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  1. Article: Clinical Characteristics of the Cleft Lip and/or Palate: Association with Congenital Anomalies, Syndromes, and Chromosomal Anomalies.

    Fujii, Nobuyuki / Doi, Rieko / Narai, Takashi / Chiuriki, Naoki / Ikuta, Mika / Kodani, Isamu

    Yonago acta medica

    2023  Volume 66, Issue 4, Page(s) 440–447

    Abstract: Background: Cleft lip and/or palate (CL/P) can be accompanied by other congenital anomalies. We conducted a long-term evaluation of the associations between cleft patterns, sex distribution, and accompanying congenital anomalies of patients with CL/P.!## ...

    Abstract Background: Cleft lip and/or palate (CL/P) can be accompanied by other congenital anomalies. We conducted a long-term evaluation of the associations between cleft patterns, sex distribution, and accompanying congenital anomalies of patients with CL/P.
    Methods: The medical records of 739 patients with CL/P, seen between January 1967 and December 2020, were retrospectively reviewed. Fisher's exact test was used for statistical analysis.
    Results: Among the 739 patients with CL/P, the male-to-female ratio was 1.1. Regarding the cleft pattern, 121 (16.4%), 104 (14.1%), 280 (37.9%), 198 (26.8%), and 36 (4.9%) patients had cleft lip (CL), cleft lip and alveolus (CLA), cleft lip and palate (CLP), cleft palate (CP), and submucous cleft palate (SMCP), respectively. Congenital anomalies were identified in 107 (14.5%) cases, of which 53 (49.5%) had congenital heart disease. The frequencies of congenital anomalies patients with in CL/P were 14/225 (6.2%), 36/280 (12.9%), 43/198 (21.7%), and 14/36 (38.9%) for a combination of CL and CLA, CLP, CP, and SMCP, respectively. Accompanying syndromes and chromosomal anomalies were identified in 40 (5.4%) cases, in which Pierre Robin sequence (16 cases of CP and 4 cases of SMCP) was the most frequent.
    Conclusion: No sex differences were observed in CL/P, and CLP and CP were the most common cleft patterns. Congenital anomalies associated with CL/P were dominated by congenital heart disease and were most frequently identified in CP and SMCP cases. Notably, the Pierre Robin sequence, a complex syndrome characterized by micrognathia, glossoptosis, respiratory obstruction, and a U- or V-shaped CP, was found in cases of both CP and SMCP, and accounted for the symptoms in most cases.
    Language English
    Publishing date 2023-11-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 840719-8
    ISSN 1346-8049 ; 0513-5710
    ISSN (online) 1346-8049
    ISSN 0513-5710
    DOI 10.33160/yam.2023.11.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 268: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Establishment of human immortalized mesenchymal stem cells lines for the monitoring and analysis of osteogenic differentiation in living cells.

    Narai, Takashi / Watase, Ryohei / Nakayama, Yuji / Kodani, Isamu / Inoue, Toshiaki / Kokura, Kenji

    Heliyon

    2020  Volume 6, Issue 10, Page(s) e05398

    Abstract: Mesenchymal stem cells (MSCs) are expected to be useful in bone regeneration treatment for various diseases and conditions, including cleft lip and palate, fracture, and bone absorption. However, to date, MSCs have failed to produce satisfactory results ... ...

    Abstract Mesenchymal stem cells (MSCs) are expected to be useful in bone regeneration treatment for various diseases and conditions, including cleft lip and palate, fracture, and bone absorption. However, to date, MSCs have failed to produce satisfactory results in clinical settings. This is primarily due to the low rate of induced osteogenic differentiation. To realize MSC potential, it is necessary to establish methods for the isolation of MSC-derived living osteoblasts. However, no osteoblast markers have been reported to date. In an attempt to develop a method for the assessment of osteoblast differentiation, we established reporter human immortalized MSC (hiMSC) lines for
    Language English
    Publishing date 2020-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2020.e05398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [A Case of Consciousness Disorder Induced by the Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Cisplatin and 5-Fluorouracil Chemotherapy in a Patient with Tongue Cancer].

    Tamura, Takayuki / Taniguchi, Naomi / Otsuki, Kazuma / Narai, Takashi / Kawasaki, Makoto / Fujii, Nobuyuki / Doi, Rieko / Kodani, Isamu

    Gan to kagaku ryoho. Cancer & chemotherapy

    2018  Volume 45, Issue 5, Page(s) 855–857

    Abstract: We herein report a case of a consciousness disorder that was induced by the syndrome of inappropriate antidiuretic hormone secretion following cisplatin (CDDP) and 5 -fluorouracil (5-FU) chemotherapy in a patient with tongue cancer. A 72- year-old woman ... ...

    Abstract We herein report a case of a consciousness disorder that was induced by the syndrome of inappropriate antidiuretic hormone secretion following cisplatin (CDDP) and 5 -fluorouracil (5-FU) chemotherapy in a patient with tongue cancer. A 72- year-old woman complained of tongue pain and was admitted to our hospital for neoadjuvant chemotherapy, under a diagnosis of tongue squamous cell carcinoma (T4aN2bM0). She was treated with CDDP and 5-FU. On the second day after administration, she complained of nausea and anorexia, and on the third day, she showed impaired consciousness. Laboratory studies revealed that the patient had a serum sodium concentration 112mEq/L, and no dehydration was noted. The patient was diagnosed with SIADH, using the appropriate diagnostic criteria based on serum and urine hypoosmolality. We subsequently discontinued chemotherapy and initiated fluid restriction and sodium supplements. Two days after this treatment, her consciousness level improved, and on the fifth day of treatment, laboratory studies revealed a serum sodium level of 134mEq/ L.
    MeSH term(s) Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Squamous Cell/drug therapy ; Cisplatin/administration & dosage ; Cisplatin/adverse effects ; Consciousness Disorders/chemically induced ; Female ; Fluorouracil/administration & dosage ; Fluorouracil/adverse effects ; Head and Neck Neoplasms/drug therapy ; Humans ; Inappropriate ADH Syndrome/etiology ; Neoadjuvant Therapy ; Squamous Cell Carcinoma of Head and Neck ; Tongue Neoplasms/drug therapy ; Tongue Neoplasms/pathology
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Fluorouracil (U3P01618RT)
    Language Japanese
    Publishing date 2018-07-19
    Publishing country Japan
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2573: Show issues Location:
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  4. Article: Study on the Development of a New Device with Dual Cameras for Evaluating Expiratory Nasal Flow.

    Doi, Rieko / Akagami, Shuko / Kondo, Katsuya / Yoshida, Yu / Chiuriki, Naoki / Ikuta, Mika / Saiki, Kazuki / Kataoka, Tomoki / Narai, Takashi / Fujii, Nobuyuki / Kawasaki, Makoto / Otsuki, Kazuma / Kodani, Isamu

    Yonago acta medica

    2020  Volume 63, Issue 4, Page(s) 255–265

    Abstract: Background: Use of the Glatzel mirror for measuring expiratory nasal flow in preschool children has the disadvantage of vagueness, and the mirror may induce fear and inhibition of interest in those children. In response to these limitations, we ... ...

    Abstract Background: Use of the Glatzel mirror for measuring expiratory nasal flow in preschool children has the disadvantage of vagueness, and the mirror may induce fear and inhibition of interest in those children. In response to these limitations, we developed a new device with dual cameras for measuring expiratory nasal flow in 2 to 6 year old children. The aim of this study is to compare the Glatzel mirror and the new device, in terms of accurate assessment of expiratory nasal flow, children's feelings, and correlation to each child's profile.
    Methods: This study evaluated 20 cleft lip and palate patients and 21 healthy children aged between 2 and 6 (under 7) years. After consent was granted, a 4-week screening period was undertaken followed by inspection at weeks 8, 16, 24, and 32. Each inspection was conducted while the children were asked to pronounce various sounds and comprised three stages: i) use of the Glatzel mirror, ii) subjective visual assessment using the new device, and iii) image recording by dual cameras of the new device. Questionnaires for the new device were administered at the initial and final inspections. To contrast the results between the Glatzel mirror and the new device, the numbers that indicated values of subjective visual assessment and camera assessment greater than the assessment values of the Glatzel mirror were compared. For measuring the children's responses to the new device compared with those to the Glatzel mirror, the answers to the questionnaires were compared. For the comparison of the children's profiles (age and sex) and feelings, the numbers of subjects who could use the new device were measured.
    Results: The camera assessment of the new device indicated significantly greater values than that of the Glatzel mirror (
    Conclusion: This study demonstrated the superiority of the new device with dual cameras to the Glatzel mirror in terms of functionality and attitude of children.
    Language English
    Publishing date 2020-09-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 840719-8
    ISSN 1346-8049 ; 0513-5710
    ISSN (online) 1346-8049
    ISSN 0513-5710
    DOI 10.33160/yam.2020.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 268: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Treatment outcomes of adjunctive teriparatide therapy for medication-related osteonecrosis of the jaw (MRONJ): A multicenter retrospective analysis in Japan.

    Morishita, Kota / Yamada, Shin-Ichi / Kawakita, Akiko / Hashidume, Masao / Tachibana, Akira / Takeuchi, Noritami / Ohbayashi, Yumiko / Kanno, Takahiro / Yoshiga, Daigo / Narai, Takashi / Sasaki, Noboru / Shinohara, Hisayuki / Uzawa, Narikazu / Miyake, Minoru / Tominaga, Kazuhiro / Kodani, Isamu / Umeda, Masahiro / Kurita, Hiroshi

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

    2020  Volume 25, Issue 6, Page(s) 1079–1083

    Abstract: Background: Therapeutic strategies for patients with medication-related osteonecrosis of the jaw (MRONJ) remain controversial. The aim of the present study was to clarify the effectiveness and safety of teriparatide therapy in Japanese MRONJ patients ... ...

    Abstract Background: Therapeutic strategies for patients with medication-related osteonecrosis of the jaw (MRONJ) remain controversial. The aim of the present study was to clarify the effectiveness and safety of teriparatide therapy in Japanese MRONJ patients based on a large number of case series with a multicenter retrospective analysis.
    Patients and methods: Between January 2012 and December 2016, 29 patients who were diagnosed with MRONJ at 10 hospitals were treated with teriparatide. The medical records of these patients were retrospectively reviewed to assess the efficacy and safety of teriparatide therapy for MRONJ patients.
    Results: Adverse events occurred in 17.2% of patients (5/29). One patient developed severe arthralgia and discontinued teriparatide therapy after 12 days, while others continued the treatment. Among 29 patients, the median period of administration of teriparatide was 14.0 months (range, 0.3-26 months), and treatment outcomes were evaluated as effective in 75.9% of patients with complete resolution in 65.5%. Among patients treated with oral bisphosphonates (BPs), 83.3% were effectively treated with teriparatide and 40% with intravenous BPs. The oral administration of BPs was associated with successful treatment outcomes with teriparatide (p = 0.062).
    Conclusions: Teriparatide therapy has potential as an effective treatment option for MRONJ.
    MeSH term(s) Bisphosphonate-Associated Osteonecrosis of the Jaw/diagnostic imaging ; Bisphosphonate-Associated Osteonecrosis of the Jaw/drug therapy ; Bone Density Conservation Agents/adverse effects ; Humans ; Japan ; Retrospective Studies ; Teriparatide ; Treatment Outcome
    Chemical Substances Bone Density Conservation Agents ; Teriparatide (10T9CSU89I)
    Language English
    Publishing date 2020-02-25
    Publishing country Japan
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1314243-4
    ISSN 1436-2023 ; 0949-2658
    ISSN (online) 1436-2023
    ISSN 0949-2658
    DOI 10.1016/j.jos.2020.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4484: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Construction of a Luciferase Reporter System to Monitor Osteogenic Differentiation of Mesenchymal Stem Cells by Using a Mammalian Artificial Chromosome Vector.

    Narai, Takashi / Katoh, Motonobu / Inoue, Toshiaki / Taniguchi, Makoto / Kazuki, Kanako / Kazuki, Yasuhiro / Sato, Kenzo / Kodani, Isamu / Ryoke, Kazuo / Oshimura, Mitsuo

    Yonago acta medica

    2015  Volume 58, Issue 1, Page(s) 23–29

    Abstract: Background: Mesenchymal stem cells (MSCs) hold promise for application in adult stem cell-mediated regenerative medicine in bone remodeling and fracture repair. MSCs in vitro can be directed to osteogenic lineage by dexamethasone (DEX); however, the use ...

    Abstract Background: Mesenchymal stem cells (MSCs) hold promise for application in adult stem cell-mediated regenerative medicine in bone remodeling and fracture repair. MSCs in vitro can be directed to osteogenic lineage by dexamethasone (DEX); however, the use of DEX is not practical in clinical settings because of adverse side effects such as glucocorticoid-induced osteoporosis. For identifying substances that facilitate osteogenesis, a monitoring system, which detects the osteogenic differentiation stage of MSCs accurately and easily, is required.
    Methods: By focusing on the human osteocalcin (OC) gene whose expression profile is described along with osteogenic differentiation, we constructed the luciferase (Luc) reporter gene driven by the enhancer/promoter sequence of the human OC gene (OC-Luc) utilizing a mammalian artificial chromosome. Mammalian artificial chromosome is a suitable platform for loading reporter constructs, because of its stable episomal maintenance in host cells, transferability into any cell and assurance of long-term physiological transgene expression. We loaded the OC-Luc on a mammalian artificial chromosome vector engineered from mouse chromosome (designated as mouse artificial chromosome, MAC) in Chinese hamster ovary cells (OC-Luc/MAC) and transferred this into human MSC cells via chromosome transfer.
    Results: OC-Luc/MAC in human MSC cells are responsive to positive and negative stimulation by 1 alpha,25-dihydroxyvitamin D3 and DEX in differentiation stage of MSCs to osteoblasts, reflecting the manner of physiological expression.
    Conclusion: The OC-Luc/MAC reporter system may contribute not only to monitoring the osteogenic differentiation stage from MSC but also to identify novel osteogenic drugs.
    Language English
    Publishing date 2015-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 840719-8
    ISSN 1346-8049 ; 0513-5710
    ISSN (online) 1346-8049
    ISSN 0513-5710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 268: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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