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  1. Book ; Online: Dentistry vs Severe Acute Respiratory Syndrome Coronavirus 2

    NAPIMOGA, Marcelo Henrique / FREITAS, André Ricardo Ribas de

    RGO - Revista Gaúcha de Odontologia v.68 2020

    How to face this enemy

    2020  

    Abstract: ABSTRACT Since the beginning of the SARS-CoV-2 pandemic, numerous restrictive measures have been taken by the governments of different countries. Recently, due to the high possibility of transmission in dental offices, there was a recommendation by the ... ...

    Abstract ABSTRACT Since the beginning of the SARS-CoV-2 pandemic, numerous restrictive measures have been taken by the governments of different countries. Recently, due to the high possibility of transmission in dental offices, there was a recommendation by the American, European and Brazilian governments to request the closing of the offices. In this commentary, we will give an overview of the reasons and perspectives of this scenario.
    Keywords SARS-CoV-2 ; Covid-19 ; Coronavirus ; Dentistry ; Dental office ; Odontology ; covid19
    Language English
    Publishing date 2020-01-01
    Publisher Faculdade São Leopoldo Mandic
    Publishing country br
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Assessing the severity of COVID-19.

    Freitas, André Ricardo Ribas / Napimoga, Marcelo / Donalisio, Maria Rita

    Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil

    2020  Volume 29, Issue 2, Page(s) e2020119

    Title translation Análise da gravidade da pandemia de Covid-19.
    MeSH term(s) Basic Reproduction Number ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Coronavirus Infections/transmission ; Health Personnel ; Hospitalization/statistics & numerical data ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; United States ; United States Dept. of Health and Human Services
    Keywords covid19
    Language Portuguese
    Publishing date 2020-04-06
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2880588-4
    ISSN 2237-9622 ; 1679-4974
    ISSN (online) 2237-9622
    ISSN 1679-4974
    DOI 10.5123/S1679-49742020000200008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Análise da gravidade da pandemia de Covid-19

    Freitas, André Ricardo Ribas / Napimoga, Marcelo / Donalisio, Maria Rita

    Epidemiologia e Serviços de Saúde v.29 n.2 2020

    2020  

    Keywords covid19
    Language Portuguese
    Publishing date 2020-01-01
    Publisher Secretaria de Vigilância em Saúde - Ministério da Saúde do Brasil
    Publishing country br
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Sema4D is diminished in leukocyte platelet-rich fibrin and impairs pre-osteoblastic MC3T3-E1 cells' functionality.

    Smanio Neto, Henrique / Moy, Peter Karyen / Martinez, Elizabeth Ferreira / Pelegrine, André Antonio / Abdalla, Henrique Ballassini / Clemente-Napimoga, Juliana Trindade / Napimoga, Marcelo Henrique

    Archives of oral biology

    2023  Volume 155, Page(s) 105778

    Abstract: Objective: Semaphorin 4D (Sema4D) is a coupling factor expressed on osteoclasts that may hinder osteoblast differentiation. Since the leukocyte platelet-rich fibrin (L-PRF) membrane promotes growth factor concentration, this study aims to quantify the ... ...

    Abstract Objective: Semaphorin 4D (Sema4D) is a coupling factor expressed on osteoclasts that may hinder osteoblast differentiation. Since the leukocyte platelet-rich fibrin (L-PRF) membrane promotes growth factor concentration, this study aims to quantify the amount of Sema4D in L-PRF membranes, and analyze the impact of Sema4D on osteoblast cell function in vitro.
    Design: Enzyme-linked immunosorbent assay (ELISA) was used to quantify the levels of Sema4D in both L-PRF and whole blood (serum). To analyze the impairment of Sema4D on osteoblasts, MC3T3-E1 cells were induced to osteogenic differentiation and exposed to Sema4D ranging from 10 to 500 ng/ml concentrations. The following parameters were assayed: 1) cell viability by MTT assay after 24, 48, and 72 h; 2) matrix mineralization by Alizarin Red staining after 14 days, 3) Runt-related transcription factor 2 (RUNX-2), osteocalcin (OCN), osteonectin (ONC), bone sialoprotein (BSP) and alkaline phosphatase (ALP) gene expression by qPCR. For all data, the significance level was set at 5%.
    Results: The amount of Sema4D in the whole blood (serum) was higher than in L-PRF. Osteoblasts exposed to Sema4D at all tested concentrations exhibited a decrease in matrix mineralization formation as well in RUNX-2, OCN, ONC, BSP, and ALP gene expression (p < 0.05).
    Conclusion: The presence of Sema4D, a molecule known for suppressing osteoblast activity, diminishes within L-PRF, enhancing its ability to facilitate bone regeneration.
    MeSH term(s) Cell Differentiation/genetics ; Leukocytes/metabolism ; Osteoblasts ; Osteocalcin/metabolism ; Osteogenesis/genetics ; Platelet-Rich Fibrin/metabolism ; Semaphorins/pharmacology ; Semaphorins/metabolism ; Animals ; Mice
    Chemical Substances CD100 antigen ; Osteocalcin (104982-03-8) ; Semaphorins ; Sema4d protein, mouse
    Language English
    Publishing date 2023-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 80227-x
    ISSN 1879-1506 ; 0003-9969
    ISSN (online) 1879-1506
    ISSN 0003-9969
    DOI 10.1016/j.archoralbio.2023.105778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.151: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article ; Online: Orofacial musculoskeletal pain: An evidence-based bio-psycho-social matrix model.

    Ettlin, Dominik A / Napimoga, Marcelo Henrique / Meira E Cruz, Miguel / Clemente-Napimoga, Juliana Trindade

    Neuroscience and biobehavioral reviews

    2021  Volume 128, Page(s) 12–20

    Abstract: Pain is a multidimensional experience comprising sensory-discriminative, affective-motivational, and cognitive-evaluative dimensions. Clinical and research findings have demonstrated a complex interplay between social burdens, individual coping ... ...

    Abstract Pain is a multidimensional experience comprising sensory-discriminative, affective-motivational, and cognitive-evaluative dimensions. Clinical and research findings have demonstrated a complex interplay between social burdens, individual coping strategies, mood states, psychological disorders, sleep disturbances, masticatory muscle tone, and orofacial musculoskeletal pain. Accordingly, current classification systems for orofacial pain require psychosocial assessments to be an integral part of the multidimensional diagnostic process. Here, we review evidence on how psychosocial and biological factors may generate and perpetuate musculoskeletal orofacial pain. Specifically, we discuss studies investigating a putative causal relationship between stress, bruxism, and pain in the masticatory system. We present findings that attribute brain structures various roles in modulating pain perception and pain-related behavior. We also examine studies investigating how the nervous and immune system on cellular and molecular levels may account for orofacial nociceptive signaling. Furthermore, we review evidence pointing towards associations between orofacial musculoskeletal pain and neuroendocrine imbalances, sleep disturbances, and alterations of the circadian timing system. We conclude with several proposals that may help to alleviate orofacial pain in the future.
    MeSH term(s) Facial Pain ; Humans ; Motivation ; Musculoskeletal Pain ; Pain Perception ; Sleep Wake Disorders
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2021.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1371: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Peroxisome proliferator-activated receptor-gamma (PPARγ) and its immunomodulation function: current understanding and future therapeutic implications.

    Trindade da Silva, Carlos Antonio / Clemente-Napimoga, Juliana Trindade / Abdalla, Henrique Ballassini / Basting, Rosanna Tarkany / Napimoga, Marcelo Henrique

    Expert review of clinical pharmacology

    2022  Volume 15, Issue 3, Page(s) 295–303

    Abstract: Introduction: Pain is a multidimensional experience involving the biological, psychological, and social dimensions of each individual. Particularly, the biological aspects of pain conditions are a response of the neuroimmunology system and the control ... ...

    Abstract Introduction: Pain is a multidimensional experience involving the biological, psychological, and social dimensions of each individual. Particularly, the biological aspects of pain conditions are a response of the neuroimmunology system and the control of painful conditions is a worldwide challenge for researchers. Although years of investigation on pain experience and treatment exist, the high prevalence of chronic pain is still a fact.
    Areas covered: Peroxisome proliferator-activated receptor-gamma (PPARγ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. It regulates several metabolic pathways, including lipid biosynthesis and glucose metabolism, when activated. However, PPARγ activation also has a critical immunomodulatory and neuroprotective effect.
    Expert opinion: This review summarizes the evidence of synthetic or natural PPARγ ligands such as 15d-PGJ
    MeSH term(s) Humans ; Immunomodulation/drug effects ; Immunomodulation/physiology ; Ligands ; PPAR gamma/metabolism ; Pain ; Prostaglandin D2/metabolism ; Thiazolidinediones/therapeutic use
    Chemical Substances Ligands ; PPAR gamma ; Thiazolidinediones ; Prostaglandin D2 (RXY07S6CZ2)
    Language English
    Publishing date 2022-05-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2022.2071697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Dentistry vs Severe Acute Respiratory Syndrome Coronavirus 2: How to face this enemy/ Odontologia vs Síndrome Respiratória Aguda Severa Coronavirus 2: Como enfrentar o inimigo

    NAPIMOGA, Marcelo Henrique / FREITAS, André Ricardo Ribas de

    RGO (Porto Alegre)

    Abstract: ABSTRACT Since the beginning of the SARS-CoV-2 pandemic, numerous restrictive measures have been taken by the governments of different countries. Recently, due to the high possibility of transmission in dental offices, there was a recommendation by the ... ...

    Abstract ABSTRACT Since the beginning of the SARS-CoV-2 pandemic, numerous restrictive measures have been taken by the governments of different countries. Recently, due to the high possibility of transmission in dental offices, there was a recommendation by the American, European and Brazilian governments to request the closing of the offices. In this commentary, we will give an overview of the reasons and perspectives of this scenario.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #818583
    Database COVID19

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  8. Article: Assessing the severity of COVID-19/ Analise da gravidade da pandemia de Covid-19

    Freitas, Andre Ricardo Ribas / Napimoga, Marcelo / Donalisio, Maria Rita

    Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #47368
    Database COVID19

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  9. Article: Análise da gravidade da pandemia de Covid-19./ Análise da gravidade da pandemia de Covid-19./ Assessing the severity of COVID-19

    Freitas, André Ricardo Ribas / Napimoga, Marcelo / Donalisio, Maria Rita

    Epidemiol Serv Saude

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #51367
    Database COVID19

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  10. Article ; Online: Influence of abutment angulation on loss of prosthetic abutment torque under mechanical cycling.

    Hein, Decio / Joly, Júlio C / Napimoga, Marcelo H / Peruzzo, Daiane C / Martinez, Elizabeth F

    The Journal of prosthetic dentistry

    2020  Volume 125, Issue 2, Page(s) 349.e1–349.e6

    Abstract: Statement of problem: Internal conical connections provide mechanical stability for the prosthetic abutment and implant connection. However, some clinical situations require the use of angled prosthetic abutments that may increase stress on supportive ... ...

    Abstract Statement of problem: Internal conical connections provide mechanical stability for the prosthetic abutment and implant connection. However, some clinical situations require the use of angled prosthetic abutments that may increase stress on supportive implants by difference force vectors under cyclic loading.
    Purpose: The purpose of this in vitro study was to measure the screw loosening values of prosthetic abutments with internal conical connections (indexed and nonindexed) having different angles under mechanical cycling.
    Material and methods: Thirty-six implants (4.0×13 mm, Titamax) with internal conical connections and their respective universal prosthetic abutments (n=36, 3.5×3.3 mm) were divided into indexed and nonindexed groups (n=18) with abutment inclinations of 0 (straight), 17, and 30 degrees. An insertion torque of 15 Ncm was applied according to the manufacturer's specifications. The specimens underwent fatigue testing of 500 000 cycles at a frequency of 2 Hz with a dynamic compressive load of 120 N at an angle of 30 degrees. The detorque values were measured by using a digital torque meter and tabulated for statistical analyses.
    Results: The specimens with indexed abutments had mean ±standard deviation detorque values of 6.72 ±2.29 Ncm under mechanical cycling, whereas those with nonindexed abutments had values of 8.98 ±1.84 Ncm. In the indexed group, the lowest detorque value was observed for abutments at 30 degrees compared with the straight group (P<.05). As for nonindexed abutments, similar detorque values were observed after increasing the abutment inclination (P>.05).
    Conclusions: A decrease in detorque values in the indexed abutments related to their inclination was found under mechanical cycling, whereas the prosthetic abutments with 30 degrees of angulation had the lowest values. No decrease was found in the nonindexed abutments.
    MeSH term(s) Bone Screws ; Dental Abutments ; Dental Implant-Abutment Design ; Dental Implants ; Dental Stress Analysis ; Materials Testing ; Stress, Mechanical ; Torque
    Chemical Substances Dental Implants
    Language English
    Publishing date 2020-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218157-5
    ISSN 1097-6841 ; 0022-3913
    ISSN (online) 1097-6841
    ISSN 0022-3913
    DOI 10.1016/j.prosdent.2020.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul III Zs.145: Show issues Location:
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