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  1. Article ; Online: Extreme inbreeding in a European ancestry sample from the contemporary UK population

    Loic Yengo / Naomi R. Wray / Peter M. Visscher

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 11

    Abstract: Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding ... ...

    Abstract Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding and its consequence for health and other complex traits.
    Keywords Science ; Q
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Extreme inbreeding in a European ancestry sample from the contemporary UK population

    Loic Yengo / Naomi R. Wray / Peter M. Visscher

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 11

    Abstract: Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding ... ...

    Abstract Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding and its consequence for health and other complex traits.
    Keywords Science ; Q
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose

    Zhen Qiao / Julia Sidorenko / Joana A. Revez / Angli Xue / Xueling Lu / Katri Pärna / Harold Snieder / Lifelines Cohort Study / Peter M. Visscher / Naomi R. Wray / Loic Yengo

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 11

    Abstract: Most genetic studies of glucose levels have been done on fasting samples, which can be difficult to obtain. Here, the authors identify 156 genetic loci controlling the physiological variation of glucose levels in healthy non-fasting individuals, ... ...

    Abstract Most genetic studies of glucose levels have been done on fasting samples, which can be difficult to obtain. Here, the authors identify 156 genetic loci controlling the physiological variation of glucose levels in healthy non-fasting individuals, demonstrating that the results non-fasting samples can be used to predict fasting glucose levels.
    Keywords Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes

    Angli Xue / Longda Jiang / Zhihong Zhu / Naomi R. Wray / Peter M. Visscher / Jian Zeng / Jian Yang

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: Conflicting reports have found disease to sometimes be positively and sometimes negatively correlated with alcohol consumption. Here, the authors show that misreporting and reduction of alcohol consumption is associated with disease, leading to ... ...

    Abstract Conflicting reports have found disease to sometimes be positively and sometimes negatively correlated with alcohol consumption. Here, the authors show that misreporting and reduction of alcohol consumption is associated with disease, leading to misleading associations between alcohol and disease.
    Keywords Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression

    Yeda Wu / Graham K. Murray / Enda M. Byrne / Julia Sidorenko / Peter M. Visscher / Naomi R. Wray

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 17

    Abstract: Genetic factors contribute to peptic ulcer disease (PUD). Here, the authors perform a genome-wide association analysis on PUD in the UK Biobank, highlighting shared architecture with other gastrointestinal disorders and possible causal links with ... ...

    Abstract Genetic factors contribute to peptic ulcer disease (PUD). Here, the authors perform a genome-wide association analysis on PUD in the UK Biobank, highlighting shared architecture with other gastrointestinal disorders and possible causal links with depression.
    Keywords Science ; Q
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Publisher Correction

    Angli Xue / Longda Jiang / Zhihong Zhu / Naomi R. Wray / Peter M. Visscher / Jian Zeng / Jian Yang

    Nature Communications, Vol 12, Iss 1, Pp 1-

    Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes

    2021  Volume 1

    Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21294-1. ...

    Abstract A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21294-1.
    Keywords Science ; Q
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  7. Article ; Online: Genotype–covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

    Guiyan Ni / Julius van der Werf / Xuan Zhou / Elina Hyppönen / Naomi R. Wray / S. Hong Lee

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 15

    Abstract: Complex traits are often influenced by genetic and non-genetic factors (such as environmental exposures), which are themselves interconnected. Here, the authors develop a method for disentangling genotype–covariate correlation and interaction, and ... ...

    Abstract Complex traits are often influenced by genetic and non-genetic factors (such as environmental exposures), which are themselves interconnected. Here, the authors develop a method for disentangling genotype–covariate correlation and interaction, and investigate their effects on estimating statistical genetic parameters.
    Keywords Science ; Q
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  8. Article ; Online: Correction

    Sang Hong Lee / Naomi R. Wray

    PLoS ONE, Vol 8, Iss

    Novel Genetic Analysis for Case-Control Genome-Wide Association Studies: Quantification of Power and Genomic Prediction Accuracy.

    2013  Volume 8

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  9. Article ; Online: Understanding genetic risk factors for common side effects of antidepressant medications

    Adrian I. Campos / Aoibhe Mulcahy / Jackson G. Thorp / Naomi R. Wray / Enda M. Byrne / Penelope A. Lind / Sarah E. Medland / Nicholas G. Martin / Ian B. Hickie / Miguel E. Rentería

    Communications Medicine, Vol 1, Iss 1, Pp 1-

    2021  Volume 10

    Abstract: Campos et al. study the genetic aetiology of antidepressant side effects. Using data from the Australian Genetics of Depression study, the authors show that polygenic risk scores for traits such as BMI, insomnia and headaches have a shared genetic basis ... ...

    Abstract Campos et al. study the genetic aetiology of antidepressant side effects. Using data from the Australian Genetics of Depression study, the authors show that polygenic risk scores for traits such as BMI, insomnia and headaches have a shared genetic basis with side effects to commonly used antidepressant drugs.
    Keywords Medicine ; R
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  10. Article ; Online: Novel genetic analysis for case-control genome-wide association studies

    Sang Hong Lee / Naomi R Wray

    PLoS ONE, Vol 8, Iss 8, p e

    quantification of power and genomic prediction accuracy.

    2013  Volume 71494

    Abstract: Genome-wide association studies (GWAS) are routinely conducted for both quantitative and binary (disease) traits. We present two analytical tools for use in the experimental design of GWAS. Firstly, we present power calculations quantifying power in a ... ...

    Abstract Genome-wide association studies (GWAS) are routinely conducted for both quantitative and binary (disease) traits. We present two analytical tools for use in the experimental design of GWAS. Firstly, we present power calculations quantifying power in a unified framework for a range of scenarios. In this context we consider the utility of quantitative scores (e.g. endophenotypes) that may be available on cases only or both cases and controls. Secondly, we consider, the accuracy of prediction of genetic risk from genome-wide SNPs and derive an expression for genomic prediction accuracy using a liability threshold model for disease traits in a case-control design. The expected values based on our derived equations for both power and prediction accuracy agree well with observed estimates from simulations.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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