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Artikel ; Konferenzbeitrag: Fagomine occurrence in African honey

Katerere, David / Penkova, Yana B. / Nash, Robert J

2023 Band 89, Heft 14

Veranstaltung/Kongress	71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Trinity College Dublin Ireland, 2023-07-02
Sprache	Englisch
Erscheinungsdatum	2023-11-01
Verlag	Georg Thieme Verlag KG
Erscheinungsort	Stuttgart ; New York
Dokumenttyp	Artikel ; Konferenzbeitrag
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/s-0043-1774051
Datenquelle	Thieme Verlag

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Buch ; Online: Preparing Students for Life Beyond College

Nash, Robert J

A Meaning-Centered Vision for Holistic Teaching and Learning

2015

Abstract: At a time when STEM research and new technologies are dominating the curricula of colleges and universities, this important book refocuses the conversation on holistic education for all students. Organized around the most important and difficult ... ...

Abstract	At a time when STEM research and new technologies are dominating the curricula of colleges and universities, this important book refocuses the conversation on holistic education for all students. Organized around the most important and difficult questions that students face, Preparing Students for Life Beyond College explores a vision of education that will enable students to talk about universal issues openly and honestly, preparing them for life beyond their formal education. Featuring a variety of traditional and innovative pedagogies, strategies, recommendations, and case studies, this pra
Sprache	Englisch
Umfang	Online-Ressource (203 p)
Verlag	Taylor and Francis
Erscheinungsort	Hoboken
Dokumenttyp	Buch ; Online
Anmerkung	Description based upon print version of record
ISBN	9781138815025 ; 1138815020
Datenquelle	Katalog der Technische Informationsbibliothek Hannover

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Artikel: Azobenzene derivatives show anti-cancer activity against pancreatic cancer cells only under nutrient starvation conditions via G0/G1 cell cycle arrest

Shinzawa, Kenta / Kageta, Daiki / Nash, Robert J. / Fleet, George W.J. / Imahori, Tatsushi / Kato, Atsushi

Tetrahedron. 2021 Apr. 09, v. 85

2021

Abstract: Pancreatic cancer is one of the most aggressive cancers with a poor prognosis. Previous studies suggested that nutrient-deprived conditions may play a critical role in pancreatic cancer cell survival and resistance to chemotherapy. We describe a novel ... ...

Abstract	Pancreatic cancer is one of the most aggressive cancers with a poor prognosis. Previous studies suggested that nutrient-deprived conditions may play a critical role in pancreatic cancer cell survival and resistance to chemotherapy. We describe a novel series of azobenzene derivatives including (E)-1-(4-methyl-3-((2-methyl-5-(naphthalen-1-yl)phenyl)diazenyl)phenyl)naphthalen-2-ol (9) with efficacy and selectivity in nutrient-deprived conditions. Although anticancer drug 5-fluorouracil (5-FU) was ineffective under nutrient-deprived conditions, five of our designed compounds, 9 and four other related compounds 11–14, showed anticancer activity with IC₅₀ values ranging from 1.5 to 9.6 μM. Interestingly, only 9 showed no cytotoxicity in normal conditions. This selectivity profile of 9 is clearly opposite to that of 5-FU. Furthermore, cell cycle analysis showed that, in contrast to S phase arrest induced by 5-FU, 9 caused G₀/G₁ phase arrest, which might block cancer cell growth by arresting them in quiescence. Therefore, it could be a novel and promising candidate for effective pancreatic cancer treatment under nutrient-deprived conditions.
Schlagwörter	antineoplastic activity ; cancer therapy ; cell cycle checkpoints ; cell growth ; cell viability ; cytotoxicity ; drug therapy ; fluorouracil ; interphase ; neoplasm cells ; pancreatic neoplasms ; prognosis ; starvation
Sprache	Englisch
Erscheinungsverlauf	2021-0409
Erscheinungsort	Elsevier Ltd
Dokumenttyp	Artikel
ZDB-ID	204285-x
ISSN	1464-5416 ; 0040-4020 ; 0563-2064
ISSN (online)	1464-5416
ISSN	0040-4020 ; 0563-2064
DOI	10.1016/j.tet.2021.132077
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia.

Olajide, Olumayokun A / Iwuanyanwu, Victoria U / Banjo, Owolabi W / Kato, Atsushi / Penkova, Yana B / Fleet, George W J / Nash, Robert J

Molecules (Basel, Switzerland)

2022 Band 27, Heft 10

Abstract: 1) Background. Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to ... ...

Abstract	(1) Background. Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to aging and neurodegenerative disorders, such as Alzheimer's disease. (2) Methods. A mouse BV-2 microglia cell line was activated using LPS and the anti-inflammatory cucumber-derived iminosugar amino acid idoBR1, (2
Mesh-Begriff(e)	Amino Acids/metabolism ; Animals ; Anti-Inflammatory Agents/metabolism ; Anti-Inflammatory Agents/pharmacology ; Lipopolysaccharides ; Mice ; Microglia ; Nitric Oxide Synthase Type II/metabolism
Chemische Substanzen	Amino Acids ; Anti-Inflammatory Agents ; Lipopolysaccharides ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
Sprache	Englisch
Erscheinungsdatum	2022-05-23
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27103342
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Borylated 2,3,4,5-Tetrachlorophthalimide and Their 2,3,4,5-Tetrachlorobenzamide Analogues: Synthesis, Their Glycosidase Inhibition and Anticancer Properties in View to Boron Neutron Capture Therapy.

Campkin, David M / Shimadate, Yuna / Bartholomew, Barbara / Bernhardt, Paul V / Nash, Robert J / Sakoff, Jennette A / Kato, Atsushi / Simone, Michela I

Molecules (Basel, Switzerland)

2022 Band 27, Heft 11

Abstract: Tetrachlorinated phthalimide analogues bearing a boron-pinacolate ester group were synthesised via two synthetic routes and evaluated in their glycosidase modulating and anticancer properties, with a view to use them in boron neutron capture therapy ( ... ...

Abstract	Tetrachlorinated phthalimide analogues bearing a boron-pinacolate ester group were synthesised via two synthetic routes and evaluated in their glycosidase modulating and anticancer properties, with a view to use them in boron neutron capture therapy (BNCT), a promising radiation type for cancer, as this therapy does little damage to biological tissue. An unexpected decarbonylation/decarboxylation to five 2,3,4,5-tetrachlorobenzamides was observed and confirmed by X-ray crystallography studies, thus, giving access to a family of borylated 2,3,4,5-tetrachlorobenzamides. Biological evaluation showed the benzamide drugs to possess good to weak potencies (74.7-870 μM) in the inhibition of glycosidases, and to have good to moderate selectivity in the inhibition of a panel of 18 glycosidases. Furthermore, in the inhibition of selected glycosidases, there is a core subset of three animal glycosidases, which is always inhibited (rat intestinal maltase α-glucosidase, bovine liver β-glucosidase and β-galactosidase). This could indicate the involvement of the boron atom in the binding. These glycosidases are targeted for the management of diabetes, viral infections (via a broad-spectrum approach) and lysosomal storage disorders. Assays against cancer cell lines revealed potency in growth inhibition for three molecules, and selectivity for one of these molecules, with the growth of the normal cell line MCF10A not being affected by this compound. One of these molecules showed both potency and selectivity; thus, it is a candidate for further study in this area. This paper provides numerous novel aspects, including expedited access to borylated 2,3,4,5-tetrachlorophthalimides and to 2,3,4,5-tetrachlorobenzamides. The latter constitutes a novel family of glycosidase modulating drugs. Furthermore, a greener synthetic access to such structures is described.
Mesh-Begriff(e)	Animals ; Boron/chemistry ; Boron/pharmacology ; Boron Compounds/pharmacology ; Boron Neutron Capture Therapy ; Cattle ; Glycoside Hydrolases ; Neoplasms ; Rats
Chemische Substanzen	Boron Compounds ; Glycoside Hydrolases (EC 3.2.1.-) ; Boron (N9E3X5056Q)
Sprache	Englisch
Erscheinungsdatum	2022-05-26
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27113447
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Isolation and Characterisation of Quercitrin as a Potent Anti-Sickle Cell Anaemia Agent from

Adeniyi, Olayemi / Baptista, Rafael / Bhowmick, Sumana / Cookson, Alan / Nash, Robert J / Winters, Ana / Shen, Jianying / Mur, Luis A J

Journal of clinical medicine

2022 Band 11, Heft 8

Abstract: Alchornea cordifolia Müll. Arg. (commonly known as Christmas Bush) has been used traditionally in Africa to treat sickle cell anaemia (a recessive disease, arising from the S haemoglobin (Hb) allele), but the active compounds are yet to be identified. ... ...

Abstract	Alchornea cordifolia Müll. Arg. (commonly known as Christmas Bush) has been used traditionally in Africa to treat sickle cell anaemia (a recessive disease, arising from the S haemoglobin (Hb) allele), but the active compounds are yet to be identified. Herein, we describe the use of sequential fractionation coupled with in vitro anti-sickling assays to purify the active component. Sickling was induced in HbSS genotype blood samples using sodium metabisulphite (Na2S2O5) or through incubation in 100% N2. Methanol extracts of A. cordifolia leaves and its sub-fractions showed >70% suppression of HbSS erythrocyte sickling. The purified compound demonstrated a 87.2 ± 2.39% significant anti-sickling activity and 93.1 ± 2.69% erythrocyte sickling-inhibition at 0.4 mg/mL. Nuclear magnetic resonance (NMR) spectra and high-resolution mass spectroscopy identified it as quercitrin (quercetin 3-rhamnoside). Purified quercitrin also inhibited the polymerisation of isolated HbS and stabilized sickle erythrocytes membranes. Metabolomic comparisons of blood samples using flow-infusion electrospray-high resolution mass spectrometry indicated that quercitrin could convert HbSS erythrocyte metabolomes to be like HbAA. Sickling was associated with changes in antioxidants, anaerobic bioenergy, and arachidonic acid metabolism, all of which were reversed by quercitrin. The findings described could inform efforts directed to the development of an anti-sickling drug or quality control assessments of A. cordifolia preparations.
Sprache	Englisch
Erscheinungsdatum	2022-04-13
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11082177
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Design and Pharmacological Chaperone Effects of

Kato, Atsushi / Nakagome, Izumi / Kise, Maki / Yoshimura, Kousuke / Tanaka, Nobutada / Nash, Robert J / Fleet, George W J / Kobayashi, Yota / Ikeda, Hayato / Okada, Takuya / Toyooka, Naoki

Journal of medicinal chemistry

2023 Band 66, Heft 13, Seite(n) 9023–9039

Abstract: This study provides the first example of a strategy to design a practical ligand toward lysosomal acid α-glucosidase (GAA) focusing ... ...

Abstract	This study provides the first example of a strategy to design a practical ligand toward lysosomal acid α-glucosidase (GAA) focusing on
Mesh-Begriff(e)	Humans ; alpha-Glucosidases/metabolism ; Glycogen Storage Disease Type II/drug therapy ; Glycogen Storage Disease Type II/genetics ; Glycogen Storage Disease Type II/metabolism ; Ligands ; Lysosomes/metabolism ; Fibroblasts
Chemische Substanzen	alpha-Glucosidases (EC 3.2.1.20) ; Ligands
Sprache	Englisch
Erscheinungsdatum	2023-06-14
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c00637
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial.

Nash, Robert J / Azantsa, Boris Kg / Sharp, Hazel / Shanmugham, Velmurugan

Clinical interventions in aging

2018 Band 13, Seite(n) 2119–2126

Abstract: Purpose: Osteoarthritis (OA) is an age-related disease caused by the wear and tear of the joints. Presently, there is no known cure for OA, but its management involves the use of high doses of pain killers and antiinflammatory agents with different side ...

Abstract	Purpose: Osteoarthritis (OA) is an age-related disease caused by the wear and tear of the joints. Presently, there is no known cure for OA, but its management involves the use of high doses of pain killers and antiinflammatory agents with different side and dependency effects. Alternative management strategies involve the use of high doses of glucosamine-chondroitin (GC). This study was carried out to evaluate the efficacy of Q-Actin™, an aqueous extract of Patients and methods: Overall, 122 patients (56 males and 66 females) aged between 40 and 75 years and diagnosed with moderate knee OA were included in this randomized double-blind, parallel-group clinical trial that took place in three different centers. The 180 day intervention involved two groups of 61 participants in each: the GC group, which received orally the generally prescribed dose of 1,350 mg of GC twice daily and the CSE group, which received orally10 mg twice daily of CSE. The Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), Visual Analog scale, and Lequesne's Functional Index were used to evaluate pain, stiffness, and physical function of knee OA in participants at baseline (Day 0) and on Days 30, 60, 90, 120, 150, and 180. Results: In the CSE group, the WOMAC score was decreased by 22.44% and 70.29% on Days 30 and 180, respectively, compared to a 14.80% and 32.81% decrease in the GC group. Similar trends were observed for all the other pain scores. No adverse effect was reported during the trial period. Conclusion: The use of 10 mg CSE, twice daily, was effective in reducing pain related to moderate knee OA and can be potentially used in the management of knee pain, stiffness, and physical functions related to OA.
Mesh-Begriff(e)	Adult ; Aged ; Chondroitin/therapeutic use ; Cucumis sativus/chemistry ; Double-Blind Method ; Drug Combinations ; Female ; Glucosamine/therapeutic use ; Humans ; Knee Joint/physiopathology ; Male ; Middle Aged ; Musculoskeletal Pain/drug therapy ; Musculoskeletal Pain/etiology ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/drug therapy ; Pain Measurement ; Phytotherapy ; Plant Extracts/therapeutic use ; Treatment Outcome ; Visual Analog Scale
Chemische Substanzen	Drug Combinations ; Plant Extracts ; Chondroitin (9007-27-6) ; Glucosamine (N08U5BOQ1K)
Sprache	Englisch
Erscheinungsdatum	2018-10-25
Erscheinungsland	New Zealand
Dokumenttyp	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2364924-0
ISSN	1178-1998 ; 1176-9092
ISSN (online)	1178-1998
ISSN	1176-9092
DOI	10.2147/CIA.S173227
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Garcinia kola and garcinoic acid suppress SARS-CoV-2 spike glycoprotein S1-induced hyper-inflammation in human PBMCs through inhibition of NF-κB activation.

Olajide, Olumayokun A / Iwuanyanwu, Victoria U / Lepiarz-Raba, Izabela / Al-Hindawi, Alaa A / Aderogba, Mutalib A / Sharp, Hazel L / Nash, Robert J

Phytotherapy research : PTR

2021 Band 35, Heft 12, Seite(n) 6963–6973

Abstract: Symptoms and complications associated with severe SARS-CoV-2 infection such as acute respiratory distress syndrome (ARDS) and organ damage have been linked to SARS-CoV-2 spike protein S1-induced increased production of pro-inflammatory cytokines by ... ...

Abstract	Symptoms and complications associated with severe SARS-CoV-2 infection such as acute respiratory distress syndrome (ARDS) and organ damage have been linked to SARS-CoV-2 spike protein S1-induced increased production of pro-inflammatory cytokines by immune cells. In this study, the effects of an extract of Garcinia kola seeds and garcinoic acid were investigated in SARS-CoV-2 spike protein S1-stimulated human PBMCs. Results of ELISA experiments revealed that Garcinia kola extract (6.25, 12.5, and 25 μg/ml) and garcinoic acid (1.25, 2.5, and 5 μM) significantly reduced SARS-CoV-2 spike protein S1-induced secretion of TNFα, IL-6, IL-1β, and IL-8 in PBMCs. In-cell western assays showed that pre-treatment with Garcinia kola extract and garcinoic acid reduced expressions of both phospho-p65 and phospho-IκBα proteins, as well as NF-κB DNA binding capacity and NF-κB-driven luciferase expression following stimulation of PBMCs with spike protein S1. Furthermore, pre-treatment of PBMCs with Garcinia kola extract prior to stimulation with SARS-CoV-2 spike protein S1 resulted in reduced damage to adjacent A549 lung epithelial cells. These results suggest that the seed of Garcinia kola and garcinoic acid are natural products which may possess pharmacological/therapeutic benefits in reducing cytokine storm in severe SARS-CoV-2 and other coronavirus infections.
Mesh-Begriff(e)	Benzopyrans/pharmacology ; COVID-19 ; Cells, Cultured ; Garcinia kola/chemistry ; Humans ; Inflammation/drug therapy ; Leukocytes, Mononuclear/virology ; NF-kappa B ; SARS-CoV-2/drug effects ; Spike Glycoprotein, Coronavirus/immunology
Chemische Substanzen	Benzopyrans ; NF-kappa B ; Spike Glycoprotein, Coronavirus ; garcinoic acid ; spike protein, SARS-CoV-2
Sprache	Englisch
Erscheinungsdatum	2021-10-26
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7315
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch: Our stories matter

Nash, Robert J / Viray, Sydnee

liberating the voices of marginalized students through scholarly personal narrative writing

(Counterpoints ; 446)

2013

Verfasserangabe	Robert J. Nash & Sydnee Viray
Serientitel	Counterpoints ; 446
Schlagwörter	Academic writing/Study and teaching ; Autobiography/Authorship ; English language/Rhetoric/Study and teaching ; Minority college students/Attitudes ; Narration (Rhetoric)/Psychological aspects ; Social justice/Study and teaching (Higher) ; Randgruppe ; Autobiographische Literatur ; Schreiben ; Student
Sprache	Englisch
Umfang	XIII, 186 S., 23 cm
Verlag	Lang
Erscheinungsort	New York, NY u.a.
Dokumenttyp	Buch
Anmerkung	Includes bibliographical references (pages 183-186)
ISBN	9781433121135 ; 9781433121142 ; 9781453910504 ; 1433121131 ; 143312114X ; 1453910506
Datenquelle	Katalog der Technische Informationsbibliothek Hannover

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