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Article ; Online: Hyperbaric Oxygen Therapy Combined with Immunosuppression for Acute Macular Neuroretinopathy in Systemic Lupus Erythematosus.

Shroff, Daraius / Kothari, Abhishek / Gupta, Priyanka / Sahni, Tarun Kumar / Narain, Shishir

2022 Volume 31, Issue 2, Page(s) 355–361

Abstract: Purpose: To describe the use of hyperbaric oxygen therapy (HBOT) in conjunction with immunosuppression for acute macular neuroretinopathy (AMN) in systemic lupus erythematosus (SLE).: Methods: Two known cases of SLE presented to us with blurred ... ...

Abstract	Purpose: To describe the use of hyperbaric oxygen therapy (HBOT) in conjunction with immunosuppression for acute macular neuroretinopathy (AMN) in systemic lupus erythematosus (SLE). Methods: Two known cases of SLE presented to us with blurred vision and paracentral scotomas due to AMN. Both cases reported worsening of their conditions despite the initiation of high-dose steroid therapy. HBOT was added on as a treatment modality to address vaso-occlusive ischemic injury. Results: Both patients underwent a total of twelve cycles of HBOT. Functional and anatomical improvements were noted immediately after the initiation of therapy and were maintained over more than one year of follow-up. No significant retinal thinning was noted on optical coherence tomography on disease resolution, as has been noted previously. Visual field scotoma showed a complete resolution. Conclusion: Our cases suggest that HBOT may have a role in aiding functional and anatomical recovery in AMN associated with SLE.
MeSH term(s)	Humans ; Hyperbaric Oxygenation ; Retinal Diseases/diagnosis ; Retinal Diseases/etiology ; Retinal Diseases/therapy ; Macula Lutea ; Acute Disease ; Scotoma/diagnosis ; Scotoma/etiology ; Scotoma/therapy ; Tomography, Optical Coherence/methods ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/therapy ; Immunosuppression Therapy ; White Dot Syndromes/complications
Language	English
Publishing date	2022-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2022.2029497
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Article ; Online: Multimodal Imaging in Ocular Toxoplasmosis.

Brandão-de-Resende, Camilo / Balasundaram, Manohar Babu / Narain, Shishir / Mahendradas, Padmamalini / Vasconcelos-Santos, Daniel V

Ocular immunology and inflammation

2020 Volume 28, Issue 8, Page(s) 1196–1204

Abstract: Multimodal imaging relies on combination of multiple imaging modalities to precisely delineate pathological changes in the posterior segment of the eye associated with a wide range of conditions. This combined application of fundus photography, optical ... ...

Abstract	Multimodal imaging relies on combination of multiple imaging modalities to precisely delineate pathological changes in the posterior segment of the eye associated with a wide range of conditions. This combined application of fundus photography, optical coherence tomography, fundus reflectance/autofluorescence and fundus angiography (with fluorescein, indocyanine green and/or optical coherence tomography) is of great utility for assessment of patients with ocular toxoplasmosis. Multimodal imaging is helpful to characterize the typical pattern of toxoplasmic retinochoroiditis, with primary focal inflammatory involvement of the neurosensory retina, and secondary changes at the level of underlying choroid, retinal blood vessels, vitreous and even optic disc. It may also be valuable to document and follow local complications, including macular edema, vascular occlusions, and choroidal neovascularization, among others.
MeSH term(s)	Coloring Agents/administration & dosage ; Eye Infections, Parasitic/diagnostic imaging ; Fluorescein Angiography ; Humans ; Indocyanine Green/administration & dosage ; Multimodal Imaging ; Optical Imaging ; Tomography, Optical Coherence ; Toxoplasmosis, Ocular/diagnostic imaging
Chemical Substances	Coloring Agents ; Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2020-03-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2020.1737142
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Article ; Online: Endogenous fungal endophthalmitis following intensive corticosteroid therapy in severe COVID-19 disease.

Shroff, Daraius / Narula, Ritesh / Atri, Neelam / Chakravarti, Arindam / Gandhi, Arpan / Sapra, Neelam / Bhatia, Gagan / Pawar, Shraddha R / Narain, Shishir

Indian journal of ophthalmology

2021 Volume 69, Issue 7, Page(s) 1909–1914

Abstract: Purpose: To report endogenous fungal endophthalmitis, postrecovery from severe COVID-19 infection in otherwise immunocompetent individuals, treated with prolonged systemic steroids.: Methods: Retrospective chart review of cases with confirmed and ... ...

Abstract	Purpose: To report endogenous fungal endophthalmitis, postrecovery from severe COVID-19 infection in otherwise immunocompetent individuals, treated with prolonged systemic steroids. Methods: Retrospective chart review of cases with confirmed and presumed fungal endogenous endophthalmitis, following severe COVID-19 disease, treated at two tertiary care referral eye institutes in North India. Results: Seven eyes of five cases of endogenous fungal endophthalmitis were studied. All cases had been hospitalized for severe COVID-19 pneumonia and had received systemic steroid therapy for an average duration of 42 ± 25.1 days (range 18-80 days). All the cases initially complained of floaters with blurred vision after an average of 6 days (range 1-14 days) following discharge from hospital. They had all been misdiagnosed as noninfectious uveitis by their primary ophthalmologists. All eyes underwent pars plana vitrectomy (PPV) with intravitreal antifungal therapy. Five of the seven eyes grew fungus as the causative organism (Candida sp. in four eyes, Aspergillus sp. in one eye). Postoperatively, all eyes showed control of the infection with a marked reduction in vitreous exudates and improvement in vision. Conclusion: Floaters and blurred vision developed in patients after they recovered from severe COVID-19 infection. They had received prolonged corticosteroid treatment for COVID-19 as well as for suspected noninfectious uveitis. We diagnosed and treated them for endogenous fungal endophthalmitis. All eyes showed anatomical and functional improvement after PPV with antifungal therapy. It is important for ophthalmologists and physicians to be aware of this as prompt treatment could control the infection and salvage vision.
MeSH term(s)	COVID-19 ; Endophthalmitis/diagnosis ; Endophthalmitis/drug therapy ; Endophthalmitis/etiology ; Eye Infections, Fungal/diagnosis ; Eye Infections, Fungal/drug therapy ; Eye Infections, Fungal/surgery ; Fungi ; Humans ; India/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Visual Acuity ; Vitrectomy
Language	English
Publishing date	2021-06-11
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_592_21
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Zs.MO 598: Show issues

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Article ; Online: Ultra-widefield versus conventional angiography in a postvitrectomy, partially gas-filled eye.

Shroff, Daraius / Narain, Shishir / Gupta, Charu / Shroff, Cyrus

BMJ case reports

2016 Volume 2016

MeSH term(s)	Adult ; Diabetic Retinopathy/diagnosis ; Fluorescein Angiography/methods ; Humans ; Male ; Vitrectomy
Language	English
Publishing date	2016-02-25
Publishing country	England
Document type	Case Reports ; Comparative Study ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2016-214477
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Article ; Online: Non-contact Ultra-widefield Imaging in Lasered Retinopathy of Prematurity.

Shroff, Daraius / Narain, Shishir / Gupta, Charu / Dutta, Ranjan / Shroff, Cyrus

Indian journal of pediatrics

2016 Volume 83, Issue 7, Page(s) 748–749

Language	English
Publishing date	2016-07
Publishing country	India
Document type	Letter
ZDB-ID	218231-2
ISSN	0973-7693 ; 0019-5456
ISSN (online)	0973-7693
ISSN	0019-5456
DOI	10.1007/s12098-015-1972-3
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Article ; Online: Evaluation of lymphocyte proliferation assay to purified protein derivative, enzyme linked immunosorbant assay, and tuberculin hypersensitivity in Eales′ disease

Biswas Jyotirmay / Narain Shishir / Roy Sara / Madhavan Hajib

Indian Journal of Ophthalmology, Vol 45, Iss 2, Pp 93-

1997 Volume 97

Abstract: The purpose of this study was to evaluate the immunological responses against mycobacterial antigens in Eales′ disease. Fifty six patients with Eales′ disease and fifty age-and-sex-matched healthy volunteers with normal fundus findings taken as controls, ...

Abstract	The purpose of this study was to evaluate the immunological responses against mycobacterial antigens in Eales′ disease. Fifty six patients with Eales′ disease and fifty age-and-sex-matched healthy volunteers with normal fundus findings taken as controls, were subjected to Mantoux test, using 2 TU/0.1 ml of purified protein derivative (PPD), lymphocyte proliferation assay to PPD, and ELISA to detect IgM and IgG antibodies against mycobacterial A-60 antigen. The results of Mantoux test and lymphocytes proliferation assay did not differ significantly in the two groups suggesting a similar cellular immune response. The number of individuals with recent exposure/reexposure to tuberculosis (IgM+) was significantly higher among patients. However the number of people with past exposure (IgM-IgG+) was significantly higher among controls. Our study indicates that there are no statistically significant differences in the humoral and cellular immune responses to mycobacterial antigens between the patients with Eales′ disease and controls, except for a significantly higher IgM positivity among the patients.
Keywords	Eales′ disease ; ELISA ; Lymphocyte Proliferation Assay ; Tuberculosis ; Mantoux test ; Ophthalmology ; RE1-994 ; Medicine ; R ; DOAJ:Ophthalmology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	1997-01-01T00:00:00Z
Publisher	Medknow Publications
Document type	Article ; Online
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Article ; Online: The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis.

Agrawal, Rupesh / Betzler, Bjorn Kaijun / Testi, Ilaria / Mahajan, Sarakshi / Agarwal, Aniruddha / Gunasekeran, Dinesh Visva / Raje, Dhananjay / Aggarwal, Kanika / Murthy, Somasheila I / Westcott, Mark / Chee, Soon-Phaik / McCluskey, Peter / Ho, Su Ling / Teoh, Stephen / Cimino, Luca / Biswas, Jyotirmay / Narain, Shishir / Agarwal, Manisha / Mahendradas, Padmamalini /

Khairallah, Moncef / Jones, Nicholas / Tugal-Tutkun, Ilknur / Babu, Kalpana / Basu, Soumayava / Carreño, Ester / Lee, Richard / Al-Dhibi, Hassan / Bodaghi, Bahram / Invernizzi, Alessandro / Goldstein, Debra A / Barisani-Asenbauer, Talin / González-López, Julio J / Androudi, Sofia / Bansal, Reema / Moharana, Bruttendu / Esposti, Simona Degli / Tasiopoulou, Anastasia / Nadarajah, Sengal / Agarwal, Mamta / Abraham, Sharanaya / Vala, Ruchi / Singh, Ramandeep / Sharma, Aman / Sharma, Kusum / Zierhut, Manfred / Kon, Onn Min / Cunningham, Emmett T / Kempen, John H / Nguyen, Quan Dong / Pavesio, Carlos / Gupta, Vishali

Ocular immunology and inflammation

2020 Volume 28, Issue sup1, Page(s) 27–37

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2020-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2020.1808226
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Article ; Online: The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population.

Testi, Ilaria / Agrawal, Rupesh / Mahajan, Sarakshi / Agarwal, Aniruddha / Gunasekeran, Dinesh Visva / Raje, Dhananjay / Aggarwal, Kanika / Murthy, Somasheila I / Westcott, Mark / Chee, Soon-Phaik / Mccluskey, Peter / Ho, Su Ling / Teoh, Stephen / Cimino, Luca / Biswas, Jyotirmay / Narain, Shishir / Agarwal, Manisha / Mahendradas, Padmamalini / Khairallah, Moncef /

Jones, Nicholas / Tugal-Tutkun, Ilknur / Babu, Kalpana / Basu, Soumayava / Carreño, Ester / Lee, Richard / Al-Dhibi, Hassan / Bodaghi, Bahram / Invernizzi, Alessandro / Goldstein, Debra A / Herbort, Carl P / Barisani-Asenbauer, Talin / González-López, Julio J / Androudi, Sofia / Bansal, Reema / Moharana, Bruttendu / Esposti, Simona Degli / Tasiopoulou, Anastasia / Nadarajah, Sengal / Agarwal, Mamta / Abraham, Sharanaya / Vala, Ruchi / Singh, Ramandeep / Sharma, Aman / Sharma, Kusum / Zierhut, Manfred / Kon, Onn Min / Cunningham, Emmett T / Kempen, John H / Nguyen, Quan Dong / Pavesio, Carlos / Gupta, Vishali

Ocular immunology and inflammation

2020 Volume 28, Issue sup1, Page(s) 58–64

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2020-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2020.1781197
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Article ; Online: Twenty-four Month Outcomes in the Collaborative Ocular Tuberculosis Study (COTS)-1: Defining the "Cure" in Ocular Tuberculosis.

Agarwal, Aniruddha / Agrawal, Rupesh / Raje, Dhananjay / Testi, Ilaria / Mahajan, Sarakshi / Gunasekeran, Dinesh Visva / Aggarwal, Kanika / Murthy, Somasheila I / Westcott, Mark / Chee, Soon-Phaik / Mccluskey, Peter / Ho, Su Ling / Teoh, Stephen / Cimino, Luca / Biswas, Jyotirmay / Narain, Shishir / Agarwal, Manisha / Mahendradas, Padmamalini / Khairallah, Moncef /

Jones, Nicholas / Tugal-Tutkun, Ilknur / Babu, Kalpana / Basu, Soumayava / Carreño, Ester / Lee, Richard / Al-Dhibi, Hassan / Bodaghi, Bahram / Invernizzi, Alessandro / Goldstein, Debra A / Herbort, Carl P / Barisani-Asenbauer, Talin / González-López, Julio J / Androudi, Sofia / Bansal, Reema / Moharana, Bruttendu / Esposti, Simona Degli / Tasiopoulou, Anastasia / Nadarajah, Sengal / Agarwal, Mamta / Abraham, Sharanya / Vala, Ruchi / Singh, Ramandeep / Sharma, Aman / Sharma, Kusum / Zierhut, Manfred / Kon, Onn Min / Cunningham, Emmett T / Kempen, John H / Nguyen, Quan Dong / Pavesio, Carlos / Gupta, Vishali

Ocular immunology and inflammation

2020 Volume 28, Issue sup1, Page(s) 65–73

Abstract: ... ...

Abstract	Purpose
Language	English
Publishing date	2020-06-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2020.1761401
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Article ; Online: The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis.

Agrawal, Rupesh / Betzler, Bjorn / Testi, Ilaria / Mahajan, Sarakshi / Agarwal, Aniruddha / Gunasekeran, Dinesh Visva / Raje, Dhananjay / Aggarwal, Kanika / Murthy, Somasheila I / Westcott, Mark / Chee, Soon-Phaik / Mccluskey, Peter / Ho, Su Ling / Teoh, Stephen / Cimino, Luca / Biswas, Jyotirmay / Narain, Shishir / Agarwal, Manisha / Mahendradas, Padmamalini /

Khairallah, Moncef / Jones, Nicholas / Tugal-Tutkun, Ilknur / Babu, Kalpana / Basu, Soumayava / Carreño, Ester / Lee, Richard / Al-Dhibi, Hassan / Bodaghi, Bahram / Invernizzi, Alessandro / Goldstein, Debra A / Herbort, Carl P / Barisani-Asenbauer, Talin / González-López, Julio J / Androudi, Sofia / Bansal, Reema / Moharana, Bruttendu / Esposti, Simona / Tasiopoulou, Anastasia / Nadarajah, Sengal / Agarwal, Mamta / Abraham, Sharanya / Vala, Ruchi / Singh, Ramandeep / Sharma, Aman / Sharma, Kusum / Zierhut, Manfred / Kon, Onn Min / Cunningham, Emmett T / Kempen, John H / Nguyen, Quan Dong / Pavesio, Carlos / Gupta, Vishali

Ocular immunology and inflammation

2020 Volume 28, Issue sup1, Page(s) 17–26

Abstract: ... ...

Abstract	Purpose
Language	English
Publishing date	2020-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2020.1761400
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