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Book ; Online: Artificial Intelligence in Medical Imaging: The Beginning of a New Era

Nardi, Cosimo

2023

Keywords	Technology: general issues ; History of engineering & technology ; Artificial Intelligence ; Automatic ; Diagnostics ; Engineering ; Imaging ; Machine Learning ; Deep Learning ; Features ; Biomedics
Language	English
Size	1 electronic resource (370 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030645790
ISBN	9783036594859 ; 303659485X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Correction for Nardi, "Antiracist Opportunities in the

Nardi, C L

Journal of microbiology & biology education

2022 Volume 23, Issue 2

Abstract: This corrects the article DOI: 10.1128/jmbe.00151-21.]. ...

Abstract	[This corrects the article DOI: 10.1128/jmbe.00151-21.].
Language	English
Publishing date	2022-06-14
Publishing country	United States
Document type	Published Erratum
ISSN	1935-7877
ISSN	1935-7877
DOI	10.1128/jmbe.00074-22
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Article: Antiracist Opportunities in the

Nardi, C L

Journal of microbiology & biology education

2021 Volume 22, Issue 2

Abstract: Authors in ... ...

Abstract	Authors in the
Language	English
Publishing date	2021-07-30
Publishing country	United States
Document type	Journal Article
ISSN	1935-7877
ISSN	1935-7877
DOI	10.1128/jmbe.00151-21
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Article ; Online: Editorial for "Diffusion-Weighted MRI of the Liver in Patients With Chronic Liver Disease: A Comparative Study Between Different Fitting Approaches and Diffusion Models".

Colagrande, Stefano / Nardi, Cosimo / Calistri, Linda

Journal of magnetic resonance imaging : JMRI

2023 Volume 59, Issue 3, Page(s) 907–908

MeSH term(s)	Humans ; Diffusion Magnetic Resonance Imaging ; Liver Diseases ; Abdomen
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Editorial
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28822
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Article ; Online: Monocrotaline presence in the Crotalaria (Fabaceae) plant genus and its influence on arthropods in agroecosystems.

Rech, C / Ribeiro, L P / Bento, J M S / Pott, C A / Nardi, C

Brazilian journal of biology = Revista brasleira de biologia

2022 Volume 84, Page(s) e256916

Abstract: Crotalaria (Fabaceae) occurs abundantly in tropical and subtropical regions and has about 600 known species. These plants are widely used in agriculture, mainly as cover plants and green manures, in addition to their use in the management of ... ...

Abstract	Crotalaria (Fabaceae) occurs abundantly in tropical and subtropical regions and has about 600 known species. These plants are widely used in agriculture, mainly as cover plants and green manures, in addition to their use in the management of phytonematodes. A striking feature of these species is the production of pyrrolizidine alkaloids (PAs), secondary allelochemicals involved in plant defense against herbivores. In Crotalaria species, monocrotaline is the predominant PA, which has many biological activities reported, including cytotoxicity, tumorigenicity, hepatotoxicity and neurotoxicity, with a wide range of ecological interactions. Thus, studies have sought to elucidate the effects of this compound to promote an increase in flora and fauna (mainly insects and nematodes) associated with agroecosystems, favoring the natural biological control. This review summarizes information about the monocrotaline, showing such effects in these environments, both above and below ground, and their potential use in pest management programs.
MeSH term(s)	Animals ; Arthropods ; Crotalaria ; Fabaceae ; Monocrotaline/toxicity ; Pyrrolizidine Alkaloids
Chemical Substances	Pyrrolizidine Alkaloids ; Monocrotaline (73077K8HYV)
Language	English
Publishing date	2022-01-17
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2036257-2
ISSN	1678-4375 ; 1519-6984
ISSN (online)	1678-4375
ISSN	1519-6984
DOI	10.1590/1519-6984.256916
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Article: Knowledge Graphs for COVID-19: An Exploratory Review of the Current Landscape.

Chatterjee, Avishek / Nardi, Cosimo / Oberije, Cary / Lambin, Philippe

Journal of personalized medicine

2021 Volume 11, Issue 4

Abstract: Background: Searching through the COVID-19 research literature to gain actionable clinical insight is a formidable task, even for experts. The usefulness of this corpus in terms of improving patient care is tied to the ability to see the big picture ... ...

Abstract	Background: Searching through the COVID-19 research literature to gain actionable clinical insight is a formidable task, even for experts. The usefulness of this corpus in terms of improving patient care is tied to the ability to see the big picture that emerges when the studies are seen in conjunction rather than in isolation. When the answer to a search query requires linking together multiple pieces of information across documents, simple keyword searches are insufficient. To answer such complex information needs, an innovative artificial intelligence (AI) technology named a knowledge graph (KG) could prove to be effective. Methods: We conducted an exploratory literature review of KG applications in the context of COVID-19. The search term used was "covid-19 knowledge graph". In addition to PubMed, the first five pages of search results for Google Scholar and Google were considered for inclusion. Google Scholar was used to include non-peer-reviewed or non-indexed articles such as pre-prints and conference proceedings. Google was used to identify companies or consortiums active in this domain that have not published any literature, peer-reviewed or otherwise. Results: Our search yielded 34 results on PubMed and 50 results each on Google and Google Scholar. We found KGs being used for facilitating literature search, drug repurposing, clinical trial mapping, and risk factor analysis. Conclusions: Our synopses of these works make a compelling case for the utility of this nascent field of research.
Language	English
Publishing date	2021-04-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm11040300
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Article ; Online: Liver Biliary Function Evaluation on a 1.5T Magnetic Resonance Imaging Scan by T1 Reduction Rate Assessment Using Variable-Flip-Angle Sequences.

Di Stasio, Marco / Cordopatri, Cesare / Nardi, Cosimo / Busoni, Simone / Noferini, Linhsia / Colagrande, Stefano / Calistri, Linda

Journal of computer assisted tomography

2024

Abstract: Objective: Magnetic resonance (MR) relaxometry is an absolute and reproducible quantitative method, compared with signal intensity for the evaluation of liver biliary function. This is obtainable by the T1 reduction rate (T1RR), as it carries a smaller ... ...

Abstract	Objective: Magnetic resonance (MR) relaxometry is an absolute and reproducible quantitative method, compared with signal intensity for the evaluation of liver biliary function. This is obtainable by the T1 reduction rate (T1RR), as it carries a smaller systematic error than the pre/post contrast agent T1 measurement. We aimed to develop and test an MR T1 relaxometry tool tailored for the evaluation of liver T1RR after gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid administration on 1.5T MR. Methods: In vitro/vivo (liver) T1RR values with two 3D FLASH variable-flip-angle sequences were calculated by a MATLAB algorithm. In vitro measurements were done by 2 physicists, in consensus. The prospective in vivo study was approved by the local ethical committee and performed on 13 normal/26 cirrhotic livers. A supplemental test in 5 normal/5 cirrhotic livers, out of the studied series, was done to compare the results of our method (without B1 inhomogeneity correction) and those of a standardized commercial tool (with B1 inhomogeneity correction). All in vivo evaluations were performed by 2 radiologists with 7 years of experience in abdominal imaging. Open-source Java-based software ImageJ was used to draw the free-hand regions of interest on liver section and for the measurement of hepatic T1RR values. The T1RR values of each group of patients were compared to assess statistically significant differences. All statistical analyses were performed with IBM-SPSS Statistics. In vivo evaluations, the intrareader and interreader reliability was assessed by intraclass correlation coefficient. Results: Our method showed good accuracy in evaluating in vitro T1RR with a maximum percentage error of 9% (constant at various time points) with T1 values in the 200- to 1400-millisecond range. In vivo, a high concordance between the T1RR evaluated with the proposed method and that calculated from the standardized commercial software was verified (P < 0.05). The median T1RRs were 74.8, 67.9, and 52.1 for the normal liver, Child-Pugh A, and Child-Pugh B cirrhotic groups, respectively. A very good agreement was found, both within intrareader and interreader reliability, with intraclass correlation coefficient values ranging from 0.88 to 0.95 and from 0.85 to 0.90, respectively. Conclusions: The proposed method allowed accurate reliable in vitro/vivo T1RR assessment evaluation of the liver biliary function after gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid administration.
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	80392-3
ISSN	1532-3145 ; 0363-8715
ISSN (online)	1532-3145
ISSN	0363-8715
DOI	10.1097/RCT.0000000000001582
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Article ; Online: The Impact of Rapid On-site Evaluation on Diagnostic Performance of Computed Tomography-Guided Core Needle Biopsy in Lung Cancer.

Magnini, Andrea / Lorini, Chiara / Calistri, Linda / Calcagni, Francesca / Giuntoli, Federico / Foxi, Prassede / Nardi, Cosimo / Colagrande, Stefano

Journal of computer assisted tomography

2024

Abstract: Purpose: Rapid on-site-evaluation (ROSE) is a technique aimed at improving the diagnostic performance of computed tomography (CT)-guided core needle biopsy (CNB) in lung cancer. The aim of this retrospective study was to investigate the impact of ROSE ... ...

Abstract	Purpose: Rapid on-site-evaluation (ROSE) is a technique aimed at improving the diagnostic performance of computed tomography (CT)-guided core needle biopsy (CNB) in lung cancer. The aim of this retrospective study was to investigate the impact of ROSE on the rate of nondiagnostic specimens and on accuracy computed on diagnostic specimens. Materials and methods: During a 3-year period, 417 CT-guided CNBs were performed at our center. The biopsies were retrospectively classified into 2 groups: 141 procedures were assisted by ROSE and 276 were not. All of them were reviewed for clinical, procedural, and pathological data. Pathology results were classified as diagnostic (positive or negative for malignancy) or nondiagnostic. The results were compared with the final diagnosis after surgery or clinical follow-up. Nondiagnostic rate, sensitivity/specificity/negative predictive value/positive predictive value for the ROSE and non-ROSE groups were calculated. Finally, procedural complications and the adequacy of the specimens for the molecular analysis were recorded. Results: The study evaluated 417 CNBs (mean patients' age 71 years, 278 men). Nondiagnostic rates with and without ROSE were 4% (6/142) and 11% (29/276), respectively (P = 0.028). Sensitivity/specificity/negative predictive value/positive predictive value with and without ROSE did not show statistically significant differences, and no difference in major/minor complication rates was observed between the 2 groups. The adequacy of specimen for subsequent molecular analysis was 100% with (42/42) and 82% without ROSE (51/62). Conclusions: Rapid on-site-evaluation reduced the rate of nondiagnostic specimens by 50% with no change in complication rates or accuracy and increased by 20% the chances of a successful subsequent molecular analysis.
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	80392-3
ISSN	1532-3145 ; 0363-8715
ISSN (online)	1532-3145
ISSN	0363-8715
DOI	10.1097/RCT.0000000000001606
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: MRI of Peliosis Hepatis: A Case Series Presentation With a 2022 Systematic Literature Update.

Calistri, Linda / Nardi, Cosimo / Rastrelli, Vieri / Maraghelli, Davide / Grazioli, Luigi / Messerini, Luca / Colagrande, Stefano

Journal of magnetic resonance imaging : JMRI

2023 Volume 58, Issue 5, Page(s) 1386–1405

Abstract: Background: Peliosis hepatis (PH) is a rare benign condition, characterized by hepatic sinusoidal dilatation and blood-filled cystic cavities, often found incidentally, with still challenging diagnosis by imaging due to polymorphic appearance.: ... ...

Abstract	Background: Peliosis hepatis (PH) is a rare benign condition, characterized by hepatic sinusoidal dilatation and blood-filled cystic cavities, often found incidentally, with still challenging diagnosis by imaging due to polymorphic appearance. Purpose: Based on a retrospective analysis of our series (12 patients) and systematic literature review (1990-2022), to organize data about PH and identify features to improve characterization. Study type: Retrospective case series and systematic review. Population: Twelve patients (mean age 48 years, 55% female) with pathology-proven PH and 49 patients (mean age 52 years, 67% female) identified in 33 studies from the literature (1990-2022). Field strength/sequence: 1,5-T; T1-weighted (T1W), T2-weighted (T2W), diffusion-weighted (DW), contrast-enhanced (CE) T1W imaging. Assessment: We compared our series and literature data in terms of demographic (gender/age/ethnicity), clinical characteristics (symptoms/physical examination/liver test), associated conditions (malignancies/infectious/hematologic/genetic or chronic disorders/drugs or toxic exposure) percentage. On magnetic resonance imaging lesion numbers/shape/mean maximum diameter/location/mass effect/signal intensity were compared. PH pathological type/proposed imaging diagnosis/patient follow-up were also considered. Statistical tests: Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports/Series quality assessment. Intraclass correlation and Cohen's kappa coefficients for levels of inter/intrareader agreement in our experience. Results: Patients were mainly asymptomatic (92% vs. 70% in our study and literature) with associated conditions (83% vs. 80%). Lesions showed homogeneous T1W-hypointensity (58% vs. 65%) and T2W-hyperintensity (58% vs. 66%). Heterogeneous nonspecific (25% vs. 51%), centrifugal (34% vs. 8%), or rim-like centripetal (25% vs. 23%) patterns of enhancement were most frequent, with hypointensity on the hepatobiliary phase (HBP), without restricted diffusivity. Good inter- and intrareader agreement was observed in our experience. Concerning JBI Checklist, 19 out of 31 case reports met at least 7 out of 8 criteria, whereas 2 case series fulfilled 5 and 6 out of 10 items respectively. Data conclusion: A homogeneous, not well-demarcated T1W-hypointense and T2W-hyperintense mass, with heterogeneous nonspecific or rim-like centripetal or centrifugal pattern of enhancement, and hypointensity on HBP, may be helpful for PH diagnosis. Among associated conditions, malignancies and drug exposures were the most frequent. Level of evidence: 4 TECHNICAL EFFICACY: Stage 2.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Peliosis Hepatis/diagnostic imaging ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Contrast Media
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28673
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Article: Development of 3D Printed Networks in Self-Healing Concrete.

De Nardi, Cristina / Gardner, Diane / Jefferson, Anthony Duncan

Materials (Basel, Switzerland)

2020 Volume 13, Issue 6

Abstract: This paper presents a new form of biomimetic cementitious material, which employs 3D-printed tetrahedral mini-vascular networks (MVNs) to store and deliver healing agents to damage sites within cementitious matrices. The MVNs are required to not only ... ...

Abstract	This paper presents a new form of biomimetic cementitious material, which employs 3D-printed tetrahedral mini-vascular networks (MVNs) to store and deliver healing agents to damage sites within cementitious matrices. The MVNs are required to not only protect the healing agent for a sufficient period of time but also survive the mixing process, release the healing agent when the cementitious matrix is damaged, and have minimal impact on the physical and mechanical properties of the host cementitious matrix. A systematic study is described which fulfilled these design requirements and determined the most appropriate form and material for the MVNs. A subsequent series of experiments showed that MVNs filled with sodium silicate, embedded in concrete specimens, are able to respond effectively to damage, behave as a perfusable vascular system and thus act as healing agent reservoirs that are available for multiple damage-healing events. It was also proved that healing agents encapsulated within these MVNs can be transported to cracked zones in concrete elements under capillary driving action, and produce a recovery of strength, stiffness and fracture energy.
Language	English
Publishing date	2020-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma13061328
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