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  1. Article: Severe acute hepatitis of unknown etiology in children in 2022: A Narrative Review.

    Namakin, Kosar / Naserghandi, Alvand / Allameh, Seyed Farshad

    New microbes and new infections

    2023  Volume 51, Page(s) 101087

    Abstract: Severe cases of acute hepatitis have been reported all around the world since 5 April 2022. Common viral hepatitis agents (HAV, HBV, HCV, HDV, and HEV) were ruled out by laboratory investigations, impelling the term "acute non-A-E hepatitis". Common ... ...

    Abstract Severe cases of acute hepatitis have been reported all around the world since 5 April 2022. Common viral hepatitis agents (HAV, HBV, HCV, HDV, and HEV) were ruled out by laboratory investigations, impelling the term "acute non-A-E hepatitis". Common manifestations consist of abdominal pain, jaundice, and vomiting. A highly elevated level of liver enzymes was a remarkable laboratory finding among the patients. Currently, there is no clear etiology and thus treatment for the condition. Adenovirus serotype 41 (ad-41) was detected in most of the patients even though there is no elucidated link between Adenovirus and acute hepatitis. Other viral agents such as SARS-CoV-2 tested positive in a few cases. Treatment strategies depend on the severity, complications, and sequela of acute hepatitis and can vary widely from supportive therapy to liver transplantation. As of 8 July 2022, 1010 probable cases were reported from 35 countries. More than half were from the European region and were mostly children under the age of 6 years. Among different hypotheses about the etiology of severe acute non-A-E hepatitis, adenovirus-41 is of great importance but further assessments are needed to prove any definite link between ad-41 and severe acute hepatitis.
    Language English
    Publishing date 2023-01-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2023.101087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intra Operative Mild Cooling of Large Tumors Reduces Their Invasive and Metastatic Functions While Increasing Their Resistance to Apoptosis.

    Tavassoli, Noureddin / Ghahremani, Alireza / Namakin, Kosar / Naserghandi, Alvand / Miri, Seyed Rouhollah / Abdolahad, Mohammad

    Therapeutic hypothermia and temperature management

    2023  

    Abstract: Cancer treatment often involves excisional surgery, but this approach may leave behind minimal residual disease, leading to tumor regrowth. Proinflammatory cytokines and their role in altering residual cancerous cells postsurgery have garnered attention. ...

    Abstract Cancer treatment often involves excisional surgery, but this approach may leave behind minimal residual disease, leading to tumor regrowth. Proinflammatory cytokines and their role in altering residual cancerous cells postsurgery have garnered attention. The study examines how mild intraoperative cooling affects cancer cells and their gene expression. It aims to discover strategies for reducing tumor growth after surgery. Nine cases of solid tumor were included in the study, nine samples were cooled with the Peltier-Seebeck device down to12°C, and cooled and noncooled regions of tumors were analyzed using reverse transcription-polymerase chain reaction. Key transcriptomes, including neural-cadherin, cadherins (
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609342-X
    ISSN 2153-7933 ; 2153-7658
    ISSN (online) 2153-7933
    ISSN 2153-7658
    DOI 10.1089/ther.2023.0060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevalence of overweight and obesity among Iranian population: a systematic review and meta-analysis.

    Abiri, Behnaz / Ahmadi, Amirhossein Ramezani / Amini, Shirin / Akbari, Mojtaba / Hosseinpanah, Farhad / Madinehzad, Seyed Ataollah / Hejazi, Mahdi / Rishehri, Amirreza Pouladi / Naserghandi, Alvand / Valizadeh, Majid

    Journal of health, population, and nutrition

    2023  Volume 42, Issue 1, Page(s) 70

    Abstract: Background: Obesity is a major risk factor for chronic diseases. Politicians and practitioners should be aware of the dramatic increase in obesity and its subsequent complications to prevent associated health risks. This systematic review aimed to ... ...

    Abstract Background: Obesity is a major risk factor for chronic diseases. Politicians and practitioners should be aware of the dramatic increase in obesity and its subsequent complications to prevent associated health risks. This systematic review aimed to provide better insight into the prevalence of overweight and obesity in the Iranian population.
    Method: An evaluation was conducted on all published observational studies from both national (SID, Irandoc, Iranmedex) and international (Web of Knowledge, PubMed, Scopus) sources, which reported the prevalence of overweight/obesity among normal population samples, between January 2012 and December 2021.
    Result: A total of 152 eligible studies were included in this meta-analysis. Of the 152 selected studies, 74 reported the prevalence of overweight/obesity in patients aged ≤ 18 years, and 61 studies in adults. In the rest of the articles (17 studies), the results were reported for a combination of these age groups. The prevalence of overweight and obesity in Iran was estimated at 20.1 (95% CI 17.92-22.30) and 13.44 (95% CI 11.76-15.22), respectively. This percentage (95% CI) was 11.71 (10.98-12.46) for overweight and 8.08 (7.02-9.22) for obesity in those aged ≤ 18 years, and 35.26 (32.61-37.99) for overweight and 21.38 (19.61-23.20) for obesity in those aged > 18 years. The overall prevalence of overweight and obesity in the entire population was 35.09% (95% CI 31.31-38.98).
    Conclusion: As obesity is on the rise in Iran, we should seek both weight loss strategies and ways to control comorbidities associated with high BMI.
    MeSH term(s) Adult ; Humans ; Overweight ; Iran ; Prevalence ; Obesity ; Risk Factors
    Language English
    Publishing date 2023-07-24
    Publishing country Bangladesh
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2025045-9
    ISSN 2072-1315 ; 1606-0997
    ISSN (online) 2072-1315
    ISSN 1606-0997
    DOI 10.1186/s41043-023-00419-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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