Article ; Online: Immunoregulation via Cell Density and Quorum Sensing-like Mechanisms: An Underexplored Emerging Field with Potential Translational Implications.
2022 Volume 11, Issue 15
Abstract: Quorum sensing (QS) was historically described as a mechanism by which bacteria detect and optimize their population density via gene regulation based on dynamic environmental cues. Recently, it was proposed that QS or similar mechanisms may have broader ...
Abstract | Quorum sensing (QS) was historically described as a mechanism by which bacteria detect and optimize their population density via gene regulation based on dynamic environmental cues. Recently, it was proposed that QS or similar mechanisms may have broader applications across different species and cell types. Indeed, emerging evidence shows that the mammalian immune system can also elicit coordinated responses on a population level to regulate cell density and function, thus suggesting that QS-like mechanisms may also be a beneficial trait of the immune system. In this review, we explore and discuss potential QS-like mechanisms deployed by the immune system to coordinate cellular-level responses, such as T cell responses mediated via the common gamma chain (γc) receptor cytokines and the aryl hydrocarbon receptors (AhRs). We present evidence regarding a novel role of QS as a multifunctional mechanism coordinating CD4 |
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MeSH term(s) | Animals ; Bacteria ; Cell Count ; Humans ; Immune System ; Mammals ; Quorum Sensing/genetics ; Signal Transduction |
Language | English |
Publishing date | 2022-08-06 |
Publishing country | Switzerland |
Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
ZDB-ID | 2661518-6 |
ISSN | 2073-4409 ; 2073-4409 |
ISSN (online) | 2073-4409 |
ISSN | 2073-4409 |
DOI | 10.3390/cells11152442 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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