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  1. Article: Polymalic acid-based nano biopolymers for targeting of multiple tumor markers: an opportunity for personalized medicine?

    Ljubimova, Julia Y / Ding, Hui / Portilla-Arias, Jose / Patil, Rameshwar / Gangalum, Pallavi R / Chesnokova, Alexandra / Inoue, Satoshi / Rekechenetskiy, Arthur / Nassoura, Tala / Black, Keith L / Holler, Eggehard

    Journal of visualized experiments. 2014 June 13, , no. 88

    2014  

    Abstract: Tumors with similar grade and morphology often respond differently to the same treatment because of variations in molecular profiling. To account for this diversity, personalized medicine is developed for silencing malignancy associated genes. Nano drugs ...

    Abstract Tumors with similar grade and morphology often respond differently to the same treatment because of variations in molecular profiling. To account for this diversity, personalized medicine is developed for silencing malignancy associated genes. Nano drugs fit these needs by targeting tumor and delivering antisense oligonucleotides for silencing of genes. As drugs for the treatment are often administered repeatedly, absence of toxicity and negligible immune response are desirable. In the example presented here, a nano medicine is synthesized from the biodegradable, non-toxic and non-immunogenic platform polymalic acid by controlled chemical ligation of antisense oligonucleotides and tumor targeting molecules. The synthesis and treatment is exemplified for human Her2-positive breast cancer using an experimental mouse model. The case can be translated towards synthesis and treatment of other tumors.
    Keywords animal models ; biodegradability ; biopolymers ; breast neoplasms ; drugs ; genes ; humans ; immune response ; nanomedicine ; oligonucleotides ; precision medicine ; toxicity
    Language English
    Dates of publication 2014-0613
    Size p. e50668.
    Publishing place Journal of Visualized Experiments
    Document type Article
    ZDB-ID 2259946-0
    ISSN 1940-087X
    ISSN 1940-087X
    DOI 10.3791/50668
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Polymalic acid-based nano biopolymers for targeting of multiple tumor markers: an opportunity for personalized medicine?

    Ljubimova, Julia Y / Ding, Hui / Portilla-Arias, Jose / Patil, Rameshwar / Gangalum, Pallavi R / Chesnokova, Alexandra / Inoue, Satoshi / Rekechenetskiy, Arthur / Nassoura, Tala / Black, Keith L / Holler, Eggehard

    Journal of visualized experiments : JoVE

    2014  , Issue 88

    Abstract: Tumors with similar grade and morphology often respond differently to the same treatment because of variations in molecular profiling. To account for this diversity, personalized medicine is developed for silencing malignancy associated genes. Nano drugs ...

    Abstract Tumors with similar grade and morphology often respond differently to the same treatment because of variations in molecular profiling. To account for this diversity, personalized medicine is developed for silencing malignancy associated genes. Nano drugs fit these needs by targeting tumor and delivering antisense oligonucleotides for silencing of genes. As drugs for the treatment are often administered repeatedly, absence of toxicity and negligible immune response are desirable. In the example presented here, a nano medicine is synthesized from the biodegradable, non-toxic and non-immunogenic platform polymalic acid by controlled chemical ligation of antisense oligonucleotides and tumor targeting molecules. The synthesis and treatment is exemplified for human Her2-positive breast cancer using an experimental mouse model. The case can be translated towards synthesis and treatment of other tumors.
    MeSH term(s) Animals ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/drug therapy ; Breast Neoplasms/enzymology ; Female ; Gene Silencing ; Humans ; Malates/administration & dosage ; Malates/chemical synthesis ; Malates/chemistry ; Malates/metabolism ; Mice ; Mice, Nude ; Molecular Targeted Therapy/methods ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Oligonucleotides, Antisense/administration & dosage ; Oligonucleotides, Antisense/chemistry ; Oligonucleotides, Antisense/genetics ; Physarum polycephalum/genetics ; Physarum polycephalum/metabolism ; Polymers/administration & dosage ; Polymers/chemical synthesis ; Polymers/chemistry ; Polymers/metabolism ; Precision Medicine/methods ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/biosynthesis ; Receptor, ErbB-2/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
    Chemical Substances Biomarkers, Tumor ; Malates ; Oligonucleotides, Antisense ; Polymers ; poly(malic acid) ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2014-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/50668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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