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  1. Article ; Online: Data and Tools Integration in the Canadian Open Neuroscience Platform

    Jean-Baptiste Poline / Samir Das / Tristan Glatard / Cécile Madjar / Erin W. Dickie / Xavier Lecours / Thomas Beaudry / Natacha Beck / Brendan Behan / Shawn T. Brown / David Bujold / Michael Beauvais / Bryan Caron / Candice Czech / Moyez Dharsee / Mathieu Dugré / Ken Evans / Tom Gee / Giulia Ippoliti /
    Gregory Kiar / Bartha Maria Knoppers / Tristan Kuehn / Diana Le / Derek Lo / Mandana Mazaheri / Dave MacFarlane / Naser Muja / Emmet A. O’Brien / Liam O’Callaghan / Santiago Paiva / Patrick Park / Darcy Quesnel / Henri Rabelais / Pierre Rioux / Mélanie Legault / Jennifer Tremblay-Mercier / David Rotenberg / Jessica Stone / Ted Strauss / Ksenia Zaytseva / Joey Zhou / Simon Duchesne / Ali R. Khan / Sean Hill / Alan C. Evans

    Scientific Data, Vol 10, Iss 1, Pp 1-

    2023  Volume 11

    Abstract: Measurement(s) Digital Data Repository Technology Type(s) Digital Data ... ...

    Abstract Measurement(s) Digital Data Repository Technology Type(s) Digital Data Repository
    Keywords Science ; Q
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Osteoblastic differentiation under controlled bioactive ion release by silica and titania doped sodium-free calcium phosphate-based glass

    Shah Mohammadi, Maziar / Christoph Stähli / Florencia Chicatun / Martin N. Bureau / Naser Muja / Showan N. Nazhat

    Colloids and Surfaces B: Biointerfaces. 2014 Sept. 01, v. 121

    2014  

    Abstract: Sodium-free phosphate-based glasses (PGs) doped with both SiO2 and TiO2 (50P2O5-40CaO-xSiO2-(10−x)TiO2, where x=10, 7, 5, 3, and 0mol%) were developed and characterised for controlled ion release applications in bone tissue engineering. Substituting ... ...

    Abstract Sodium-free phosphate-based glasses (PGs) doped with both SiO2 and TiO2 (50P2O5-40CaO-xSiO2-(10−x)TiO2, where x=10, 7, 5, 3, and 0mol%) were developed and characterised for controlled ion release applications in bone tissue engineering. Substituting SiO2 with TiO2 directly increased PG density and glass transition temperature, indicating a cross-linking effect of Ti on the glass network which was reflected by significantly reduced degradation rates in an aqueous environment. X-ray diffraction confirmed the presence of Ti(P2O7) in crystallised TiO2-containing PGs, and nuclear magnetic resonance showed an increase in Q1 phosphate species with increasing TiO2 content. Substitution of SiO2 with TiO2 also reduced hydrophilicity and surface energy. In biological assays, MC3T3-E1 pre-osteoblasts effectively adhered to the surface of PG discs and the incorporation of TiO2, and hence higher stability of the PG network, significantly increased cell viability and metabolic activity indicating the biocompatibility of the PGs. Addition of SiO2 increased ionic release from the PG, which stimulated alkaline phosphatase (ALP) activity in MC3T3-E1 cells upon ion exposure. The incorporation of 3mol% TiO2 was required to stabilise the PG network against unfavourable rapid degradation in aqueous environments. However, ALP activity was greatest in PGs doped with 5–7mol% SiO2 due to up-regulation of ionic concentrations. Thus, the properties of PGs can be readily controlled by modifying the extent of Si and Ti doping in order to optimise ion release and osteoblastic differentiation for bone tissue engineering applications.
    Keywords alkaline phosphatase ; bioassays ; biocompatibility ; bones ; calcium ; cell viability ; colloids ; crosslinking ; crystallization ; energy ; glass ; glass transition temperature ; hydrophilicity ; nuclear magnetic resonance spectroscopy ; phosphates ; silica ; silicon ; tissue engineering ; titanium dioxide ; X-ray diffraction
    Language English
    Dates of publication 2014-0901
    Size p. 82-91.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2014.05.037
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Ectopic bone formation in rapidly fabricated acellular injectable dense collagen-Bioglass hybrid scaffolds via gel aspiration-ejection

    Miri, Amir K / Aldo R. Boccaccini / Naser Muja / Neysan O. Kamranpour / Showan N. Nazhat / Susan A. Clarke / William C. Lepry

    Biomaterials. 2016 Apr., v. 85

    2016  

    Abstract: Gel aspiration-ejection (GAE) has recently been introduced as an effective technique for the rapid production of injectable dense collagen (IDC) gel scaffolds with tunable collagen fibrillar densities (CFDs) and microstructures. Herein, a GAE system was ... ...

    Abstract Gel aspiration-ejection (GAE) has recently been introduced as an effective technique for the rapid production of injectable dense collagen (IDC) gel scaffolds with tunable collagen fibrillar densities (CFDs) and microstructures. Herein, a GAE system was applied for the advanced production and delivery of IDC and IDC-Bioglass® (IDC-BG) hybrid gel scaffolds for potential bone tissue engineering applications. The efficacy of GAE in generating mineralizable IDC-BG gels (from an initial 75–25 collagen-BG ratio) produced through needle gauge numbers 8G (3.4 mm diameter and 6 wt% CFD) and 14G (1.6 mm diameter and 14 wt% CFD) was investigated. Second harmonic generation (SHG) imaging of as-made gels revealed an increase in collagen fibril alignment with needle gauge number. In vitro mineralization of IDC-BG gels was confirmed where carbonated hydroxyapatite was detected as early as day 1 in simulated body fluid, which progressively increased up to day 14. In vivo mineralization of, and host response to, acellular IDC and IDC-BG gel scaffolds were further investigated following subcutaneous injection in adult rats. Mineralization, neovascularization and cell infiltration into the scaffolds was enhanced by the addition of BG and at day 21 post injection, there was evidence of remodelling of granulation tissue into woven bone-like tissue in IDC-BG. SHG imaging of explanted scaffolds indicated collagen fibril remodelling through cell infiltration and mineralization over time. In sum, the results suggest that IDC-BG hybrid gels have osteoinductive properties and potentially offer a novel therapeutic approach for procedures requiring the injectable delivery of a malleable and dynamic bone graft that mineralizes under physiological conditions.
    Keywords adults ; angiogenesis ; body fluids ; bone formation ; bones ; collagen ; gels ; granulation tissue ; hydroxyapatite ; image analysis ; microstructure ; mineralization ; rats ; subcutaneous injection ; therapeutics ; tissue engineering
    Language English
    Dates of publication 2016-04
    Size p. 128-141.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2016.01.047
    Database NAL-Catalogue (AGRICOLA)

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