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  1. Article: Diagnostics and treatments of COVID-19: two-year update to a living systematic review of economic evaluations.

    Elvidge, Jamie / Hopkin, Gareth / Narayanan, Nithin / Nicholls, David / Dawoud, Dalia

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1291164

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1291164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Evidence to Underpin Vitamin A Requirements and Upper Limits in Children Aged 0 to 48 Months: A Scoping Review

    Hooper, Lee / Esio-Bassey, Chizoba / Brainard, Julii / Fynn, Judith / Jennings, Amy / Jones, Natalia / Tailor, Bhavesh V. / Abdelhamid, Asmaa / Coe, Calvin / Esgunoglu, Latife / Fallon, Ciara / Gyamfi, Ernestina / Hill, Claire / Howard Wilsher, Stephanie / Narayanan, Nithin / Oladosu, Titilopemi / Parkinson, Ellice / Prentice, Emma / Qurashi, Meysoon /
    Read, Luke / Getley, Harriet / Song, Fujian / Welch, Ailsa A. / Aggett, Peter / Lietz, Georg

    Nutrients. 2022 Jan. 18, v. 14, no. 3

    2022  

    Abstract: Vitamin A deficiency is a major health risk for infants and children in low- and middle-income countries. This scoping review identified, quantified, and mapped research for use in updating nutrient requirements and upper limits for vitamin A in children ...

    Abstract Vitamin A deficiency is a major health risk for infants and children in low- and middle-income countries. This scoping review identified, quantified, and mapped research for use in updating nutrient requirements and upper limits for vitamin A in children aged 0 to 48 months, using health-based or modelling-based approaches. Structured searches were run on Medline, EMBASE, and Cochrane Central, from inception to 19 March 2021. Titles and abstracts were assessed independently in duplicate, as were 20% of full texts. Included studies were tabulated by question, methodology and date, with the most relevant data extracted and assessed for risk of bias. We found that the most recent health-based systematic reviews and trials assessed the effects of supplementation, though some addressed the effects of staple food fortification, complementary foods, biofortified maize or cassava, and fortified drinks, on health outcomes. Recent isotopic tracer studies and modelling approaches may help quantify the effects of bio-fortification, fortification, and food-based approaches for increasing vitamin A depots. A systematic review and several trials identified adverse events associated with higher vitamin A intakes, which should be useful for setting upper limits. We have generated and provide a database of relevant research. Full systematic reviews, based on this scoping review, are needed to answer specific questions to set vitamin A requirements and upper limits.
    Keywords biofortification ; cassava ; corn ; databases ; food fortification ; isotope labeling ; risk ; staple foods ; systematic review ; vitamin A ; vitamin A deficiency
    Language English
    Dates of publication 2022-0118
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14030407
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Evidence to Underpin Vitamin A Requirements and Upper Limits in Children Aged 0 to 48 Months: A Scoping Review.

    Hooper, Lee / Esio-Bassey, Chizoba / Brainard, Julii / Fynn, Judith / Jennings, Amy / Jones, Natalia / Tailor, Bhavesh V / Abdelhamid, Asmaa / Coe, Calvin / Esgunoglu, Latife / Fallon, Ciara / Gyamfi, Ernestina / Hill, Claire / Howard Wilsher, Stephanie / Narayanan, Nithin / Oladosu, Titilopemi / Parkinson, Ellice / Prentice, Emma / Qurashi, Meysoon /
    Read, Luke / Getley, Harriet / Song, Fujian / Welch, Ailsa A / Aggett, Peter / Lietz, Georg

    Nutrients

    2022  Volume 14, Issue 3

    Abstract: Vitamin A deficiency is a major health risk for infants and children in low- and middle-income countries. This scoping review identified, quantified, and mapped research for use in updating nutrient requirements and upper limits for vitamin A in children ...

    Abstract Vitamin A deficiency is a major health risk for infants and children in low- and middle-income countries. This scoping review identified, quantified, and mapped research for use in updating nutrient requirements and upper limits for vitamin A in children aged 0 to 48 months, using health-based or modelling-based approaches. Structured searches were run on Medline, EMBASE, and Cochrane Central, from inception to 19 March 2021. Titles and abstracts were assessed independently in duplicate, as were 20% of full texts. Included studies were tabulated by question, methodology and date, with the most relevant data extracted and assessed for risk of bias. We found that the most recent health-based systematic reviews and trials assessed the effects of supplementation, though some addressed the effects of staple food fortification, complementary foods, biofortified maize or cassava, and fortified drinks, on health outcomes. Recent isotopic tracer studies and modelling approaches may help quantify the effects of bio-fortification, fortification, and food-based approaches for increasing vitamin A depots. A systematic review and several trials identified adverse events associated with higher vitamin A intakes, which should be useful for setting upper limits. We have generated and provide a database of relevant research. Full systematic reviews, based on this scoping review, are needed to answer specific questions to set vitamin A requirements and upper limits.
    MeSH term(s) Child ; Child, Preschool ; Food, Fortified ; Humans ; Infant ; Infant, Newborn ; Nutritional Requirements ; Nutritional Status ; Vitamin A ; Vitamin A Deficiency/prevention & control
    Chemical Substances Vitamin A (11103-57-4)
    Language English
    Publishing date 2022-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14030407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A microfabricated electrical SPLITT system.

    Narayanan, Nithin / Saldanha, Avinash / Gale, Bruce K

    Lab on a chip

    2006  Volume 6, Issue 1, Page(s) 105–114

    Abstract: A growing need for methods to analyze and prepare monodisperse nanoparticles on an industrial scale exists and may be solved by the application of split flow thin fractionation (SPLITT) at the microscale. Microfluidic systems of this type have the ... ...

    Abstract A growing need for methods to analyze and prepare monodisperse nanoparticles on an industrial scale exists and may be solved by the application of split flow thin fractionation (SPLITT) at the microscale. Microfluidic systems of this type have the ability to separate nanoparticles with high precision in a continuous manner. A miniaturized SPLITT system can be fabricated using standard microfabrication technologies, works in a continuous mode, and can be used as a sample preparation instrument in a micro-total-analysis-system (micro-TAS). In this paper, a miniaturized electrical SPLITT system, which separates particles continuously based on electrophoretic mobility, has been characterized. The advantages of miniaturization have been elucidated. The various aspects of the micro SPLITT system discussed in this paper can be broadly classified into: micro SPLITT system design, fluidics modeling to refine the splitter arrangements, and experimental characterization of the SPLITT system. The design of the micro SPLITT system has been elucidated focusing on the two designs that were implemented. Fluid modeling, used to arrive at a new SPLITT design, was done using a commercially available CFD package to investigate behavior of the fluid in the microchannel with various splitter arrangements. Testing was done with nanoparticles of varying diameter and electrophoretic mobilities to verify the modeling results and demonstrate functionality of the SPLITT system. Particles eluted from both outlets of the SPLITT system were characterized using AFM and SEM to verify the function of the system.
    MeSH term(s) Chemical Fractionation/methods ; Colloids/chemistry ; Electrophoresis, Microchip/methods ; Fractionation, Field Flow/methods ; Microfluidics/instrumentation ; Microscopy, Atomic Force ; Microscopy, Electron, Scanning ; Nanostructures/analysis ; Nanostructures/chemistry
    Chemical Substances Colloids
    Language English
    Publishing date 2006-01
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/b504936a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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