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  1. Article ; Online: Cladosporium tenuissimum-induced sinusitis in a woman with immune-deficiency disorder.

    Nasiri-Jahrodi, Abozar / Sheikholeslami, Fatemeh-Maryam / Barati, Mehdi

    Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

    2023  Volume 54, Issue 2, Page(s) 637–643

    Abstract: Fungal sinusitis is a widespread infection that affects both healthy and immunocompromised individuals. Reports of sinus fungal infections have increased due to recent advances in diagnosis. Furthermore, susceptible and immune-compromised patients play ... ...

    Abstract Fungal sinusitis is a widespread infection that affects both healthy and immunocompromised individuals. Reports of sinus fungal infections have increased due to recent advances in diagnosis. Furthermore, susceptible and immune-compromised patients play an important role in increasing the number of reported cases. Infections with lesser-known fungi have been reported infrequently around the world. This paper describes a Cladosporium tenuissimum infection caused by chronic fungal sinusitis in a woman who had traveled to several countries. We used morphological and molecular methods to confirm the infection. The infection is most likely caused by the use of sulfasalazine, which is related to the patient's rheumatism. Sulfasalazine inhibits neutrophilic chemoattractant lipid synthesis in neutrophils, which play a key role in antifungal immunity. The patient is also undergoing root canal therapy and has several upper jaw implants, which may have contributed to the development of sinusitis.
    MeSH term(s) Female ; Humans ; Sulfasalazine ; Sinusitis/drug therapy ; Sinusitis/diagnosis ; Mycoses ; Cladosporium/genetics
    Chemical Substances Sulfasalazine (3XC8GUZ6CB)
    Language English
    Publishing date 2023-04-27
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2017175-4
    ISSN 1678-4405 ; 1517-8382
    ISSN (online) 1678-4405
    ISSN 1517-8382
    DOI 10.1007/s42770-023-00978-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A comprehensive review on the role of T cell subsets and CAR-T cell therapy in Aspergillus fumigatus infection.

    Nasiri-Jahrodi, Abozar / Barati, Mehdi / Namdar Ahmadabad, Hasan / Badali, Hamid / Morovati, Hamid

    Human immunology

    2024  Volume 85, Issue 2, Page(s) 110763

    Abstract: Understanding the immune response to Aspergillus fumigatus, a common cause of invasive fungal infections (IFIs) in immunocompromised individuals, is critical for developing effective treatments. Tcells play a critical role in the immune response to A. ... ...

    Abstract Understanding the immune response to Aspergillus fumigatus, a common cause of invasive fungal infections (IFIs) in immunocompromised individuals, is critical for developing effective treatments. Tcells play a critical role in the immune response to A. fumigatus, with different subsets having distinct functions. Th1 cells are important for controlling fungal growth, while Th2 cells can exacerbate infection. Th17 cells promote the clearance of fungi indirectly by stimulating the production of various antimicrobial peptides from epithelial cells and directly by recruiting and activating neutrophils. Regulatory T cells have varied functions in A.fumigatus infection. They expand after exposure to A. fumigatus conidia and prevent organ injury and fungal sepsis by downregulating inflammation and inhibiting neutrophils or suppressing Th17 cells. Regulatory T cells also block Th2 cells to stop aspergillosis allergies. Immunotherapy with CAR T cells is a promising treatment for fungal infections, including A. fumigatus infections, especially in immunocompromised individuals. However, further research is needed to fully understand the mechanisms underlying the immune response to A. fumigatus and to develop effective immunotherapies with CAR-T cells for this infection. This literature review explores the role of Tcell subsets in A.fumigatus infection, and the effects of CAR-T cell therapy on this fungal infection.
    MeSH term(s) Humans ; Aspergillus fumigatus ; Receptors, Chimeric Antigen ; Aspergillosis/therapy ; Th1 Cells ; Cell- and Tissue-Based Therapy
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2024.110763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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