09 vs. 0.51+/-0.11, P = 0.016; atrophy, 1.77+/-0.13 vs. 0.65+/-0.14, P<0.0001; metaplasia, 1.68+/-0.13 vs. 0.48+/-0.1, P<0.0001). The degree of endoscopic atrophy improved in the patients with longer post-H. pylori eradication periods; however, this trend was not observed for the histological parameters, and high degrees of atrophy and metaplasia were observed in the adjacent mucosa of the EGCs compared with the corpus during all periods (all P<0.05). The histological degrees of atrophy and metaplasia in the adjacent mucosa were particularly higher in the patients who underwent eradication due to gastric ulcers.Severe gastric atrophy remained in the adjacent mucosa of the EGCs after H. pylori eradication, which may be linked to gastric carcinogenesis.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of colon polyp detection rate with full-spectrum endoscopy versus forward-viewing colonoscopy

Dai Yoshida / Yoshihito Nakagawa / Toshiaki Kamano / Naruomi Komura / Hirokazu Ikuno / Yasutaka Jodai / Haruka Uchibori-Nakai / Tomohiko Kawamura / Masaaki Okubo / Tomomitsu Tahara / Mitsuo Nagasaka / Tomoyuki Shibata / Naoki Ohmiya

Fujita Medical Journal, Vol 4, Iss 1, Pp 6-

2018 Volume 10

Abstract: Objectives: Full-spectrum endoscopy (FUSE) provides a 330° angle of view with two side-viewing cameras in addition to a forward-viewing camera and may improve the colorectal polyp detection rate in blind spots. We evaluated whether FUSE improved colonic ... ...

Abstract	Objectives: Full-spectrum endoscopy (FUSE) provides a 330° angle of view with two side-viewing cameras in addition to a forward-viewing camera and may improve the colorectal polyp detection rate in blind spots. We evaluated whether FUSE improved colonic polyp detection in a single-center, randomized, crossover trial. Methods: Between July 2016 and May 2017, 55 participants (40 men, 15 women) aged 23 to 82 years were enrolled for colorectal polyp screening. Participants were randomly allocated to a forward-viewing (FV)-first group or a FUSE-first group, with stratification according to participant age, sex, and endoscopist. The right colon was examined twice in succession from the cecum to the splenic flexure. Colonic polyp miss rates (PMRs) and endoscopic observation times were compared. Results: Five participants were excluded: three because of insertion difficulty and two because of reinsertion difficulty. In the per-protocol analysis, 23 participants (46.0%) were randomly assigned to the FUSE-first group and 27 (54.0%) to the FV-first group. In the per-lesion analysis, the PMR was significantly lower with FUSE (1/29, 3.4%) than with FV (12/39, 30.7%; P=0.025). However, by per-participant analysis, polyp detection rates were not significantly different (11/23 [47.8%] with FUSE vs 9/27 [33.3%] with FV; P=0.667). All missed polyps were less than 6 mm in size. The observation time was significantly longer with FUSE than with FV in the FUSE-first group, but not in the FV-first group. Conclusions: This study provides evidence that FUSE improves colonic polyp detection, especially in the right colon, and might improve interval colorectal cancer screening efficacy.
Keywords	full-spectrum endoscopy ; polyp miss rate ; polyp detection rate ; Medicine (General) ; R5-920
Subject code	630
Language	English
Publishing date	2018-02-01T00:00:00Z
Publisher	Fujita Medical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: DNA methylation status of epithelial-mesenchymal transition (EMT)--related genes is associated with severe clinical phenotypes in ulcerative colitis (UC).

Tomomitsu Tahara / Tomoyuki Shibata / Masaaki Okubo / Takamitsu Ishizuka / Masakatsu Nakamura / Mitsuo Nagasaka / Yoshihito Nakagawa / Naoki Ohmiya / Tomiyasu Arisawa / Ichiro Hirata

PLoS ONE, Vol 9, Iss 10, p e

2014 Volume 107947

Abstract: BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is a phenomenon that allows the conversion of adherent epithelial cells to a mesenchymal cell phenotype, which enhances migratory capacity and invasiveness. Recent studies have suggested that EMT ... ...

Abstract	BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is a phenomenon that allows the conversion of adherent epithelial cells to a mesenchymal cell phenotype, which enhances migratory capacity and invasiveness. Recent studies have suggested that EMT contributes to the pathogenesis of ulcerative colitis (UC). We investigated the promoter DNA methylation status of EMT-related genes in the colonic mucosa in UC. METHODS: Colonic biopsies were obtained from the rectal inflammatory mucosa of 86 UC patients and the non-inflammatory proximal colonic mucosa of 10 paired patients. Bisulfite pyrosequencing was used to quantify the methylation of 5 candidate CpG island promoters (NEUROG1, CDX1, miR-1247, CDH1, and CDH13) and LINE1. RESULTS: Using an unsupervised hierarchical clustering analysis, inflamed rectal mucosa was well separated from mucosa that appeared normal. The CDH1 and CDH13 promoters were significantly associated with patient age (p = 0.04, 0.03, respectively). A similar trend was found between those genes and the duration of disease (CDH1: p = 0.07, CDH13: p = 0.0002, mean of both: p<0.00001). Several positive associations were found between hypermethylation and severe clinical phenotypes (CDX1 and miR-1247 and a refractory phenotype: p = 0.04 and 0.006, respectively. miR-1247 and CDH1 hyper methylation and a more severe Mayo endoscopic subscore: miR-1247: p = 0.0008, CDH1: p = 0.03, mean of both: p = 0.003). When the severe clinical phenotype was defined as having any of five phenotypes (hospitalized more than twice, highest Mayo endoscopic subscore, steroid dependence, refractory, or a history of surgery) miR-1247 hypermethylation was associated with the same phenotype (p = 0.008). CONCLUSIONS: Our data suggest that variability in the methylation status of EMT-related genes is associated with more severe clinical phenotypes in UC.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Endoscopic features of lymphoid follicles using blue laser imaging (BLI) endoscopy in the colorectum and its association with chronic bowel symptoms.

Tomomitsu Tahara / Kazuya Takahama / Sayumi Tahara / Dai Yoshida / Noriyuki Horiguchi / Tomohiko Kawamura / Masaaki Okubo / Mitsuo Nagasaka / Yoshihito Nakagawa / Makoto Urano / Tomoyuki Shibata / Tetsuya Tuskamoto / Hiro-O Ieda / Makoto Kuroda / Naoki Ohmiya

PLoS ONE, Vol 12, Iss 8, p e

2017 Volume 0182224

Abstract: In the colorectum, lymphoid follicles hyperplasia (LH) is sometimes observed as small, round, yellowish-white nodules. The novel image-enhanced endoscopy system named blue laser imaging (BLI) provides enhanced the contrast of surface vessels using lasers ...

Abstract	In the colorectum, lymphoid follicles hyperplasia (LH) is sometimes observed as small, round, yellowish-white nodules. The novel image-enhanced endoscopy system named blue laser imaging (BLI) provides enhanced the contrast of surface vessels using lasers for light illumination. We investigated the endoscopic features of LH observed by using BLI endoscopy and its association with chronic bowel symptoms.300 participants undergoing colonoscopy for various indications were enrolled. Entire colorectum was observed by using BLI-bright mode with non-magnification view. LH was defined as well demarcated white nodules. Elevated LH with erythema was distinguished as LH severe.LHs were observed more clearly by using BLI-bright mode compared to conventional white light colonoscopy and were also histologically confirmed as intense infiltration of lymphocytes or plasmacytes. LH was observed in 134 subjects (44.6%) and 67 (22.3%) were LH severe. LH was associated younger age (Odds ratio (OR) = 1.05, 95%Confidence Interval (95%CI) = 1.03-1.07, P<0.0001) and chronic bowel symptoms including constipation, hard stools, diarrhea and loose stools (all LH: OR = 4.03, 95%CI = 2.36-6.89, P<0.0001, LH severe: OR = 5.31, 95%CI = 2.64-10.71, P<0.0001). LH severe was closely associated with both constipation associated symptoms (OR = 3.94, 95%CI = 1.79-8.66, P = 0.0007) and diarrhea associated symptoms (OR = 5.22, 95%CI = 2.09-13.05, P = 0.0004). In particular, LH severe in the ascending colon was strongly associated with bowel symptoms (P<0.0001).LH, visualized by using BLI endoscopy was associated with bowel symptom, raising the possibility of pathogenic role of this endoscopic finding in the functional lower gastrointestinal disorders.
Keywords	Medicine ; R ; Science ; Q
Subject code	150
Language	English
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Magnifying narrow-band imaging of gastric mucosal morphology predicts the H. pylori-related epigenetic field defect

Tomomitsu Tahara / Jumpei Yamazaki / Sayumi Tahara / Masaaki Okubo / Tomohiko Kawamura / Noriyuki Horiguchi / Takamitsu Ishizuka / Mitsuo Nagasaka / Yoshihito Nakagawa / Tomoyuki Shibata / Makoto Kuroda / Naoki Ohmiya

Scientific Reports, Vol 7, Iss 1, Pp 1-

2017 Volume 8

Abstract: Abstract DNA methylation is associated with “field defect” in the gastric mucosa. To characterize “field defect” morphologically, we examined DNA methylation of non-neoplastic gastric mucosa in relation to their morphology seen by narrow-band imaging ( ... ...

Abstract	Abstract DNA methylation is associated with “field defect” in the gastric mucosa. To characterize “field defect” morphologically, we examined DNA methylation of non-neoplastic gastric mucosa in relation to their morphology seen by narrow-band imaging (NBI) with magnifying endoscopy. Magnifying NBI of non-neoplastic gastric body was classified as follows: normal—small and round pits with uniform subepithelial capillary networks; type 1—a little enlarged round pits with indistinct subepithelial capillary networks; type 2—remarkably enlarged pits with irregular vessels; and type 3—clearly demarcated oval or tubulovillous pits with bulky coiled or wavy vessels. Methylation of nine candidate genes (MYOD1, SLC16A12, GDNF, IGF2, MIR 124A1, CDH1, PRDM5, RORA and MLF1) were determined by bisulfite pyrosequencing. Infinium HumanMethylation450 array was used to characterize the methylation of >450,000 CpG sites. Mean Z score methylation of nine genes positively correlated with the changes of mucosal patterns from normal to types 1, 2, and 3 (P < 0.0001). Genome-wide analysis showed that development of mucosal patterns correlated with methylation accumulation especially at CpG islands. Genes with promoter CpG islands that were gradually methylated with the development of mucosal patterns significantly enriched the genes involved in zinc-related pathways. The results indicates that gastric mucosal morphology predicts a “field defect” in this tissue type. Accumulation of DNA methylation is associated with “field defect” in the non-neoplastic gastric mucosa. Endoscopic identification of “field defect” has important implications for preventing gastric cancer. Our results suggest that magnifying NBI of gastric mucosal morphology predicts a “field defect” in the gastric mucosa.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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