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  1. Article ; Online: Antibody array strategy for human growth factor secretome profiling of GH-secreting adenomas.

    Ozeri, Orly / Cohen, Zvi R / Hadani, Moshe / Nass, Dvora / Shimon, Ilan / Rubinfeld, Hadara

    Pituitary

    2019  Volume 22, Issue 4, Page(s) 344–352

    Abstract: Purposes: To test if the antibody array strategy could be utilized to simultaneously detect the secretion of multiple growth factors by human pituitary GH-adenomas and to measure octreotide-induced alterations.: Methods: Specimens of human pituitary ... ...

    Abstract Purposes: To test if the antibody array strategy could be utilized to simultaneously detect the secretion of multiple growth factors by human pituitary GH-adenomas and to measure octreotide-induced alterations.
    Methods: Specimens of human pituitary adenomas were cultured and incubated with or without octreotide for 24 h. Conditional media were analyzed by human growth factor antibody array and VEGF concentrations were measured by ELISA. Media were also analyzed for GH concentrations. p21 expression levels were examined by Western blot of the specimens lysates.
    Results: The antibody arrays successfully identified growth factors secreted by GH-adenomas in vitro. Octreotide treatment induced both elevations and reductions in growth factors secretion. GH response to octreotide was measured, and in this small-sized study resistant and sensitive GH-adenomas presented with no unique secretome pattern of each of the groups. Octreotide-induced VEGF alterations analyzed by the antibody array and by ELISA were not fully matched.
    Conclusions: This study suggests that the broad proteomic strategy of antibody arrays may be utilized to study the growth factors secretion pattern of GH-adenomas and its regulation by somatostatin analogs or other compounds.
    MeSH term(s) Adenoma/metabolism ; Antibodies/metabolism ; Enzyme-Linked Immunosorbent Assay ; Gene Expression/drug effects ; Gene Expression/genetics ; Human Growth Hormone/metabolism ; Humans ; Octreotide/pharmacology ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Antibodies ; Vascular Endothelial Growth Factor A ; Human Growth Hormone (12629-01-5) ; Octreotide (RWM8CCW8GP)
    Language English
    Publishing date 2019-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1385151-2
    ISSN 1573-7403 ; 1386-341X
    ISSN (online) 1573-7403
    ISSN 1386-341X
    DOI 10.1007/s11102-019-00955-x
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  2. Article ; Online: Human cytomegalovirus viral load in tumor and peripheral blood samples of patients with malignant gliomas.

    Priel, Eldar / Wohl, Anton / Teperberg, Michal / Nass, Dvora / Cohen, Zvi R

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2015  Volume 22, Issue 2, Page(s) 326–330

    Abstract: Malignant gliomas are the most common primary brain tumors in adults. The disease has no known etiology, progresses rapidly, and is fatal despite current therapies. Human cytomegalovirus (HCMV) is a beta herpes virus that is trophic for glial cells and ... ...

    Abstract Malignant gliomas are the most common primary brain tumors in adults. The disease has no known etiology, progresses rapidly, and is fatal despite current therapies. Human cytomegalovirus (HCMV) is a beta herpes virus that is trophic for glial cells and infects 50% to 90% of the adult human population. HCMV-mediated disease in immunosuppressed patients has highlighted the possible role of this virus in the development of other diseases, particularly inflammatory diseases such as vascular diseases, autoimmune diseases, and certain malignancies. Sensitive detection of viral DNA, mRNA, and antigens in tumor tissues, as well as seroepidemiologic evidence, suggest a link between HCMV and several human malignancies. HCMV gene products are proposed to dysregulate multiple cellular pathways involved in oncogenesis, such as cell cycle regulation, apoptosis, migration, and angiogenesis. These theories, currently being researched, suggest that HCMV acts as an oncomodulator in malignancies. We investigated the association between HCMV infection and reactivation, and malignant gliomas. An open, matched case-control, parallel group pilot study was performed in a tertiary referral center. The HCMV viral load in peripheral blood and tumor samples of 19 patients newly diagnosed with glioblastoma multiforme was compared with a matched control cohort comprising 19 patients newly diagnosed with non-malignant brain tumors. There was no significant correlation between peripheral blood and tumor tissue HCMV viral load in patients with glioblastoma multiforme compared to the control cohort. The findings of the present study did not support an oncomodulatory role for HCMV in malignant gliomas.
    MeSH term(s) Adult ; Aged ; Brain Neoplasms/virology ; Case-Control Studies ; Cytomegalovirus ; Cytomegalovirus Infections/epidemiology ; DNA, Viral/analysis ; Female ; Glioma/virology ; Humans ; Male ; Middle Aged ; Pilot Projects ; Viral Load
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2015-02
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2014.06.099
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  3. Article ; Online: Brain Metastases from Ovarian Carcinoma: An Evaluation of Prognostic Factors and Treatment.

    Wohl, Anton / Kimchi, Gil / Korach, Jacob / Perri, Tamar / Zach, Leor / Zibly, Zion / Harel, Ran / Nissim, Uzi / Spiegelmann, Roberto / Nass, Dvora / Cohen, Zvi R

    Neurology India

    2019  Volume 67, Issue 6, Page(s) 1431–1436

    Abstract: Aims and objectives: To review a series of patients with brain metastases from ovarian cancer at a single institution. To describe treatment modalities, their outcomes and to determine prognostic factors.: Patients and methods: Between January 1995 ... ...

    Abstract Aims and objectives: To review a series of patients with brain metastases from ovarian cancer at a single institution. To describe treatment modalities, their outcomes and to determine prognostic factors.
    Patients and methods: Between January 1995 and December 2014, 25 patients with ovarian cancer brain metastases were treated at The Sheba Medical Center. The medical records were retrospectively reviewed to collect demographic, clinical, and imaging data as well as the information on the treatment modalities used and their outcomes.
    Results: Mean patient age at the time of brain metastasis diagnosis was 62.7 years. The median interval between the diagnosis of primary cancer and brain metastasis was 42.3 months. Neurologic deficits, headache, and seizure were the most common symptoms. The brain was the only site of metastasis in 20% of the patients. Active ovarian cancer at the time of diagnosis of brain metastasis was observed in half of the patients with systemic disease. Multiple brain metastases were observed in 25% of the patients. We treated 11 patients with surgery plus radiation therapy protocols in various orders: surgery followed by complementary whole-brain radiation therapy (WBRT), surgery followed by stereotactic radiosurgery (SRS), and surgery followed by WBRT and then by adjuvant SRS. Five patients underwent surgery alone and nine patients were treated with radiation alone (WBRT, SRS, or both). Univariate analysis for predictors of survival demonstrated that age above 62.7 years at the time of central nervous system involvement was a significant risk factor and leptomeningeal disease was a poor prognostic factor in reference to supra-tentorial lesions. Multivariate analysis for predictors of survival, however, showed that multiple brain lesions (>4) were a poor prognostic factor, and multivariate analysis of the time to progression revealed that combined treatments of surgery and radiation resulted in longer median periods of progression-free survival than each modality alone.
    Conclusion: We conclude that the only significant predictors of survival or progression-free survival in our cohort were the number of brain metastases and the treatment modality.
    MeSH term(s) Aged ; Brain Neoplasms/mortality ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Combined Modality Therapy ; Cranial Irradiation ; Cystadenocarcinoma, Serous/mortality ; Cystadenocarcinoma, Serous/secondary ; Cystadenocarcinoma, Serous/therapy ; Databases, Factual ; Female ; Humans ; Middle Aged ; Neurosurgical Procedures ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/therapy ; Prognosis ; Retrospective Studies ; Survival Rate ; Treatment Outcome
    Language English
    Publishing date 2019-12-19
    Publishing country India
    Document type Journal Article
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.273627
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    Zs.A 698: Show issues Location:
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  4. Article ; Online: Role of Klotho Protein in Tumor Genesis, Cancer Progression, and Prognosis in Patients with High-Grade Glioma.

    Peshes-Yeloz, Naama / Ungar, Lior / Wohl, Anton / Jacoby, Elad / Fisher, Tamar / Leitner, Moshe / Nass, Dvora / Rubinek, Tamar / Wolf, Ido / Cohen, Zvi R

    World neurosurgery

    2019  Volume 130, Page(s) e324–e332

    Abstract: Background: Klotho, a single-pass transmembrane protein associated with premature aging, acts as a tumor suppressor gene by inhibiting insulin/insulin-like growth factor-1 and fibroblast growth factor pathways. Downregulated Klotho expression is ... ...

    Abstract Background: Klotho, a single-pass transmembrane protein associated with premature aging, acts as a tumor suppressor gene by inhibiting insulin/insulin-like growth factor-1 and fibroblast growth factor pathways. Downregulated Klotho expression is reported in melanoma, mesothelioma, bladder, breast, gastric, cervix, lung, and kidney cancers and is associated with a poor prognosis. Klotho expression and Klotho promoter hypermethylation are predictive factors for patient prognosis.
    Methods: To investigate the potential role of Klotho in glioblastoma-multiforme (GBM), 22 GBM samples were collected from the Sheba Tumor Bank and examined.
    Results: We found that increased Klotho messenger ribonucleic acid (RNA) expression predicted longer survival (P = 0.03) of GBM patients. Methylation analysis was performed on bisulfite-treated deoxyribonucleic acid from the GBM patient samples using ionization time-of-flight mass spectrometry according to the Sequenom EpiTYPER protocols. Klotho promoter hypermethylation was detected in 65% of the GBM samples and correlated significantly with improved survival (P < 0.04). We found 3 major Klotho promotor hypermethylation sites located 585-579 bp, 540-533 bp, and 537-534 bp upstream of the transcription start site. Methylated deoxyribonucleic acid immunoprecipitation studies confirmed these results. Notably, the messenger RNA expression in these GBM samples revealed an unexpected linear correlation with methylation of these 3 hypermethylation sites identified in the Klotho promotor. Thus Klotho expression and methylation could predict prognosis in patients with GBM.
    Conclusions: Epigenetic regulation in GBM appears to be complicated. Specific CpG islands affect genes or micro RNAs that interact to control Klotho expression. The diverse effects of these islands may be due to unique factors of GBM.
    MeSH term(s) Brain Neoplasms/diagnosis ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Glioblastoma/diagnosis ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Glioma/diagnosis ; Glioma/genetics ; Glioma/metabolism ; Glucuronidase/biosynthesis ; Glucuronidase/genetics ; Humans ; MCF-7 Cells ; Neoplasm Grading/methods ; Prognosis
    Chemical Substances Glucuronidase (EC 3.2.1.31) ; klotho protein (EC 3.2.1.31)
    Language English
    Publishing date 2019-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2019.06.082
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    Zs.A 1159: Show issues Location:
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  5. Article ; Online: Cerebral phaeohyphomycosis in an immunocompetent patient: a case report and literature summary.

    Litchevski, Vlady / Goldschmidt, Anna / Nass, Dvora / Rahav, Galia / Cohen, Zvi R

    Clinical neurology and neurosurgery

    2014  Volume 124, Page(s) 179–181

    MeSH term(s) Adult ; Antifungal Agents/therapeutic use ; Brain Abscess/diagnosis ; Brain Abscess/drug therapy ; Brain Abscess/microbiology ; Cerebral Phaeohyphomycosis/diagnosis ; Cerebral Phaeohyphomycosis/drug therapy ; Cerebral Phaeohyphomycosis/microbiology ; Humans ; Male ; Treatment Outcome ; Voriconazole/therapeutic use ; Young Adult
    Chemical Substances Antifungal Agents ; Voriconazole (JFU09I87TR)
    Language English
    Publishing date 2014-09
    Publishing country Netherlands
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2014.07.003
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  6. Article ; Online: Steroid-responsive, progressive, focal measles virus brain infection.

    Steiner, Israel / Livneh, Vered / Hoffmann, Chen / Nass, Dvora / Mor, Orna / Chapman, Joab

    Annals of neurology

    2014  Volume 75, Issue 6, Page(s) 967–970

    Abstract: Chronic measles virus infection of the brain causes subacute sclerosing panencephalitis (SSPE), a progressive, relentless fatal disorder. We report a 52-year-old male who developed focal, chronic persistent measles virus infection of the brain following ... ...

    Abstract Chronic measles virus infection of the brain causes subacute sclerosing panencephalitis (SSPE), a progressive, relentless fatal disorder. We report a 52-year-old male who developed focal, chronic persistent measles virus infection of the brain following interferon and ribavirin therapy for hepatitis C, and who responded to steroid therapy. This case, diametrically different from SSPE, has 2 unique features, its focal nature and its permissive response to steroids, that may add to the understanding of the pathogenesis of SSPE and the mechanism enabling viruses to evade the immune response and establish persistent brain infection.
    MeSH term(s) Antigens, CD/metabolism ; Encephalitis, Viral/drug therapy ; Encephalitis, Viral/pathology ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Measles virus/pathogenicity ; Middle Aged ; Steroids/therapeutic use
    Chemical Substances Antigens, CD ; Steroids
    Language English
    Publishing date 2014-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.24183
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    Zs.MO 478: Show issues

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  7. Article ; Online: α-methylacyl-CoA racemase (AMACR) expression in chordomas differentiates them from chondrosarcomas.

    Aviel-Ronen, Sarit / Zadok, Oranit / Vituri, Aya / Nass, Dvora / Schwartz, Ignat / Avivi, Camila / Barshack, Iris

    Scientific reports

    2016  Volume 6, Page(s) 21277

    Abstract: Aims: Chordomas and chondrosarcomas are malignant mesenchymal tumours with overlapping morphological and immunohistochemical (IHC) characteristics. Our aim was to evaluate the IHC expression of α-methylacyl-CoA racemase (AMACR/P504S), β-catenin and E- ... ...

    Abstract Aims: Chordomas and chondrosarcomas are malignant mesenchymal tumours with overlapping morphological and immunohistochemical (IHC) characteristics. Our aim was to evaluate the IHC expression of α-methylacyl-CoA racemase (AMACR/P504S), β-catenin and E-cadherin in chordomas relative to chondrosarcomas and assess the utility of these markers for differential diagnosis.
    Methods: Archival sections of 18 chordomas, 19 chondrosarcomas and 10 mature cartilage samples were immunostained and scored for AMACR, β-catenin and E-cadherin and the relative differential capacity of each marker was calculated. In addition, AMACR mRNA level was assessed in 5 chordomas by RT-PCR and evaluated by comparative CT method.
    Results: AMACR and β-catenin stained 88.9% and 94.1% of the chordomas respectively, 21.1% and 10.5% of the chondrosarcomas correspondingly and none of the mature cartilage samples. E-cadherin stained positively 82.4% of the chordomas, 36.8% of the chondrosarcomas and 42.9% of the mature cartilage cases. Both AMACR and β-catenin showed statistically significant difference between chordomas and chondrosarcomas (p < 0.001 for both), unlike E-cadherin. AMACR was detected at the mRNA level.
    Conclusions: AMACR is expressed in most of the chordomas but only in a minority of chondrosarcomas. AMACR may serve as IHC marker of chordoma with differentiating ability comparable to that of β-catenin.
    MeSH term(s) Biomarkers, Tumor/biosynthesis ; Cartilage/enzymology ; Cartilage/pathology ; Chondroma/enzymology ; Chondroma/pathology ; Chondrosarcoma/enzymology ; Chondrosarcoma/pathology ; Female ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Neoplasm Proteins/biosynthesis ; Racemases and Epimerases/biosynthesis
    Chemical Substances Biomarkers, Tumor ; Neoplasm Proteins ; Racemases and Epimerases (EC 5.1.-) ; alpha-methylacyl-CoA racemase (EC 5.1.99.4)
    Language English
    Publishing date 2016-02-18
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep21277
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  8. Article ; Online: Long-term response in high-grade optic glioma treated with medically induced hypothyroidism and carboplatin: a case report and review of the literature.

    Ashur-Fabian, Osnat / Blumenthal, Deborah T / Bakon, Mati / Nass, Dvora / Davis, Paul J / Hercbergs, Aleck

    Anti-cancer drugs

    2013  Volume 24, Issue 3, Page(s) 315–323

    Abstract: Glioblastoma multiforme (GBM) is the most malignant and frequent brain tumor, with an aggressive growth pattern and poor prognosis despite best treatment modalities. Long-term survival of patients with GBM is rare. Optic glioma represents 0.6-1.2% of all ...

    Abstract Glioblastoma multiforme (GBM) is the most malignant and frequent brain tumor, with an aggressive growth pattern and poor prognosis despite best treatment modalities. Long-term survival of patients with GBM is rare. Optic glioma represents 0.6-1.2% of all brain tumors. Unlike low-grade optic gliomas in children, optic gliomas in adults are highly aggressive and death usually occurs in less than a year. Prolonged progression-free survival and survival rates have been reported in association with induced hypothyroidism in two clinical trials for recurrent GBM. We present the clinical, radiological, and pathological findings in a patient with inoperable GBM of the optic chiasm. Following failure of initial, standard radiation and temozolomide therapy, chemical hypothyroidism was induced using the antithyroid thioamide, propylthiouracil, followed by carboplatin chemotherapy. Initial thyroid stimulating hormone, free T4, and free T3 analysis was carried out and then monthly. This patient responded rapidly to treatment (clinically and with tumor regression within 4 weeks) on two separate occasions with an extended remission period (2.5 years) and prolonged overall survival (4.5 years). We report the successful long-term tumor response to medically induced chemical hypothyroidism in conjunction with carboplatinum chemotherapy of an adult patient with grade IV GBM of the optic chiasm. These clinical observations find mechanistic support from the recent identification of potent mitogenic actions of the thyroid hormone, L-thyroxine, in malignant glioma through binding to a cognate thyroid hormone receptor on the αvβ3 integrin. Approaches to block its activity are now explored in preclinical studies.
    MeSH term(s) Antithyroid Agents/therapeutic use ; Carboplatin/therapeutic use ; Combined Modality Therapy ; Humans ; Hypothyroidism/blood ; Hypothyroidism/chemically induced ; Male ; Middle Aged ; Optic Chiasm/pathology ; Optic Nerve Glioma/drug therapy ; Optic Nerve Glioma/mortality ; Optic Nerve Glioma/pathology ; Optic Nerve Glioma/radiotherapy ; Propylthiouracil/therapeutic use ; Thyroxine/blood ; Treatment Outcome ; Triiodothyronine/blood
    Chemical Substances Antithyroid Agents ; Triiodothyronine (06LU7C9H1V) ; Propylthiouracil (721M9407IY) ; Carboplatin (BG3F62OND5) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2013-03
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1065301-6
    ISSN 1473-5741 ; 0959-4973
    ISSN (online) 1473-5741
    ISSN 0959-4973
    DOI 10.1097/CAD.0b013e32835c7a47
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  9. Article ; Online: Cerebellar tumor extension as a late event of long-standing, supratentorial low-grade gliomas: case report.

    Roth, Jonathan / Nass, Dvora / Ram, Zvi

    Neurosurgery

    2006  Volume 58, Issue 6, Page(s) E1210; discussion E1210

    Abstract: Objective and importance: Nonpilocytic low-grade glial tumors in adults occur mostly in the supratentorial compartment. However, a few cases of infratentorial low-grade gliomas (LGG) have been described. The occurrence of LGG in the cerebellum in the ... ...

    Abstract Objective and importance: Nonpilocytic low-grade glial tumors in adults occur mostly in the supratentorial compartment. However, a few cases of infratentorial low-grade gliomas (LGG) have been described. The occurrence of LGG in the cerebellum in the setting of a previously existing supratentorial glioma is rare.
    Clinical presentation: We present three young patients with a histologically confirmed diagnosis of long-standing supratentorial LGG. All three patients presented years after their initial diagnosis with a second, nonenhancing lesion in the cerebellum, compatible with the radiological appearance of LGG. Two patients subsequently became symptomatic from these lesions and underwent surgical resection of the cerebellar lesions that were found to have similar pathological features to the original supratentorial tumors. This was confirmed by histology (both patients) and genetic markers (one patient).
    Intervention: Magnetic resonance imaging did not demonstrate tumor continuity between the supratentorial and infratentorial lesions in any of the patients. The third patient has shown no cerebellar symptoms to date and is only followed with periodic magnetic resonance imaging.
    Conclusion: The anatomic/pathological basis of these rare cases may include a primary, multicentric tumor formation, or a secondary tumor infiltration of the cerebrocerebellar pathways, leading to the formation of the cerebellar tumor.
    MeSH term(s) Adult ; Cerebellar Neoplasms/diagnosis ; Female ; Glioma/diagnosis ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasms, Second Primary/diagnosis ; Supratentorial Neoplasms/diagnosis
    Language English
    Publishing date 2006-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/01.NEU.0000215987.74391.8E
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  10. Article: Presentation patterns and outcome of gliomatosis cerebri.

    Rajz, Gustavo G / Nass, Dvora / Talianski, Elisa / Pfeffer, Raphael / Spiegelmann, Roberto / Cohen, Zvi R

    Oncology letters

    2011  Volume 3, Issue 1, Page(s) 209–213

    Abstract: A total of 25 patients with gliomatosis cerebri (19 males and 6 females; median age 51 years, range 10-73 years) were diagnosed and treated at the Sheba Medical Center between 1995 and 2009. Of these, 3 patients were 10 years old at the time of diagnosis. ...

    Abstract A total of 25 patients with gliomatosis cerebri (19 males and 6 females; median age 51 years, range 10-73 years) were diagnosed and treated at the Sheba Medical Center between 1995 and 2009. Of these, 3 patients were 10 years old at the time of diagnosis. Seizures were the initial clinical presentation in 19 patients, focal signs in 16 patients, headaches in 7 patients, cognitive disorder in 4 patients and rapidly progressive hemiparesis in 1 patient. Magnetic resonance imaging (MRI) was performed in the patients and demonstrated a diffuse infiltrative process with a hyperintensity signal on T2-weighted images and a minimal mass effect. Some level of enhancement on MRI was observed in 6 patients. The infiltrative process involved at least two lobes in each patient. Biopsy was performed for diagnosis in the majority of patients. In 1 patient with a markedly rapid deterioration, the diagnosis was established at autopsy. The pathology was compatible with gliomatosis with a diffuse infiltrative low-grade astrocytoma in 21 patients and anaplastic astrocytoma in 5 patients. The patients were treated with whole-brain radiation therapy and 7 patients were treated with combined whole-brain radiation therapy and chemotherapy. Treatment appeared to stabilize 6 patients or improve the clinical condition in 7 patients. Due to the small number of patients in the present study, however, further studies are required to determine the effect of treatment on the natural history of the disease.
    Language English
    Publishing date 2011-10-18
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2011.445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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