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Article ; Online: Analysis of the structure and function of the epidermal barrier in patients with ichthyoses-clinical and electron microscopical investigations.

Fölster-Holst, R / Naß, C / Dähnhardt-Pfeiffer, S / Freitag-Wolf, S

Journal of the European Academy of Dermatology and Venereology : JEADV

2022 Volume 36, Issue 5, Page(s) 726–738

Abstract: Background: Ichthyoses are pathogenetically characterized by a pronounced disorder of the epidermal barrier. Clinically, hyperkeratosis, severe scaling and erythroderma are present on the entire integument. The time-consuming therapy includes daily ... ...

Abstract	Background: Ichthyoses are pathogenetically characterized by a pronounced disorder of the epidermal barrier. Clinically, hyperkeratosis, severe scaling and erythroderma are present on the entire integument. The time-consuming therapy includes daily baths and the application of skin care products to restore the epidermal barrier. Objectives and methods: To enhance the knowledge about the structure and function of the epidermal barrier in ichthyoses, we conducted clinical, biophysical and electron microscopical measurements on 46 patients with ichthyoses, including autosomal recessive ichthyoses, keratinopathic ichthyoses, X-chromosomal-recessive ichthyosis and Netherton syndrome. Results: The patients displayed a significantly decreased skin hydration along with unexpectedly low transepidermal waterloss values. Electron microscopical examinations demonstrated a severe occlusion of the epidermis by lipid remnants of skin care products in the stratum corneum. We found decreased intercellular lipid lamellae and an increased undulation of the corneocyte membrane of all ichthyoses, mostly pronounced in Netherton syndrome. The lipid profiles of ichthyoses showed decreased esterified Ω-hydroxy-sphingosine (EOS) ceramide levels. Conclusions: The results demonstrate the extent of the epidermal barrier disruption in ichthyoses. In combination with the knowledge about pathogenetic causes, individually improved therapeutic options can be derived from our results. In the future, the analyses of the organization of intercellular lipid lamellae and corneocyte membrane undulation will enable improved investigations of the epidermal barrier in ichthyoses and may be used to study and evaluate possible effects of topical skin preparations.
MeSH term(s)	Ceramides ; Epidermis/pathology ; Humans ; Ichthyosis/pathology ; Ichthyosis, Lamellar ; Microscopy, Electron ; Netherton Syndrome
Chemical Substances	Ceramides
Language	English
Publishing date	2022-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.17914
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Article ; Online: Development of a New Additive Based on Textile Fibers of End-of-Life Tires (ELT) for Sustainable Asphalt Mixtures with Improved Mechanical Properties.

Valdés-Vidal, Gonzalo / Calabi-Floody, Alejandra / Duarte-Nass, Carla / Mignolet, Cristian / Díaz, Cristian

Polymers

2022 Volume 14, Issue 16

Abstract: End-of-life tires (ELT) are a worldwide problem. Rubber, steel, and different textile fibers are the by-products of ELT. Unlike rubber and steel, waste tire textile fibers (WTTF) are disposed of in landfills or burned. This study developed an additive ... ...

Abstract	End-of-life tires (ELT) are a worldwide problem. Rubber, steel, and different textile fibers are the by-products of ELT. Unlike rubber and steel, waste tire textile fibers (WTTF) are disposed of in landfills or burned. This study developed an additive made with WTTF to be incorporated into conventional hot mix asphalt (HMA), and its performance properties were evaluated. First, a characterization of the WTTF used was made and a manufacture protocol was established. Then, a reference HMA was designed and mixtures with different addition percentages (2%, 5% and 8%) of the WTTF-based additive were evaluated. The mechanical properties studied were stiffness modulus, moisture susceptibility, rutting resistance, stripping, and cracking resistance. The results indicated that the addition of the 2% and 5% WTTF-based additive improved these performance properties. Moreover, all addition percentages of the WTTF-based additive evaluated demonstrated a decrease of over 29% in permanent deformation according to the Hamburg Wheel Tracking Test. Thus, the use of the WTTF would not only be valuing a waste, but an asphalt mixture with improved properties would be obtained, contributing to the circular economy by reusing a material and prolonging the useful life of the asphalt mixture.
Language	English
Publishing date	2022-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14163250
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Article ; Online: Racial Disparities in Access and Use of Diabetes Technology Among Adult Patients With Type 1 Diabetes in a U.S. Academic Medical Center.

Kanbour, Sarah / Jones, Marissa / Abusamaan, Mohammed S / Nass, Caitlin / Everett, Estelle / Wolf, Risa M / Sidhaye, Aniket / Mathioudakis, Nestoras

Diabetes care

2022 Volume 46, Issue 1, Page(s) 56–64

Abstract: Objective: Recent studies highlight racial disparities in insulin pump (PUMP) and continuous glucose monitor (CGM) use in children and adolescents with type 1 diabetes (T1D). This study explored racial disparities in diabetes technology among adult ... ...

Abstract	Objective: Recent studies highlight racial disparities in insulin pump (PUMP) and continuous glucose monitor (CGM) use in children and adolescents with type 1 diabetes (T1D). This study explored racial disparities in diabetes technology among adult patients with T1D. Research design and methods: This was a retrospective clinic-based cohort study of adult patients with T1D seen consecutively from April 2013 to January 2020. Race was categorized into non-Black (reference group) and Black. The primary outcomes were baseline and prevalent technology use, rates of diabetes technology discussions (CGMdiscn, PUMPdiscn), and prescribing (CGMrx, PUMPrx). Multivariable logistic regression analysis evaluated the association of technology discussions and prescribing with race, adjusting for social determinants of health and diabetes outcomes. Results: Among 1,258 adults with T1D, baseline technology use was significantly lower for Black compared with non-Black patients (7.9% vs. 30.3% for CGM; 18.7% vs. 49.6% for PUMP), as was prevalent use (43.6% vs. 72.1% for CGM; 30.7% vs. 64.2% for PUMP). Black patients had adjusted odds ratios (aORs) of 0.51 (95% CI 0.29, 0.90) for CGMdiscn and 0.61 (95% CI 0.41, 0.93) for CGMrx. Black patients had aORs of 0.74 (95% CI 0.44, 1.25) for PUMPdiscn and 0.40 (95% CI, 0.22, 0.70) for PUMPrx. Neighborhood context, insurance, marital and employment status, and number of clinic visits were also associated with the outcomes. Conclusions: Significant racial disparities were observed in discussions, prescribing, and use of diabetes technology. Further research is needed to identify the causes behind these disparities and develop and evaluate strategies to reduce them.
MeSH term(s)	Child ; Adolescent ; Humans ; Adult ; Diabetes Mellitus, Type 1/drug therapy ; Retrospective Studies ; Cohort Studies ; Blood Glucose ; Academic Medical Centers
Chemical Substances	Blood Glucose
Language	English
Publishing date	2022-11-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc22-1055
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Article: Consistently High Frequency of Scooter Injuries in Children-Retrospective Data Analysis in a Level I Trauma Centre.

Schuller, Andrea / Hohensteiner, Anna / Sator, Thomas / Pichler, Lorenz / Dangl, Theresia / Nass, Cornelia / Jaindl, Manuela / Schwendenwein, Elisabeth / Tiefenboeck, Thomas M / Payr, Stephan

Children (Basel, Switzerland)

2023 Volume 10, Issue 9

Abstract: The aim of this retrospective study was to present an epidemiological overview of paediatric nonelectric-scooter-related injuries, focusing on changes in injury mechanism and frequency. A retrospective, descriptive data analysis at a Level I trauma ... ...

Abstract	The aim of this retrospective study was to present an epidemiological overview of paediatric nonelectric-scooter-related injuries, focusing on changes in injury mechanism and frequency. A retrospective, descriptive data analysis at a Level I trauma centre, including patients aged from 0 to 18 years injured by riding nonelectric scooters, was performed. The observation period ranged from January 2015 to December 2022. The total study population consisted of 983 (mean age: 7.9 ± 4.0 years) children and adolescents, with most patients being male (800/983; 81.4%). The frequency of nonelectric scooter injuries was relatively consistent over the observation period. Patients sustained mostly minor injuries (lacerations, bone contusions, sprains) (527/983; 53.6%), followed by head injuries (238/983; 24.5%), limb fractures (166/983; 16.9%) and trunk injuries (52/983; 5.3%). However, a few patients sustained severe injuries, including skull fractures (7/238; 2.9%), intracranial haematoma (4/238; 1.7%) or lacerations of abdominal organs (4/52; 7.7%). This study presented a consistently high frequency of scooter injuries in children. Children under 15 years were the most affected by scooter-related injuries. Although most injuries were minor, serious injuries occurred that should not be underestimated. Hence, we emphasise the use of protection gear and recommend raising awareness among parents and children.
Language	English
Publishing date	2023-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10091464
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Article ; Online: Single-Port-Access-Cholezystektomie als sichere Alternative zum 4-Port-Vorgehen: Ein retrospektiver Vergleich.

Cziupka, K / Partecke, L I / Nass, C / Mirow, L

Zentralblatt fur Chirurgie

2013 Volume 138, Issue 1, Page(s) 70–75

Abstract: Purpose: As laparoscopic surgery develops, one current goal is the reduction of scarring and operative trauma to a minimum. Single-port access surgery (SPA) uses a single small incision hidden in the umbilicus. This report describes our experiences with ...

Title translation	Single-port access cholecystectomy is a safe alternative to conventional laparoscopic cholecystectomy: a retrospective comparison of single-port access versus standard laparoscopic cholecystectomy.
Abstract	Purpose: As laparoscopic surgery develops, one current goal is the reduction of scarring and operative trauma to a minimum. Single-port access surgery (SPA) uses a single small incision hidden in the umbilicus. This report describes our experiences with 69 SPA cholecystectomies compared to the conventional laparoscopic approach. Methods: Within two years 69 SPA cholecystectomies were performed. Data including demographic distribution, incision to closure time, duration of the postoperative hospital stay, rates of intraoperative and postoperative complications, and conversion rates were collected retrospectively. Data for a matched control group treated by standard laparoscopic cholecystectomy were gathered within the same time frame and then compared. Results: There were no significant differences in the rates of intraoperative or postoperative complications in the SPA group when compared to the standard laparoscopy group. The incision-to-closure time strongly depended on the surgeon but did not depend on the method. The duration of postoperative hospital stay was slightly decreased in the SPA group. However, this effect was statistically not significant. Conclusions: For selected patient groups, SPA cholecystectomy is on par with the conventional laparoscopic method. The cosmetic advantage that it offers does not come at the cost of any loss of safety.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cholecystectomy, Laparoscopic/education ; Cholecystectomy, Laparoscopic/methods ; Female ; Germany ; Humans ; Learning Curve ; Male ; Middle Aged ; Minimally Invasive Surgical Procedures/education ; Minimally Invasive Surgical Procedures/methods ; Pain Measurement ; Pain, Postoperative/diagnosis ; Pain, Postoperative/prevention & control ; Patient Satisfaction ; Retrospective Studies ; Time and Motion Studies ; Young Adult
Language	German
Publishing date	2013-02
Publishing country	Germany
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	200935-3
ISSN	1438-9592 ; 0044-409X
ISSN (online)	1438-9592
ISSN	0044-409X
DOI	10.1055/s-0031-1283886
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Zs.MO 95: Show issues

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Article: Application of microbe-induced carbonate precipitation for copper removal from copper-enriched waters: Challenges to future industrial application

Duarte-Nass, Carla / Azócar, Laura / Ciudad, Gustavo / Jeison, David / Kopp, Matías / Rebolledo, Katherina / Rivas, Mariella / Torres-Aravena, Álvaro / Valenzuela, Tamara

Journal of environmental management. 2020 Feb. 15, v. 256

2020

Abstract: Copper contamination in watercourses is a recent issue in countries where mining operations are prevalent. In this study, the application of copper precipitation through microbe-induced carbonate precipitation (MICP) was analyzed using urea hydrolysis by ...

Abstract	Copper contamination in watercourses is a recent issue in countries where mining operations are prevalent. In this study, the application of copper precipitation through microbe-induced carbonate precipitation (MICP) was analyzed using urea hydrolysis by bacteria to evaluate precipitated copper carbonates. This article demonstrates the application of a copper precipitation assay involving Sporosarcina pasteurii (in 0.5 mM Cu2+ and 333 mM urea) and analyzes the resultant low removal (10%). The analysis indicates that the low removal was a consequence of Cu2+ complexation with the ammonia resulting from the hydrolysis of urea. However, the results indicate that there should be a positive correlation between the initial urea concentration and the bacterial tolerance to copper. This identifies a challenge in the industrial application of the process, wherein a minimum consumption of urea represents an economic advantage. Therefore, it is necessary to design a sequential process that decouples bacterial growth and copper precipitation, thereby decreasing the urea requirement.
Keywords	ammonia ; bacteria ; bacterial growth ; carbonates ; copper ; hydrolysis ; industrial applications ; mining ; Sporosarcina pasteurii ; urea
Language	English
Dates of publication	2020-0215
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2019.109938
Database	NAL-Catalogue (AGRICOLA)

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Article: Does computer-synthesized speech manifest personality? Experimental tests of recognition, similarity-attraction, and consistency-attraction.

Nass, C / Lee, K M

Journal of experimental psychology. Applied

2001 Volume 7, Issue 3, Page(s) 171–181

Abstract: Would people exhibit similarity-attraction and consistency-attraction toward unambiguously computer-generated speech even when personality is clearly not relevant? In Experiment 1, participants (extrovert or introvert) heard a synthesized voice ( ... ...

Abstract	Would people exhibit similarity-attraction and consistency-attraction toward unambiguously computer-generated speech even when personality is clearly not relevant? In Experiment 1, participants (extrovert or introvert) heard a synthesized voice (extrovert or introvert) on a book-buying Web site. Participants accurately recognized personality cues in text to speech and showed similarity-attraction in their evaluation of the computer voice, the book reviews, and the reviewer. Experiment 2, in a Web auction context, added personality of the text to the previous design. The results replicated Experiment 1 and demonstrated consistency (voice and text personality)-attraction. To maximize liking and trust, designers should set parameters, for example, words per minute or frequency range, that create a personality that is consistent with the user and the content being presented.
MeSH term(s)	Adolescent ; Adult ; Extraversion (Psychology) ; Female ; Humans ; Internet ; Introversion (Psychology) ; Male ; Social Perception ; Speech Acoustics ; Speech Perception
Language	English
Publishing date	2001-09
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2103149-6
ISSN	1939-2192 ; 1076-898X
ISSN (online)	1939-2192
ISSN	1076-898X
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Article ; Online: Application of microbe-induced carbonate precipitation for copper removal from copper-enriched waters: Challenges to future industrial application.

Duarte-Nass, Carla / Rebolledo, Katherina / Valenzuela, Tamara / Kopp, Matías / Jeison, David / Rivas, Mariella / Azócar, Laura / Torres-Aravena, Álvaro / Ciudad, Gustavo

Journal of environmental management

2019 Volume 256, Page(s) 109938

Abstract	Copper contamination in watercourses is a recent issue in countries where mining operations are prevalent. In this study, the application of copper precipitation through microbe-induced carbonate precipitation (MICP) was analyzed using urea hydrolysis by bacteria to evaluate precipitated copper carbonates. This article demonstrates the application of a copper precipitation assay involving Sporosarcina pasteurii (in 0.5 mM Cu
MeSH term(s)	Calcium Carbonate ; Carbonates ; Chemical Precipitation ; Copper ; Sporosarcina ; Urea
Chemical Substances	Carbonates ; Copper (789U1901C5) ; Urea (8W8T17847W) ; Calcium Carbonate (H0G9379FGK)
Language	English
Publishing date	2019-12-13
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2019.109938
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Article: Assessing the effectiveness of interactive media in improving drowsy driver safety.

Takayama, Leila / Nass, Clifford

Human factors

2008 Volume 50, Issue 5, Page(s) 772–781

Abstract: Objective: This study investigated the possibility of using interactive media to help drowsy drivers wake up, thereby enabling them to drive more safely.: Background: Many studies have investigated the negative impacts of driver drowsiness and ... ...

Abstract	Objective: This study investigated the possibility of using interactive media to help drowsy drivers wake up, thereby enabling them to drive more safely. Background: Many studies have investigated the negative impacts of driver drowsiness and distraction in cars, separately. However, none has studied the potentially positive effects of slightly interactive media for rousing drowsy drivers to help them drive more safely. Method: In a 2 (drowsy vs. nondrowsy drivers) x 2 (passive vs. slightly interactive voice-based media) x 2 (monotonous vs. varied driving courses) study, participants (N = 79) used a driving simulator while interacting with a language-learning system that was either passive (i.e., drivers merely listen to phrases in another language) or slightly interactive (i.e., drivers verbally repeat those phrases). Results: (a) Drowsy drivers preferred and drove more safely with slightly interactive media, as compared with passive media. (b) Interactive media did not harm nondrowsy driver safety. (c) Drivers drove more safely on varied driving courses than on monotonous ones. Conclusion: Slightly interactive media hold the potential to improve the performance of drowsy drivers on the primary task of driving safely. Application: Applications include the design of interactive systems that increase user alertness, safety, and engagement on primary tasks, as opposed to systems that take attentional resources away from the primary task of driving.
MeSH term(s)	Accidents, Traffic/prevention & control ; Adolescent ; Adult ; Automobile Driving ; Female ; Humans ; Male ; Multimedia ; Sleep Stages ; User-Computer Interface ; Young Adult
Language	English
Publishing date	2008-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	212725-8
ISSN	1547-8181 ; 0018-7208
ISSN (online)	1547-8181
ISSN	0018-7208
DOI	10.1518/001872008X312341
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Article: [No title information]

Cziupka, K. / Partecke, L. I. / Nass, C. / Mirow, L.

Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie

2012 Volume 138, Issue 01, Page(s) 70–75

Abstract: Einleitung: Mit der Weiterentwicklung der laparoskopischen Chirurgie ist ein Ziel, Narben und operatives Trauma auf ein Minimum zu reduzieren. Die Single-Port-Chirurgie erfolgt über lediglich eine einzige Inzision in der Nabelgrube. Wir ... ...

Abstract	Einleitung: Mit der Weiterentwicklung der laparoskopischen Chirurgie ist ein Ziel, Narben und operatives Trauma auf ein Minimum zu reduzieren. Die Single-Port-Chirurgie erfolgt über lediglich eine einzige Inzision in der Nabelgrube. Wir berichten über unsere Erfahrungen mit 69 Single-Port-Cholezystektomien im Vergleich zum Standard-4-Port Vorgehen. Methode: Innerhalb von zwei Jahren führten wir 69 Single-Port-Cholezystektomien durch. Diese wurden in einer Fall-Kontroll-Studie mit in diesem Zeitraum durchgeführten 4-Port-Cholezystektomien verglichen. Dazu wurden demografische Daten der Patienten, Schnitt-Naht-Zeiten, postoperative Krankenhausaufenthaltsdauer, intra- und postoperative Komplikationen sowie Konversionsraten retrospektiv erfasst. Ergebnisse: Zwischen der Single-Port-Methode und der Standard-4-Port-Cholezystektomie ergaben sich keine Unterschiede hinsichtlich der Rate intra- oder postoperativer Komplikationen. Die Schnitt-Naht-Zeiten waren abhängig vom Operateur und unterschieden sich zwischen beiden Methoden nicht. Die postoperative Krankenhausaufenthaltsdauer war tendenziell in der Single-Port-Gruppe kürzer, dies war jedoch statistisch nicht signifikant. Schlussfolgerung: In ausgewählten Patientengruppen ist die Single-Port-Cholezystektomie dem Standard-4-Port-Vorgehen ebenbürtig. Der kosmetische Vorteil wird dabei nicht mit einem Verlust von Patientensicherheit erkauft.
Keywords	Abdominalchirurgie ; laparoskopische Chirurgie ; chirurgische Technik ; abdominal surgery ; laparoscopic surgery ; surgical technique
Language	German
Publishing date	2012-03-16
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	200935-3
ISSN	1438-9592 ; 0044-409X
ISSN (online)	1438-9592
ISSN	0044-409X
DOI	10.1055/s-0031-1283886
Database	Thieme publisher's database

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