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  1. Article: Nature and significance of stromal differentiation in carcinosarcoma (MMMT): unravelling the biology and shifting current paradigms.

    Hacking, Sean / Wu, Dongling / Nasim, Rafae / Chavarria, Hector / Nasim, Mansoor

    Rare tumors

    2021  Volume 13, Page(s) 20363613211010876

    Abstract: Carcinosarcoma (CS) is a rare, aggressive malignancy of the Mullerian system often termed mixed malignant Mullerian tumor (MMMT). It is biphasic in nature, differentiating into epithelial and sarcomatous components. Tumor-node-metastasis (TNM) staging ... ...

    Abstract Carcinosarcoma (CS) is a rare, aggressive malignancy of the Mullerian system often termed mixed malignant Mullerian tumor (MMMT). It is biphasic in nature, differentiating into epithelial and sarcomatous components. Tumor-node-metastasis (TNM) staging and mismatch repair (MMR) status is the basis for both prognostication and therapeutic decision making. However, stromal differentiation (SD) is a new frontier in the field of histopathology and many studies have demonstrated its prognostic significance. The present study is the first study to evaluate the role of SD in carcinosarcoma. Here we found immature SD to be a significant prognostic signature (
    Language English
    Publishing date 2021-05-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514363-3
    ISSN 2036-3613 ; 2036-3605
    ISSN (online) 2036-3613
    ISSN 2036-3605
    DOI 10.1177/20363613211010876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An Analysis of Otolaryngology's NIH Research Funding Compared to Other Specialties.

    Ramsey, Tam / Ostrowski, Tyler / Akhtar, Saad / Panse, Drishti / Nasim, Rafae / Mortensen, Melissa

    The Annals of otology, rhinology, and laryngology

    2022  Volume 132, Issue 5, Page(s) 536–544

    Abstract: Objective: To compare NIH funding in the field of Otolaryngology to other medical and surgical specialties between 2009 and 2019.: Methods: Data was collected from the NIH RePORTER database on funding dollars received by each specialty from 2009 to ... ...

    Abstract Objective: To compare NIH funding in the field of Otolaryngology to other medical and surgical specialties between 2009 and 2019.
    Methods: Data was collected from the NIH RePORTER database on funding dollars received by each specialty from 2009 to 2019. Along with data on total active physicians per specialty using the Physician Specialty Data Book, comparisons were drawn between Otolaryngology and other medical and surgical specialties with regards to trends in total funding and NIH funding dollars per physician. The distributions of grant funding, within Otolaryngology from various NIH institutes among principal investigators, organizations, and subspecialties were further explored.
    Results: There were 3810 grants (1147 unique projects) for a total of $1 276 198 555 funded by the NIH to Otolaryngology departments from 2009 to 2019. Statistically insignificant funding increases (
    Conclusion and relevance: NIH funding in Otolaryngology has remained stable and is highly concentrated among a small number of organizations, geographic regions, and principal investigators. Recent initiatives by academic communities have sought to address funding disparities by incorporating diversity and inclusion into clinician-scientist pipelines. We urge our colleagues to strive toward identification of the factors that contribute to successful acquisition of funding and implementation of a more conducive institutional infrastructure to produce research.
    MeSH term(s) Humans ; United States ; Medicine ; Otolaryngology ; Biomedical Research ; Physicians
    Language English
    Publishing date 2022-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120642-4
    ISSN 1943-572X ; 0003-4894
    ISSN (online) 1943-572X
    ISSN 0003-4894
    DOI 10.1177/00034894221100024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.75: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: A Holistic Appraisal of Stromal Differentiation in Colorectal Cancer: Biology, Histopathology, Computation, and Genomics.

    Hacking, Sean M / Chakraborty, Baidarbhi / Nasim, Rafae / Vitkovski, Taisia / Thomas, Rebecca

    Pathology, research and practice

    2021  Volume 220, Page(s) 153378

    Abstract: Cancer comprises epithelial tumor cells and associated stroma, often times referred to as the "tumoral microenvironment". Cancer-associated fibroblasts (CAFs) are the most notable components of the tumor mesenchyme. CAFs promote the initiation of cancer ... ...

    Abstract Cancer comprises epithelial tumor cells and associated stroma, often times referred to as the "tumoral microenvironment". Cancer-associated fibroblasts (CAFs) are the most notable components of the tumor mesenchyme. CAFs promote the initiation of cancer through angiogenesis, invasion and metastasis. Histologically, the differentiation of stroma has been reported to correlate with prognostic outcomes in patients with colorectal cancer. This review summarizes our current understanding of the extracellular matrix (ECM) in colorectal carcinoma (CRC), showcasing the functions of CAFs and its role in stromal differentiation (SD). We also review current state-of-the-art biology, histopathology, computation, and genomics in the setting of the stroma. SD is distinctive morphologically, and is easily recognized by a surgical pathologist; we offer a lexicon and guide for discovering the essence of stroma, as well as an incipient vision of the future for computation and molecular genomics. We propose that the mesenchymal phenotype, which encompasses a cancer migratory/metastatic capacity, could occur through the process of SD. Looking forward, pathologists will need to invest time and energy into SD, embracing the concept and propagating its use. For patients with colorectal cancer, stroma is a brave new frontier, one not only rich in biologic diversity, but also potentially critical for therapeutic decision making.
    MeSH term(s) ADAMTS Proteins/genetics ; ADAMTS Proteins/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Biopsy ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Cell Communication ; Cell Differentiation ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Diagnosis, Computer-Assisted ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Gene Expression Regulation, Neoplastic ; Genomics ; Humans ; Matrix Metalloproteinases/genetics ; Matrix Metalloproteinases/metabolism ; Predictive Value of Tests ; Prognosis ; Stromal Cells/metabolism ; Stromal Cells/pathology ; Tumor Microenvironment
    Chemical Substances Biomarkers, Tumor ; ADAMTS Proteins (EC 3.4.24.-) ; Matrix Metalloproteinases (EC 3.4.24.-)
    Language English
    Publishing date 2021-02-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2021.153378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud III Zs.20: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Whole slide imaging and colorectal carcinoma: A validation study for tumor budding and stromal differentiation.

    Hacking, Sean / Nasim, Rafae / Lee, Lili / Vitkovski, Taisia / Thomas, Rebecca / Shaffer, Emily / Nasim, Mansoor

    Pathology, research and practice

    2020  Volume 216, Issue 11, Page(s) 153233

    Abstract: Whole slide imaging (WSI) has recently received FDA approval for sign out in surgical pathology and some anticipate this to mature into the gold standard. During this transition, it will be important to validate WSI for its intended use. And many studies ...

    Abstract Whole slide imaging (WSI) has recently received FDA approval for sign out in surgical pathology and some anticipate this to mature into the gold standard. During this transition, it will be important to validate WSI for its intended use. And many studies have validated whole slide imaging by comparing diagnostic accuracy with that of conventual light microscopy (CLM); however, the assessment of histopathologic markers is prone to much more discrepancy. One of the best examples being tumor-bud scoring in colorectal carcinoma. Other signatures, including stromal differentiation or desmoplastic reaction; could better represent the epithelial-mesenchymal transition. The findings in our study suggest stromal differentiation on both digital and glass slides to be much more reproducible (0.3585-0.9368) when compared to tumor budding (0.0968-0.7871). When comparing interobserver variation between glass and digital slides for three observers; stromal differentiation was more reliable on glass slides (0.4492), when compared to its digital counterpart (0.3016). On the other hand, interobserver variation for tumor bud scoring was more reliable on digital (0.1661), than glass slides (0.1026). Overall, there is significant variation between different observers and reproducibility issues present on conventual light microscopy transfer to digital slides. Although it is possible that too much emphasis is being placed on the concordance of WSI with CLM. In future, applications in artificial intelligence may be key to diagnostic precision and improved patient outcomes.
    MeSH term(s) Cell Differentiation/physiology ; Colorectal Neoplasms/pathology ; Humans ; Image Interpretation, Computer-Assisted/methods ; Image Processing, Computer-Assisted/methods ; Observer Variation ; Pathology, Surgical/methods ; Reproducibility of Results
    Language English
    Publishing date 2020-09-28
    Publishing country Germany
    Document type Journal Article ; Validation Study
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2020.153233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud III Zs.20: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Conformational change of the

    Kim, David / Tracey, John / Becerra Flores, Manuel / Chaudhry, Kanita / Nasim, Rafae / Correa-Medina, Abraham / Knipling, Leslie / Chen, Qing / Stibitz, Scott / Jenkins, Lisa M M / Moon, Kyung / Cardozo, Tim / Hinton, Deborah M

    Computational and structural biotechnology journal

    2022  Volume 20, Page(s) 6431–6442

    Abstract: The BvgAS two-component system regulates virulence gene expression ... ...

    Abstract The BvgAS two-component system regulates virulence gene expression in
    Language English
    Publishing date 2022-11-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.10.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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