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Article ; Online: Commentary to 'A retrospective observational study of enuresis, daytime voiding symptoms, and response to medical therapy in children with attention deficit hyperactivity disorder and autism spectrum disorder'.

Nappo, Simona

2012 Volume 8, Issue 3, Page(s) 318–319

MeSH term(s)	Attention Deficit and Disruptive Behavior Disorders/complications ; Child Development Disorders, Pervasive/complications ; Cholinergic Antagonists/therapeutic use ; Deamino Arginine Vasopressin/therapeutic use ; Enuresis/drug therapy ; Female ; Humans ; Male ; Urination/physiology
Chemical Substances	Cholinergic Antagonists ; Deamino Arginine Vasopressin (ENR1LLB0FP)
Language	English
Publishing date	2012-06
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	2237683-5
ISSN	1873-4898 ; 1477-5131
ISSN (online)	1873-4898
ISSN	1477-5131
DOI	10.1016/j.jpurol.2010.10.011
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Article: Prechemotherapy Transperitoneal Robotic-Assisted Partial Nephrectomy (RAPN) for a Wilms Tumor: Surgical and Oncological Outcomes in a Four-Year-Old Patient.

Della Corte, Marcello / Cerchia, Elisa / Oderda, Marco / Quarello, Paola / Fagioli, Franca / Gontero, Paolo / Gerocarni Nappo, Simona

Pediatric reports

2023 Volume 15, Issue 3, Page(s) 560–570

Abstract: Background: Wilms tumor (WT) is the most frequent renal tumor in children. The SIOP-UMBRELLA Guidelines allow for nephron-sparing surgery (NSS) in syndromic patients, as well as in cases of small (<300 mL) non-syndromic unilateral WTs, without lymph ... ...

Abstract	Background: Wilms tumor (WT) is the most frequent renal tumor in children. The SIOP-UMBRELLA Guidelines allow for nephron-sparing surgery (NSS) in syndromic patients, as well as in cases of small (<300 mL) non-syndromic unilateral WTs, without lymph node involvement, and with a substantial expected remnant renal function, following neoadjuvant chemotherapy. We present a case of prechemotherapy transperitoneal robot-assisted partial nephrectomy (RAPN) for a unilateral, non-syndromic Wilms tumor. Methods: A four-year-old child presented with a solid mass measuring 3.6 cm in diameter involving the upper right renal pole, incidentally detected during an abdominal echotomography. CT scan and abdominal MRI revealed no local infiltration or lymph node involvement, suggesting that the exophytic mass could be easily resected via an NSS robotic approach. Preoperative imaging did not strongly suggest WT. A virtual 3D reconstruction of the tumor was performed. Results: After the oncologic board approval, a robot-assisted partial nephrectomy with an intraperitoneal approach was performed. Histopathological analysis confirmed the diagnosis of WT. The patient subsequently received 10 doses of vincristine as adjuvant chemotherapy. A 28-month follow-up showed no tumor recurrence. Conclusions: Intraperitoneal RAPN may be an option for selected WT and warrants consideration as a challenging but advantageous approach.
Language	English
Publishing date	2023-09-21
Publishing country	Switzerland
Document type	Case Reports
ISSN	2036-749X
ISSN	2036-749X
DOI	10.3390/pediatric15030051
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Article ; Online: JJ stent dislodgement in the distal ureter: how to recover it in preschool children?

Della Corte, Marcello / Cerchia, Elisa / Fiori, Cristian / Mandaletti, Martina / Ruggiero, Elena / Porpiglia, Francesco / Catti, Massimo / Gerocarni Nappo, Simona

Minerva urology and nephrology

2023 Volume 76, Issue 1, Page(s) 116–119

Abstract: Double-J ureteral stents are usually placed after various urological procedures. The dislodgement of their distal ringlet is a rare complication, whose retrieval is arduous in younger children, due to the small ureteral caliber. We propose our innovative ...

Abstract	Double-J ureteral stents are usually placed after various urological procedures. The dislodgement of their distal ringlet is a rare complication, whose retrieval is arduous in younger children, due to the small ureteral caliber. We propose our innovative endoscopic approach to recover the dislodged JJ stent. Under 8-9.8 Ch cystoscopy, the ureteral meatus is gently cannulated with a 00.18″ guidewire, then a balloon catheter Passeo 18 3-4 mm (Biotronik, Lake Oswego, OR, USA) is coaxially inserted. A pneumatic dilatation of the vesical-ureteral junction is performed up to 8 atmospheres for 5 minutes under direct vision. Consequently, the ureteral meatus allows the cystoscope passage, and the JJ-stent can be recovered thanks to endoscopic grasping forceps. A mono-J stent is then left in place for 24 hours. Four patients aged 8 months - 4 years have been successfully treated with this approach after that JJ migration was found intraoperatively or during ultrasonography. No intra- or postoperative complications occurred. Postoperative hospital stay was prolonged for one day. During 29.5 medium follow-up no clinical or ultrasonographic signs of vesical-ureteral reflux ensued. Our cystoscopic approach is effective and safe to ensure a prompt endoscopic JJ retrieval without changing neither surgical approach nor the anesthesiological support. We believe that all the pediatric urology centers should know the procedure and have small size balloon catheter available.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Ureter/diagnostic imaging ; Ureter/surgery ; Vesico-Ureteral Reflux/surgery ; Cystoscopy ; Atmosphere ; Stents
Language	English
Publishing date	2023-11-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062840-4
ISSN	2724-6442
ISSN (online)	2724-6442
DOI	10.23736/S2724-6051.23.05550-7
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Article ; Online: Retrograde Intrarenal Surgery for Renal Stones: Is It a Safe and Effective Option in Preschool Children?

Gatti, Claudia / Cerchia, Elisa / Della Corte, Marcello / Catti, Massimo / Caravaggi, Francesca / Campobasso, Davide / Granelli, Pietro / Gerocarni Nappo, Simona / Ferretti, Stefania

Journal of pediatric surgery

2023 Volume 59, Issue 3, Page(s) 407–411

Abstract: Introduction: Few studies in the literature describe the Retrograde Intra-Renal Surgery (RIRS) outcome in preschool children. We evaluated the feasibility, stone-free rate and complications of RIRS in preschool children at two European tertiary care ... ...

Abstract	Introduction: Few studies in the literature describe the Retrograde Intra-Renal Surgery (RIRS) outcome in preschool children. We evaluated the feasibility, stone-free rate and complications of RIRS in preschool children at two European tertiary care centres of Pediatric Urology. Material and methods: The retrospective study includes all children undergone RIRS for stones <25 mm from 2017 to 2022. Patients were divided into Group 1 <5 years (G1) and Group 2 >5 years (G2). Semirigid ureterorenoscope 4.5-6.5 Ch and a 7.5 Fr flexible ureteroscope with a 9.5/11 Ch ureteral access sheath (UAS) were used. Stone-free rate (SFR) was evaluated at 3 months. Fischer/Chi-square test for qualitative data and Mann-Whitney for quantitative data were used for statistical analysis. Results: 63 patients underwent RIRS, 19 G1-patients, median age 3.55 ± 1.06 years (range 1.5-5 years), and 44 G2-patients, median age 11.25 ± 2.95 (range 6-17 years) (p < 0.00001). Intraoperative complications occurred in 1 case in G1(5%) and 3 in G2(7%) (p = 1): two minor ureteric injuries in G2 were treated by a prolonged JJ-stent. Postoperative fever was reported in 3 cases in G1 (16%) and 4 in G2(9%) (p = 0.42), while post-operative hematuria in 4 G1-patients (21%) and in 7 G2-patients (16%) (p = 0.72). SFR was 84.2% in G1 and 88.6% in G2. At an average follow-up of 15.05 ± 4.83 months in G1 and 19.95 ± 10.36 months in G2, reintervention for residual stones was necessary in 3 cases in G1(16%) and in 6 cases in G2(14%) (p = 1). Conclusions: In a European country with low-volume pediatric stone centers, RIRS is a promising therapeutic option in young children as it offers acceptable stone-free rate and a low incidence of high-grade complications. Level of evidence: III.
MeSH term(s)	Humans ; Child, Preschool ; Infant ; Child ; Adolescent ; Retrospective Studies ; Treatment Outcome ; Kidney Calculi/surgery ; Kidney/surgery ; Ureter
Language	English
Publishing date	2023-10-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2023.10.056
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Article: Laparoscopic Dismembered Repair in Two Patients with Retrocaval Ureter.

Cavaleri, Yuri / Farullo, Giuseppe / Nappo, Simona Gerocarni / Caione, Paolo

European journal of pediatric surgery reports

2020 Volume 8, Issue 1, Page(s) e32–e34

Abstract: Retrocaval ureter (RCU) or circumcaval ureter is a rare cause of congenital hydronephrosis. The surgical correction of RCU should be performed in all patients with obstruction and hydronephrosis symptoms, lumbar pain, urinary tract infections, hematuria, ...

Abstract	Retrocaval ureter (RCU) or circumcaval ureter is a rare cause of congenital hydronephrosis. The surgical correction of RCU should be performed in all patients with obstruction and hydronephrosis symptoms, lumbar pain, urinary tract infections, hematuria, or urolithiasis. Traditionally, an open surgical approach was used for the treatment of RCU. Nowadays, surgical correction of these anomalies is performed using minimally invasive techniques. We report on two cases treated with our standardized laparoscopic technique using only three 5-mm trocars. The proposed approach could be considered as the first-line treatment for RCU.
Language	English
Publishing date	2020-04-23
Publishing country	Germany
Document type	Case Reports
ZDB-ID	2674016-3
ISSN	2194-7627 ; 2194-7619
ISSN (online)	2194-7627
ISSN	2194-7619
DOI	10.1055/s-0040-1705156
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Zs.A 6998: Show issues

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Article: Implications of an Underlying Beckwith-Wiedemann Syndrome for Wilms Tumor Treatment Strategies.

Quarello, Paola / Carli, Diana / Biasoni, Davide / Gerocarni Nappo, Simona / Morosi, Carlo / Cotti, Roberta / Garelli, Emanuela / Zucchetti, Giulia / Spadea, Manuela / Tirtei, Elisa / Spreafico, Filippo / Fagioli, Franca

Cancers

2023 Volume 15, Issue 4

Abstract: Beckwith-Wiedemann Syndrome (BWS) is a pediatric overgrowth disorder involving a predisposition to embryonal tumors. Most of the tumors associated with BWS occur in the first 8-10 years of life, and the most common is Wilms tumor (WT). BWS clinical ... ...

Abstract	Beckwith-Wiedemann Syndrome (BWS) is a pediatric overgrowth disorder involving a predisposition to embryonal tumors. Most of the tumors associated with BWS occur in the first 8-10 years of life, and the most common is Wilms tumor (WT). BWS clinical heterogeneity includes subtle overgrowth features or even silent phenotypes, and WT may be the presenting symptom of BWS. WT in BWS individuals exhibit distinct characteristics from those of sporadic WT, and the management of these patients needs a peculiar approach. The most important feature is a higher risk of developing bilateral disease at some time in the course of the illness (synchronous bilateral disease at diagnosis or metachronous recurrence after initial presentation with unilateral disease). Accordingly, neoadjuvant chemotherapy is the recommended approach also for BWS patients with unilateral WT to facilitate nephron-sparing surgical approaches. This review emphasizes the importance of early BWS recognition, particularly if a WT has already occurred, as this will result in an urgent consideration of first-line cancer therapy.
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15041292
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Article: Intravesical Agents in the Treatment of Bladder Clots in Children.

Della Corte, Marcello / Clemente, Erica / Cerchia, Elisa / De Cillis, Sabrina / Checcucci, Enrico / Amparore, Daniele / Fiori, Cristian / Porpiglia, Francesco / Gerocarni Nappo, Simona

Pediatric reports

2023 Volume 15, Issue 2, Page(s) 282–292

Abstract: Bladder blood clots represent an infrequent urinary condition in children. They usually result from hematuria with many underlying causes, such as urinary tract infections and urethral/bladder traumas. Treatment options for clot removal include trans- ... ...

Abstract	Bladder blood clots represent an infrequent urinary condition in children. They usually result from hematuria with many underlying causes, such as urinary tract infections and urethral/bladder traumas. Treatment options for clot removal include trans-urethral or suprapubic bladder irrigation and, if unsuccessful, endoscopic management under general anesthesia with a resectoscope. In younger male children, however, the repeated passage of a trans-urethral resectoscope may be challenging and traumatic, due to the small lumen diameter. Eventually, an open surgical approach can be required in many patients. Few anecdotal non-surgical approaches have been proposed for the management of bladder blood clots in children. This review aims to summarize the conservative techniques described in the literature with the instillation of intravesical agents, analyzing the different strategies and their advantages.
Language	English
Publishing date	2023-04-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2036-749X
ISSN	2036-749X
DOI	10.3390/pediatric15020024
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Article: Laparoscopic Dismembered Repair in Two Patients with Retrocaval Ureter

Cavaleri, Yuri / Farullo, Giuseppe / Nappo, Simona Gerocarni / Caione, Paolo

European Journal of Pediatric Surgery Reports

2020 Volume 08, Issue 01, Page(s) e32–e34

Abstract	Retrocaval ureter (RCU) or circumcaval ureter is a rare cause of congenital hydronephrosis. The surgical correction of RCU should be performed in all patients with obstruction and hydronephrosis symptoms, lumbar pain, urinary tract infections, hematuria, or urolithiasis. Traditionally, an open surgical approach was used for the treatment of RCU. Nowadays, surgical correction of these anomalies is performed using minimally invasive techniques. We report on two cases treated with our standardized laparoscopic technique using only three 5-mm trocars. The proposed approach could be considered as the first-line treatment for RCU.
Keywords	retrocaval ureter ; ureteroureterostomy ; laparoscopy
Language	English
Publishing date	2020-01-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2674016-3
ISSN	2194-7627 ; 2194-7619
ISSN (online)	2194-7627
ISSN	2194-7619
DOI	10.1055/s-0040-1705156
Database	Thieme publisher's database

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Article ; Online: Current trends in 2021 in surgical management of vesico-ureteral reflux in pediatric patients: results of a multicenter international survey on 552 patients.

Esposito, Ciro / Yamataka, Atsuyuki / Varlet, Francois / Castagnetti, Marco / Scalabre, Aurelien / Fourcade, Laurent / Ballouhey, Quentin / Nappo, Simona / Escolino, Maria

Minerva urology and nephrology

2021 Volume 75, Issue 1, Page(s) 106–115

Abstract: Background: The selection of best surgical approach for treatment of vesico-ureteral reflux (VUR) in the pediatric population remains debated. This study aimed to report the results of a multicenter survey about the current trends in surgical management ...

Abstract	Background: The selection of best surgical approach for treatment of vesico-ureteral reflux (VUR) in the pediatric population remains debated. This study aimed to report the results of a multicenter survey about the current trends in surgical management of pediatric VUR. Methods: An online questionnaire-based survey was performed, with participation of six international institutions. All children (age <18 years) affected by primary III-V grade VUR, who were operated over the last 5 years, were included. The incidence of each VUR intervention, patients' demographics and outcomes were analyzed. Results: A total of 552 patients (331 girls), with a median age of 4.6 years (range 0.5-17.6), were included. Deflux Conclusions: This survey confirmed that the choice of the technique remains based on surgeon's preference. Deflux
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Laparoscopy/methods ; Retrospective Studies ; Treatment Outcome ; Ureter/surgery ; Vesico-Ureteral Reflux/surgery ; Male
Language	English
Publishing date	2021-06-11
Publishing country	Italy
Document type	Multicenter Study ; Journal Article
ZDB-ID	3062840-4
ISSN	2724-6442
ISSN (online)	2724-6442
DOI	10.23736/S2724-6051.21.04430-X
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Article ; Online: The concealed penis: the "two-corner" surgical technique.

Caione, Paolo / Cavaleri, Yuri / Gerocarni Nappo, Simona / Collura, Giuseppe / Capozza, Nicola

Minerva urology and nephrology

2019 Volume 73, Issue 1, Page(s) 122–127

Abstract: Background: Concealed penis is an uncommon genital abnormality that requires surgical repair. Several techniques are offered but not fully accepted. We present a novel standardized approach that is suitable for concealed penis and penoscrotal webbing.!## ...

Abstract	Background: Concealed penis is an uncommon genital abnormality that requires surgical repair. Several techniques are offered but not fully accepted. We present a novel standardized approach that is suitable for concealed penis and penoscrotal webbing. Methods: From January 2005 to December 2013, patients presenting concealed penis were treated utilizing the "two corners" technique: through a midline penoscrotal incision, the superficial ventral chordee is removed, freeing the corpus spongiosum till the peno-scrotal angle. Circumferential degloving of the shaft is performed and the scrotal septum is separated from the urethra, allowing the penile shaft to pull out. The new peno-scrotal junction is rebuilt downwards, anchoring the peno-scrotal dartos corners to the peripubic tissue bilaterally and stabilizing the penile lengthening. Tension-free skin coverage is allowed by a series of Z-plasty at the penoscrotal angle avoiding circumcision if not needed. Results: Forty-nine patients aged 3-14 years (mean age 4.7 years) underwent correction of the concealed penis according to our technique. Of them, 26 were primary and 23 after previous to hypospadias repair or other genital surgery. Penile lengthening varied from 1 to 2.5 cm (median 1.8 cm). Hospital stay varied from 1 to 4 days (mean 1.6 days). Follow-up ranged from 4 to 14 years (median 7.3 years). Forty-five parents were satisfied with the results (92%), while the defect was judged imperfectly repaired in four patients. Conclusions: The "two-corners" technique allows easy and effective correction of the concealed penis in both congenital and acquired conditions. It can be performed as outpatient procedure and results are stable at long-term follow-up.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Follow-Up Studies ; Humans ; Hypospadias/surgery ; Length of Stay ; Male ; Penis/abnormalities ; Penis/surgery ; Reconstructive Surgical Procedures ; Scrotum/surgery ; Treatment Outcome ; Urethra/surgery ; Urologic Surgical Procedures, Male/methods
Language	English
Publishing date	2019-11-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062840-4
ISSN	2724-6442
ISSN (online)	2724-6442
DOI	10.23736/S2724-6051.19.03532-X
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