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  1. Article ; Online: Umbilical artery Thrombosis: A case report of prenatal diagnosis and systematic review of the literature.

    Romani, Eleonora / Marinelli, Laura / Ponziani, Ilaria / Masini, Giulia / Castiglione, Francesca / Nardi, Eleonora / Pasquini, Lucia

    European journal of obstetrics, gynecology, and reproductive biology

    2024  Volume 296, Page(s) 6–12

    Abstract: Umbilical Artery Thrombosis (UAT) is an extremely rare complication of pregnancy strongly associated with severe fetal distress and death. The pathogenesis is still unclear but it is often associated with anatomical cord abnormalities that leads to blood ...

    Abstract Umbilical Artery Thrombosis (UAT) is an extremely rare complication of pregnancy strongly associated with severe fetal distress and death. The pathogenesis is still unclear but it is often associated with anatomical cord abnormalities that leads to blood stasis and thrombosis formation. Other possible risk factors are maternal thrombophilia, autoimmune disease, gestational diabetes, hypertension disorders of pregnancy and Rh-alloimmunization. The most common clinical symptom is the reduction of fetal movements. The diagnosis is histopathological, but it can be suspected by clinical and prenatal ultrasound findings. Generally, the first choice therapy is the immediate delivery with cesarean section. This study reported a case of a spontaneous intrauterine UAT in a low-risk pregnancy and a systematic review of the literature on clinical, ultrasound and histopathological findings of UAT, in order to help clinicians in the diagnostic process and management of this rare complication.
    MeSH term(s) Pregnancy ; Humans ; Female ; Umbilical Arteries/diagnostic imaging ; Cesarean Section/adverse effects ; Pregnancy Complications/pathology ; Prenatal Diagnosis ; Thrombosis/etiology ; Ultrasonography, Prenatal/adverse effects
    Language English
    Publishing date 2024-02-10
    Publishing country Ireland
    Document type Systematic Review ; Case Reports ; Journal Article ; Review
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2024.02.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 837: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Professional liability subsequent to the Cartabia Reform: implications for pathologists.

    Orlandi, Edoardo / Nardi, Eleonora / Siodambro, Chiara / Massi, Daniela / Pinchi, Vilma

    Pathologica

    2023  Volume 115, Issue 4, Page(s) 217–220

    Abstract: The Cartabia Reform modifies the standard used by the Public Prosecutor for the submission of requests for filing or referral for trial. The standard has shifted to the "reasonable prediction of conviction" by moving the principle ... ...

    Abstract The Cartabia Reform modifies the standard used by the Public Prosecutor for the submission of requests for filing or referral for trial. The standard has shifted to the "reasonable prediction of conviction" by moving the principle of
    MeSH term(s) Humans ; Liability, Legal ; Pathologists ; Health Personnel
    Language English
    Publishing date 2023-09-13
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 418229-7
    ISSN 1591-951X ; 0031-2983
    ISSN (online) 1591-951X
    ISSN 0031-2983
    DOI 10.32074/1591-951X-878
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  3. Article ; Online: Antepartum unscarred uterine rupture caused by placenta percreta: a case report and literature review.

    Nardi, Eleonora / Seravalli, Viola / Abati, Isabella / Castiglione, Francesca / Di Tommaso, Mariarosaria

    Pathologica

    2023  Volume 115, Issue 4, Page(s) 232–236

    Abstract: The main risk for uterine rupture is the presence of a uterine scar due to prior cesarean delivery or other uterine surgery. However, rupture in an unscarred uterus is extremely rare, and risk factors include multiple gestations, trauma, congenital ... ...

    Abstract The main risk for uterine rupture is the presence of a uterine scar due to prior cesarean delivery or other uterine surgery. However, rupture in an unscarred uterus is extremely rare, and risk factors include multiple gestations, trauma, congenital anomalies, use of uterotonics and placenta accreta spectrum.
    Placenta accreta spectrum, also known as morbidly adherent placenta, is becoming increasingly common and is associated with significant maternal and neonatal morbidity and mortality.
    We report a case of unscarred uterine rupture due to placenta percreta in a multiparous woman that required emergency peripartum hysterectomy.
    MeSH term(s) Female ; Pregnancy ; Infant, Newborn ; Humans ; Placenta Accreta/surgery ; Uterine Rupture/etiology ; Uterine Rupture/surgery ; Hysterectomy ; Pelvis ; Risk Factors
    Language English
    Publishing date 2023-09-14
    Publishing country Italy
    Document type Review ; Case Reports
    ZDB-ID 418229-7
    ISSN 1591-951X ; 0031-2983
    ISSN (online) 1591-951X
    ISSN 0031-2983
    DOI 10.32074/1591-951X-882
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  4. Article ; Online: Corrigendum to "Effects of SARS-Cov-2 mRNA vaccine on placental histopathology: Comparison of a population of uncomplicated COVID-19 positive pregnant women" [Placenta 149 (2024) 64-71].

    Tartaglia, Silvio / Di Ilio, Chiara / Romanzi, Federica / Moresi, Sascia / Nardi, Eleonora / Bevilacqua, Elisa / Arena, Vincenzo / Lanzone, Antonio

    Placenta

    2024  Volume 151, Page(s) 18

    Language English
    Publishing date 2024-04-17
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2024.04.004
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    Zs.A 1578: Show issues Location:
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  5. Article ; Online: Effects of SARS-Cov-2 mRNA vaccine on placental histopathology: Comparison of a population of uncomplicated COVID-19 positive pregnant women.

    Tartaglia, Silvio / Di Ilio, Chiara / Romanzi, Federica / Moresi, Sascia / Nardi, Eleonora / Bevilacqua, Elisa / Arena, Vincenzo / Lanzone, Antonio

    Placenta

    2024  Volume 149, Page(s) 64–71

    Abstract: 1.: Introduction: This study investigates the impact of SARS-CoV-2 infection on placental histopathology in pregnant women, comparing outcomes between vaccinated and non-vaccinated individuals. Despite known adverse pregnancy outcomes linked to SARS- ... ...

    Abstract 1.
    Introduction: This study investigates the impact of SARS-CoV-2 infection on placental histopathology in pregnant women, comparing outcomes between vaccinated and non-vaccinated individuals. Despite known adverse pregnancy outcomes linked to SARS-CoV-2 infection, the specific effects on the placenta remain unclear. Although vaccination has demonstrated a substantial reduction in infection severity, its impact on placental health requires more insight. 2.
    Methods: Between March 2021 and July 2022, 387 COVID-19-positive women were admitted for delivery. Of these, 98 with non-severe symptoms were analyzed: 35 vaccinated during pregnancy, and 63 non-vaccinated. Two independent pathologists evaluated all placental specimens. 3.
    Results: The only differing obstetrical characteristic between groups was the mode of delivery (p 0.047), lacking clinical implications. Over 85% of placentas exhibited microscopic abnormalities, predominantly maternal vascular supply disorders (vaccinated 89.1%; unvaccinated 85.5%). Comparing vaccinated and unvaccinated groups revealed statistically significant differences, notably in increased focal perivillous fibrin deposits (IFPFD) [17.1% vs. 33.3% (p 0.04)] and avascular fibrotic villi (AFV) [0% vs. 11.1% (p 0.04)]. Binomial logistic regression confirmed the vaccine's protective role against IFPFD (aOR 0.36; 95%CI 013-0.99) and AVF (aOR 0.06, 95% CI 0.003-0.98). A sub-analysis in vaccinated women showed a positive correlation between the timing of the first dose and IFPFD presence (p 0.018). 4.
    Discussion: The lower incidence of maternal and fetal vascular malperfusion placental features in vaccinated women, coupled with the timing correlation, supports the vaccine's protective effect on placental tissue in COVID-19-infected pregnant patients. Notably, no side effects were reported post-vaccination, emphasizing the vaccine's safety and advocating for its secure administration in pregnant populations.
    MeSH term(s) Pregnancy ; Humans ; Female ; COVID-19 Vaccines ; COVID-19/prevention & control ; mRNA Vaccines ; SARS-CoV-2 ; Pregnant Women ; Placenta ; Pregnancy Complications, Infectious/prevention & control
    Chemical Substances COVID-19 Vaccines ; mRNA Vaccines
    Language English
    Publishing date 2024-03-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2024.03.008
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    Zs.A 1578: Show issues Location:
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  6. Article ; Online: Imaging and molecular features of adenomyosis after menopause.

    Vannuccini, Silvia / Gabbrielli, Silvia / Castiglione, Francesca / Nardi, Eleonora / Rossi, Margherita / Orlandi, Gretha / Wu, Elisa / Bertoli, Francesca / Miele, Vittorio / Donati, Chiara / Petraglia, Felice

    Maturitas

    2024  Volume 185, Page(s) 107996

    Abstract: Objectives: To explore the imaging features and the molecular characterization of adenomyosis after menopause.: Study design: An observational cross-sectional study was performed in a group of postmenopausal patients undergoing a transvaginal ... ...

    Abstract Objectives: To explore the imaging features and the molecular characterization of adenomyosis after menopause.
    Study design: An observational cross-sectional study was performed in a group of postmenopausal patients undergoing a transvaginal ultrasound (TVUS) (n = 468). Among those presenting the US criteria for adenomyosis, also confirmed by magnetic resonance imaging (MRI), previous menstrual symptoms, gynecological and obstetric history were reviewed. In a subgroup undergoing hysterectomy, uterine specimens were analyzed by histology and expression of genes implicated in the epithelial-mesenchymal transition, inflammation and fibrosis, including the sphingosine-1-phosphate (S1P) pathway, was evaluated and compared to matched non-menopausal adenomyosis specimens.
    Main outcome measures: Direct and indirect US features of adenomyosis according to Morphological Uterus Sonographic Assessment at TVUS. Molecular characterization of postmenopausal versus pre-menopausal adenomyosis samples.
    Results: According to TVUS and MRI, adenomyosis was identified in 49 patients (10.4 %). On US, diffuse adenomyosis was the most common phenotype, whereas internal adenomyosis with diffuse pattern and asymmetric type was the most prevalent on MRI. Molecular analysis showed that adenomyosis lesions express markers of epithelial-mesenchymal transition, inflammation and fibrosis also in postmenopausal women. By comparing the results with those from pre-menopausal samples, the expression of α smooth muscle actin (αSMA), a marker of fibrosis, was significantly greater after menopause, and altered S1P catabolism and signaling were observed.
    Conclusions: Adenomyosis may be identified in postmenopausal women by imaging, either TVUS or MRI, and fibrosis is one of the key features on molecular analysis.
    Language English
    Publishing date 2024-04-12
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 80460-5
    ISSN 1873-4111 ; 0378-5122
    ISSN (online) 1873-4111
    ISSN 0378-5122
    DOI 10.1016/j.maturitas.2024.107996
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    Zs.A 1432: Show issues Location:
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  7. Article ; Online: A study on the placenta in stillbirth: an evaluation of molecular alterations through next generation sequencing.

    Nardi, Eleonora / Seravalli, Viola / Serena, Caterina / Mecacci, Federico / Massi, Daniela / Bertaccini, Bruno / Di Tommaso, Mariarosaria / Castiglione, Francesca

    Placenta

    2022  Volume 129, Page(s) 7–11

    Abstract: Introduction: Placental dysfunction is one of the most common causes of Intrauterine Fetal Demise (IUFD). Due to its characteristics, the placenta may be the target of molecular research aimed to investigate potential causes of IUFD. In the literature, ... ...

    Abstract Introduction: Placental dysfunction is one of the most common causes of Intrauterine Fetal Demise (IUFD). Due to its characteristics, the placenta may be the target of molecular research aimed to investigate potential causes of IUFD. In the literature, there are no studies on human placentas that have investigated possible associations between somatic mutations and the occurrence of IUFD. The aim of this study was to identify the presence of gene mutations in placental tissues in a series of cases of IUFD and to evaluate potential correlations with placental microscopic findings.
    Materials and methods: Thirty-seven samples of formalin-fixed and paraffin-embedded placental tissues were retrospectively selected from pregnancies ending in IUFD between 23rd to 40th week. Six control placentas of physiological pregnancies were included as controls. After sampling, made according to standardized protocol and conventional histopathological examination, placental tissues were subjected to DNA extraction and sequencing by means of Next Generation Sequencing with a 56-gene panel.
    Results: The most frequent mutation observed in 32/37 IUFD cases (86.5%) and absent in any of the 6 control placentas was in c-KIT gene, which is implicated in placental tissue differentiation. However, no significant correlation was found between the presence of individual gene mutations and placental histopatological findings.
    Discussion: As the present study found an elevated frequency of c-KIT mutation in IUFD, it further supports the hypothesis that c-KIT is involved in abnormal tissue differentiation leading to altered placental vascularization and function.
    MeSH term(s) Pregnancy ; Female ; Humans ; Stillbirth/genetics ; Stillbirth/epidemiology ; Placenta/pathology ; Fetal Death/etiology ; Retrospective Studies ; High-Throughput Nucleotide Sequencing
    Language English
    Publishing date 2022-09-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 603951-0
    ISSN 1532-3102 ; 0143-4004
    ISSN (online) 1532-3102
    ISSN 0143-4004
    DOI 10.1016/j.placenta.2022.09.004
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