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Article ; Online: All-optical half-adder in a linear three-core fiber device.

Martins, F L B / Rodrigues, J P T / Nascimento, J C

Applied optics

2023 Volume 62, Issue 18, Page(s) 4935–4941

Abstract: The half-adder is one of the most useful combinational logic functions for data processing. Many research papers in the literature propose nonlinear all-optical half-adders. Few studies propose linear all-optical devices, and those that do usually employ ...

Abstract	The half-adder is one of the most useful combinational logic functions for data processing. Many research papers in the literature propose nonlinear all-optical half-adders. Few studies propose linear all-optical devices, and those that do usually employ microstructured 2D photonic crystals. This work presents the numerical acquisition of an all-optical half-adder using a linear three-core fiber device. The device presents high performance and acceptable values of fabrication and modulation tolerance. It can be made using any fiber technology and propagated by pulses of any wavelength. Depending on the type of fiber used, the precision needed to fabricate the device's smallest structures can range from 20 nm to 90 nm. This result is evidence of the possibility of obtaining nonlinear logical processing using only fiber design.
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.489687
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Article ; Online: All-optical digital multiplexer/demultiplexer in a linear three-core fiber device.

Martins, F L B / Rodrigues, J P T / Nascimento, J C

Applied optics

2022 Volume 61, Issue 28, Page(s) 8515–8521

Abstract: Digital multiplexers/demultiplexers (MUX/DEMUXes) are essential for computing, data transmission, and data processing. However, research on all-optical digital MUX/DEMUXes is scarce and generally proposes single-function nonlinear devices. This work ... ...

Abstract	Digital multiplexers/demultiplexers (MUX/DEMUXes) are essential for computing, data transmission, and data processing. However, research on all-optical digital MUX/DEMUXes is scarce and generally proposes single-function nonlinear devices. This work presents the numerical acquisition of all-optical digital MUX/DEMUXes using a linear three-core fiber device. Our device, called the interchanging-cores planar three-core fiber coupler, is propagated by low-powered amplitude modulated pulses, can operate with pulses of any wavelength, and can be made using any fiber technology. This result is further evidence of the possibility of obtaining logical processing, even nonlinear logical processing, using fiber-only design.
Language	English
Publishing date	2022-10-03
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.470630
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Article ; Online: Linear multi-functional logic gate in a three-core photonic crystal fiber.

Rodrigues, J P T / Martins, F L B / Júnior, V P P / Nascimento, J C

Applied optics

2021 Volume 60, Issue 29, Page(s) 9225–9230

Abstract: The growth of transmission rates in optical fibers can increase the demand for devices that perform network node processing. Usually, such devices achieve complex optical signal processing through high non-linearity effects and optoelectronic devices. In ...

Abstract	The growth of transmission rates in optical fibers can increase the demand for devices that perform network node processing. Usually, such devices achieve complex optical signal processing through high non-linearity effects and optoelectronic devices. In this work, we present the numerical acquisition of a configurable multi-function logic gate in which the OR and AND gates can be enabled based on the logic values entered in a selector. Our device consists of a single piece of three-core PCF, with linear pulse propagation, and without the need for any other mechanisms. This result presents evidence that information processing within functional fibers is possible and might be achieved using only fiber design.
Language	English
Publishing date	2021-10-08
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.440191
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Article ; Online: High-Fat Diet Induces Disruption of the Tight Junction-Mediated Paracellular Barrier in the Proximal Small Intestine Before the Onset of Type 2 Diabetes and Endotoxemia.

Nascimento, J C / Matheus, V A / Oliveira, R B / Tada, S F S / Collares-Buzato, Carla B

Digestive diseases and sciences

2020 Volume 66, Issue 10, Page(s) 3359–3374

Abstract: Background/aim: A link between an impaired intestinal barrier, endotoxemia, and the pathogenesis of metabolic diseases, such as type 2 diabetes mellitus (T2DM), has been proposed. In previous work, we have demonstrated that the tight junction (TJ)- ... ...

Abstract	Background/aim: A link between an impaired intestinal barrier, endotoxemia, and the pathogenesis of metabolic diseases, such as type 2 diabetes mellitus (T2DM), has been proposed. In previous work, we have demonstrated that the tight junction (TJ)-mediated intestinal barrier in ileum/colon was marginally changed in prediabetic mice; therefore, it does not seem to mainly contribute to the T2DM onset. In this study, the TJ-mediated epithelial barrier in the duodenum and jejunum was evaluated in mice during the development of type 2 prediabetes. Methods/results: HF diet induced prediabetes after 60 days associated with a significant rise in intestinal permeability to the small-sized marker Lucifer yellow in these mice, with no histological signs of mucosal inflammation or rupture of the proximal intestine epithelium. As revealed by immunofluorescence, TJ proteins, such as claudins-1, -2, -3, and ZO-1, showed a significant decrease in junctional content in duodenum and jejunum epithelia, already after 15 days of treatment, suggesting a rearrangement of the TJ structure. However, no significant change in total cell content of these proteins was observed in intestinal epithelium homogenates, as assessed by immunoblotting. Despite the changes in intestinal permeability and TJ structure, the prediabetic mice showed similar LPS, zonulin, and TNF-α levels in plasma or adipose tissue, and in intestinal segments as compared to the controls. Conclusion: Disruption of the TJ-mediated paracellular barrier in the duodenum and jejunum is an early event in prediabetes development, which occurs in the absence of detectable endotoxemia/inflammation and may contribute to the HF diet-induced increase in intestinal permeability.
MeSH term(s)	Animals ; Diabetes Mellitus, Type 2/chemically induced ; Diet, High-Fat/adverse effects ; Endotoxemia/chemically induced ; Haptoglobins/metabolism ; Intestinal Mucosa/drug effects ; Intestine, Small/drug effects ; Intestine, Small/pathology ; Lipopolysaccharides/blood ; Lipopolysaccharides/metabolism ; Male ; Mice ; Protein Precursors/blood ; Protein Precursors/metabolism ; Random Allocation ; Tight Junctions/drug effects ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Haptoglobins ; Lipopolysaccharides ; Protein Precursors ; Tumor Necrosis Factor-alpha ; zonulin
Language	English
Publishing date	2020-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-020-06664-x
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Article ; Online: Frequency of the Val1016Ile mutation on the kdr gene in Aedes aegypti (Diptera: Culicidae) in south Brazil.

Collet, M L / Frizzo, C / Orlandin, E / Rona, L D P / Nascimento, J C / Montano, M A E / Müller, G A / Wagner, G

Genetics and molecular research : GMR

2016 Volume 15, Issue 4

Abstract: Recently, the number of Aedes aegypti foci has increased in west of Santa Catarina, south Brazil, which has increased concern regarding mosquito-borne disease outbreaks such as dengue fever, Zika virus, and chikungunya. Therefore, it is important to ... ...

Abstract	Recently, the number of Aedes aegypti foci has increased in west of Santa Catarina, south Brazil, which has increased concern regarding mosquito-borne disease outbreaks such as dengue fever, Zika virus, and chikungunya. Therefore, it is important to monitor genetic resistance to insecticides through "knockdown resistance". Homozygosity (Ile/Ile) at position 1016 in the coding region of a voltage-dependent sodium channel gene (Na
MeSH term(s)	Aedes/genetics ; Animals ; Brazil ; Insect Proteins/genetics ; Insecticide Resistance ; Isoleucine/genetics ; Mutation ; Mutation Rate ; Sodium Channels/genetics ; Valine/genetics
Chemical Substances	Insect Proteins ; Sodium Channels ; Isoleucine (04Y7590D77) ; Valine (HG18B9YRS7)
Language	English
Publishing date	2016-11-21
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/gmr15048940
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Article ; Online: Apolipoprotein E, periodontal disease and the risk for atherosclerosis: a review.

Pereira, L C / Nascimento, J C R / Rêgo, J M C / Canuto, K M / Crespo-Lopez, M E / Alvarez-Leite, J I / Baysan, A / Oriá, R B

Archives of oral biology

2018 Volume 98, Page(s) 204–212

Abstract: The association between cardiovascular and periodontal diseases is characterized by chronic inflammatory processes, with a high prevalence worldwide and complex genetic-environment interactions. Although apolipoprotein E4 (ApoE4), one of the isoforms ... ...

Abstract	The association between cardiovascular and periodontal diseases is characterized by chronic inflammatory processes, with a high prevalence worldwide and complex genetic-environment interactions. Although apolipoprotein E4 (ApoE4), one of the isoforms coded by a polymorphic APOE gene, has been widely recognized as a risk factor for cardiovascular diseases and as an immunoinflammatory factor, less is known regarding how ApoE4 affects atherosclerosis in periodontitis patients. The aim of this review was to investigate the potential underlying mechanisms related to APOE4 that could increase the risk of periodontal disease and, ultimately, of atherosclerosis. There have only been a few studies addressing apoE polymorphisms in patients with chronic periodontitis. To date, no studies have been performed that have assessed how ApoE4 affects atherosclerotic disease in chronic periodontitis patients. Although clinical studies are warranted, experimental studies have consistently documented the presence of periodontal pathogens, which are usually found in the oral cavity and saliva, in the atherosclerotic plaques of ApoE-deficient mice. In addition, in this review, the potential role of the APOE4 allele as an example of antagonistic pleiotropy during human evolution and its relation to oral health is discussed.
MeSH term(s)	Animals ; Apolipoprotein E3/metabolism ; Apolipoprotein E4 ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism ; Atherosclerosis/etiology ; Cardiovascular Diseases/etiology ; Genetic Pleiotropy ; Humans ; Inflammation/etiology ; Mice ; Microbiota ; Mouth ; Periodontal Diseases/complications ; Polymorphism, Genetic ; Protein Isoforms ; Risk Factors
Chemical Substances	Apolipoprotein E3 ; Apolipoprotein E4 ; Apolipoproteins E ; Protein Isoforms
Language	English
Publishing date	2018-11-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80227-x
ISSN	1879-1506 ; 0003-9969
ISSN (online)	1879-1506
ISSN	0003-9969
DOI	10.1016/j.archoralbio.2018.11.009
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Article ; Online: A Brazilian regional basic diet-induced chronic malnutrition drives liver inflammation with higher ApoA-I activity in C57BL6J mice.

Santos, M J S / Canuto, K M / de Aquino, C C / Martins, C S / Brito, G A C / Pessoa, T M R P / Bertolini, L R / de Sá Carneiro, I / Pinto, D V / Nascimento, J C R / da Silva, B B / Valença, J T / Guedes, M I F / Owen, J S / Oriá, R B

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

2020 Volume 53, Issue 6, Page(s) e9031

Abstract: Malnutrition is still considered endemic in many developing countries. Malnutrition-enteric infections may cause lasting deleterious effects on lipid metabolism, especially in children living in poor settings. The regional basic diet (RBD), produced to ... ...

Abstract	Malnutrition is still considered endemic in many developing countries. Malnutrition-enteric infections may cause lasting deleterious effects on lipid metabolism, especially in children living in poor settings. The regional basic diet (RBD), produced to mimic the Brazilian northeastern dietary characteristics (rich in carbohydrate and low in protein) has been used in experimental malnutrition models, but few studies have explored the effect of chronic RBD on liver function, a central organ involved in cholesterol metabolism. This study aimed to investigate whether RBD leads to liver inflammatory changes and altered reverse cholesterol metabolism in C57BL6/J mice compared to the control group, receiving a standard chow diet. To evaluate liver inflammation, ionized calcium-binding adapter protein-1 (IBA-1) positive cell counting, interleukin (IL)-1β immunohistochemistry, and tumor necrosis factor (TNF)-α and IL-10 transcription levels were analyzed. In addition, we assessed reverse cholesterol transport by measuring liver apolipoprotein (Apo)E, ApoA-I, and lecithin-cholesterol acyltransferase (LCAT) by RT-PCR. Furthermore, serum alanine aminotransferase (ALT) was measured to assess liver function. RBD markedly impaired body weight gain compared with the control group (P<0.05). Higher hepatic TNF-α (P<0.0001) and IL-10 (P=0.001) mRNA levels were found in RBD-challenged mice, although without detectable non-alcoholic fatty liver disease. Marked IBA-1 immunolabeling and increased number of positive-IBA-1 cells were found in the undernourished group. No statistical difference in serum ALT was found. There was also a significant increase in ApoA mRNA expression in the undernourished group, but not ApoE and LCAT, compared with the control. Altogether our findings suggested that chronic RBD-induced malnutrition leads to liver inflammation with increased ApoA-I activity.
MeSH term(s)	Animals ; Apolipoprotein A-I/blood ; Apolipoprotein A-I/metabolism ; Brazil ; Chronic Disease ; Diet/adverse effects ; Humans ; Inflammation/blood ; Inflammation/metabolism ; Inflammation/pathology ; Liver/metabolism ; Male ; Malnutrition/blood ; Malnutrition/metabolism ; Malnutrition/pathology ; Mice ; Mice, Inbred C57BL
Chemical Substances	Apolipoprotein A-I
Language	English
Publishing date	2020-05-08
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	786234-9
ISSN	1414-431X ; 0100-879X
ISSN (online)	1414-431X
ISSN	0100-879X
DOI	10.1590/1414-431x20209031
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Article ; Online: Toxoplasma gondii promotes changes in VIPergic submucosal neurons, mucosal intraepithelial lymphocytes, and goblet cells during acute infection in the ileum of rats.

Schneider, L C L / do Nascimento, J C P / Trevizan, A R / Góis, M B / Borges, S C / Beraldi, E J / Garcia, J L / Sant'Ana, D M G / Buttow, N C

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

2017 Volume 30, Issue 5, Page(s) e13264

Abstract: Background: The intestinal mucosa plays an important role in the mechanical barrier against pathogens. During Toxoplasma gondii infection, however, the parasites invade the epithelial cells of the small intestine and initiate a local immune response. In ...

Abstract	Background: The intestinal mucosa plays an important role in the mechanical barrier against pathogens. During Toxoplasma gondii infection, however, the parasites invade the epithelial cells of the small intestine and initiate a local immune response. In the submucosal plexus, this response promotes an imbalance of neurotransmitters and induces neuroplasticity, which can change the integrity of the epithelium and its secretory function. This study evaluated the submucosal neurons throughout acute T. gondii infection and the relationship between possible alterations and the epithelial and immune defense cells of the mucosa. Methods: Forty Wistar rats were randomly assigned to 8 groups (n = 5): 1 control group, uninfected, and 7 groups infected with an inoculation of 5000 sporulated T. gondii oocysts (ME-49 strain, genotype II). Segments of the ileum were collected for standard histological processing, histochemical techniques, and immunofluorescence. Key results: The infection caused progressive neuronal loss in the submucosal general population and changed the proportion of VIPergic neurons throughout the infection periods. These changes may be related to the observed reduction in goblet cells that secret sialomucins and increase in intraepithelial lymphocytes after 24 hours, and the increase in immune cells in the lamina propria after 10 days of infection. The submucosa also presented fibrogenesis, characterizing injury and tissue repair. Conclusions and inferences: The acute T. gondii infection in the ileum of rats changes the proportion of VIPergic neurons and the epithelial cells, which can compromise the mucosal defense during infection.
MeSH term(s)	Animals ; Cell Count ; Cell Death/physiology ; Goblet Cells/metabolism ; Goblet Cells/microbiology ; Goblet Cells/pathology ; Ileum/metabolism ; Ileum/microbiology ; Ileum/pathology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/microbiology ; Intestinal Mucosa/pathology ; Intraepithelial Lymphocytes/metabolism ; Intraepithelial Lymphocytes/microbiology ; Intraepithelial Lymphocytes/pathology ; Male ; Myenteric Plexus/metabolism ; Myenteric Plexus/microbiology ; Myenteric Plexus/pathology ; Neurons/metabolism ; Neurons/microbiology ; Neurons/pathology ; Rats ; Rats, Wistar ; Toxoplasma ; Toxoplasmosis/metabolism ; Toxoplasmosis/microbiology ; Toxoplasmosis/pathology ; Vasoactive Intestinal Peptide/metabolism
Chemical Substances	Vasoactive Intestinal Peptide (37221-79-7)
Language	English
Publishing date	2017-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.13264
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Article ; Online: Dietary supplementation with tannin and soybean oil on intake, digestibility, feeding behavior, ruminal protozoa and methane emission in sheep

Lima, P.R. / Apdini, T. / Freire, A.S. / Santana, A.S. / Moura, L.M.L. / Nascimento, J.C.S. / Rodrigues, R.T.S. / Dijkstra, J. / Garcez Neto, A.F. / Queiroz, M.A.Á. / Menezes, D.R.

Animal Feed Science and Technology

2019 Volume 249

Abstract: Tannins and soybean oil are supplements used in diets that depending on concentration may promote beneficial or negative effects on animal productivity. This study aimed to evaluate the effect of supplementation with tannins extract or soybean oil, as ... ...

Abstract	Tannins and soybean oil are supplements used in diets that depending on concentration may promote beneficial or negative effects on animal productivity. This study aimed to evaluate the effect of supplementation with tannins extract or soybean oil, as well as their combination, on intake, digestibility, methane production, feeding behavior and rumen parameters in Santa Inês crossbred uncastrated male sheep. Eight sheep were assigned to a double 4 × 4 Latin square (4 treatments and 4 periods), and 4 sheep to a simple 4 × 4 Latin square (for ruminal fluid collection) and fed a basal diet of 60% elephant grass and 40% concentrate (dry matter (DM) basis). The treatments were: control (no tannins or soybean oil); tannins (30 g/kg DM); soybean oil (50 g/kg DM); and tannins plus soybean oil (30 g/kg DM of tannin and 50 g/kg DM of soybean oil). Intake did not differ between treatments. Tannins supplementation increased eating time (ET) (P < 0.01) and decreased DM intake rate (DMIR) (P = 0.02) and rumen fluid pH (P = 0.04), but did not affect digestibility. Supplementation with soybean oil decreased acid detergent fibre (P = 0.04) and neutral detergent fibre (NDF) (P = 0.02) digestibility, and increased number (P < 0.05) and time (P = 0.04) of chewing per ruminal bolus. The combination of tannins and soybean oil decreased digestibility of organic matter (DOM) (P = 0.04) and NDF (P = 0.01), increased ET (P < 0.01) and decreased DMIR (P < 0.01) and NDF intake rate (P = 0.02). The inclusion of tannins did not decrease methane production. However, the inclusion of soybean oil or soybean oil plus tannins reduced methane production (absolute value and per unit of ingested DM and digestible organic matter) (P < 0.01). The number of rumen protozoa decreased in the treatments with tannins, soybean oil and soybean oil plus tannins compared to control treatment (P < 0.01), and a greater proportion of reduction was obtained using only soybean oil. The inclusion of soybean oil alone is sufficient to reduce methane ...
Keywords	Feeding behavior ; Fibre digestibility ; Methane mitigation ; Sheep ; Soybean oil ; Tannins
Subject code	660
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	196563-3
ISSN	0377-8401
ISSN	0377-8401
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Article: Intermediate metabolism during the ontogenetic development of Anastrepha fraterculus (Diptera: Tephritidae).

Dutra, B K / Fernandes, F A / Nascimento, J C / Quadros, F C / Oliveira, G T

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

2006 Volume 147, Issue 3, Page(s) 594–599

Abstract: The fruit fly Anastrepha fraterculus is a major pest of native and exotic fruit trees in South America. Changes in weight, water content and metabolism were observed during its ontogenetic development in standard conditions (25 degrees C, RH=60% and 14 h: ...

Abstract	The fruit fly Anastrepha fraterculus is a major pest of native and exotic fruit trees in South America. Changes in weight, water content and metabolism were observed during its ontogenetic development in standard conditions (25 degrees C, RH=60% and 14 h:10 h photoperiod). The metabolic variables glycogen, total proteins, triglycerides and total lipids were measured by means of spectrophotometric methods. The results were correlated with pupae metamorphosis, temporal pattern, and beginning of adult life. Pupae were observed daily, and a sub-sample of 10 individuals was collected and maintained at -20 degrees C. The same procedure was performed with adults at 4 days after adult eclosion. Levels of total lipids and triglycerides were constant during pupal development, peaking in 312-h-old pupae. In 0-h-old pupae, glycogen levels were high, and decreased progressively until the insects were 312 h old. The peak in total proteins coincides with the post-histolysis period of the larval tissue (96-120 h). These results indicated that glycogen and proteins may be the principal sources of energy for metamorphosis. Total lipid and triglyceride contents remained steady during metamorphosis, and these were consumed in the first 4 days of adult life.
MeSH term(s)	Animals ; Body Weight ; Glycogen/analysis ; Insect Proteins/analysis ; Pupa/chemistry ; Pupa/growth & development ; Tephritidae/growth & development ; Tephritidae/metabolism ; Triglycerides/analysis
Chemical Substances	Insect Proteins ; Triglycerides ; Glycogen (9005-79-2)
Language	English
Publishing date	2006-08-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121246-1
ISSN	1531-4332 ; 1095-6433 ; 0300-9629
ISSN (online)	1531-4332
ISSN	1095-6433 ; 0300-9629
DOI	10.1016/j.cbpa.2006.08.033
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