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Article ; Online: Resurgence of Urgent-Start Peritoneal Dialysis in COVID-19 and Its Application to Advanced Heart Failure.

Nassiri, Amir Ahmad / Ronco, Claudio / Kazory, Amir

2021 Volume 11, Issue 1, Page(s) 1–4

MeSH term(s)	Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Ambulatory Care ; COVID-19/complications ; COVID-19/epidemiology ; Heart Failure/therapy ; Humans ; Pandemics ; Peritoneal Dialysis ; SARS-CoV-2
Language	English
Publishing date	2021-01-07
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2595659-0
ISSN	1664-5502 ; 1664-3828
ISSN (online)	1664-5502
ISSN	1664-3828
DOI	10.1159/000513496
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Article ; Online: The Renal Histopathological Findings in Patients with Renal Allograft Dysfunction: A Retrospective Single Center Study.

Mohammadi Afrakoti, Mana / Nassiri, Amir Ahmad / Hakemi, Monir Sadat / Afroughe, Arya / Ganji, Mohammad Reza

Iranian journal of kidney diseases

2023 Volume 17, Issue 3, Page(s) 168–173

Abstract: Introduction: Despite many advances in the development of knowledge and application of new immunosuppressive medications over the past two decades, the improvement has only been seen in the short-term outcome of kidney transplantation while the long- ... ...

Abstract	Introduction: Despite many advances in the development of knowledge and application of new immunosuppressive medications over the past two decades, the improvement has only been seen in the short-term outcome of kidney transplantation while the long-term survival of kidney transplantation has not significantly improved. Allograft kidney biopsy may help to determine the causes of allograft dysfunction which may change the treatment strategy. Methods: In this retrospective study, kidney transplant recipients who underwent kidney biopsy in Shariati hospital during the years 2004 to 2015, at least three months after the kidney transplantation, were included for evaluation. Chi-square, ANOVA, post-hoc LSD, and T-test were used for data analysis. Results: A total number of 525 renal transplant biopsies were performed; 300 of them had complete medical records. The reported pathologies consisted of acute T-Cell mediated rejection (TCMR) (17%), interstitial fibrosis and tubular atrophy/chronic allograft nephropathy (IFTA/CAN) (15%), calcineurin inhibitor (CNI) nephrotoxicity (12.8%), borderline changes (10.3%), glomerulonephritis (GN) (8.9%), antibody mediated rejection (ABMR) (6.7%), transplant glomerulopathy (TG) (5.3%), normal (8.4%), and other pathologies (15.6%). C4d was positive in 19.9% of the biopsies. The pathology category had a significant correlation with allograft function (P < .001), but it had no significant relationship with age and gender of the recipient, donor and donor source (P > .05). Moreover, in about 50% of cases, treatment interventions were based on pathological results, which were effective in 77% of cases. The two-year graft and patient survival after kidney biopsy were 89% and 98%, respectively. Conclusion: Acute TCMR, IFTA/CAN, CNI nephrotoxicity were the most common causes of allograft dysfunction based on the transplanted kidney biopsy. In addition, pathologic reports were helpful for proper treatment. DOI: 10.52547/ijkd.7256.
MeSH term(s)	Humans ; Kidney Transplantation/adverse effects ; Retrospective Studies ; Graft Rejection ; Transplantation, Homologous ; Kidney ; Kidney Diseases/pathology ; Biopsy ; Allografts/pathology ; Graft Survival
Language	English
Publishing date	2023-07-05
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2388271-2
ISSN	1735-8604 ; 1735-8582
ISSN (online)	1735-8604
ISSN	1735-8582
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Article ; Online: Comparison Between Vancomycin Lock and Taurolock Solution for the Prevention of Catheter- related Infections in Hemodialysis Patients, A Multicenter Study.

Nassiri, Amir Ahmad / Ahmadi Koomleh, Azadeh / Sabaghian, Tahereh / Delgosha, Maryam / Hakemi, Monir Sadat

Iranian journal of kidney diseases

2023 Volume 17, Issue 4, Page(s) 215–221

Abstract: Introduction: Central venous catheters, frequently used in patients undergoing hemodialysis, place the patients at high risk of catheter-related infections. Therefore, it is essential to select the optimal prevention protocol for these infections. This ... ...

Abstract	Introduction: Central venous catheters, frequently used in patients undergoing hemodialysis, place the patients at high risk of catheter-related infections. Therefore, it is essential to select the optimal prevention protocol for these infections. This study aims to compare the efficacy of the Taurolock solution and antibiotic lock in preventing tunneled catheter (permcath) related infections. Methods: This multicenter study was conducted between June 2020 and July 2021 on 86 hemodialysis patients with a central venous catheter from four dialysis centers in Tehran, Iran. The patients were randomly assigned into two groups. The first group received Taurolock, and the second group received antibiotic lock (a combination of vancomycin and heparin) at the end of each dialysis session. Peripheral blood and catheter blood samples were collected once before the intervention and monthly thereafter, for up to six months, and blood culture performed for detection of various bacterial strains. Results: The findings showed no significant difference in the infection rate (positive peripheral blood or catheter cultures) between the Taurolock and vancomycin groups (P > .05). Additionally, there was no significant difference in the duration of catheter implantation in individuals with positive and negative cultures (P > .05). Furthermore, no significant correlation was found between comorbidities and catheter-related infection in patients of the two groups (P > .05). Conclusion: There was no significant difference between the two groups in the rate of catheter-related infection. Therefore, vancomycin lock solutions can be good alternatives to Taurolock solution for preventing catheter-related infections. DOI: 10.52547/ijkd.7615.
MeSH term(s)	Humans ; Vancomycin/therapeutic use ; Catheter-Related Infections/prevention & control ; Iran ; Anti-Bacterial Agents/therapeutic use ; Central Venous Catheters/adverse effects ; Renal Dialysis/adverse effects
Chemical Substances	Vancomycin (6Q205EH1VU) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-08-27
Publishing country	Iran
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	2388271-2
ISSN	1735-8604 ; 1735-8582
ISSN (online)	1735-8604
ISSN	1735-8582
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Article ; Online: Acute Kidney Injury Outcome in COVID-19 Patients.

Sabaghian, Tahereh / Ahmadi Koomleh, Azadeh / Nassiri, Amir Ahmad / Kharazmi, Amir Behnam / Khalili, Shayesteh

Iranian journal of kidney diseases

2022 Volume 1, Issue 1, Page(s) 44–51

Abstract: Introduction: Despite the high incidence of AKI in patients with COVID-19, the characteristics and consequences of this condition have not been well studied.: Methods: This retrospective cohort study investigated the clinical characteristics, ... ...

Abstract	Introduction: Despite the high incidence of AKI in patients with COVID-19, the characteristics and consequences of this condition have not been well studied. Methods: This retrospective cohort study investigated the clinical characteristics, treatment methods, and outcome of COVID-19 patients aged 18 years and older who were hospitalized in Imam Hossein Hospital, Tehran, from February 20th, 2020 to June 20th, 2020. Results: Out of the total 367 patients with COVID-19, 104 (28%) patients were diagnosed with AKI at the time of admission or during hospitalization, 86 (23%) and 18 (5%) patients were diagnosed with the AKI on admission (early AKI) and after the first 24 h (late AKI), respectively. Concerning the AKI stages, 20 (19%) and 18 (17%) patients were in stages 2 and 3, and the cause of AKI in 52 (50%) patients was renal. Moreover, out of all patients with AKI, 25 (24%) and 29 (28%) patients had transient (Kidney function improvement within 48 h) and persistent AKI (kidney function improvement between 48 h to 7 days). Furthermore, 32 (31%) patients developed acute kidney damage (AKD) (no improvement in AKI after 7 days). The survival rate of AKI patients was lower in higher stages of AKI, and in cases that the reason for kidney dysfunction was renal or unknown. However, there was no difference in the mortality rate between the early and late AKI. Conclusion: Since about one-third of the patients with AKI eventually develop AKD, it is of great importance to closely monitor all COVID-19 patients, especially the high-risk ones, for the appropriate diagnosis and treatment of AKI. DOI: 10.52547/ijkd.6610.
MeSH term(s)	Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Adolescent ; COVID-19/complications ; COVID-19/therapy ; Humans ; Iran/epidemiology ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2022-03-10
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2388271-2
ISSN	1735-8604 ; 1735-8582
ISSN (online)	1735-8604
ISSN	1735-8582
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Article ; Online: The potential role of extracorporeal cytokine removal with CytoSorb® as an adjuvant therapy in Acute Respiratory Distress Syndrome.

Tomescu, Dana / Popescu, Mihai / Akil, Ali / Nassiri, Amir Ahmad / Wunderlich-Sperl, Florian / Kogelmann, Klaus / Molnar, Zsolt / Alharthy, Abdulrahman / Karakitsos, Dimitrios

The International journal of artificial organs

2023 Volume 46, Issue 12, Page(s) 605–617

Abstract: Management of acute respiratory distress syndrome (ARDS) represents one of the greatest challenges in intensive care and despite all efforts mortality remains high. One common phenotype of ARDS is that of a secondary injury to a dysregulated inflammatory ...

Abstract	Management of acute respiratory distress syndrome (ARDS) represents one of the greatest challenges in intensive care and despite all efforts mortality remains high. One common phenotype of ARDS is that of a secondary injury to a dysregulated inflammatory host response resulting in increased capillary congestion, interstitial lung edema, atelectasis, pulmonary embolism, muscle wasting, recurring infectious episodes, and multiple organ failure. In cases of hyperinflammation, immunomodulation by extracorporeal cytokine removal such as the CytoSorb hemoadsorption cartridge could conceptually enhance lung recovery during the early course of the disease. The aim of this narrative review is to summarize the currently available data in this field and to provide an overview of pathophysiology and rationale for the use of CytoSorb hemoadsorption in patients with hyperinflammatory ARDS.
MeSH term(s)	Humans ; Cytokines ; Extracorporeal Membrane Oxygenation/methods ; Hemoperfusion/methods ; Multiple Organ Failure ; Respiratory Distress Syndrome/therapy
Chemical Substances	Cytokines
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80456-3
ISSN	1724-6040 ; 0391-3988
ISSN (online)	1724-6040
ISSN	0391-3988
DOI	10.1177/03913988231211740
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Zs.A 1439: Show issues

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Article ; Online: Blood purification with CytoSorb in critically ill COVID-19 patients: A case series of 26 patients.

Nassiri, Amir Ahmad / Hakemi, Monir Sadat / Miri, Mir Mohammad / Shahrami, Reza / Koomleh, Azadeh Ahmadi / Sabaghian, Tahereh

Artificial organs

2021 Volume 45, Issue 11, Page(s) 1338–1347

Abstract: Severe forms of the coronavirus disease 2019 (COVID-19) can progress to sepsis-like complications accompanied by "cytokine storm" for which the most effective treatment has not yet been established. Our study describes the results of CytoSorb ... ...

Abstract	Severe forms of the coronavirus disease 2019 (COVID-19) can progress to sepsis-like complications accompanied by "cytokine storm" for which the most effective treatment has not yet been established. Our study describes the results of CytoSorb hemoadsorption in COVID-19 patients treated on the intensive care unit (ICU). In this retrospective study, 26 patients with COVID-19 and acute respiratory distress syndrome (ARDS) were treated with hemoadsorption therapy. Pre-, and post-treatment values (clinical and laboratory) were compared. Data are expressed as mean (confidence intervals, CI), or median [interquartile ranges, IQR], as appropriate. Patients received 2 hemoadsorption treatments. This resulted in a significant decrease in norepinephrine requirements, and inflammatory marker plasma concentrations (procalcitonin, C-reactive protein, ferritin) when comparing pre versus post treatment levels. The PaO
MeSH term(s)	Biomarkers/blood ; COVID-19/mortality ; COVID-19/therapy ; Comorbidity ; Critical Illness ; Cytokine Release Syndrome/therapy ; Cytokine Release Syndrome/virology ; Female ; Hemadsorption ; Hospital Mortality ; Humans ; Intensive Care Units ; Iran ; Male ; Middle Aged ; Organ Dysfunction Scores ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Retrospective Studies ; SARS-CoV-2 ; Survival Rate
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-07-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.14024
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Zs.A 1463: Show issues

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Article ; Online: Re: Interferon-gamma release assay agreement with tuberculin skin test in pretransplant screening for latent tuberculosis in a high-prevalence country.

Nassiri, Amir Ahmad / Tabarsi, Payam

Iranian journal of kidney diseases

2014 Volume 8, Issue 5, Page(s) 432–433

MeSH term(s)	Female ; Humans ; Interferon-gamma Release Tests ; Kidney Failure, Chronic ; Kidney Transplantation ; Latent Tuberculosis/diagnosis ; Male ; Tuberculin Test
Language	English
Publishing date	2014-09
Publishing country	Iran
Document type	Comment ; Letter
ZDB-ID	2388271-2
ISSN	1735-8604 ; 1735-8582
ISSN (online)	1735-8604
ISSN	1735-8582
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Article: Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements.

Mehta, Yatin / Paul, Rajib / Ansari, Abdul Samad / Banerjee, Tanmay / Gunaydin, Serdar / Nassiri, Amir Ahmad / Pappalardo, Federico / Premužić, Vedran / Sathe, Prachee / Singh, Vinod / Vela, Emilio Rey

World journal of critical care medicine

2023 Volume 12, Issue 2, Page(s) 71–88

Abstract: Background: Despite various therapies to treat sepsis, it is one of the leading causes of mortality in the intensive care unit patients globally. Knowledge about the pathophysiology of sepsis has sparked interest in extracorporeal therapies (ECT) which ... ...

Abstract	Background: Despite various therapies to treat sepsis, it is one of the leading causes of mortality in the intensive care unit patients globally. Knowledge about the pathophysiology of sepsis has sparked interest in extracorporeal therapies (ECT) which are intended to balance the dysregulation of the immune system by removing excessive levels of inflammatory mediators. Aim: To review recent data on the use of ECT in sepsis and to assess their effects on various inflammatory and clinical outcomes. Methods: In this review, an extensive English literature search was conducted from the last two decades to identify the use of ECT in sepsis. A total of 68 articles from peer-reviewed and indexed journals were selected excluding publications with only abstracts. Results: Results showed that ECT techniques such as high-volume hemofiltration, coupled plasma adsorption/filtration, resin or polymer adsorbers, and CytoSorb Conclusion: Clinical acceptance of ECT in sepsis and septic shock is currently still limited due to a lack of large random clinical trials. In addition to patient-tailored therapies, future research developments with therapies targeting the cellular level of the immune response are expected.
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2220-3141
ISSN	2220-3141
DOI	10.5492/wjccm.v12.i2.71
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Article ; Online: Serum magnesium level and cardiovascular disease in dialysis patients.

Nassiri, Amir Ahmad / Hakemi, Monir Sadat

Iranian journal of kidney diseases

2013 Volume 7, Issue 1, Page(s) 2–4

MeSH term(s)	Cardiovascular Diseases/blood ; Female ; Humans ; Kidney Failure, Chronic/blood ; Magnesium/blood ; Male ; Renal Dialysis
Chemical Substances	Magnesium (I38ZP9992A)
Language	English
Publishing date	2013-01
Publishing country	Iran
Document type	Comment ; Journal Article
ZDB-ID	2388271-2
ISSN	1735-8604 ; 1735-8582
ISSN (online)	1735-8604
ISSN	1735-8582
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Article ; Online: Benefit of Hemoadsorption Therapy in Patients Suffering Sepsis-Associated Acute Kidney Injury: A Case Series.

Hakemi, Monir Sadat / Nassiri, Amir Ahmad / Nobakht, Ali / Mardani, Masoud / Darazam, Ilad Alavi / Parsa, Maziyar / Miri, Mir Mohammmad / Shahrami, Reza / Koomleh, Azadeh Ahmadi / Entezarmahdi, Kiana / Karimi, Anita

Blood purification

2022 Volume 51, Issue 10, Page(s) 823–830

Abstract: Introduction: Sepsis is defined as life-threatening organ dysfunction in result of the host's dysregulated response to infection and septic shock. Sepsis-associated kidney injury is usually defined as concurrent presence of acute kidney injury (AKI) and ...

Abstract	Introduction: Sepsis is defined as life-threatening organ dysfunction in result of the host's dysregulated response to infection and septic shock. Sepsis-associated kidney injury is usually defined as concurrent presence of acute kidney injury (AKI) and sepsis without other significant causative factors. Method: The current retrospective study was conducted to elucidate beneficial and side effects of CytoSorb®. A total of 17 patients were primarily treated with continuous renal replacement therapy in combination with CytoSorb. The demand for norepinephrine, mean arterial pressure, lactate, and procalcitonin (PCT) levels, as well as ICU length of stay, was measured. Result: The blood lactate levels decreased by 32.30% when comparing mean levels before and after treatment. All patients who survived (n = 14) had reduction in vasopressor demand to 68.96% of their initial dose before the start of treatment. Hospital survival was greater in patients who initially had higher vasopressor demand compared to their nonsurviving counterparts, but in whom vasopressor dosages were reduced significantly during their treatments. Mortality as predicted by APACHE II score in the overall patient population was 79.9%, whereas, the observed ICU mortality was 31%. The baseline PCT levels on patients received 1, 2, and 3 CytoSorbs were 27.08 ± 5.81 ng/mL, 13.28 ± 2.62 ng/mL, and 21.03 ± 6.56 ng/mL, respectively. Observed PCT levels at 24 h after the last treatment on patients received 1, 2, and 3 CytoSorb were 31.55 ± 15.70 ng/mL, 5.61 ± 1.77 ng/mL, and 8.11 ± 3.62 ng/mL, respectively. Conclusion: In conclusion, it seems that applying the CytoSorb in combination with CRRT in ICU septic patients with AKI, is related to a significant decrease in mortality, if the integrity and continuity of the treatment be kept, as much as possible. This study presented an effectively positive outcome with cytokine adsorber treatment as an adjuvant along with standard treatment in a high-risk mortality case of septic shock with organ failure.
MeSH term(s)	Acute Kidney Injury/complications ; Acute Kidney Injury/therapy ; Cytokines ; Humans ; Lactates ; Norepinephrine ; Procalcitonin ; Retrospective Studies ; Sepsis/complications ; Sepsis/therapy ; Shock, Septic/therapy ; Vasoconstrictor Agents
Chemical Substances	Cytokines ; Lactates ; Procalcitonin ; Vasoconstrictor Agents ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2022-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000521228
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