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  1. AU="Nardelli, S."
  2. AU="Clark, Sarah Elizabeth"
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  1. Artikel ; Online: Reply to: "Hepatic encephalopathy and survival after transjugular intra-hepatic portosystemic shunt: Do spontaneous portosystemic shunts matter?"

    Nardelli, Silvia / Schepis, Filippo / Vizzutti, Francesco

    Journal of hepatology

    2024  Band 80, Heft 6, Seite(n) e262–e263

    Mesh-Begriff(e) Humans ; Hepatic Encephalopathy/etiology ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects ; Portasystemic Shunt, Transjugular Intrahepatic/methods
    Sprache Englisch
    Erscheinungsdatum 2024-02-15
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2024.01.040
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The egg and the chicken: Does sarcopenia or cognitive impairment come first?

    Ridola, Lorenzo / Gioia, Stefania / Nardelli, Silvia / Faccioli, Jessica / Riggio, Oliviero

    Clinical nutrition (Edinburgh, Scotland)

    2024  Band 43, Heft 4, Seite(n) 1085–1086

    Mesh-Begriff(e) Animals ; Sarcopenia/diagnosis ; Chickens ; Risk Factors ; Hepatic Encephalopathy ; Cognitive Dysfunction/diagnosis ; Liver Cirrhosis ; Portasystemic Shunt, Transjugular Intrahepatic
    Sprache Englisch
    Erscheinungsdatum 2024-01-20
    Erscheinungsland England
    Dokumenttyp Letter ; Comment
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2024.01.021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Reply to: "Post-TIPS OHE: Are we really making a mountain out of a molehill?"

    Nardelli, Silvia / Vizzutti, Francesco / Marra, Fabio / Schepis, Filippo / Riggio, Oliviero

    Journal of hepatology

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-05-09
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2024.05.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Primary Prophylaxis of Overt Hepatic Encephalopathy: Is It Time to Consider It?

    Faccioli, Jessica / Nardelli, Silvia / Gioia, Stefania / Riggio, Oliviero / Ridola, Lorenzo

    Journal of clinical medicine

    2023  Band 12, Heft 12

    Abstract: Hepatic encephalopathy (HE) represents one of the most frequent complications of liver cirrhosis and one of the most debilitating clinical manifestations of liver disease due to the accumulation of toxic substances in the blood and central nervous system ...

    Abstract Hepatic encephalopathy (HE) represents one of the most frequent complications of liver cirrhosis and one of the most debilitating clinical manifestations of liver disease due to the accumulation of toxic substances in the blood and central nervous system [...].
    Sprache Englisch
    Erscheinungsdatum 2023-06-07
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12123903
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Hepatic encephalopathy - recent advances in treatment and diagnosis.

    Nardelli, Silvia / Gioia, Stefania / Faccioli, Jessica / Riggio, Oliviero / Ridola, Lorenzo

    Expert review of gastroenterology & hepatology

    2023  Band 17, Heft 3, Seite(n) 225–235

    Abstract: Introduction: Hepatic encephalopathy (HE) is a peculiar kind of brain dysfunction typical of liver cirrhosis characterized by nonspecific neurological and psychiatric manifestations. HE ranges from minimal hepatic encephalopathy (MHE) to the most severe ...

    Abstract Introduction: Hepatic encephalopathy (HE) is a peculiar kind of brain dysfunction typical of liver cirrhosis characterized by nonspecific neurological and psychiatric manifestations. HE ranges from minimal hepatic encephalopathy (MHE) to the most severe form characterized by alteration of consciousness or coma (overt HE, OHE). Once the diagnosis of OHE is made, every effort to identify and correct the precipitating cause is essential for the resolution of symptoms. Clinical studies that assessed the prevalence and incidence of any type of HE (MHE and OHE) in patients affected by cirrhosis were included in this review. No language, publication date, or publication status restrictions were imposed. The studies were identified by searching electronic databases (PubMed and SCOPUS).
    Areas covered: The most widely empirical pharmacological approach consists of non-absorbable antibiotics (rifaximin) and non-absorbable disaccharides (lactulose, lactitol per os and per enemas). Other agents (including branched-chain amino acids, probiotics, other antibiotics, or intravenous L-ornithine L-aspartate) are available, but the evidence supporting their efficacy remains under debate.
    Expert opinion: Gray areas and future needs remain the therapeutic approach to MHE and issues in the design of therapeutic studies for HE which have been extensively discussed in this review.
    Mesh-Begriff(e) Humans ; Hepatic Encephalopathy/diagnosis ; Hepatic Encephalopathy/drug therapy ; Hepatic Encephalopathy/epidemiology ; Lactulose/adverse effects ; Rifaximin/therapeutic use ; Disaccharides/therapeutic use ; Anti-Bacterial Agents/adverse effects ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/drug therapy
    Chemische Substanzen Lactulose (4618-18-2) ; Rifaximin (L36O5T016N) ; Disaccharides ; Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2023-02-26
    Erscheinungsland England
    Dokumenttyp Review ; Journal Article
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2023.2183386
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Clinical outcomes and prognostic factors in non-cirrhotic non-neoplastic patients with portal vein thrombosis: A single-centre experience.

    Gioia, Stefania / Riggio, Oliviero / Nardelli, Silvia / Ridola, Lorenzo / Marzano, Chiara

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2023  Band 55, Heft 11, Seite(n) 1487–1495

    Abstract: Introduction: The knowledge of natural history and prognostic factors of portal vein thrombosis (PVT) is still based on a limited number of studies.: Aim: To describe our single-center experience with 79 consecutive non-neoplastic non-cirrhotic ... ...

    Abstract Introduction: The knowledge of natural history and prognostic factors of portal vein thrombosis (PVT) is still based on a limited number of studies.
    Aim: To describe our single-center experience with 79 consecutive non-neoplastic non-cirrhotic patients with PVT (15 recent/64 chronic PVT).
    Results: Among patients with recent PVT, 7 received anticoagulation alone, 4 systemic thrombolysis, 3 direct thrombolysis through a TIPS and 1 TIPS alone. Portal recanalization was achieved in 11 patients. In patients with chronic PVT, the rate of variceal progression was high (20% at one year and 50% at two years). The thrombotic involvement of splenic and superior mesenteric veins was the only risk factor for variceal enlargement. The cumulative bleeding rates were 10% at one year and 20% at two years. A multisegmental thrombosis and large varices at entry and a previous variceal bleeding were the independent predictors for variceal bleeding. The cumulative rate of new thrombotic events was 14% at one year and 18% at two years. Eight patients died, 2 because of thrombotic events. There were no bleeding-related deaths. Two-year cumulative survival rate was 90%.
    Conclusions: Our study supports the importance of anticoagulation especially when a more extended thrombosis is present. Moreover, in patients with chronic PVT, the timing of follow-up endoscopy should be based on the extension of thrombosis and not, as in cirrhosis, on the size of varices at first endoscopy.
    Mesh-Begriff(e) Humans ; Portal Vein/pathology ; Esophageal and Gastric Varices/therapy ; Esophageal and Gastric Varices/complications ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects ; Prognosis ; Gastrointestinal Hemorrhage/therapy ; Gastrointestinal Hemorrhage/chemically induced ; Venous Thrombosis/complications ; Liver Cirrhosis/pathology ; Thrombosis/pathology ; Varicose Veins/complications ; Anticoagulants/therapeutic use ; Treatment Outcome
    Chemische Substanzen Anticoagulants
    Sprache Englisch
    Erscheinungsdatum 2023-05-23
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2023.05.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Post TIPS hepatic encephalopathy: Look at muscle and fat!

    Gioia, Stefania / Nardelli, Silvia / Faccioli, Jessica / Ridola, Lorenzo

    Clinical nutrition (Edinburgh, Scotland)

    2022  Band 41, Heft 5, Seite(n) 1150

    Mesh-Begriff(e) Hepatic Encephalopathy/etiology ; Humans ; Liver Cirrhosis ; Muscles ; Portasystemic Shunt, Transjugular Intrahepatic ; Sarcopenia
    Sprache Englisch
    Erscheinungsdatum 2022-03-08
    Erscheinungsland England
    Dokumenttyp Letter ; Comment
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2022.03.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Erectile dysfunction in patients with liver cirrhosis.

    Riggio, O / Ridola, L / Gioia, S / Nardelli, S

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2019  Band 51, Heft 6, Seite(n) 856–857

    Mesh-Begriff(e) Erectile Dysfunction ; Humans ; Liver Cirrhosis ; Male
    Sprache Englisch
    Erscheinungsdatum 2019-05-22
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2019.05.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: The Management of Hepatic Encephalopathy from Ward to Domiciliary Care: Current Evidence and Gray Areas.

    Bellafante, Daniele / Gioia, Stefania / Faccioli, Jessica / Riggio, Oliviero / Ridola, Lorenzo / Nardelli, Silvia

    Journal of clinical medicine

    2023  Band 13, Heft 1

    Abstract: Hepatic encephalopathy (HE) is a common complication of advanced liver disease and acute liver failure. It is a condition that features several neuropsychiatric symptoms that affect mortality, morbidity and the quality of patients' and caregivers' lives. ...

    Abstract Hepatic encephalopathy (HE) is a common complication of advanced liver disease and acute liver failure. It is a condition that features several neuropsychiatric symptoms that affect mortality, morbidity and the quality of patients' and caregivers' lives. An HE diagnosis is generally an exclusion diagnosis. Once the patient is admitted to the hospital, clinical examination, blood tests and eventually neuroimaging should be performed with the aim of ruling out other causes of acute brain dysfunction. Moreover, HE is recognized using various precipitants that can potentially promote its onset, alone or in combination, and must be identified. Once the diagnostic process is complete, a correct treatment should be started. The anti-HE treatment is based on a combination of the correction of precipitants; non-absorbable antibiotics, such as rifaximin; and non-absorbable disaccharides. Once the patient is discharged from the hospital, specific anti-HE therapy should be maintained in order to prevent other HE episodes.
    Sprache Englisch
    Erscheinungsdatum 2023-12-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13010166
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Minimal Hepatic Encephalopathy Affects Daily Life of Cirrhotic Patients: A Viewpoint on Clinical Consequences and Therapeutic Opportunities.

    Faccioli, Jessica / Nardelli, Silvia / Gioia, Stefania / Riggio, Oliviero / Ridola, Lorenzo

    Journal of clinical medicine

    2022  Band 11, Heft 23

    Abstract: Minimal hepatic encephalopathy (MHE) is a frequent complication of hepatic encephalopathy (HE) and can affect up to 80% of patients with liver cirrhosis. It is characterized by the lack of obvious clinical signs and the presence of alterations detectable ...

    Abstract Minimal hepatic encephalopathy (MHE) is a frequent complication of hepatic encephalopathy (HE) and can affect up to 80% of patients with liver cirrhosis. It is characterized by the lack of obvious clinical signs and the presence of alterations detectable using psychometric or electrophysiological testing focused on attention, working memory, psychomotor speed and visuospatial ability. Ideally, each patient should be tested for this condition because, despite the absence of symptoms, it has severe repercussions on daily life activities. It may be responsible for an inability to drive, sleep disturbances, risk of falls and inability to work. Some studies have highlighted its prognostically unfavorable role on mortality and risk of "overt" HE (OHE). Finally, MHE severely affects the lives of patients and caregivers, altering their quality of life and their socioeconomic status. Several treatments have been proposed for MHE treatment, including non-absorbable disaccharides, poorly absorbable antibiotics, such as rifaximin, probiotics and branched-chain amino acids, with promising results. For this reason, early diagnosis and intervention with appropriate measures is essential, with the aim of improving both performance on psychometric tests, as well as clinical aspects related to this condition.
    Sprache Englisch
    Erscheinungsdatum 2022-12-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11237246
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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