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  1. AU="Narayanasami, Uma"
  2. AU="Chen, Ruichao"
  3. AU=Li Xuefeng AU=Li Xuefeng
  4. AU="Stef J.F. Letteboer"
  5. AU="Gewurz, H"
  6. AU="Linares, Mauricio"
  7. AU="Gnesi, Marco"
  8. AU="Park, Jinny"
  9. AU="Hill, Benjamin D"
  10. AU=Huang Chunfa
  11. AU="Skonieczny, Paul"
  12. AU="LIVINGSTON, M S"
  13. AU="Lidia Gonzalez-Quereda"
  14. AU="Korkmaz, Asli"
  15. AU="Patel, Mrinal"
  16. AU="Louis Chauvel"
  17. AU="Jampen, Laurent"
  18. AU="Tan, Jiacheng"
  19. AU="Weiss, Jonathan D"

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  1. Artikel ; Online: Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset.

    Sasisekharan, Varun / Pentakota, Niharika / Jayaraman, Akila / Tharakaraman, Kannan / Wogan, Gerald N / Narayanasami, Uma

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Band 118, Heft 5

    Abstract: Immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the current pandemic remains a field of immense interest and active research worldwide. Although the severity of acute infection may depend on the intensity ... ...

    Abstract Immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the current pandemic remains a field of immense interest and active research worldwide. Although the severity of acute infection may depend on the intensity of innate and adaptive immunity, leading to higher morbidity and mortality, the longevity of IgG antibodies, including neutralizing activity to SARS-CoV-2, is viewed as a key correlate of immune protection. Amid reports and concern that there is a rapid decay of IgG antibody levels within 1 mo to 2 mo after acute infection, we set out to study the pattern and duration of IgG antibody response to various SARS-CoV-2 antigens in asymptomatic and symptomatic patients in a community setting. Herein, we show the correlation of IgG anti-spike protein S1 subunit, receptor binding domain, nucleocapsid, and virus neutralizing antibody titers with each other and with clinical features such as length and severity of COVID-19 illness. More importantly, using orthogonal measurements, we found the IgG titers to persist for more than 4 mo post symptom onset, implying that long-lasting immunity to COVID-19 from infection or vaccination might be observed, as seen with other coronaviruses such as SARS and Middle East respiratory syndrome.
    Mesh-Begriff(e) Adult ; Antibodies, Viral/blood ; COVID-19/immunology ; Female ; Humans ; Immunity, Humoral ; Immunoassay ; Immunoglobulin G/blood ; Longitudinal Studies ; Male ; Middle Aged ; SARS-CoV-2/immunology
    Chemische Substanzen Antibodies, Viral ; Immunoglobulin G
    Sprache Englisch
    Erscheinungsdatum 2020-12-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2021615118
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Rare Pedal Manifestation of Diffuse Multiple Myeloma Lesions.

    Saviet, Benjamin M / Marcoux, John T / Narayanasami, Uma

    The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

    2017  Band 56, Heft 2, Seite(n) 357–361

    Abstract: Multiple myeloma is a malignancy of plasma cell proliferation leading to production of monoclonal immunoglobins. Among the classic features of multiple myeloma are bone lesions, which typically manifest in the axial skeleton, vertebrae, pelvis, skull, ... ...

    Abstract Multiple myeloma is a malignancy of plasma cell proliferation leading to production of monoclonal immunoglobins. Among the classic features of multiple myeloma are bone lesions, which typically manifest in the axial skeleton, vertebrae, pelvis, skull, ribs, and proximal extremities. The several types of multiple myeloma include symptomatic multiple myeloma, monoclonal gammopathy of undetermined significance, smoldering/indolent myeloma, and solitary plasmacytoma of bone. Although rare, plasmacytomas of the foot and ankle have been described in published studies. We present, to the best of our knowledge, the first description of classic diffuse myelomatosis lesions associated with symptomatic myeloma in the foot of a patient with advanced disease who was treated in the podiatric surgery clinic for pathologic fracture.
    Sprache Englisch
    Erscheinungsdatum 2017-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1146972-9
    ISSN 1542-2224 ; 1067-2516
    ISSN (online) 1542-2224
    ISSN 1067-2516
    DOI 10.1053/j.jfas.2016.11.020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Recovery of kidney function following delayed use of Theralite™ dialyzer in a patient with myeloma cast nephropathy.

    Dahal, Khagendra / Shastri, Shani / Narayanasami, Uma / Bijol, Vanesa / Rider, Karen / Strom, James A / Jaber, Bertrand L

    Clinical nephrology

    2013  Band 79, Heft 4, Seite(n) 318–322

    Abstract: We report the case of a 60- year- old man who presented with newly diagnosed multiple myeloma complicated by biopsy-proven acute cast nephropathy, requiring hemodialysis, plasmapheresis and chemotherapy. After remaining dialysis dependent for 5 weeks, a ... ...

    Abstract We report the case of a 60- year- old man who presented with newly diagnosed multiple myeloma complicated by biopsy-proven acute cast nephropathy, requiring hemodialysis, plasmapheresis and chemotherapy. After remaining dialysis dependent for 5 weeks, a high cut-off (HCO) dialyzer, intended to use for the removal of plasma substances with a molecular weight of up to 45 kDa such as free light chains, was introduced to his outpatient 4-hour hemodialysis regimen with an increase in treatment frequency to 4 sessions per week. Following 6 weeks of dialysis with the HCO dialyzer, serum levels of free κ light chains declined by more than 75%. Concurrently, he recovered kidney function and discontinued dialysis. He subsequently received a successful autologous stem-cell transplant. We discuss the potential merit of using the HCO dialyzer late in the course of the care of patients with myeloma cast nephropathy who are dialysis dependent.
    Mesh-Begriff(e) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/immunology ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biopsy ; Equipment Design ; Humans ; Immunoglobulin kappa-Chains/blood ; Kidney/immunology ; Kidney/pathology ; Kidney/physiopathology ; Kidneys, Artificial ; Male ; Middle Aged ; Multiple Myeloma/complications ; Multiple Myeloma/diagnosis ; Multiple Myeloma/immunology ; Multiple Myeloma/therapy ; Plasmapheresis ; Recovery of Function ; Renal Dialysis/instrumentation ; Stem Cell Transplantation ; Time Factors ; Treatment Outcome
    Chemische Substanzen Immunoglobulin kappa-Chains
    Sprache Englisch
    Erscheinungsdatum 2013-04
    Erscheinungsland Germany
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CN107357
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Roles of heparan-sulphate glycosaminoglycans in cancer.

    Sasisekharan, Ram / Shriver, Zachary / Venkataraman, Ganesh / Narayanasami, Uma

    Nature reviews. Cancer

    2002  Band 2, Heft 7, Seite(n) 521–528

    Mesh-Begriff(e) Animals ; Cell Membrane/metabolism ; Glucuronidase/metabolism ; Heparan Sulfate Proteoglycans/physiology ; Heparin/chemistry ; Humans ; Models, Chemical ; Models, Molecular ; Neoplasms/metabolism ; Polysaccharides/chemistry ; Protein Binding ; Protein Conformation ; Structure-Activity Relationship
    Chemische Substanzen Heparan Sulfate Proteoglycans ; Polysaccharides ; Heparin (9005-49-6) ; heparanase (EC 3.2.1.-) ; Glucuronidase (EC 3.2.1.31)
    Sprache Englisch
    Erscheinungsdatum 2002-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/nrc842
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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