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Article: A case report of a colouterine fistula treatment: when the patient chooses the steeplechase.

Pontone, Stefano / Nardis, Pier Giorgio / Eberspacher, Chiara / Mascagni, Domenico

2021 Volume 39, Issue 4, Page(s) 366–370

Abstract: Colouterine fistula is a rare disease that is primarily treated using surgical approaches. Although invasive surgery is controversial in terms of techniques and results, minimally invasive endoscopic treatments have not been widely described. However, ... ...

Abstract	Colouterine fistula is a rare disease that is primarily treated using surgical approaches. Although invasive surgery is controversial in terms of techniques and results, minimally invasive endoscopic treatments have not been widely described. However, because it is rare for these fistulas to close spontaneously, surgical treatment is often mandatory. Appropriate management of colouterine fistula is complicated, especially when the patient refuses surgery. In this case study, we provide the first description of a minimally invasive endoscopic treatment of an iatrogenic colouterine fistula using a self-expandable metallic stent after an over-the-scope clip malposition.
Language	English
Publishing date	2021-08-09
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	2711906-3
ISSN	2287-9722 ; 2287-9714
ISSN (online)	2287-9722
ISSN	2287-9714
DOI	10.3393/ac.2021.00318.0045
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Article ; Online: Two-dimensional perfusion angiography permits direct visualization of redistribution of flow in hepatocellular carcinoma during b-TACE.

Lucatelli, Pierleone / Ciaglia, Simone / Rocco, Bianca / De Rubeis, Gianluca / Bolognesi, Guido / Damato, Elio / Corona, Mario / Nardis, Pier Giorgio / Cannavale, Alessandro / Ricci, Paolo / Catalano, Carlo

La Radiologia medica

2024

Abstract: Objectives: To demonstrate in vivo redistribution of the blood flow towards HCC's lesions by utilizing two-dimensional perfusion angiography in b-TACE procedures.: Material and methods: In total, 30 patients with 35 HCC nodules treated in the period ... ...

Abstract	Objectives: To demonstrate in vivo redistribution of the blood flow towards HCC's lesions by utilizing two-dimensional perfusion angiography in b-TACE procedures. Material and methods: In total, 30 patients with 35 HCC nodules treated in the period between January 2019 and November 2021. For each patient, a post-processing software leading to a two-dimensional perfusion angiography was applied on each angiography performed via balloon microcatheter, before and after inflation. On the colour map obtained, reflecting the evolution of contrast intensity change over time, five regions of interests (ROIs) were assessed: one on the tumour (ROI-t), two in the immediate peritumoural healthy liver parenchyma (ROI-ihl) and two in the peripheral healthy liver parenchyma (ROI-phl). The results have been interpreted with a novel in silico model that simulates the hemodynamics of the hepatic arterial system. Results: Among the ROIs drawn inside the same segment of target lesion, the time-to-peak of the ROI-t and of the ROI-ihl have a significantly higher mean value when the balloon was inflated compared with the ROIs obtained with deflated balloon (10.33 ± 3.66 s vs 8.87 ± 2.60 s (p = 0.015) for ROI-t; 10.50 ± 3.65 s vs 9.23 ± 2.70 s (p = 0.047) for ROI-ihl). The in silico model prediction time-to-peak delays when balloon was inflated, match with those observed in vivo. The numerical flow analysis shows how time-to-peak delays are caused by the obstruction of the balloon-occluded artery and the opening of intra-hepatic collateral. Conclusion: The measurements identify predictively the flow redistribution in the hepatic arteries during b-TACE, supporting a proper positioning of the balloon microcatheter.
Language	English
Publishing date	2024-04-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	205751-7
ISSN	1826-6983 ; 0033-8362
ISSN (online)	1826-6983
ISSN	0033-8362
DOI	10.1007/s11547-024-01816-9
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Article ; Online: Bleeding in COVID Patients: What We Have Understood So Far.

Lucatelli, Pierleone / Rocco, Bianca / Nardis, Pier Giorgio / Cannavale, Alessandro / Bezzi, Mario / Catalano, Carlo / Corona, Mario

Cardiovascular and interventional radiology

2021 Volume 44, Issue 4, Page(s) 666–668

Language	English
Publishing date	2021-01-28
Publishing country	United States
Document type	Letter
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-021-02775-8
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Article ; Online: CT-guided Pulsed Radiofrequency Combined with Steroid Injection for Sciatica from Herniated Disk: A Randomized Trial.

Napoli, Alessandro / Alfieri, Giulia / De Maio, Alessandro / Panella, Emanuela / Scipione, Roberto / Facchini, Giancarlo / Albisinni, Ugo / Spinnato, Paolo / Nardis, Pier Giorgio / Tramutoli, Roberto / Lenzi, Jacopo / Ghanouni, Pejman / Bazzocchi, Alberto / Perotti, Stefano / Schoenfeld, Andrew J / Catalano, Carlo

Radiology

2023 Volume 307, Issue 4, Page(s) e221478

Abstract: Background Evidence regarding effective nonsurgical management of sciatica remains limited. Purpose To determine a difference in effectiveness between combined pulsed radiofrequency (PRF) and transforaminal epidural steroid injection (TFESI) treatment ... ...

Abstract	Background Evidence regarding effective nonsurgical management of sciatica remains limited. Purpose To determine a difference in effectiveness between combined pulsed radiofrequency (PRF) and transforaminal epidural steroid injection (TFESI) treatment versus TFESI alone for sciatic pain due to lumbar disk herniation. Materials and Methods This prospective multicenter double-blind randomized clinical trial was conducted between February 2017 and September 2019 in participants with sciatica due to lumbar disk herniation lasting 12 weeks or longer that was not responsive to conservative treatment. Study participants were randomly assigned to undergo one CT-guided treatment with combined PRF and TFESI (
MeSH term(s)	Male ; Humans ; Middle Aged ; Intervertebral Disc Displacement/complications ; Intervertebral Disc Displacement/diagnostic imaging ; Intervertebral Disc Displacement/therapy ; Sciatica/drug therapy ; Sciatica/etiology ; Prospective Studies ; Pulsed Radiofrequency Treatment ; Treatment Outcome ; Injections, Epidural/adverse effects ; Injections, Epidural/methods ; Pain/etiology ; Steroids ; Tomography, X-Ray Computed
Chemical Substances	Steroids
Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.221478
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Article ; Online: Cone-Beam CT-Guided Transarterial Tagging of Endophytic Renal Tumors with Indocyanine Green for Robot-Assisted Partial Nephrectomy.

Nardis, Pier Giorgio / Cipollari, Stefano / Lucatelli, Pierleone / Basilico, Fabrizio / Rocco, Bianca / Corona, Mario / Cannavale, Alessandro / Leonardo, Costantino / Flammia, Rocco Simone / Proietti, Flavia / Vallati, Giulio / Gallucci, Michele / Catalano, Carlo

Journal of vascular and interventional radiology : JVIR

2022 Volume 33, Issue 8, Page(s) 934–941

Abstract: Purpose: To evaluate the safety, efficacy, and clinical impact of preoperative cone-beam computed tomography (CT)-guided selective embolization of endophytic renal tumors with the fluorescent dye indocyanine green (ICG) and ethiodized oil in patients ... ...

Abstract	Purpose: To evaluate the safety, efficacy, and clinical impact of preoperative cone-beam computed tomography (CT)-guided selective embolization of endophytic renal tumors with the fluorescent dye indocyanine green (ICG) and ethiodized oil in patients undergoing robot-assisted partial nephrectomy (RAPN) using near-infrared fluorescence imaging (NIR-FI). Materials and methods: Patients with renal endophytic tumors eligible for RAPN and transarterial embolization with ICG and ethiodized oil were prospectively enrolled. Technical success was defined as the completion of the embolization procedure. Radiographic success, defined as ethiodized oil accumulation in the nodule, was classified as poor, moderate, good, or optimal on the basis of postembolization cone-beam CT. Surgical visibility of the tumors during RAPN with the use of NIR-FI was classified as follows: (a) not visible, (b) visible with poorly defined margins, and (c) visible with well-defined margins. Results: Forty-one patients underwent preoperative selective embolization. Technical success was 100%. Ethiodized oil accumulation on cone-beam CT was poor in 2 (4.9%), moderate in 6 (14.6%), good in 25 (61.0%), and optimal in 8 (19.5%) of 41 patients. During RAPN with NIR-FI, tumors were visible with well-defined margins in 26 (63.4%), visible with blurred margins in 14 (34.1%), and not visible in 1 (2.4%) of 41 cases. There were no adverse events following endovascular embolization. Conclusions: Preoperative transarterial superselective embolization of endophytic renal tumors with ICG and ethodized oil in patients undergoing RAPN is safe and effective, allowing accurate intraoperative visualization and resection of endophytic tumors.
MeSH term(s)	Cone-Beam Computed Tomography ; Ethiodized Oil ; Humans ; Indocyanine Green ; Kidney Neoplasms/diagnostic imaging ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Margins of Excision ; Nephrectomy/adverse effects ; Nephrectomy/methods ; Robotic Surgical Procedures/adverse effects ; Robotic Surgical Procedures/methods ; Robotics ; Treatment Outcome
Chemical Substances	Ethiodized Oil (8008-53-5) ; Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2022-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2022.04.016
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Article ; Online: Correction to: Balloon occluded TACE (B-TACE) vs DEM-TACE for HCC: a single center retrospective case control study.

Lucatelli, Pierleone / De Rubeis, Gianluca / Rocco, Bianca / Basilico, Fabrizio / Cannavale, Alessandro / Abbatecola, Aurelio / Nardis, Pier Giorgio / Corona, Mario / Brozzetti, Stefania / Catalano, Carlo / Bezzi, Mario

BMC gastroenterology

2021 Volume 21, Issue 1, Page(s) 282

Language	English
Publishing date	2021-07-09
Publishing country	England
Document type	Published Erratum
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-021-01861-y
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Article ; Online: Balloon occluded TACE (B-TACE) vs DEM-TACE for HCC: a single center retrospective case control study.

Lucatelli, Pierleone / De Rubeis, Gianluca / Rocco, Bianca / Basilico, Fabrizio / Cannavale, Alessandro / Abbatecola, Aurelio / Nardis, Pier Giorgio / Corona, Mario / Brozetti, Stefania / Catalano, Carlo / Bezzi, Mario

BMC gastroenterology

2021 Volume 21, Issue 1, Page(s) 51

Abstract: Background: To compare oncological results and safety profile of balloon micro-catheter trans-arterial chemoembolization (b-TACE) and drug-eluting-microsphere (DEM-TACE) in patients with hepatocellular-carcinoma (HCC).: Methods: This is a case- ... ...

Abstract	Background: To compare oncological results and safety profile of balloon micro-catheter trans-arterial chemoembolization (b-TACE) and drug-eluting-microsphere (DEM-TACE) in patients with hepatocellular-carcinoma (HCC). Methods: This is a case-control, retrospective, single-center study. Between January-2015/March-2019, 149 patients (131 males [87.9%]) with 226 HCC were treated, 22 patients (35 HCC; 19 [86.4%] males) with b-TACE and 127 with DEM-TACE (191 HCC, 112 [88.2%] males). Embolization protocol was standardized (sequential 100 ± 25 and 200 ± 25 μm microspheres). Results were evaluated by modified-response-evaluation-criteria-in-solid-tumor [mRECIST] at 1, 3-6 and 9-12 months and time to recurrence after complete response [TTR] at 1 years. Cox's regression weighted with tumor dimensions was performed. Adverse events (AEs) were recorded. Results: mRECIST oncological response at all time points (1, 3-6 and 9-12 months) for both treatments were similar, with the exception of Objective response rate at 9-12 months. Objective response at 1 and 3-6 months between b-TACE vs DEM-TACE [23/35 (65.7%) vs 119/191 (62.3%), 21/29 (72.4%) vs 78/136 (57.4%) (p > 0.05), respectively]. On the contrary, at 9-12 months, it was significantly higher in b-TACE subgroup than DEM-TACE (15/19 [78.9%] vs 48/89 [53.9%], p = 0.05). TTR for complete response at 1 year had a better trend for b-TACE vs DEM-TACE (278.0 days [196.0-342.0] vs 219.0 days [161.0-238.0], OR 0.68 [0.4-1.0], p = 0.10). The use of balloon micro-catheter reduced the relative risk of the event of recurrence by 0.63 [CI95% 0.38-1.04]; p = 0.07). No significant differences were found in AEs rate. Conclusion: b-TACE showed a trend of better oncological response over DEM-TACE with and longer TTR with a similar adverse events rate, in patients presenting with larger tumors.
MeSH term(s)	Carcinoma, Hepatocellular/therapy ; Case-Control Studies ; Chemoembolization, Therapeutic/adverse effects ; Humans ; Liver Neoplasms/therapy ; Male ; Neoplasm Recurrence, Local ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-02-03
Publishing country	England
Document type	Journal Article
ISSN	1471-230X
ISSN (online)	1471-230X
DOI	10.1186/s12876-021-01631-w
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Article ; Online: Balloon-Occluded Transcatheter Arterial Chemoembolization (b-TACE) for Hepatocellular Carcinoma Performed with Polyethylene-Glycol Epirubicin-Loaded Drug-Eluting Embolics: Safety and Preliminary Results.

Lucatelli, Pierleone / Ginnani Corradini, Luca / De Rubeis, Gianluca / Rocco, Bianca / Basilico, Fabrizio / Cannavale, Alessandro / Nardis, Pier Giorgio / Corona, Mario / Saba, Luca / Catalano, Carlo / Bezzi, Mario

Cardiovascular and interventional radiology

2019 Volume 42, Issue 6, Page(s) 853–862

Abstract: Purpose: To report technical success, safety profile and oncological results of balloon-occluded transcatheter arterial chemoembolization using a balloon micro-catheter and epirubicin-loaded polyethylene-glycol (PEG) microsphere (100 ± 25 µm and 200 ± ... ...

Abstract	Purpose: To report technical success, safety profile and oncological results of balloon-occluded transcatheter arterial chemoembolization using a balloon micro-catheter and epirubicin-loaded polyethylene-glycol (PEG) microsphere (100 ± 25 µm and 200 ± 50 µm) in patients with hepatocellular carcinoma (HCC). Materials and methods: This is a single-centre, single-arm, retrospective study with 6-month follow-up. Twenty-two patients (Child-Pugh A 68% [15/22], B in 32% [7/22]; age 67.05 ± 14 years) with 29 HCC were treated in 24 procedures. Technical success is defined: ability to place the balloon micro-catheter within the required vascular segment, balloon-occluded arterial stump pressure drops and assessment of microsphere deposition. Laboratory assessment pre/post-procedural and complications were analysed, respectively, according to Common Terminology Criteria for Adverse Events (CTCAEv5) and CIRSE system. Postembolization syndrome (PES) was defined as fever and/or nausea and/or pain onset. Oncological results were evaluated using m-RECIST criteria with CT/MRI imaging at 1 and 3-6 months. In partial responder patients, pre/post-procedural tumour volume was compared. Results: Pre-planned feeder was reached in all cases. Pressure drop average was 51.1 ± 21.6 mmHg. Exclusive target embolization was achieved in 14/24 procedures (58.3%). Laboratory test modifications were all grade 1. 4/24 adverse events occurred (17%): pseudo-aneurysm of the feeder (grade 3), liver abscess (grade 2) and 2 asymptomatic segmentary biliary tree dilatations (grade 2). PES occurred in 8/24 (33%). The complete response at 1 and 3-6 months was 44.8% (13/29) and 52.9% (9/17), respectively. The partial response at 1 and 3-6 months was 55% (16/29) and 4/17 (23.5%), respectively. Among partial responder patients, the average percentage of tumour volume reduction was 64.9 ± 27.3%. Conclusion: Epirubicin-loaded PEG microsphere b-TACE is technically feasible, safe and effective procedure for HCC treatment.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antibiotics, Antineoplastic/administration & dosage ; Balloon Occlusion/methods ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic/methods ; Epirubicin/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Liver/diagnostic imaging ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/therapy ; Magnetic Resonance Imaging ; Male ; Microspheres ; Middle Aged ; Multimodal Imaging ; Polyethylene Glycols/administration & dosage ; Response Evaluation Criteria in Solid Tumors ; Retrospective Studies ; Tomography, X-Ray Computed ; Treatment Outcome
Chemical Substances	Antibiotics, Antineoplastic ; Polyethylene Glycols (3WJQ0SDW1A) ; Epirubicin (3Z8479ZZ5X)
Language	English
Publishing date	2019-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-019-02192-y
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Article ; Online: Polyethylene Glycol Epirubicin-Loaded Transcatheter Arterial Chemoembolization Procedures Utilizing a Combined Approach with 100 and 200 μm Microspheres: A Promising Alternative to Current Standards.

Lucatelli, Pierleone / Argirò, Renato / De Rubeis, Gianluca / Rocco, Bianca / Corradini, Stefano Ginanni / Corona, Mario / Nardis, Pier Giorgio / Saba, Luca / Mennini, Gianluca / Fiorentino, Francesco / Corsi, Alessandro / Catalano, Carlo / Bezzi, Mario

Journal of vascular and interventional radiology : JVIR

2019 Volume 30, Issue 3, Page(s) 305–313

Abstract: Purpose: To report clinical effectiveness, toxicity profile, and prognostic factors of combined 100 μm ± 25 and 200 μm ± 50 epirubicin-loaded polyethylene glycol (PEG) microsphere drug-eluting embolic transcatheter arterial chemoembolization protocol in ...

Abstract	Purpose: To report clinical effectiveness, toxicity profile, and prognostic factors of combined 100 μm ± 25 and 200 μm ± 50 epirubicin-loaded polyethylene glycol (PEG) microsphere drug-eluting embolic transcatheter arterial chemoembolization protocol in patients with hepatocellular carcinoma. Materials and methods: In this prospective, single-center, single-arm study with 18 months of follow-up, 36 consecutive patients (mean age 69.9 y ± 10.8; 26 men, 10 women; 54 naïve lesions) were treated. Embolization was initiated with 100 μm ± 25 microspheres, and if stasis (10 heart beats) was not achieved, 200 μm ± 50 microspheres were administered. Each syringe (2 mL) of PEG microsphere was loaded with 50 mg of epirubicin. Results were evaluated using Modified Response Evaluation Criteria In Solid Tumors with multidetector computed tomography/magnetic resonance imaging at 1, 3-6, 9-12, and 15-18 months. Toxicity profile was assessed by laboratory testing before and after the procedure. Complications were recorded. Postembolization syndrome (PES) was defined as onset of fever/nausea/pain after the procedure. Patient/lesion characteristics and treatment results were correlated with predicted outcome using regression analysis. Child-Pugh score was A in 86.1% of patients (31/36) and B in 13.9% (5/36). Results: In 10 of 21 lesions, < 2 cm in diameter (47.5%) stasis was achieved with 100 μm ± 25 microspheres only, whereas all other lesions required adjunctive treatment with 200 μm ± 50 microspheres. Reported adverse events were grade 1 acute liver bile duct injury (3/39 cases, 7.7%) and PES (grade 2; 3/39 cases, 7.7%). Complete response (CR) at 1, 3-6, 9-12, and 15-18 months was 61.1%, 65.5%, 63.63%, and 62.5%. Objective response (CR + partial response) at 1, 3-6, 9-12, and 15-18 months was 83.3%, 65.85%, 63.63%, and 62.5%. No single factor (laboratory testing, etiology, patient status, hepatic status, tumor characteristics, administration protocol) predicted outcomes except for albumin level at baseline for CR (P < .05, odds ratio = 1.09). Conclusions: The combined microsphere sizing strategy was technically feasible and yielded promising results in terms of effectiveness and toxicity.
MeSH term(s)	Aged ; Aged, 80 and over ; Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/adverse effects ; Biopsy ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic/adverse effects ; Chemoembolization, Therapeutic/methods ; Chemoembolization, Therapeutic/mortality ; Disease Progression ; Drug Carriers ; Epirubicin/administration & dosage ; Epirubicin/adverse effects ; Feasibility Studies ; Female ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Male ; Microspheres ; Middle Aged ; Particle Size ; Polyethylene Glycols/chemistry ; Progression-Free Survival ; Prospective Studies ; Rome ; Time Factors ; Tomography, X-Ray Computed ; Tumor Burden
Chemical Substances	Antibiotics, Antineoplastic ; Drug Carriers ; Polyethylene Glycols (3WJQ0SDW1A) ; Epirubicin (3Z8479ZZ5X)
Language	English
Publishing date	2019-01-31
Publishing country	United States
Document type	Clinical Study ; Journal Article
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2018.10.026
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Article ; Online: Intra-procedural dual phase cone beam computed tomography has a better diagnostic accuracy over pre-procedural MRI and MDCT in detection and characterization of HCC in cirrhotic patients undergoing TACE procedure.

Lucatelli, Pierleone / De Rubeis, Gianluca / Ginnani Corradini, Luca / Basilico, Fabrizio / Di Martino, Michele / Lai, Quirino / Ginanni Corradini, Stefano / Cannavale, Alessandro / Nardis, Pier Giorgio / Corona, Mario / Saba, Luca / Catalano, Carlo / Bezzi, Mario

European journal of radiology

2019 Volume 124, Page(s) 108806

Abstract: Purpose: This study was directed to compare diagnostic accuracy of dual-phase cone beam computed tomography (DP-CBCT) vs pre-procedural second line imaging modality (SLIM [multidetector computed tomography and magnetic resonance imaging]) to detect and ... ...

Abstract	Purpose: This study was directed to compare diagnostic accuracy of dual-phase cone beam computed tomography (DP-CBCT) vs pre-procedural second line imaging modality (SLIM [multidetector computed tomography and magnetic resonance imaging]) to detect and characterize hepatocellular carcinoma (HCC) in cirrhotic patients with indication for trans-arterial chemoembolization (TACE). Methods: This is a single centre, retrospective, and observational study. Exclusion criteria were not-assisted DP-CBCT TACE, and unavailable follow-up SLIM. We evaluated 280 consecutive patients (January/2015-Febraury/2019). Seventy-two patients were eligible. Three radiologists in consensus reviewed: pre-procedural SLIM, DP-CBCT, and SLIM at follow-up, with 4 months of interval between each reading. Hyper-vascular foci (HVF) were detected and characterized. Diameter was recorded. Radiological behaviour, according to LI-RADS criteria, of HFV throughout follow-up time was the reference standard. Diagnostic accuracy was calculated for pre-procedural SLIM and DP-CBCT and evaluated through receiver operating characteristic curve. HVF only visible on DP-CBCT (defined as occult) were analysed. Tumour diameters were compared. Results: Median time between pre-procedural SLIM and DP-CBCT and between DP-CBCT and definitive radiological diagnosis of HVF were 46.0 days (95%CI 36.5-55.0) and 30.5 days (95%CI 29.0-33.0), respectively. DP-CBCT had a better diagnostic performance than pre-examination SLIM (sensitivity 99%vs78%; specificity 89%vs85%; PPV 99%vs99%; NPV 92%vs30%; and accuracy 94%vs79%). DP-CBCT diagnosed 63 occult HVF. Occult HCC were 54/243 (22.2%). Six were occult angiomas. Three were false positive. Mean diameter was significantly higher in DP-CBCT vs pre-procedural SLIM (+7.5% [95%CI 3.7-11.3], p < 0.05). Conclusions: DP-CBCT has a better diagnostic accuracy and NPV than pre-procedural SLIM in cirrhotic patients with indication for TACE.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Algorithms ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic ; Cone-Beam Computed Tomography/methods ; Female ; Humans ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/etiology ; Liver Cirrhosis/therapy ; Liver Neoplasms/complications ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/therapy ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Multidetector Computed Tomography/methods ; ROC Curve ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity
Language	English
Publishing date	2019-12-24
Publishing country	Ireland
Document type	Journal Article ; Observational Study
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2019.108806
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