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  1. Article: A dual lanthanide probe suitable for optical (Tb3+ luminescence) and magnetic resonance imaging (Gd3+ relaxometry).

    Picard, Claude / Geum, Neri / Nasso, Isabelle / Mestre, Béatrice / Tisnès, Pierre / Laurent, Sophie / Muller, Robert N / Elst, Luce Vander

    Bioorganic & medicinal chemistry letters

    2006  Volume 16, Issue 20, Page(s) 5309–5312

    Abstract: A new polyaminocarboxylate ligand derived from N,C-pyrazolylpyridine was synthesized. The luminescence and relaxometry properties of its Tb(3+) and Gd(3+) chelates were investigated in aqueous solutions. The Tb(3+) chelate is strongly luminescent having ... ...

    Abstract A new polyaminocarboxylate ligand derived from N,C-pyrazolylpyridine was synthesized. The luminescence and relaxometry properties of its Tb(3+) and Gd(3+) chelates were investigated in aqueous solutions. The Tb(3+) chelate is strongly luminescent having remarkable lifetime and quantum yield (tau=1.82ms and Phi=0.42). The 1/T(1) proton relaxivity at 20MHz and 25 degrees C (5.3s(-1)mM(-1)) of the Gd(3+) chelate was found to be comparable to that of the clinically used Gd-DTPA.
    MeSH term(s) Chelating Agents/chemical synthesis ; Chelating Agents/chemistry ; Gadolinium/chemistry ; Ligands ; Luminescence ; Magnetic Resonance Imaging/methods ; Molecular Structure ; Pyrazoles/chemistry ; Pyridines/chemistry ; Quantum Theory ; Sensitivity and Specificity ; Solutions/chemistry ; Terbium/chemistry ; Water/chemistry
    Chemical Substances Chelating Agents ; Ligands ; Pyrazoles ; Pyridines ; Solutions ; Water (059QF0KO0R) ; Terbium (06SSF7P179) ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2006-10-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2006.07.091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bimodal system (luminophore and paramagnetic contrastophore) derived from Ln(III) complexes based on a bipyridine-containing macrocyclic ligand.

    Nasso, Isabelle / Galaup, Chantal / Havas, Fabien / Tisnès, Pierre / Picard, Claude / Laurent, Sophie / Vander Elst, Luce / Muller, Robert N

    Inorganic chemistry

    2005  Volume 44, Issue 23, Page(s) 8293–8305

    Abstract: The synthesis of a new 15-membered polyaza-macrocyclic ligand L3H3, which is based on a 2,2'-bipyridine moiety and a diethylenetriaminetriacetic acid core, is reported. The lanthanide chelates of this octadentate ligand were programmed for bimodal probes, ...

    Abstract The synthesis of a new 15-membered polyaza-macrocyclic ligand L3H3, which is based on a 2,2'-bipyridine moiety and a diethylenetriaminetriacetic acid core, is reported. The lanthanide chelates of this octadentate ligand were programmed for bimodal probes, luminescent agents (Sm, Eu, Tb, Dy), and magnetic resonance imaging agents (Gd3+). The neutral 1:1 complexes with these Ln3+ ions were prepared and studied in aqueous solution by luminescence and NMR techniques. The main photophysical characteristics of these complexes (i.e., the absorption and luminescence spectra, the metal-centered lifetimes, and the overall luminescence yields, Phi) were measured. In addition, the role played by nonradiative pathways (vibrational energy transfer involving coordinated water molecules, involvement of ligand-to-metal charge-transfer excited states, or metal --> ligand back transfer) is discussed. The L3.Eu and L3.Tb complexes show very bright luminescence when photoexcited from the lowest-energy absorption band of the bipyridine chromophore. The luminescence quantum yields in an air-equilibrated water solution at room temperature are 0.10 and 0.21, respectively, despite the presence of one water molecule in the first coordination sphere of the metal ion. NMR data show that L3.Gd contains also one H2O molecule in the inner sphere. The proton longitudinal relaxivity, r1, of this complex is 3.4 s(-1) mM(-1) (0.47 T, 310 K) and the rotational correlation time, tau(R), is 57 ps (310 K). These values are comparable to those of the clinically used Gd-DTPA. Interestingly, the water exchange rate between the coordination site and the bulk solvent is slow (tau(M) = 3.5 micros at 310 K). The presence of water molecules in the second sphere and in rapid exchange with the solvent is discussed. Finally, it was found by luminescence and NMR experiments that these lanthanide complexes are stable versus transmetalation by several cations (especially Ca2+ and Zn2+) at physiological pH and have no interaction with blood proteins.
    Language English
    Publishing date 2005-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/ic0507722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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