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Article ; Online: Clinical features of pneumonia in severely malnourished children with diarrhoea compared to those without diarrhoea.

Islam, Sufia / Nasrin, Nishat / Tithi, Nigar Sultana / Lehmann, Christian / Chisti, Mohammod Jobayer

Frontiers in bioscience (Landmark edition)

2021 Volume 26, Issue 10, Page(s) 717–722

Abstract: ... ...

Abstract	Introduction
MeSH term(s)	Bangladesh/epidemiology ; Child ; Child, Preschool ; Diarrhea ; Hospitalization ; Humans ; Infant ; Pneumonia/complications ; Retrospective Studies
Language	English
Publishing date	2021-10-30
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2704569-9
ISSN	2768-6698 ; 1093-9946
ISSN (online)	2768-6698
ISSN	1093-9946
DOI	10.52586/4982
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Iron Overload and Breast Cancer: Iron Chelation as a Potential Therapeutic Approach.

Islam, Sufia / Hoque, Nazia / Nasrin, Nishat / Hossain, Mehnaz / Rizwan, Farhana / Biswas, Kushal / Asaduzzaman, Muhammad / Rahman, Sabera / Hoskin, David W / Sultana, Saki / Lehmann, Christian

Life (Basel, Switzerland)

2022 Volume 12, Issue 7

Abstract: Breast cancer has historically been one of the leading causes of death for women worldwide. As of 2020, breast cancer was reported to have overtaken lung cancer as the most common type of cancer globally, representing an estimated 11.3% of all cancer ... ...

Abstract	Breast cancer has historically been one of the leading causes of death for women worldwide. As of 2020, breast cancer was reported to have overtaken lung cancer as the most common type of cancer globally, representing an estimated 11.3% of all cancer diagnoses. A multidisciplinary approach is taken for the diagnosis and treatment of breast cancer that includes conventional and targeted treatments. However, current therapeutic approaches to treating breast cancer have limitations, necessitating the search for new treatment options. Cancer cells require adequate iron for their continuous and rapid proliferation. Excess iron saturates the iron-binding capacity of transferrin, resulting in non-transferrin-bound iron (NTBI) that can catalyze free-radical reactions and may lead to oxidant-mediated breast carcinogenesis. Moreover, excess iron and the disruption of iron metabolism by local estrogen in the breast leads to the generation of reactive oxygen species (ROS). Therefore, iron concentration reduction using an iron chelator can be a novel therapeutic strategy for countering breast cancer development and progression. This review focuses on the use of iron chelators to deplete iron levels in tumor cells, specifically in the breast, thereby preventing the generation of free radicals. The inhibition of DNA synthesis and promotion of cancer cell apoptosis are the targets of breast cancer treatment, which can be achieved by restricting the iron environment in the body. We hypothesize that the usage of iron chelators has the therapeutic potential to control intracellular iron levels and inhibit the breast tumor growth. In clinical settings, iron chelators can be used to reduce cancer cell growth and thus reduce the morbidity and mortality in breast cancer patients.
Language	English
Publishing date	2022-06-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12070963
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Article ; Online: Evaluation of CNS effects of Dhatri Lauha

Nasrin Nishat / Asaduzzaman Muhammad / Md. Sakil Habib Abdullah / Chowdhury Shahabuddin Kabir

International Journal of Drug Development & Research, Vol 4, Iss 1, Pp 234-

An Ayurvedic Preparation

2012 Volume 240

Abstract: A total of four experiments were carried out at different doses (100, 200 and 400 mg/kg, p.o.) of Dhatri Lauha in different animal model in an attempt to confirm the safety of the general patients or users of the society and country as a whole. These ... ...

Abstract	A total of four experiments were carried out at different doses (100, 200 and 400 mg/kg, p.o.) of Dhatri Lauha in different animal model in an attempt to confirm the safety of the general patients or users of the society and country as a whole. These were Hole cross test, Hole board test, Open field test and Climbing out test. In Hole cross test highly significant (p<0.005) increase in motor activity was observed but only at a dose of 200mg/kg and only at min 30. Highly significant (p<0.005) increase in ambulation behavior was observed in Hole board test only at a dose of 100mg/kg after 240 min and a significant increase (p<0.01) was observed at the same dose after 180 min. No statistically significant changes were observed in case of head-dipping and emotional defecation in the Hole board test. Open field test showed no significant changes in ambulation, center ambulation, standing up behavior and emotional defecation. Climbing out test also did not produce any significant changes in activity. Overall the study reflects inconsistent and insignificant changes in behavior related to CNS activities which clearly demonstrates the safety of Dhatri Lauha.
Keywords	Dhatri Lauha ; Hole cross test ; Hole board test ; Open field test and Climbing out test ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R
Subject code	150
Language	English
Publishing date	2012-03-01T00:00:00Z
Publisher	Chauhan Publishers
Document type	Article ; Online
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Article: Emergence of Multidrug Resistant Extended-Spectrum β-Lactamase Producing Eshcherichia coli Associated With Urinary Tract Infections in Bangladesh.

Mowla, Rumana / Imam, K M Al-Hasan / Asaduzzaman, Muhammad / Nasrin, Nishat / Raihan, Sheikh Zahir / Chowdhury, A K Azad

Journal of basic and clinical pharmacy

2012 Volume 3, Issue 1, Page(s) 225–228

Abstract: The incidence of infections due to extended-spectrum β-lactamase (ESBL)-producing Escherichia coli has been increased dramatically in recent years. Treatment is difficult because of frequent multidrug resistance. To identify the sensitivity of commonly ... ...

Abstract	The incidence of infections due to extended-spectrum β-lactamase (ESBL)-producing Escherichia coli has been increased dramatically in recent years. Treatment is difficult because of frequent multidrug resistance. To identify the sensitivity of commonly used antibiotics, 36 ESBL producing E. coli strains were isolated from young adult female patients in a govt. medical college hospital in Bangladesh. The samples were studied for antimicrobial sensitivity against nine (9) commonly used antibiotics namely ampicillin (amp), trimethoprim-sulfomethoxazole (tms), tetracycline (tet), ciprofloxacin (cip), mecillinum (mel), ceftriaxone (cef), nalidixic acid (nal), Azithromycin (azm) and Chloramphenicol (chl) and the MIC values were determined by agar dilution method. Overall, 72% of the strains were multidrug resistant (MDR) i.e. resistant to two or more drugs. Among 36 strains, 14 isolates were initially found to be resistant against third generation cephalosporin, ceftriaxone. Those were subjected to the test for production of ESBL (Extended Spectrum β-Lactamase) and 7 showed positive results.
Language	English
Publishing date	2012-02-15
Publishing country	India
Document type	Journal Article
ZDB-ID	2577663-0
ISSN	0976-0113 ; 0976-0105
ISSN (online)	0976-0113
ISSN	0976-0105
DOI	10.4103/0976-0105.103829
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Article ; Online: Antibiotic sensitivity pattern of causative organisms of neonatal septicemia in an urban hospital of Bangladesh.

Monjur, Forhad / Rizwan, Farhana / Asaduzzaman, Muhammad / Nasrin, Nishat / Ghosh, Nobo Krishna / Apu, Apurba Sarker / Haque, Fazlul

Indian journal of medical sciences

2012 Volume 64, Issue 6, Page(s) 265–271

Abstract: Background: The information of the sensitivity pattern of the causative organisms is very important for effective control of septicemia in neonates.: Objective: To determine the proportion and profile of pathogenic bacteria in the blood cultures of ... ...

Abstract	Background: The information of the sensitivity pattern of the causative organisms is very important for effective control of septicemia in neonates. Objective: To determine the proportion and profile of pathogenic bacteria in the blood cultures of the neonates with clinically suspected septicemia and their susceptibility pattern to antimicrobial agents for developing a unified antibiotic treatment protocol. Materials and methods: A cross-sectional retrospective study was conducted over a period of 3 year and 4 months (39 months). The study included 1000 patients admitted in the selected hospital in Bangladesh. Blood samples for culture were taken aseptically before starting antibiotic therapy. Microorganisms were isolated and identified by standard microbiological processes which include colony morphology, Gram stain, and biochemical profiles. Antimicrobial sensitivity patterns were performed by Kirby-Bauer's disc diffusion method against imipenem, ciprofloxacin, ceftazidime, chloramphenicol, netilmicin, gentamicin, ceftriaxone, aztreonam, cefotaxime, cephalexin, and ampicillin. Results: Among the patients, 633 (63.3%) were males and 367 (36.7%) were females. Blood cultures were found positive in 194 (19.4%) neonates. The organisms isolated were Pseudomonas spp. (31.4%), Klebsiella pneumoniae (23.2%), Staphylococcus aureus (12.4%), Escherichia coli (7.2%), Acinatobactor (5.7%), Gram-negative Bacilli (4.1%), Flavobacterium spp. (3.6%), Serratia spp. (5.7%), Citrobacter fruendi (3.1%), Streptococcus species (2.6%), and Enterobacter spp. (1.0%). A majority of the bacterial isolates in neonatal sepsis were found sensitive to imipenem (91.8%) and ciprofloxacin (57.2%) and resistant to commonly used antibiotics, eg. ampicillin (96.4%) and cephalexin (89.2%). Conclusion: The problem can be mitigated by careful selection and prudent use of available antibiotics.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Bangladesh ; Cross-Sectional Studies ; Drug Resistance, Bacterial ; Female ; Hospitals, Urban ; Humans ; Infant, Newborn ; Male ; Microbial Sensitivity Tests ; Retrospective Studies ; Sepsis/drug therapy ; Sepsis/microbiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2012-07-26
Publishing country	India
Document type	Journal Article
ZDB-ID	411616-1
ISSN	1998-3654 ; 0019-5359
ISSN (online)	1998-3654
ISSN	0019-5359
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Phytochemical screening and in vitro bioactivities of the extracts of aerial part of Boerhavia diffusa Linn.

Apu, Apurba Sarker / Liza, Mahmuda Sultana / Jamaluddin, A T M / Howlader, Md Amran / Saha, Repon Kumer / Rizwan, Farhana / Nasrin, Nishat

Asian Pacific journal of tropical biomedicine

2012 Volume 2, Issue 9, Page(s) 673–678

Abstract: Objective: To investigate the bioactivities of crude n-hexane, ethyl acetate and methanol extracts of aerial part of Boerhavia diffusa Linn. (B. diffusa) and its phytochemical analysis.: Methods: The identification of phytoconstituents and assay of ... ...

Abstract	Objective: To investigate the bioactivities of crude n-hexane, ethyl acetate and methanol extracts of aerial part of Boerhavia diffusa Linn. (B. diffusa) and its phytochemical analysis. Methods: The identification of phytoconstituents and assay of antioxidant, thrombolytic, cytotoxic, antimicrobial activities were conducted using specific standard in vitro procedures. Results: The results showed that the plant extracts were a rich source of phytoconstituents. Methanol extract showed higher antioxidant, thrombolytic activity and less cytotoxic activity than those of n-hexane and ethyl acetate extracts of B. diffusa. Among the bioactivities, antioxidant activity was the most notable compared to the positive control and thus could be a potential rich source of natural antioxidant. In case of antimicrobial screening, crude extracts of the plant showed remarkable antibacterial activity against tested microorganisms. All the extracts showed significant inhibitory activity against Candida albicuns, at a concentration of 1000 µg/disc. Conclusions: The present findings suggest that, the plant widely available in Bangladesh, could be a prominent source of medicinally important natural compounds.
MeSH term(s)	Animals ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Antioxidants/chemistry ; Artemia/drug effects ; Bacteria/drug effects ; Biphenyl Compounds/antagonists & inhibitors ; Lethal Dose 50 ; Microbial Sensitivity Tests ; Nitric Oxide/antagonists & inhibitors ; Nyctaginaceae/chemistry ; Phenols/chemistry ; Phytochemicals/chemistry ; Picrates/antagonists & inhibitors ; Plant Components, Aerial/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/toxicity
Chemical Substances	Anti-Infective Agents ; Antioxidants ; Biphenyl Compounds ; Phenols ; Phytochemicals ; Picrates ; Plant Extracts ; Nitric Oxide (31C4KY9ESH) ; 1,1-diphenyl-2-picrylhydrazyl (DFD3H4VGDH)
Language	English
Publishing date	2012-12-19
Publishing country	China
Document type	Journal Article
ISSN	2221-1691
ISSN	2221-1691
DOI	10.1016/S2221-1691(12)60208-1
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Article: MICROBIAL CONTAMINATION OF STREET VENDED FOODS FROM A UNIVERSITY CAMPUS IN BANGLADESH.

Islam, Sufia / Nasrin, Nishat / Rizwan, Farhana / Nahar, Lutfun / Bhowmik, Adity / Esha, Sayma Afrin / Talukder, Kaisar Ali / Akter, Mahmuda / Roy, Ajoy / Ahmed, Muniruddin

The Southeast Asian journal of tropical medicine and public health

2015 Volume 46, Issue 3, Page(s) 480–485

Abstract: The microbiological quality of street vended food samples from Dhaka, Bangladesh was evaluated. The objective of the study was to identify the presence of common pathogens (Escherichia coli, Shigella spp, Salmonella and Vibrio spp) and to describe the ... ...

Abstract	The microbiological quality of street vended food samples from Dhaka, Bangladesh was evaluated. The objective of the study was to identify the presence of common pathogens (Escherichia coli, Shigella spp, Salmonella and Vibrio spp) and to describe the molecular characterization of E coli, a commonly found pathogen in various street foods. Fifty food samples were collected from fixed and mobile vendors from two sampling locations (Mohakhali and Aftabnagar) in Dhaka city, Bangladesh. The tested samples included deep fried and fried snacks; quick lunch items; pickles; fruit chutney; baked items; spicy, sour and hot snacks etc: Juices, tamarind water and plain drinking water were also tested. Sterile polythene bags were used for collecting 200 g of each category of samples. They were tested for the presence of microorganisms following conventional microbiological processes. Biochemical tests followed by serology were done for the confirmation of Shigella and Salmonella. Serological reaction was carried out for confirmation of Vibrio spp. DNA was isolated for the molecular characterization to detect the pathogenic E. coli by polymerase chain reaction (PCR). Out of 50 food samples, six (12%) were confirmed to contain different species of E. coli and Shigella. Molecular characterization of E. coli revealed that three samples were contaminated with enteroaggregative E. coli (EAEC) and one was contaminated with enterotoxigenic E. coli (ETEC). Shigellaflexneri X variant was detected in one food item and Shigella flexneri 2a was found in drinking water. All these enteric pathogens could be the potential cause for foodborne illnesses.
MeSH term(s)	Bangladesh ; Escherichia coli/genetics ; Escherichia coli/isolation & purification ; Food Contamination ; Food Handling ; Food Microbiology ; Humans ; Polymerase Chain Reaction ; Salmonella/isolation & purification ; Shigella/isolation & purification ; Universities ; Vibrio/isolation & purification
Language	English
Publishing date	2015-05
Publishing country	Thailand
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	800646-5
ISSN	0125-1562 ; 0038-3619
ISSN	0125-1562 ; 0038-3619
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A comprehensive situation assessment of injection practices in primary health care hospitals in Bangladesh

Lutful Kabir Abul / Gazi Hamidur / Akter Nahid / Nasrin Nishat / Asaduzzaman Muhammad / Bachar Sitesh C / Faroque ABM / Roy Tapash / Chowdhury AK Azad / Parvin Masuma / Anderson Claire

BMC Public Health, Vol 11, Iss 1, p

2011 Volume 779

Abstract: Abstract Background Understanding injection practices is crucial for evidence-based development of intervention initiatives. This study explored the extent of injection use and injection safety practices in primary care hospitals in Bangladesh. Methods ... ...

Abstract	Abstract Background Understanding injection practices is crucial for evidence-based development of intervention initiatives. This study explored the extent of injection use and injection safety practices in primary care hospitals in Bangladesh. Methods The study employed both quantitative and qualitative research methods. The methods used were - a retrospective audit of prescriptions (n = 4320), focus group discussions (six with 43 participants), in-depth interviews (n = 38) with a range service providers, and systematic observation of the activities of injection providers (n = 120), waste handlers (n = 48) and hospital facilities (n = 24). Quantitative and qualitative data were assessed with statistical and thematic analysis, respectively, and then combined. Results As many as 78% of our study sample (n = 4230) received an injection. The most commonly prescribed injections (n = 3354) including antibiotics (78.3%), IV fluids (38.6%), analgesics/pain killers (29.4%), vitamins (26.7%), and anti-histamines (18.5%). Further, 43.7% (n = 1145) of the prescribed antibiotics (n = 2626) were given to treat diarrhea and 42.3% (n = 600) of IV fluids (n = 1295) were used to manage general weakness conditions. Nearly one-third (29.8%; n = 36/120) of injection providers reported needle-stick injuries in the last 6 months with highest incidences in Rajshahi division followed by Dhaka division. Disposal of injection needles, syringes and other materials was not done properly in 83.5% (n = 20/24) of the facilities. Health providers' safety concerns were not addressed properly; only 23% (n = 28/120) of the health providers and 4.2% (n = 2/48) of the waste handlers were fully immunized against Hepatitis B virus. Moreover, 73% (n = 87/120) of the injection providers and 90% (n = 43/48) of the waste handlers were not trained in injection safety practices and infection prevention. Qualitative data further confirmed that both providers and patients preferred injections, believing that they provide quick relief. The doctors' perceived ...
Keywords	Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2011-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A comprehensive situation assessment of injection practices in primary health care hospitals in Bangladesh.

Chowdhury, A K Azad / Roy, Tapash / Faroque, A B M / Bachar, Sitesh C / Asaduzzaman, Muhammad / Nasrin, Nishat / Akter, Nahid / Gazi, Hamidur Rahman / Lutful Kabir, Abul Kalam / Parvin, Masuma / Anderson, Claire

BMC public health

2011 Volume 11, Page(s) 779

Abstract: Background: Understanding injection practices is crucial for evidence-based development of intervention initiatives. This study explored the extent of injection use and injection safety practices in primary care hospitals in Bangladesh.: Methods: The ...

Abstract	Background: Understanding injection practices is crucial for evidence-based development of intervention initiatives. This study explored the extent of injection use and injection safety practices in primary care hospitals in Bangladesh. Methods: The study employed both quantitative and qualitative research methods. The methods used were--a retrospective audit of prescriptions (n = 4320), focus group discussions (six with 43 participants), in-depth interviews (n = 38) with a range service providers, and systematic observation of the activities of injection providers (n = 120), waste handlers (n = 48) and hospital facilities (n = 24). Quantitative and qualitative data were assessed with statistical and thematic analysis, respectively, and then combined. Results: As many as 78% of our study sample (n = 4230) received an injection. The most commonly prescribed injections (n = 3354) including antibiotics (78.3%), IV fluids (38.6%), analgesics/pain killers (29.4%), vitamins (26.7%), and anti-histamines (18.5%). Further, 43.7% (n = 1145) of the prescribed antibiotics (n = 2626) were given to treat diarrhea and 42.3% (n = 600) of IV fluids (n = 1295) were used to manage general weakness conditions. Nearly one-third (29.8%; n = 36/120) of injection providers reported needle-stick injuries in the last 6 months with highest incidences in Rajshahi division followed by Dhaka division. Disposal of injection needles, syringes and other materials was not done properly in 83.5% (n = 20/24) of the facilities. Health providers' safety concerns were not addressed properly; only 23% (n = 28/120) of the health providers and 4.2% (n = 2/48) of the waste handlers were fully immunized against Hepatitis B virus. Moreover, 73% (n = 87/120) of the injection providers and 90% (n = 43/48) of the waste handlers were not trained in injection safety practices and infection prevention. Qualitative data further confirmed that both providers and patients preferred injections, believing that they provide quick relief. The doctors' perceived injection use as their prescribing norm that enabled them to prove their professional credibility and to remain popular in a competitive health care market. Additionally, persistent pressure from hospital administration to use up injections before their expiry dates also influenced doctors to prescribe injections regardless of actual indications. Conclusions: As far as the patients and providers' safety is concerned, this study demonstrated a need for further research exploring the dynamics of injection use and safety in Bangladesh. In a context where a high level of injection use and unsafe practices were reported, immediate prevention initiatives need to be operated through continued intervention efforts and health providers' training in primary care hospitals in Bangladesh.
MeSH term(s)	Bangladesh ; Cluster Analysis ; Focus Groups ; Hospitals ; Humans ; Injections/standards ; Medical Waste Disposal/standards ; Needlestick Injuries/epidemiology ; Observation ; Primary Health Care ; Retrospective Studies ; Surveys and Questionnaires
Chemical Substances	Medical Waste Disposal
Language	English
Publishing date	2011-10-10
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/1471-2458-11-779
Database	MEDical Literature Analysis and Retrieval System OnLINE

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