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Article ; Online: Generalized lymph node activation after Influenza vaccination on 18F FDG-PET/CT imaging, an important pitfall in PET interpretation

Narjess Ayati / Sarah Jesudason / Salvatore Berlangieri / Andrew Scott

Asia Oceania Journal of Nuclear Medicine and Biology, Vol 5, Iss 2, Pp 157-

2017 Volume 160

Abstract: We report on a 59-year-old female patient with an infected vascular graft investigated with 18F FDG-PET/CT. The first of two studies showed FDG activity in the left deltoid and ipsilateral axillary lymph nodes explained by influenza vaccination the day ... ...

Abstract	We report on a 59-year-old female patient with an infected vascular graft investigated with 18F FDG-PET/CT. The first of two studies showed FDG activity in the left deltoid and ipsilateral axillary lymph nodes explained by influenza vaccination the day prior. The second 18F FDG-PET/CT showed multiple FDG-avid lymph nodes on both sides of the diaphragm without tracer accumulation at the vaccination site. Three months later the CT was negative for lymphadenopathy within the chest or abdominal region. Although influenza vaccination is a potential source of false positive results in FDG PET studies, generalised lymph node activation post vaccination is a rare finding with only one prior published report in individuals infected with HIV-1. This case emphasizes the necessity of taking a history of vaccination prior to a FDG PET study, and consideration of a vaccine-related immune response even without evidence of tracer activity at the vaccination site when generalised FDG-avid lymphadenopathy is encountered.
Keywords	18F FDG-PET ; Influenza vaccination ; Immunization ; Lymph node ; false positive ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sagliker Syndrome in a Patient with Secondary Hyperparathyroidism and Chronic Renal Insufficiency

Sara Shakeri / Soroush Zarehparvar Moghadam / Ramin Sadeghi / Narjess Ayati

Asia Oceania Journal of Nuclear Medicine and Biology, Vol 6, Iss 2, Pp 167-

A Case Report

2018 Volume 170

Abstract: Sagliker syndrome is a rare form of renal osteodystrophy resulted fromuntreated secondary hyperparathyroidism. It is described by severeskeletal deformities, high level of PTH in patients with chronic renalfailure, and deformed face. This paper reports a ...

Abstract	Sagliker syndrome is a rare form of renal osteodystrophy resulted fromuntreated secondary hyperparathyroidism. It is described by severeskeletal deformities, high level of PTH in patients with chronic renalfailure, and deformed face. This paper reports a 44-year-old male patientwith the mentioned characteristics. In addition to the unique clinicalfeatures, high levels of ALP and PTH hormones encouraged us to searchfor syndrome-like a disease, which clinically and paraclinically matchedthe Sagliker syndrome.This case highlights the importance of clinicians’ attention for earlymonitoring and appropriate treatment as it is shown to be effectivein preventing irreversible complications such as soft tissue andbone abnormalities and cardiovascular impairment in patientswith Sagliker syndrome. Therefore, considering the syndrome isrecommended as one of the diagnostic hypothesis in young patientswith renal insufficiency, secondary hyperparathyroidism, and skeletaldeformities.
Keywords	chronic renal failure ; renal osteodystrophy ; Sagliker syndrome ; secondary hyperparathyroidism ; skeletal deformity ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ectopic papillary thyroid carcinoma in the mediastinum without any tumoral involvement in the thyroid gland. A Case report

Susan Shafiee / Narjess Ayati

Asia Oceania Journal of Nuclear Medicine and Biology, Vol 1, Iss 1, Pp 44-

2013 Volume 46

Abstract: Ectopic thyroid tissue results from abnormal embryologic development and migration of the thyroid gland. True malignant transformation in ectopic thyroid tissue is extremely rare and is always diagnosed after surgical excision of the lesion by pathology ... ...

Abstract	Ectopic thyroid tissue results from abnormal embryologic development and migration of the thyroid gland. True malignant transformation in ectopic thyroid tissue is extremely rare and is always diagnosed after surgical excision of the lesion by pathology examinations. There are well-documented cases of ectopic thyroid cancer while primary tumoral lesion occurs in the orthotopic thyroid, but only rare cases of ectopic PTC without any evidence of occult thyroid cancer in the orthotopic thyroid or cervical lymph nodes have been reported. We report on a 39 year old woman who was operated for a mediastinal mass. The initial diagnosis was a malignant thymic lesion, which was later confirmed to be a papillary thyroid carcinoma. Consequently, total thyroidectomy was performed and pathology report showed normal thyroid tissue with no evidence of any neoplastic involvement. Until now, only one similar case has been reported.
Keywords	Papillary thyroid carcinoma ; Ectopic PTC ; Ectopic thyroid ; mediastinal mass ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2013-04-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Treatment efficacy of 153Sm-EDTMP for painful bone metastasis

Narjess Ayati / Kamran Aryana

Asia Oceania Journal of Nuclear Medicine and Biology, Vol 1, Iss 1, Pp 27-

2013 Volume 31

Abstract: Introduction: Involvement of the skeleton can cause an excruciating pain in two-thirds of terminal patients with a history of malignancy. Due to several limitations of other therapies, such as analgesics, bisphosphonates, chemotherapy, hormonal therapy ... ...

Abstract	Introduction: Involvement of the skeleton can cause an excruciating pain in two-thirds of terminal patients with a history of malignancy. Due to several limitations of other therapies, such as analgesics, bisphosphonates, chemotherapy, hormonal therapy and external beam radiotherapy; bone-seeking radiopharmaceuticals have an important role in palliation of pain from bone metastases. Although these kinds of therapies have many advantages including the ability to treat multiple sites of tumoral involvement simultaneously, no significant confliction with other treatments, ease of administration and the potential to be used repetitively; in Iran using of this modality is not widely practiced. In this study we evaluated the clinical usefulness of Sm-153 lexidronamfor pain management of bone metastases. Methods: 28 patients (14 males and 14 females) aged 38-77 years with a history of painful bone metastases caused by different cancers, not responding to conventional treatments were included in the study. All patients had a recent whole body bone scan indicating multiple bone metastases. 1 mCi/Kg Sm-153 lexidronam was injected intravenously to the patients. Whole body scintigraphy was done 3 or 18 hours post injection. Pain relief and quality of life have been evaluated by analog pain scale and Karnofsky index every week, respectively. Also, all patients were evaluated for hematological toxicity every two weeks. Active follow ups were performed. Results: 43% of patients showed the presence of the flare phenomenon during the first three days after Sm injection with a mean duration of 2.2 days. The pain relief began between 2 and 16 days post injection and the duration of pain palliation was in the range of 4 to 32 weeks (mean±SD=15.22±7.8). 64.3% of patients showed complete relief of pain and 21.4% achieved partial response to therapy. (Over all response to therapy was 85.7%). The lowest amount of peripheral blood cells was detected in the fourth week for RBCs and in the 6th week for WBCs and PLTs. No one experienced ...
Keywords	Radionuclide Therapy ; Samarium ; 153Sm-EDTMP ; painful bone metastasis ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2013-04-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of radioiodine therapy on pregnancy and its complication in differentiated thyroid cancer comparing with their healthy sisters

Atiyeh Vatanchi / Narjess Ayati / Susan Shafiei / Farzane Ashourzade / Leila Purali / Seyed Rasoul Zakavi

Tehran University Medical Journal, Vol 77, Iss 7, Pp 445-

2019 Volume 452

Abstract: Background: Differentiated thyroid cancer (DTC) frequently occurs in women at fertility age. One of the cornerstones in treating this malignancy is Radioactive Iodine (RAI) therapy following thyroid resection. In this study, we evaluated the effect of ... ...

Abstract	Background: Differentiated thyroid cancer (DTC) frequently occurs in women at fertility age. One of the cornerstones in treating this malignancy is Radioactive Iodine (RAI) therapy following thyroid resection. In this study, we evaluated the effect of RAI therapy on the fertility rate and pregnancy complications. Methods: This is a retrospective study on 41 patients with differentiated thyroid cancer, with at least one experience of pregnancy after standard treatment (thyroid resection followed by radioiodine therapy). All patients have been signed a written consent form in initial admission to our department. Furthermore, we asked our patients to fill in a questionnaire about their thyroid cancer and its treatment as well as pregnancy and its complication. As a control group with no different mean age, the same checklist has also been filled in for the patient’s healthy sister too, just related to gravidity and its complications. The complications of pregnancy were registered in these patients and compared with the control group consisted of their healthy sisters. Also, the association of abortion rate with other underlying factors has been assessed. All data has been included in SPSS software, version 22 (IBM SPSS, Armonk, NY, USA) and analyzed using logistic regression. This study conducted at the Nuclear Medicine Department of Ghaem Hospital in Mashhad, from May 2017 to February 2018 with the support of Mashhad University of Medical Sciences, Iran. Results: No significant difference was noted in the mean age between case (differentiated thyroid cancer) and control groups (P=0.9). The two groups were also statistically similar in terms of pregnancy frequency (P=0.05) and number of alive children (P=0.8). Abortion seems to be the only item in DTC patients which was more than healthy sisters (0.2 versus 0.7) (P=0.003). However, this statistical difference showed no direct relationship with radioiodine treatment (RIT). As in DTC patients before and after RIT, no significant difference has been detected in DTC ...
Keywords	abortion ; iodine ; pregnancy ; retrospective studies ; thyroid neoplasms ; Medicine (General) ; R5-920
Subject code	610
Language	Persian
Publishing date	2019-10-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Rare Presentation of Colorectal Cancer with Unusual Progressive Intramuscular and Subcutaneous Metastatic Spread

Reyhaneh Manafi-Farid / Narjess Ayati / Mohammad Eftekhari / Babak Fallahi / Fardad Masoumi

Asia Oceania Journal of Nuclear Medicine and Biology, Vol 7, Iss 1, Pp 89-

2019 Volume 94

Abstract: Colorectal carcinoma is one of the most common causes of cancer-related death, worldwide. Recently, due to the introduction of novel imaging and therapeutic techniques, five-year survival of patients has increased. However, distant metastasis is still ... ...

Abstract	Colorectal carcinoma is one of the most common causes of cancer-related death, worldwide. Recently, due to the introduction of novel imaging and therapeutic techniques, five-year survival of patients has increased. However, distant metastasis is still expected in half of the patients. Colorectal cancer tends to target the abdominal cavity, liver, lungs, and bones as the common sites of metastasis. Nevertheless, rare cases of muscle metastasis have been reported. This report presents a 23-year-old male, who despite chemotherapy, demonstrated gradual progressive disease and metastases to the submandibular region, lungs, adrenal gland as well as muscles and subcutaneous tissues. He had developed multiple asymptomatic muscular metastases metachronously over two-year time period discovered on an 18FDGPET/CT, namely in the deltoid, external oblique abdominis, rectus abdominis, and quadriceps muscles, as well as one of the extrinsic muscles of the tongue. The presence of distant, especially extrahepatic metastasis, adversely affects the prognosis of colon carcinoma. Since limited cases of muscle metastasis have been reported in carcinoma of colon, the underlying pathophysiology, optimum treatment, and prognostic issues are yet to be substantiated.
Keywords	Colorectal carcinoma ; Muscle metastasis ; Rare metastasis ; 18F-fluorodeoxyglucose PET/CT ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Extraosseous accumulation of Technetium-99m-Methyl Diphosphonate (99mTc-MDP) in a child with ALL

Farnaz Banezhad / Narjess Ayati / Farrokh Seilanian Toosi / Samineh Boloursaz / Seyed Rasoul Zakavi

Asia Oceania Journal of Nuclear Medicine and Biology, Vol 6, Iss 1, Pp 57-

A Case Report

2018 Volume 60

Abstract: Extraosseous accumulation of technetium-99m-methyl diphosphonate (99mTc-MDP) on bone scan is not common. This phenomenon is often attributed to abnormality of calcium metabolism and has been reported in a variety of conditions including metabolic ... ...

Abstract	Extraosseous accumulation of technetium-99m-methyl diphosphonate (99mTc-MDP) on bone scan is not common. This phenomenon is often attributed to abnormality of calcium metabolism and has been reported in a variety of conditions including metabolic diseases and malignancies. A five years old boy is presented here, who was admitted to the pediatric emergency suffering from fatigue, respiratory symptoms, weight loss, intermittent fevers, anorexia, nausea and vomiting, edema of legs and abdominal distension for one month. The initial laboratory analysis revealed hypercalcemia. The patient was referred for whole body bone scan with suspicion of malignancy and bone metastasis. The bone scan revealed highly increased radiotracer uptake in both lungs in the perfusion and blood pool phases. Delayed images also showed increased activity in lungs and gastric wall. The skeleton was not seen clearly. Bone marrow aspiration was done and established the diagnosis of ALL. The patient deceased due to respiratory failure 20 days later. Diffuse lung uptake in this patient was consistent with respiratory failure and poor prognosis. It is reported that bone scan may be useful for assessment of the extent of metastatic calcification and may establish suitable management to prevent organ failure.
Keywords	acute lymphoblastic leukemia ; technetium-99m-methyl diphosphonate(99mTC-MDP) ; bone scan ; lung uptake ; hypercalcemia ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of Treatment Response Achieved by Tablet Splitting Versus Whole Tablet Administration of Levothyroxine in Patients with Thyroid Cancer

Ramin Ashrafpour / Narjess Ayati / Ramin Sadeghi / Samira Zare Namdar / Nayyereh Ayati / Somaye Ghahremani / Seyed Rasoul Zakavi

Asia Oceania Journal of Nuclear Medicine and Biology, Vol 6, Iss 2, Pp 108-

2018 Volume 112

Abstract: Objective(s): TSH suppression by Levothyroxine consumption is a mainstayof thyroid cancer treatment. Tablet-splitting is a worldwide approach in doseadjustment in patients. However, it is highly recommended to evaluate the validityof tablet splitting for ...

Abstract	Objective(s): TSH suppression by Levothyroxine consumption is a mainstayof thyroid cancer treatment. Tablet-splitting is a worldwide approach in doseadjustment in patients. However, it is highly recommended to evaluate the validityof tablet splitting for each distinctive drug by clinical trials before routinely usingtablet halves in clinical practice. In this study we compared the effect of 150 μg doseof Levothyroxine by use of a100 and a 50 μg tablets or one and half 100 μg tablets inDifferentiated thyroid cancer (DTC) patients.Methods: One hundred DTC patients treated with one and half 100 μg Levothyroxinetablets were randomly divided into two groups. The first group continued takingmedication as before and the second group received the same daily dose by taking one100 and one 50 microgram Levothyroxine tablets. The mean changes in TSH and T3levels and patients weight were compared between the groups.Results: 91 patients completed the study. Levothyroxine consumption pattern, age,gender distribution, weight and TSH levels were comparable between groups at thebeginning of the study. The mean change of body weights, serum levels of T3 and TSHshowed no significant difference between groups in different time points during thestudy (P>0.05).Conclusion: This study showed similar efficacy of tablet splitting and two tabletsadministration for Levothyroxine; however, patients preferred two tablets at the endof the study. It can be concluded that tablet splitting can be used as an alternative waywhen the 50 μg tablet is not available.
Keywords	Tablet splitting ; Differentiated thyroid cancer ; TSH ; Levothyroxine ; suppressive therapy ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A pooled analysis of diagnostic value of 99mTc-ubiquicidin (UBI) scintigraphy in detection of an infectious process.

Ramin, Sadeghi / Narjess, Ayati / Kamran, Aryana

Clinical nuclear medicine

2013 Volume 38, Issue 10, Page(s) 808–809

MeSH term(s)	Humans ; Infection/diagnostic imaging ; Organotechnetium Compounds ; Peptide Fragments ; Radionuclide Imaging
Chemical Substances	Organotechnetium Compounds ; Peptide Fragments
Language	English
Publishing date	2013-10
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0b013e3182a200c7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ectopic papillary thyroid carcinoma in the mediastinum without any tumoral involvement in the thyroid gland. A Case report

Susan Shafiee / Ali Sadrizade / Amirhosein Jafarian / Seyed Rasoul Zakavi / Narjess Ayati

Asia Oceania Journal of Nuclear Medicine and Biology, Vol 1, Iss 1, Pp 44-

2013 Volume 46

Abstract	Ectopic thyroid tissue results from abnormal embryologic development and migration of the thyroid gland. True malignant transformation in ectopic thyroid tissue is extremely rare and is always diagnosed after surgical excision of the lesion by pathology examinations. There are well-documented cases of ectopic thyroid cancer while primary tumoral lesion occurs in the orthotopic thyroid, but only rare cases of ectopic PTC without any evidence of occult thyroid cancer in the orthotopic thyroid or cervical lymph nodes have been reported. We report on a 39 year old woman who was operated for a mediastinal mass. The initial diagnosis was a malignant thymic lesion, which was later confirmed to be a papillary thyroid carcinoma. Consequently, total thyroidectomy was performed and pathology report showed normal thyroid tissue with no evidence of any neoplastic involvement. Until now, only one similar case has been reported.
Keywords	Papillary thyroid carcinoma ; Ectopic PTC ; Ectopic thyroid ; Mediastinal Mass ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2013-04-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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