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Article ; Online: Effects of the angiotensin-converting enzyme inhibitor captopril on occlusal-disharmony-induced cardiac dysfunction in mice.

Ito, Aiko / Ohnuki, Yoshiki / Suita, Kenji / Matsuo, Ichiro / Ishikawa, Misao / Mitsubayashi, Takao / Mototani, Yasumasa / Kiyomoto, Kenichi / Tsunoda, Michinori / Morii, Akinaka / Nariyama, Megumi / Hayakawa, Yoshio / Tomonari, Hiroshi / Okumura, Satoshi

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19927

Abstract: Occlusal disharmony is known to affect not only the oral cavity environment, but also the autonomic nervous system in the heart. Since the renin-angiotensin system (RAS) inhibitor captopril (Cap) is one of the first-line drugs for preventing cardiac ... ...

Abstract	Occlusal disharmony is known to affect not only the oral cavity environment, but also the autonomic nervous system in the heart. Since the renin-angiotensin system (RAS) inhibitor captopril (Cap) is one of the first-line drugs for preventing cardiac remodeling in patients with heart failure, we hypothesized that Cap might prevent cardiac dysfunction induced by occlusal disharmony. Here, to test this idea, we used our bite-opening (BO) mouse model, which was developed by cementing a suitable appliance onto the mandibular incisor. Mice were divided into four groups: (1) Control, (2) BO, (3) Cap, and (4) BO + Cap. After 2 weeks, we evaluated cardiac function by echocardiography and confirmed that cardiac function was significantly decreased in the BO group compared to the control, while Cap ameliorated the dysfunction. Cardiac fibrosis, myocyte apoptosis and oxidative stress-induced myocardial damage in the BO group were significantly increased versus the control, and these increases were suppressed by Cap. Cardiac dysfunction induced by BO was associated with dual phosphorylation on PKCδ (Tyr-311/Thr-505), leading to activation of CaMKII with increased phosphorylation of RyR2 and phospholamban. Our results suggest that the RAS might play an important role in the development of cardiac diseases induced by occlusal anomalies.
MeSH term(s)	Humans ; Mice ; Animals ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Captopril/pharmacology ; Heart ; Myocardium ; Heart Failure ; Enzyme Inhibitors
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Captopril (9G64RSX1XD) ; Enzyme Inhibitors
Language	English
Publishing date	2023-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-43099-6
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Article ; Online: Oral angiotensin-converting enzyme inhibitor captopril protects the heart from Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice.

Kiyomoto, Kenichi / Matsuo, Ichiro / Suita, Kenji / Ohnuki, Yoshiki / Ishikawa, Misao / Ito, Aiko / Mototani, Yasumasa / Tsunoda, Michinori / Morii, Akinaka / Nariyama, Megumi / Hayakawa, Yoshio / Amitani, Yasuharu / Gomi, Kazuhiro / Okumura, Satoshi

PloS one

2023 Volume 18, Issue 11, Page(s) e0292624

Abstract: Although angiotensin converting enzyme (ACE) inhibitors are considered useful for the treatment of human heart failure, some experimental failing-heart models have shown little beneficial effect of ACE inhibitors in animals with poor oral health, ... ...

Abstract	Although angiotensin converting enzyme (ACE) inhibitors are considered useful for the treatment of human heart failure, some experimental failing-heart models have shown little beneficial effect of ACE inhibitors in animals with poor oral health, particularly periodontitis. In this study, we examined the effects of the ACE inhibitor captopril (Cap; 0.1 mg/mL in drinking water) on cardiac dysfunction in mice treated with Porphyromonas gingivalis lipopolysaccharide (PG-LPS) at a dose (0.8 mg/kg/day) equivalent to the circulating level in patients with periodontal disease. Mice were divided into four groups: 1) Control, 2) PG-LPS, 3) Cap, and 4) PG-LPS + Cap. After1 week, we evaluated cardiac function by echocardiography. The left ventricular ejection fraction was significantly decreased in PG-LPS-treated mice compared to the control (from 66 ± 1.8 to 59 ± 2.5%), while Cap ameliorated the dysfunction (63 ± 1.1%). The area of cardiac fibrosis was significantly increased (approximately 2.9-fold) and the number of apoptotic myocytes was significantly increased (approximately 5.6-fold) in the heart of PG-LPS-treated group versus the control, and these changes were suppressed by Cap. The impairment of cardiac function in PG-LPS-treated mice was associated with protein kinase C δ phosphorylation (Tyr-311), leading to upregulation of NADPH oxidase 4 and xanthine oxidase, and calmodulin kinase II phosphorylation (Thr-286) with increased phospholamban phosphorylation (Thr-17). These changes were also suppressed by Cap. Our results suggest that the renin-angiotensin system might play an important role in the development of cardiac diseases induced by PG-LPS.
MeSH term(s)	Humans ; Mice ; Animals ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Captopril/pharmacology ; Captopril/therapeutic use ; Lipopolysaccharides/toxicity ; Lipopolysaccharides/therapeutic use ; Porphyromonas gingivalis ; Stroke Volume ; Ventricular Function, Left ; Heart Failure/drug therapy
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Captopril (9G64RSX1XD) ; Lipopolysaccharides
Language	English
Publishing date	2023-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0292624
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Article ; Online: Vidarabine, an anti-herpes agent, improves Porphyromonas gingivalis lipopolysaccharide-induced cardiac dysfunction in mice.

Tsunoda, Michinori / Matsuo, Ichiro / Ohnuki, Yoshiki / Suita, Kenji / Ishikawa, Misao / Mitsubayashi, Takao / Ito, Aiko / Mototani, Yasumasa / Kiyomoto, Kenichi / Morii, Akinaka / Nariyama, Megumi / Hayakawa, Yoshio / Gomi, Kazuhiro / Okumura, Satoshi

The journal of physiological sciences : JPS

2023 Volume 73, Issue 1, Page(s) 18

Abstract: In this work, we examined the involvement of type 5 adenylyl cyclase (AC5) in cardiac dysfunction induced in mice given Porphyromonas gingivalis lipopolysaccharide (PG-LPS) at a dose equivalent to the circulating levels in periodontitis (PD) patients. ... ...

Abstract	In this work, we examined the involvement of type 5 adenylyl cyclase (AC5) in cardiac dysfunction induced in mice given Porphyromonas gingivalis lipopolysaccharide (PG-LPS) at a dose equivalent to the circulating levels in periodontitis (PD) patients. Cardiac function was significantly decreased in mice given PG-LPS compared to the control, but treatment for 1 week with the AC5 inhibitor vidarabine ameliorated the dysfunction. Cardiac fibrosis and myocyte apoptosis were significantly increased in the PG-LPS group, but vidarabine blocked these changes. The PG-LPS-induced cardiac dysfunction was associated with activation of cyclic AMP/Ca
MeSH term(s)	Mice ; Animals ; Vidarabine ; Lipopolysaccharides/toxicity ; Porphyromonas gingivalis ; Heart ; Cardiomyopathies
Chemical Substances	Vidarabine (FA2DM6879K) ; Lipopolysaccharides
Language	English
Publishing date	2023-08-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2234472-X
ISSN	1880-6562 ; 1880-6546
ISSN (online)	1880-6562
ISSN	1880-6546
DOI	10.1186/s12576-023-00873-5
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Article ; Online: Role of TLR4 signaling on Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice.

Matsuo, Ichiro / Kawamura, Naoya / Ohnuki, Yoshiki / Suita, Kenji / Ishikawa, Misao / Matsubara, Takehiro / Mototani, Yasumasa / Ito, Aiko / Hayakawa, Yoshio / Nariyama, Megumi / Morii, Akinaka / Kiyomoto, Kenichi / Tsunoda, Michinori / Gomi, Kazuhiro / Okumura, Satoshi

PloS one

2022 Volume 17, Issue 6, Page(s) e0258823

Abstract: Oral infections, particularly periodontitis, are a well-established risk factor for cardiovascular diseases, although the molecular mechanisms involved remain elusive. The aims of the present study were to investigate the effects of lipopolysaccharide ... ...

Abstract	Oral infections, particularly periodontitis, are a well-established risk factor for cardiovascular diseases, although the molecular mechanisms involved remain elusive. The aims of the present study were to investigate the effects of lipopolysaccharide derived from Porphyromonas gingivalis (PG-LPS) on cardiac function in mice, and to elucidate the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) with or without an inhibitor of Toll-like receptor 4 (TLR4) signaling (TAK-242, 0.8 mg/kg/day) for 4 weeks. Left ventricular ejection function was significantly decreased at 1 week (from 67 ± 0.5 to 58 ± 1.2%) and remained low at 4 weeks (57 ± 1.0%). The number of apoptotic myocytes was increased (approximately 7.4-fold), the area of fibrosis was increased (approximately 3.3-fold) and the number of 8-hydroxydeoxyguanosine-positive myocytes, a sensitive indicator of oxidative DNA damage, was increased (approximately 7.6-fold) at 4 weeks in the heart of PG-LPS treated mice. However, levels of various serum pro-inflammatory cytokines in PG-LPS-treated mice were similar to those in control mice. The impairment of cardiac function in PG-LPS-treated mice appears to involve activation of TLR4-NADPH oxidase (NOX) 4 signaling, leading to abundant production of reactive oxygen species and Ca2+ leakage from sarcoplastic reticulumn induced by calmodulin kinase II (CaMKII)-mediated phosphorylation of phospholamban (at Thr-17) and ryanodine receptor 2 (at Ser-2448). Pharmacological inhibition of TLR4 with TAK-242 attenuated the changes in cardiac function in PG-LPS-treated mice. Our results indicate that TLR4-NOX4 signaling may be a new therapeutic target for treatment of cardiovascular diseases in patients with periodontitis.
MeSH term(s)	Animals ; Cardiovascular Diseases ; Heart Diseases ; Lipopolysaccharides/pharmacology ; Mice ; Mice, Inbred C57BL ; Periodontitis ; Porphyromonas gingivalis ; Toll-Like Receptor 4/physiology
Chemical Substances	Lipopolysaccharides ; Tlr4 protein, mouse ; Toll-Like Receptor 4
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0258823
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Article ; Online: Vidarabine, an anti-herpes agent, prevents occlusal-disharmony-induced cardiac dysfunction in mice.

Hayakawa, Yoshio / Suita, Kenji / Ohnuki, Yoshiki / Mototani, Yasumasa / Ishikawa, Misao / Ito, Aiko / Nariyama, Megumi / Morii, Akinaka / Kiyomoto, Kenichi / Tsunoda, Michinori / Matsuo, Ichiro / Kawahara, Hiroshi / Okumura, Satoshi

The journal of physiological sciences : JPS

2022 Volume 72, Issue 1, Page(s) 2

Abstract: We recently reported a positive relationship between occlusal disharmony and cardiovascular disease via activation of β-adrenergic signaling in mice. Furthermore, inhibition of type 5 adenylyl cyclase (AC5), a major cardiac subtype in adults, protects ... ...

Abstract	We recently reported a positive relationship between occlusal disharmony and cardiovascular disease via activation of β-adrenergic signaling in mice. Furthermore, inhibition of type 5 adenylyl cyclase (AC5), a major cardiac subtype in adults, protects the heart against oxidative stress. Here, we examined the role of AC5 in the development of occlusal-disharmony-induced cardiovascular disease in bite-opening (BO) mice, prepared by cementing a suitable appliance onto the mandibular incisor. We first examined the effects of BO treatment on cardiac function in mice treated or not treated for 2 weeks with vidarabine, which we previously identified as an inhibitor of cardiac AC. Cardiac function was significantly decreased in the BO group compared to the control group, but vidarabine ameliorated the dysfunction. Cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage were significantly increased in the BO group, but vidarabine blocked these changes. The BO-induced cardiac dysfunction was associated with increased phospholamban phosphorylation at threonine-17 and serine-16, as well as increased activation of the Ca
MeSH term(s)	Adenylyl Cyclases ; Animals ; Apoptosis ; Heart ; Heart Diseases ; Mice ; Mice, Knockout ; Myocytes, Cardiac ; Vidarabine
Chemical Substances	Adenylyl Cyclases (EC 4.6.1.1) ; Vidarabine (FA2DM6879K)
Language	English
Publishing date	2022-02-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2234472-X
ISSN	1880-6562 ; 1880-6546
ISSN (online)	1880-6562
ISSN	1880-6546
DOI	10.1186/s12576-022-00826-4
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Article ; Online: Effects of chronic Porphylomonas gingivalis lipopolysaccharide infusion on cardiac dysfunction in mice.

Matsuo, Ichiro / Ohnuki, Yoshiki / Suita, Kenji / Ishikawa, Misao / Mototani, Yasumasa / Ito, Aiko / Hayakawa, Yoshio / Nariyama, Megumi / Morii, Akinaka / Kiyomoto, Kenichi / Tsunoda, Michinori / Gomi, Kazuhiro / Okumura, Satoshi

Journal of oral biosciences

2021 Volume 63, Issue 4, Page(s) 394–400

Abstract: Objective: Periodontitis (PD) is a chronic inflammatory disease of tooth-supportive tissue. An association between PD and cardiovascular disease (CVD) has been established. Although PD is generally accepted as a risk factor for CVD, the existence of a ... ...

Abstract	Objective: Periodontitis (PD) is a chronic inflammatory disease of tooth-supportive tissue. An association between PD and cardiovascular disease (CVD) has been established. Although PD is generally accepted as a risk factor for CVD, the existence of a relationship remains debatable. Possible mechanisms include the release of inflammatory mediators such as lipopolysaccharide (LPS), which may spread systemically and promote CVD. Methods: To compare the effects of lipopolysaccharide derived from Porphylomonas gingivalis (PG-LPS) on cardiac muscle in mice, mice were treated for 1 week with/without PG-LPS at a dose equivalent to the circulating level in PD patients (0.8 mg/kg/day). Results: Cardiac function in terms of left ventricular ejection function was significantly decreased at 1 week compared to that in the control (from 66 ± 0.5% to 57 ± 1.1%). Compared to the controls, the number of apoptotic myocytes and the area of fibrosis were significantly increased by approximately 2.7-fold and 14-fold, respectively. The impairment of cardiac function appeared to involve the activation of cAMP/PKA signaling and cAMP/calmodulin kinase II signaling (CaMKII), leading to cardiac fibrosis, myocyte apoptosis and heart failure. Conclusions: Our results indicate that cAMP/PKA and cAMP/CaMKII signaling may be a new therapeutic target for the treatment of cardiovascular diseases in patients with periodontitis.
MeSH term(s)	Animals ; Apoptosis ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/pharmacology ; Heart Failure/drug therapy ; Humans ; Lipopolysaccharides/toxicity ; Mice ; Myocardium
Chemical Substances	Lipopolysaccharides ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17)
Language	English
Publishing date	2021-10-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218267-6
ISSN	1880-3865 ; 1349-0079
ISSN (online)	1880-3865
ISSN	1349-0079
DOI	10.1016/j.job.2021.10.001
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Article ; Online: MyoD is regulated by the miR-29a-Tet1 pathway in C2C12 myoblast cells.

Chikenji, Akiyoshi / Ando, Hitoshi / Nariyama, Megumi / Suga, Takeo / Iida, Ryohei / Gomi, Kazuhiro

Journal of oral science

2016 Volume 58, Issue 2, Page(s) 219–229

Abstract: Skeletal myogenesis is regulated by a considerable number of microRNAs (miRNAs). miRNA regulatory networks are complicated, and details of how they operate remain unclear. In this study, MTT assays confirmed that miR-29a is the most effective miR-29 ... ...

Abstract	Skeletal myogenesis is regulated by a considerable number of microRNAs (miRNAs). miRNA regulatory networks are complicated, and details of how they operate remain unclear. In this study, MTT assays confirmed that miR-29a is the most effective miR-29 paralog. Microarray analysis demonstrated upregulation of ten-eleven translocation enzyme-1 (Tet1) mRNA in response to miR-29a inhibition in C2C12 murine myoblast cells. We investigated the factors acting downstream in the miR-29a-Tet1 signal pathway using real-time RT-PCR. MyoD expression was upregulated by Tet1 inhibition and downregulated by miR-29a inhibition, whereas expression of cyclin-dependent kinase 6 (Cdk6) was regulated in an opposite manner. These results suggest that the miR-29a-Tet1 pathway upregulates MyoD expression and conversely downregulates Cdk6 expression. However, changes in the expression of other myogenic factors such as serum response factor (Srf), the myocyte enhancer factor 2 family (Mef2a, b and c), myogenin, myogenic regulatory factor 4 (Mrf4), muscle creatine kinase (Mck), and other cell cycle regulators such as Cdk4 and thymine DNA glycosylase (Tdg) cannot be explained in terms of the miR-29a-Tet1 pathway alone. The miR29a-Tet1 pathway may be part of a complex myogenic regulatory network in C2C12 cells. (J Oral Sci 58, 219-229, 2016).
MeSH term(s)	Animals ; Cell Line ; DNA-Binding Proteins/genetics ; Mice ; MicroRNAs/genetics ; MyoD Protein/genetics ; Myoblasts/cytology ; Myoblasts/metabolism ; Proto-Oncogene Proteins/genetics
Chemical Substances	DNA-Binding Proteins ; MIRN29 microRNA, mouse ; MicroRNAs ; MyoD Protein ; Proto-Oncogene Proteins ; TET1 protein, mouse
Language	English
Publishing date	2016
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1434462-2
ISSN	1880-4926 ; 1343-4934
ISSN (online)	1880-4926
ISSN	1343-4934
DOI	10.2334/josnusd.15-0684
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Article ; Online: Effects of occlusal disharmony on susceptibility to atrial fibrillation in mice.

Suita, Kenji / Yagisawa, Yuka / Ohnuki, Yoshiki / Umeki, Daisuke / Nariyama, Megumi / Ito, Aiko / Hayakawa, Yoshio / Matsuo, Ichiro / Mototani, Yasumasa / Saeki, Yasutake / Okumura, Satoshi

Scientific reports

2020 Volume 10, Issue 1, Page(s) 13765

Abstract: Tooth loss or incorrect positioning causes occlusal disharmony. Furthermore, tooth loss and atrial fibrillation (AF) are both risk factors for ischemic stroke and coronary heart disease. Therefore, we hypothesized that occlusal disharmony-induced stress ... ...

Abstract	Tooth loss or incorrect positioning causes occlusal disharmony. Furthermore, tooth loss and atrial fibrillation (AF) are both risk factors for ischemic stroke and coronary heart disease. Therefore, we hypothesized that occlusal disharmony-induced stress increases susceptibility to AF, and we designed the present study to test this idea in mice. Bite-opening (BO) was done by cementing a suitable appliance onto the mandibular incisor to cause occlusal disharmony by increasing the vertical height of occlusion by 0.7 mm for a period of 2 weeks. AF susceptibility, evaluated in terms of the duration of AF induced by transesophageal burst pacing, was significantly increased concomitantly with atrial remodeling, including fibrosis, myocyte apoptosis and oxidative DNA damage, in BO mice. The BO-induced atrial remodeling was associated with increased calmodulin kinase II-mediated ryanodine receptor 2 phosphorylation on serine 2814, as well as inhibition of Akt phosphorylation. However, co-treatment with propranolol, a non-selective β-blocker, ameliorated these changes in BO mice. These data suggest that improvement of occlusal disharmony by means of orthodontic treatment might be helpful in the treatment or prevention of AF.
MeSH term(s)	Adrenergic beta-Antagonists/therapeutic use ; Animals ; Apoptosis/physiology ; Atrial Fibrillation/pathology ; Atrial Fibrillation/prevention & control ; Atrial Remodeling/physiology ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Coronary Disease/etiology ; Coronary Disease/pathology ; Disease Susceptibility ; Fibrosis/pathology ; Ischemic Stroke/etiology ; Ischemic Stroke/pathology ; Male ; Malocclusion/pathology ; Malocclusion/therapy ; Mice ; Mice, Inbred C57BL ; Muscle Cells/pathology ; Orthodontics/methods ; Oxidative Stress/genetics ; Phosphorylation ; Propranolol/therapeutic use ; Proto-Oncogene Proteins c-akt/metabolism ; Ryanodine Receptor Calcium Release Channel/metabolism
Chemical Substances	Adrenergic beta-Antagonists ; Ryanodine Receptor Calcium Release Channel ; ryanodine receptor 2. mouse ; Propranolol (9Y8NXQ24VQ) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Calcium-Calmodulin-Dependent Protein Kinases (EC 2.7.11.17)
Language	English
Publishing date	2020-08-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-70791-8
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Article ; Online: Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage in mice.

Yagisawa, Yuka / Suita, Kenji / Ohnuki, Yoshiki / Ishikawa, Misao / Mototani, Yasumasa / Ito, Aiko / Matsuo, Ichiro / Hayakawa, Yoshio / Nariyama, Megumi / Umeki, Daisuke / Saeki, Yasutake / Amitani, Yasuharu / Nakamura, Yoshiki / Tomonari, Hiroshi / Okumura, Satoshi

PloS one

2020 Volume 15, Issue 7, Page(s) e0236547

Abstract: Occlusal disharmony leads to morphological changes in the hippocampus and osteopenia of the lumbar vertebra and long bones in mice, and causes stress. Various types of stress are associated with increased incidence of cardiovascular disease, but the ... ...

Abstract	Occlusal disharmony leads to morphological changes in the hippocampus and osteopenia of the lumbar vertebra and long bones in mice, and causes stress. Various types of stress are associated with increased incidence of cardiovascular disease, but the relationship between occlusal disharmony and cardiovascular disease remain poorly understood. Therefore, in this work, we examined the effects of occlusal disharmony on cardiac homeostasis in bite-opening (BO) mice, in which a 0.7 mm space was introduced by cementing a suitable applicance onto the mandibular incisior. We first examined the effects of BO on the level of serum corticosterone, a key biomarker for stress, and on heart rate variability at 14 days after BO treatment, compared with baseline. BO treatment increased serum corticosterone levels by approximately 3.6-fold and the low frequency/high frequency ratio, an index of sympathetic nervous activity, was significantly increased by approximately 4-fold by the BO treatment. We then examined the effects of BO treatment on cardiac homeostasis in mice treated or not treated with the non-selective β-blocker propranolol for 2 weeks. Cardiac function was significantly decreased in the BO group compared to the control group, but propranolol ameliorated the dysfunction. Cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage were significantly increased in the BO group, but propranolol blocked these changes. The BO-induced cardiac dysfunction was associated with increased phospholamban phosphorylation at threonine-17 and serine-16, as well as inhibition of Akt/mTOR signaling and autophagic flux. These data suggest that occlusal disharmony might affect cardiac homeostasis via alteration of the autonomic nervous system.
MeSH term(s)	Animals ; Apoptosis ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Corticosterone/blood ; DNA Damage ; Electrocardiography ; Fibrosis ; Mice ; Mice, Inbred C57BL ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/metabolism ; Oxidative Stress ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction ; Stress, Physiological ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Proto-Oncogene Proteins c-bcl-2 ; mTOR protein, mouse (EC 2.7.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2020-07-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0236547
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Article ; Online: Gender differences in eating behavior and masticatory performance: An analysis of the Three-Factor-Eating Questionnaire and its association with body mass index in healthy subjects.

Shiozawa, Kouichi / Mototani, Yasumasa / Suita, Kenji / Ito, Aiko / Matsuo, Ichiro / Hayakawa, Yoshio / Kiyomoto, Kenichi / Tsunoda, Michinori / Nariyama, Megumi / Umeki, Daisuke / Ohnuki, Yoshiki / Okumura, Satoshi

Journal of oral biosciences

2020 Volume 62, Issue 4, Page(s) 357–362

Abstract: Objectives: The Three-Factor-Eating Questionnaire (TFEQ) is an established instrument to assess eating behavior in terms of dietary restraint, disinhibition and hunger.: Methods: The aims of this study were to examine (1) the correlation between ... ...

Abstract	Objectives: The Three-Factor-Eating Questionnaire (TFEQ) is an established instrument to assess eating behavior in terms of dietary restraint, disinhibition and hunger. Methods: The aims of this study were to examine (1) the correlation between eating behavior and body mass index (BMI), (2) the correlation between eating behavior and masticatory performance in terms of bite size and eating speed, and (3) the effects of gender on these correlations in 56 healthy subjects (33 males [21.9 ± 2.8 years old] and 23 females [21.7 ± 2.2 years old]). Results: We found a significant correlation between restraint and BMI only in females and between hunger and BMI only in males. However, disinhibition and BMI were significantly correlated in both males and females. We also found a significant correlation between bite size and hunger only in males and between eating speed and disinhibition in both males and females. Conclusions: These findings underline the importance of gender-specific counselling and behavioral treatment of obesity.
MeSH term(s)	Adult ; Body Mass Index ; Feeding Behavior ; Female ; Healthy Volunteers ; Humans ; Male ; Sex Characteristics ; Surveys and Questionnaires ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-09-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218267-6
ISSN	1880-3865 ; 1349-0079
ISSN (online)	1880-3865
ISSN	1349-0079
DOI	10.1016/j.job.2020.09.005
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