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  1. Article: Current Insights Into Oligodendrocyte Metabolism and Its Power to Sculpt the Myelin Landscape.

    Narine, Mohanlall / Colognato, Holly

    Frontiers in cellular neuroscience

    2022  Volume 16, Page(s) 892968

    Abstract: Once believed to be part of ... ...

    Abstract Once believed to be part of the
    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.892968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The AMPK activator metformin improves recovery from demyelination by shifting oligodendrocyte bioenergetics and accelerating OPC differentiation.

    Narine, Mohanlall / Azmi, Maryam A / Umali, Martin / Volz, Ashley / Colognato, Holly

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1254303

    Abstract: Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to neurological dysfunction and, if myelin repair fails, neurodegeneration of the ...

    Abstract Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to neurological dysfunction and, if myelin repair fails, neurodegeneration of the denuded axons. Virtually all treatments for MS act by suppressing immune function, but do not alter myelin repair outcomes or long-term disability. Excitingly, the diabetes drug metformin, a potent activator of the cellular "energy sensor" AMPK complex, has recently been reported to enhance recovery from demyelination. In aged mice, metformin can restore responsiveness of oligodendrocyte progenitor cells (OPCs) to pro-differentiation cues, enhancing their ability to differentiate and thus repair myelin. However, metformin's influence on young oligodendroglia remains poorly understood. Here we investigated metformin's effect on the temporal dynamics of differentiation and metabolism in young, healthy oligodendroglia and in oligodendroglia following myelin damage in young adult mice. Our findings reveal that metformin accelerates early stages of myelin repair following cuprizone-induced myelin damage. Metformin treatment of both isolated OPCs and oligodendrocytes altered cellular bioenergetics, but in distinct ways,
    Language English
    Publishing date 2023-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1254303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Development of a Dual Path Platform (DPP®) immunoassay for rapid detection of Candida albicans in human whole blood and serum.

    Gunasekera, Milan / Narine, Mohanlall / Ashton, Matthew / Esfandiari, Javan

    Journal of immunological methods

    2015  Volume 424, Page(s) 7–13

    Abstract: Candida albicans is an opportunistic pathogen which can lead to Candidiasis and blood-stream infections, resulting in a mortality rate near 40%. Given its high fatality and emerging pathogenicity, there is a strong need for the development of a rapid C. ... ...

    Abstract Candida albicans is an opportunistic pathogen which can lead to Candidiasis and blood-stream infections, resulting in a mortality rate near 40%. Given its high fatality and emerging pathogenicity, there is a strong need for the development of a rapid C. albicans diagnostic assay. Point-of-care devices, specifically lateral flow assays, are an attractive and often employed diagnostic modality for C. albicans detection. However, they lack the required performance characteristics needed for accurate pathogen detection and subsequent treatment options. Thus, we describe herein the utility of the Dual Path Platform (DPP®) device as an immunochromatographic Point-of-care assay for C. albicans. The limit of detection for hyphal and budding C. albicans in DPP® tests are reported to be as low as 7.94 × 10(5) whole cells/mL in human serum. C. albicans cells were detected with up to a 3.9 fold increase in sensitivity on DPP® when compared to conventional lateral flow modalities.
    MeSH term(s) Antibodies, Fungal/blood ; Antibodies, Fungal/immunology ; Candida albicans/immunology ; Candidiasis/blood ; Candidiasis/diagnosis ; Candidiasis/immunology ; Candidiasis/microbiology ; Cross Reactions/immunology ; Humans ; Immunoassay/methods ; Reproducibility of Results ; Sensitivity and Specificity
    Chemical Substances Antibodies, Fungal
    Language English
    Publishing date 2015-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 120142-6
    ISSN 1872-7905 ; 0022-1759
    ISSN (online) 1872-7905
    ISSN 0022-1759
    DOI 10.1016/j.jim.2015.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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